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Research article

Stability of HHV-8 and HIV-1 co-infection model with latent reservoirs and multiple distributed delays

  • Human immunodeficiency virus type 1 (HIV-1) gradually destroys the CD4+ T cells leading to immune system dysfunction. HIV-1 can result in acquired immunodeficiency syndrome (AIDS) if antiretroviral drugs are not used. HIV/AIDS patients are more vulnerable to opportunistic infections or cancers. Human herpesvirus 8 (HHV-8) targets B cells and causes an AIDS-related cancer known as kaposi sarcoma (KS). Numerous investigations have demonstrated co-infection instances between HIV-1 and HHV-8. In this research, we investigated the co-dynamics of HIV-1 and HHV-8 in vivo using a system of delay differential equations (DDEs). The model explained the interactions between uninfected CD4+ T cells, latently/actively HIV-1-infected CD4+ T cells, free HIV-1 particles, uninfected B cells, latently/actively HHV-8-infected B cells, and free HHV-8 particles. Eight distributed-time delays were incorporated into the model to account for the delays that arose during the generation of both actively and latently infected cells, the activation of latent reservoirs, and the maturation of freshly discharged virions. By examining the nonnegativity and boundedness of the solutions, we demonstrated that the model was both mathematically and biologically well-posed. We calculated the model's equilibria and threshold numbers. We studied the global asymptotic stability of the model's equilibria by building appropriate Lyapunov functionals and applying the Lyapunov-LaSalle asymptotic stability theorem. Numerical simulations were used to display the results. For the basic reproduction numbers of HHV-8 single-infection (R1) and HIV-1 single-infection (R2), sensitivity analysis was carried out. Comparing HIV-1 or HHV-8 single infections with co-infections of HHV-8 and HIV-1 was shown. It's interesting to note that we detected larger amounts of HHV-8 and HIV-1 when they co-infect than when they are infected alone. This outcome aligned with several findings seen in the literature. The effect of antiviral drugs and time delays on the co-dynamics of HIV-1 and HHV-8 was investigated. We found that the delay parameter and drug effectiveness both contributed to a decrease in the basic reproduction numbers, R1 and R2. Less treatment efficacies will be needed to keep the system at the infection-free equilibrium and remove HIV-1 and HHV-8 from the body if a model with time delays is employed.

    Citation: A. M. Elaiw, E. A. Almohaimeed, A. D. Hobiny. Stability of HHV-8 and HIV-1 co-infection model with latent reservoirs and multiple distributed delays[J]. AIMS Mathematics, 2024, 9(7): 19195-19239. doi: 10.3934/math.2024936

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  • Human immunodeficiency virus type 1 (HIV-1) gradually destroys the CD4+ T cells leading to immune system dysfunction. HIV-1 can result in acquired immunodeficiency syndrome (AIDS) if antiretroviral drugs are not used. HIV/AIDS patients are more vulnerable to opportunistic infections or cancers. Human herpesvirus 8 (HHV-8) targets B cells and causes an AIDS-related cancer known as kaposi sarcoma (KS). Numerous investigations have demonstrated co-infection instances between HIV-1 and HHV-8. In this research, we investigated the co-dynamics of HIV-1 and HHV-8 in vivo using a system of delay differential equations (DDEs). The model explained the interactions between uninfected CD4+ T cells, latently/actively HIV-1-infected CD4+ T cells, free HIV-1 particles, uninfected B cells, latently/actively HHV-8-infected B cells, and free HHV-8 particles. Eight distributed-time delays were incorporated into the model to account for the delays that arose during the generation of both actively and latently infected cells, the activation of latent reservoirs, and the maturation of freshly discharged virions. By examining the nonnegativity and boundedness of the solutions, we demonstrated that the model was both mathematically and biologically well-posed. We calculated the model's equilibria and threshold numbers. We studied the global asymptotic stability of the model's equilibria by building appropriate Lyapunov functionals and applying the Lyapunov-LaSalle asymptotic stability theorem. Numerical simulations were used to display the results. For the basic reproduction numbers of HHV-8 single-infection (R1) and HIV-1 single-infection (R2), sensitivity analysis was carried out. Comparing HIV-1 or HHV-8 single infections with co-infections of HHV-8 and HIV-1 was shown. It's interesting to note that we detected larger amounts of HHV-8 and HIV-1 when they co-infect than when they are infected alone. This outcome aligned with several findings seen in the literature. The effect of antiviral drugs and time delays on the co-dynamics of HIV-1 and HHV-8 was investigated. We found that the delay parameter and drug effectiveness both contributed to a decrease in the basic reproduction numbers, R1 and R2. Less treatment efficacies will be needed to keep the system at the infection-free equilibrium and remove HIV-1 and HHV-8 from the body if a model with time delays is employed.



    In recent years, neural networks (NNs) have garnered significant attention due to their successful applications, and there has been a notable focus on the dynamical analysis of various kinds of NNs due to their importance as significant categories of non-linear mathematical models that can be used in addressing many categories of engineering challenges in optimization, image processing, and other engineering disciplines [1,2,3,4]. Numerous NNs are available for selection, such as cellular NNs, recurrent NNs, Hopfield NNs, Cohen-Grossberg NNs, and BAM NNs. We use NNs to solve technical difficulties such as signal processing, pattern recognition, and combinatorial optimization. However, a common challenge in the development and hardware implementation of NNs is the imprecision of NNs parameters, such as the inherent variability of network circuit parameters. Estimation errors occur during the network design process when looking at important data such as neuron firing rate, synaptic connection strength, and signal transmission delay, although it is possible to look at the ranges and limits of these parameters. Consequently, a successful model needs to possess certain attributes. As a result, certain resilience characteristics must be present in an effective model. Furthermore, a single equilibrium point plays a crucial role in the modification of the network model. Dynamical NNs are largely based on many types of equilibrium point stability analysis. Many researchers have looked at different ways to find stability, including GARS, full stability, and exponential stability of dynamic models with time delays in various works [5,6,7,8,9]. Researchers have already shown different stability analysis results for time-delayed NNs using Lyapunov and non-smooth analysis to look at stability and instability. In literature, the stability criteria of delayed NNs using delay-dependent results are discussed in [10,11,12]. Consequently, a significant issue is the analysis of GARS and control techniques of many multiple time-delayed BAM NNs. Many researchers have only recently focused on studying it [13,14].

    BAM is a significant NNs technique that was first presented by B. Kosko [15,16]. The BAM NNs have two layers of neurons. A single layer of neurons lacks interconnectivity. The BAM NNs range from a monolayer auto-switching to a double-layer pattern-matched hetero junction chain that stores both forward and backward pattern pairs. Many researchers have studied in detail the dynamic characteristics and applications of BAM NNs to solve many real-time issues, including automatic control, optimization, signal processing, and pattern recognition. Some global asymptotic stability of BAM NNs with S-type distributed delays is discussed in [17]. The global stability analysis of fractional-order quaternion-valued BAM NNs is discussed in [18]. The global asymptotic stability of periodic solutions for neutral-type delayed BAM NNs by combining an abstract theorem of k-set contractive operator with the LMI method is discussed in [19]. The global asymptotic stability of periodic solutions for neutral-type BAM NNs with delays is discussed in[20]. The literature has also reported time delays in BAM NNs for GARS. In[21,22], the issue of synchronization in uncertain delayed fractional order BAM NNs is examined with state feedback control and parameters. Taking into account cost efficiency and the longevity of equipment, infinite-time synchronization is not the optimal selection in engineering contexts such as secure communication and image encryption. Moreover, we can classify the result of BAM NNs into three distinct categories. Earlier research on BAM NNs identified only two types: models with time delays and models without time delays. In the literature, many authors have looked into the stability outcomes of the two types listed above. The hybrid form of the BAM NNs is a newer research topic. In this type, both the delay and the immediate signal occur simultaneously. A precise resolution is necessary for every conceivable initial condition in hybrid BAM NNs. From a mathematical perspective, this indicates that the GARS function caused a delay in the NNs reaching the time equilibrium point. Several authors have discussed the GARS of the hybrid BAM NNs[23,24,25,26,27,28]. The study of the global stability of synaptic connection matrices in NNs leads to interval matrix theory. This will result in a significant increase in computational capacity. So, there is much room left for us to investigate the GARS of hybrid BAM NNs with temporal delays.

    The novelty of this paper deals with the GARS of hybrid BAM NNs that have time delays. The main objective of this research is to establish extensive criteria for the global asymptotic robustness of hybrid BAM NNs with delays. We also use the upper limit for the norms of interconnection matrices, Lyapunov-Krasovskii functionals (LKF), and certain activation functions to find results that make sure hybrid BAM NNs are stable. Finally, we implement a numerical example to demonstrate the efficacy of the proposed results.

    Notations: The notations that will be utilized in this paper are as follows: Rn denotes n-dimensional Euclidean space, and Rn×m is the set of all real matrices of n×m. Define E as a matrix with elements eij for n×m. The 2-norm of matrix E equals the square root of the maximum eigenvalue of ETE. The absolute value of a matrix E=(eij)n×m with real numbers is equal to the absolute value of each entry in the matrix, denoted by E∣=(eij)n×m. A matrix is positive definite (semi-definite) when it uTBu>0(0) holds for all real vectors u=(u1,u2,,un)TRn. Also that n,mi,j=1=ni=1mj=1 and m,nj,i=1=mj=1ni=1.

    Consider the system of NNs that includes delayed connections in the BAM as described below:[29]

    {˙yj(t)=ˇbjyj(t)+ni=1ˇgijϕ1i(wi(t))+ni=1ˇgτijϕ1i(wi(tˇσij))+Kj, j˙wi(t)=ˇaiwi(t)+mj=1ˇfjiϕ2j(yj(t))+mj=1ˇfτjiϕ2j(yj(tˇτji))+Ji, i (2.1)

    where wi(t) and yj(t) represent the state of the ith and jth neurons in the vectors at time t. n and m represent the total number of neurons in the proposed hybrid BAM NNs (2.1). ϕ1i and ϕ2j indicate the activation functions of the neurons; ˇfji, ˇfτji, ˇgij, and ˇgτij are the connection weight matrices; ˇai and ˇbj stand for the neuron charging time constants; Ji and Kj, for every  i=1,2,,n, j=1,2,,m are the inputs. For the stability of (2.1), the following several considerations have been made.

    Assumption 2.1. (A1). Assume that there are certain ˇli>0<ˇhj, such that the following specified conditions are satisfied:

    0ϕ1i(¯x)ϕ1i(¯y)¯x¯yˇli, 0ϕ2j(ˆx)ϕ2j(ˆy)ˆxˆyˇhj, ˆxˆy, ¯x¯y for all ˆx, ˆy, ¯x, ¯yR.

    Assumption 2.2. (A2). Assume there are positive constants ˇMi and ˇNj for which certain conditions are satisfied. |ϕ1i(w1)|ˇMi and |ϕ2j(w2)|ˇNj for all w1,w2R, where i=1,2,,n, j=1,2,,m. Based on this assumption, the activation functions are limited in type.

    The matrices ˇbj, ˇfji, ˇfτji, ˇgij, ˇgτij, ˇai, ˇτji and ˇσij are assumed to be uncertain matrices. The usual approach to dealing with the delayed system includes modifying the synaptic strength connection matrices within a specific time frame in the following manner for i=1,2,,n,j=1,2,,m.

    {BI={B=diag(ˇbj):0B_B¯B, ie., 0<ˇb_jˇbj¯ˇbj},BBIGI={G=(ˇgij):G_G¯G, ie., ˇg_ijˇgij¯ˇgij},GGIGτI={Gτ=(ˇgτij):G_τGτ¯Gτ, ie., ˇg_τijˇgτij¯ˇgτij},GτGτIœI={œ=(ˇσij):œ_œ¯œ, ie., ˇσ_ijˇσij¯ˇσij},œœI,AI={A=diag(ˇai):0A_A¯A,i.e.,., 0<ˇa_iˇai¯ˇai},AAIFI={F=(ˇfji):F_F¯F, ie., ˇf_jiˇfji¯ˇfji},FFIFτI={Fτ=(ˇfτji):F_τFτ¯Fτ, ie., ˇf_τjiˇfτji¯ˇfτji},FτFτIτI={τ=(ˇτji):τ_τ¯τ, ie., ˇτ_jiˇτji¯ˇτji},ττI. (2.2)

    Next, we move the equilibrium point of (2.1) to the origin. To achieve this, we employ the subsequent alteration:

    ˇxj()=yj()yj, ˇui()=wi()wi, for every j=1,2,,m, i=1,2,,n.

    Through the use of the transformation mentioned above, we change (2.1) into the form as shown below:

    {dˇxj(t)dt=ˇbjˇxj(t)+ni=iˇgijχ1i(ˇui(t))+ni=iˇgτijχ1i(ˇui(tˇσij)), j,dˇui(t)dt=ˇaiˇui(t)+mj=iˇfjiχ2j(ˇxj(t))+mj=iˇfτjiχ2j(ˇxj(tˇτji)), i, (2.3)
    where  χ1i(ˇui())= ϕ1i(ˇui()+wi)ϕ1i(wi), χ1i(0)=0,χ2j(ˇxj())= ϕ2j(ˇxj()+yj)ϕ2j(yj), χ2j(0)=0, for every i,j.

    Now, it is straightforward to verify that the functions χ1i and χ2j meet the requirements for ϕ1i and ϕ2j, meaning χ1i, χ2j satisfy both (A1) and (A2).

    Definition 2.3. [30] The BAM NNs (2.3) satisfying (2.2) is GARS if the origin of the unique equilibrium point of the BAM NNs (2.3) is globally asymptotically stable for all BBI, GGI, GτGτI, AAI, FFI, FτFτI. Regardless of the initial conditions, the solutions of (2.3) that converge to the origin of the unique equilibrium point constitute the system's global asymptotic stability.

    The identification and understanding of these following lemmas and facts are pivotal in establishing the prerequisites for conducting a thorough examination of global stability in (2.1).

    Lemma 2.4. [31] If FFI, then

    F2  T(F),

    where T(F)=2∥∣(F)TF+FTF2, F=12(¯F+F_), F=12(¯FF_). Similarly, G=12(¯G+G_), G=12(¯GG_). The matrices ¯F,F_,¯G and G_ are defined as in (2.2).

    Lemma 2.5. [32] The following inequality holds for any two vectors u=(u1,u2,,un)TRn and y=(y1,y2,,yn)TRn.

    2uTy=2yTuβuTu+1βyTy,  β>0.

    Lemma 2.6. [33] For each matrix F in the interval [F_,¯F], the following inequality holds:

    F2  F2+F2,

    where F=12(¯F+F_), F=12(¯FF_).

    Remark 2.7 The results described in Lemmas 2.4 and 2.6 are consistently applicable to any synaptic connection strength matrices defined as in (2.1).

    Consider the matrix E, which satisfies Eq (2.2). Now, there exists a positive constant T(E) that satisfies the following condition:

    E2  T(E),

    where E is any matrix as defined in (2.2).

    In this section, we define specific generalized sufficient conditions for the GARS of the BAM NNs described by (2.1). Through the application of the assumption (A2), BAM NNs (2.1) that fulfill (2.2) possess the existence of the equilibrium point. Hence, demonstrating the uniqueness of the equilibrium point for the GARS of (2.1) is essential.

    Theorem 3.1. Assume the activation functions χ1i, χ2j fulfill conditions (A1), (A2), and there are positive constants, γ and δ, such that the conditions below are satisfied:

    Ψ1i=mγδˇa_i12mδ(γ2ˇl2iδγm(fτ))12nγˇl2iT2(G)>0, i=1,2,...,n,Ω1j=nγδˇb_i12nδ(γ2ˇh2jδγn(gτ))12mγˇh2jT2(F)>0, j=1,2,...,m,

    where (fτ)=mj=1(ˇfτji)2, (gτ)=ni=1(ˇgτij)2, fτji=max(ˇf_τji,¯ˇfτji) and gτij=max(ˇg_τij,¯ˇgτij).

    Then, the BAM NNs defined by (2.3) with network parameters that meet (2.2) have GARS at their origin.

    Proof. This proof will be shown through a two-step process. In Step 1, we show that its origin is the only equilibrium point of (2.3). On the flip side, we show that BAM NNs (2.3) whose origin is GARS.

    Step 1. Assume that the equilibrium points of (2.3) are (ˇu1,...,ˇun)T=ˇu0 and (ˇx1,...,ˇxm)T=ˇx0. The points that satisfy the equations stated below are the equilibrium points of (2.3).

    ˇaiˇui+mj=iˇfjiχ2j(ˇxj)+mj=iˇfτjiχ2j(ˇxj)=0, i, (3.1)
    ˇbjˇxj+ni=iˇgijχ1j(ˇui)+ni=iˇgτijχ1j(ˇui)=0, j. (3.2)

    Multiplying (3.1) by 2mˇui and (3.2) by 2nˇxj, then addition of the resulting equations,

    0=2mˇaiˇui2+n,mi,j=12mˇuiˇfjiχ2j(ˇxj)+m,nj,i=12mˇuiˇfτjiχ2j(ˇxj)2nˇbjˇxj2+2nm,nj,i=1ˇxjˇgijχ1j(ˇui)+2nn,mi,j=1ˇxjˇgτijχ1j(ˇui),0=2mˇaiˇui2+m,nj,i=12mˇuiˇfjiχ2j(ˇxj)+n,mi,j=12mˇuiˇfτjiχ2j(ˇxj)2nˇbjˇxj2+2nm,nj,i=1ˇxjgijχ1j(ˇui)+2nm,nj,i=1ˇxjˇgτijχ1j(ˇui)+1γn,mi,j=1m2(ˇfτji)2χ22j(ˇxj)1γn,mi,j=1m2(ˇfτji)2χ22j(ˇxj)+1γm,nj,i=1n2(ˇgτij)2χ21j(ˇui)1γm,nj,i=1n2(ˇgτij)2χ21j(ˇui),
    2mˇaiˇui2+n,mi,j=12mˇuiˇfjiχ2j(ˇxj)+n,mi,j=12mˇuiˇfτjiχ2j(ˇxj)2nˇbjˇxj2+2nm,nj,i=1ˇxjˇgijχ1j(ˇui)+2nm,nj,i=1ˇxjgτijχ1j(ˇui)+1γn,mi,j=1m2(ˇfτji)2ˇh2j(ˇxj2)1γn,mi,j=1m2(ˇfτji)2χ22j(ˇxj)+1γm,nj,i=1n2(ˇgτij)2ˇl2i(ˇui2)1γm,nj,i=1n2(ˇgτij)2χ21j(ˇui). (3.3)

    Take into account the forthcoming inequalities:

    n,mi,j=12mˇui(t)ˇfjiχ2j(ˇxj)= 2mˇuTFS(ˇx) mδˇuTˇu+m1δST(ˇx)FTFS(ˇx) mδˇuTˇu+m1δF22S(ˇx)22 mδni=1ˇui2+m1δF22mj=1ˇh2jˇxj2, (3.4)
    n,mi,j=12nˇxjˇgijχ1j(ˇui)=2nˇxTGS(ˇu) nδˇxTˇx+n1δST(ˇu)GTGS(ˇu) nδˇxTˇx+n1δS22G(u)22 nδmj=1ˇxj2+n1δG22ni=1ˇl2iˇui2, (3.5)
    n,mi,j=12mˇuiˇfτjiχ2j(ˇxj)m,nj,i=11γm2(ˇfτji)2(ˇui)2+n,mi,j=1γχ22j(ˇxj)=1γm2m,nj,i=1(ˇfτji)2(ˇui)2+nγmj=1ˇh2j((ˇxj)2), (3.6)
    m,nj,i=12nˇxjˇgτijχ2j(ˇui)n,mi,j=11γn2(ˇgτij)2(ˇxj)2+m,nj,i=1γχ21i(ˇui)=1γn2n,mi,j=1(ˇgτij)2(ˇxj)2+mγni=1ˇl2i((ˇui)2). (3.7)

    By applying the results (3.4)–(3.7) in (3.3), we have

    0ni=12mˇai(ˇui)2+mδni=1(ˇui)2+m1δF22mj=1ˇh2j(ˇxj)2mj=12nˇbj(ˇxj)2+nδmj=1(ˇxj)2+n1δG22ni=1ˇl2i(ˇui)2+1γn2n,mi,j=1(ˇgτij)2(ˇxj)2+mγni=1ˇl2i((ˇui)2)+1γm2m,nj,i=1(ˇfτji)2(ˇui)2+nγmj=1ˇh2j((ˇxj)2).

    Since,

    G222∥∣(G)TG+GTG2=T2(G), F22 T2(F),(ˇfτji)2(fτji)2, (ˇgτij)2(gτij)2.
    0ni=1{m(2ˇa_i+γ+δ)+1δnˇl2i(2∥∣(G)TG+GTG2)+1γn2ˇl2imj=1((fτij)2)}ˇui2+mj=1{n(2ˇb_j+γ+δ)+1γm2ˇh2jni=1((fτji)2)+1δmˇh2j(2∥∣(F)TF+FTF2)}ˇxj2,
    02γδ{ni=1{mγδˇa_i12mδ(γ2ˇl2iδγm(fτ))12nγˇl2iT2(G)}ˇui2+mj=1{nγδˇb_i12mγˇh2jT2(F)12nδ(γ2ˇh2jδγn(gτ))}ˇxj2},02γδ{ni=1Ψiˇu2i+mj=1Ωjˇx2j}. (3.8)

    Since γ>0 δ>0, Ψi>0, Ωj>0 for every i,j and ˇx0ˇu. But 2γδ{ni=1Ψiˇui2+mj=1Ωjˇxj2}<0. Here (3.8) contradicts the above result, and thus, we can deduce that the only equilibrium point is ˇx=0=ˇu. Therefore, the unique equilibrium point is the origin of (2.3).

    Step 2. Let us examine the LKF provided below:

    V(ˇx(t),ˇu(t))=ni=1mˇu2i(t)+γn,mi,j=1ttˇτjiχ22j(ˇxj(η))dη+mj=1nˇx2j(t)+γm,nj,i=1ttˇσijχ21iˇui(ξ)dξ.

    Obtaining ˙V(ˇx(t),ˇu(t)) in the trajectories of (2.3) and using Lemma 2.5 yields the following result:

    ˙V(ˇx(t),ˇu(t))mδni=1ˇu2i(t)ni=12mˇaiˇu2i(t)+nδmj=1x2j(t)+m1δF22mj=1ˇh2jˇx2j(t)+n1δG22ni=1ˇl2iˇu2i(t)mj=12nˇbjˇx2j(t)+mγni=1ˇl2iˇu2i(t)+nγmj=1ˇh2jˇx2j(t)+1γni=1mj=1m2(ˇfτji)2ˇu2i(t)+1γmj=1ni=1n2(ˇgτij)2ˇx2j(t).

    Since G22  T2(G), F22  T2(F), (ˇfτji)2(fτji)2 and (ˇgτij)2(gτij)2.

    ˙V(ˇx(t),ˇu(t))ni=1{m(2ˇa_i+γl2i+δ)+1δnˇl2i(T2(G))+1γm2mj=1((fτji)2)}ˇu2i+mj=1{n(2ˇb_j+γˇh2j+δ)+1δmˇh2j(T2(F))+1γn2ni=1((gτij)2)}ˇx2j,=2γδ{ni=1{mγδˇa_i12nγˇl2iT2(G)12mδ(γ2ˇl2iδγm(fτ))}ˇui2+mj=1{nγδˇb_i12mγˇh2jT2(F)12nδ(γ2ˇh2jδγn(gτ))}ˇxj2},˙V(ˇx(t),ˇu(t))  2γδ{ni=1Ψiˇu2i+mj=1Ωjˇx2j}.

    Since γ>0, δ>0, Ψ1i>0, and Ω1j>0,i,j, for all non-zero values of ˇu(t),ˇx(t), ˙V(ˇx(t),ˇu(t))<0. Therefore, according to the theory of Lyapunov stability, the origin of (2.3) that satisfies (2.2) is GARS.

    The following theorem, which is obtained with the help of Lemmas 2.4 and 2.5, provides a different sufficient condition for GARS of the proposed system. Furthermore, this paper's numerical section discusses the effectiveness of the given results.

    Theorem 3.2. Assume the activation functions χ1i, χ2j fulfill conditions (A1), (A2), and there are positive constants γ and δ, such that the conditions below are satisfied:

    Ψ2i=mγδ(2ˇa_iγδ)nˇl2i(nδgτ+γT2(G))>0, i=1,2,...,n,Ω2j=nγδ(2ˇb_jγδ)mˇh2j(mδfτ+γT2(F))>0, j=1,2,...,m,

    where (fτ)=mj=1(ˇfτji)2, (gτ)=ni=1(ˇgτij)2, fτji=max(ˇf_τji,¯ˇfτji) and gτij=max(ˇg_τij,¯ˇgτij). Then the BAM NNs defined by (2.3) with network parameters that meet (2.2) have GARS at their origin.

    Proof. This proof will be shown through a two-step process. In Step 1, we show that its origin is the only equilibrium point of (2.3). On the flip side, we show that (2.3) has it origin in GARS.

    Step 1. Assume that the equilibrium points of (2.3) are (ˇu1,...,ˇun)T=ˇu0 and (ˇx1,...,ˇxm)T=ˇx0. The points that satisfy the equations stated below are the equilibrium points of (2.3).

    ˇaiˇui+mj=iˇfjiχ2j(ˇxj)+mj=iˇfτjiχ2j(ˇxj)=0, i, (3.9)
    ˇbjˇxj+ni=iˇgijχ1j(ˇui)+ni=iˇgτijχ1j(ˇui)=0, j. (3.10)

    Multiplying (3.1) by 2mˇui and (3.2) by 2nˇxj, then addition of the resulting equations,

    0=2mˇaiˇui2+n,mi,j=12mˇuiˇfjiχ2j(ˇxj)+m,nj,i=12mˇuiˇfτjiχ2j(ˇxj)2nˇbjˇxj2+2nm,nj,i=1ˇxjˇgijχ1j(ˇui)+2nm,nj,i=1ˇxjˇgτijχ1j(ˇui),
    0=2mˇaiˇui2+n,mi,j=12mˇuiˇfjiχ2j(ˇxj)+n,mi,j=12mˇuiˇfτjiχ2j(ˇxj)2nˇbjˇxj2+2nm,nj,i=1ˇxjgijχ1j(ˇui)+2nm,nj,i=1ˇxjˇgτijχ1j(ˇui)+1γn,mi,j=1m2(ˇfτji)2χ22j(ˇxj)1γn,mi,j=1m2(ˇfτji)2χ22j(ˇxj)+1γm,nj,i=1n2(ˇgτij)2χ21j(ˇui)1γm,nj,i=1n2(ˇgτij)2χ21j(ˇui),
    2mˇaiˇui2+n,mi,j=12mˇuiˇfjiχ2j(ˇxj)+n,mi,j=12mˇuiˇfτjiχ2j(ˇxj)2nˇbjˇxj2+2nm,nj,i=1ˇxjˇgijχ1j(ˇui)+2nm,nj,i=1ˇxjgτijχ1j(ˇui)+1γn,mi,j=1m2(ˇfτji)2ˇh2j(ˇxj2)1γn,mi,j=1m2(ˇfτji)2χ22j(ˇxj)+1γm,nj,i=1n2(ˇgτij)2ˇl2i(ˇui2)1γm,nj,i=1n2(ˇgτij)2χ21j(ˇui). (3.11)

    Take into account the forthcoming inequalities:

    n,mi,j=12mˇui(t)ˇfjiχ2j(ˇxj)= 2mˇuTFS(ˇx) mδˇuTˇu+m1δST(ˇx)FTFS(ˇx) mδˇuTˇu+m1δF22S(ˇx)22 mδni=1ˇui2+m1δF22mj=1ˇh2jˇxj2, (3.12)
    m,nj,i=12nˇxjˇgijχ1j(ˇui)=2nˇxTGS(ˇu) nδˇxTˇx+n1δST(ˇu)GTGS(ˇu) nδˇxTˇx+n1δS22G(u)22 nδmj=1ˇxj2+n1δG22ni=1ˇl2iˇui2, (3.13)
    n,mi,j=12mˇuiˇfτjiχ2j(ˇxj)n,mi,j=1γˇui2+n,mi,j=11γm2(ˇfτji)2χ22j(ˇxj)= mγni=1ˇui2+n,mi,j=11γm2(ˇfτji)2χ22j(ˇxj), (3.14)
    m,nj,i=12nˇxjˇgτijχ2j(ˇui)m,nj,i=1γˇxj+m,nj,i=11γn2(ˇgτij)2χ21i(ˇui)= nγmj=1ˇxj+m,nj,i=11γn2(ˇgτij)2χ21i(ˇui). (3.15)

    By applying the results (3.12)–(3.15) in (3.11), we have

    0ni=12mˇaiˇui2+mδni=1ˇui2+m1δF22mj=1ˇh2jˇxj2mj=12nˇbjˇxj2+nδmj=1ˇxj2+n1δG22ni=1ˇl2iˇui2+mγni=1ˇui2+nγmj=1ˇxj2+1γn,mi,j=1m2(ˇfτji)2ˇh2j(ˇxj2)+1γm,nj,i=1n2(ˇgτij)2ˇl2i(ˇui2).

    Since,

    G222∥∣(G)TG+GTG2=T2(G), F22T2(F), (ˇfτji)2(fτji)2, (ˇgτij)2(gτij)2.
    0ni=1{2mˇa_i+m(γ+δ)+1δnˇl2i(T2(G)+1γn2ˇl2imj=1((gτij)2)}ˇui2+mj=1{2nˇb_j+n(γ+δ)+1γm2ˇh2jni=1((fτji)2)+1δmˇh2j(T2(F)}ˇxj2,
    0ni=1{mγδ(2ˇa_iγδ)nˇl2i(nδgτ+γT2(G))}ˇui2mj=1{nγδ(2ˇb_jγδ)mˇh2j(mδfτ+γT2(F))}ˇxj2,0ni=1Ψ2iˇu2imj=1Ω2jˇx2j. (3.16)

    Given that Ψ2i>0 and Ω2j>0, i,j, ˇx0ˇu. But ni=1Ψ2iˇui2mj=1Ω2jˇxj2<0. Here (3.16) contradicts the above result, and thus, we can deduce that the only equilibrium point is ˇx=0=ˇu. Therefore, the unique equilibrium point is the origin of (2.3).

    Step 2. Let us examine the LKF provided below:

    V(ˇx(t),ˇu(t))=ni=1mˇu2i(t)+mj=1nˇx2j(t)+1γn,mi,j=1m2(ˇfτji)2ttˇτjiχ22j(ˇxj(η))dη+1γm,nj,i=1n2(ˇgτji)2ttˇσijχ21iˇui(ξ)dξ.

    Obtaining ˙V(ˇx(t),ˇu(t)) in the trajectories of (2.3) and using Lemma 2.5 yields the following result:

    ˙V(ˇx(t),ˇu(t))mδni=1ˇu2i(t)ni=12mˇaiˇu2i(t)+nδmj=1x2j(t)+m1δF22mj=1ˇh2jˇx2j(t)+n1δG22ni=1ˇl2iˇu2i(t)mj=12nˇbjˇx2j(t)+mγni=1ˇu2i(t)+nγmj=1ˇx2j(t)+1γmj=1ni=1n2(ˇfτji)2ˇl2iˇu2i(t)+1γni=1mj=1m2(ˇgτij)2ˇh2jˇx2j(t).

    Since G22T2(G), F22T2(F), (ˇfτji)2(fτji)2 and (ˇgτij)2(gτij)2.

    ˙V(ˇx(t),ˇu(t))ni=1{2mˇa_i+m(γ+δ)+1δnˇl2i(T2(G))+1γn2ˇl2imj=1((gτij)2)}ˇui2+mj=1{2nˇb_j+n(γ+δ)+1γm2ˇh2jni=1((fτji)2)+1δmˇh2j(T2(G))}ˇxj2,
    ni=1{mγδ(2ˇa_iγδ)nˇl2i(nδgτ+γT2(G))}ˇui2mj=1{nγδ(2ˇb_jγδ)mˇh2j(mδfτ+γT2(F))}ˇxj2,=ni=1Ψ2iˇu2imj=1Ω2jˇx2j.

    Given that Ψ2i>0 and Ω2j>0, i,j, for every non-zero values of ˇu(t),ˇx(t), ˙V(ˇx(t),ˇu(t))<0. Therefore, according to the theory of Lyapunov stability, the origin of (2.3) that satisfies (2.2) is GARS. The proof is completed.

    In this part, we demonstrate the contrast in outcomes of Theorems 3.1 and 3.2 through the following instances.

    Example 4.1. Take into account the network parameters for the specified BAM NNs (2.1) that adhere to (2.2).

    l1=l2=l3=12, h1=h2=h3=12, γ=16, δ=16,
    A_=A=¯A=[130001300013]=B_=B=¯B, G_=F_=12[000000200], ¯G=¯F=12[222222004],
    G=F=12[111111102], G=F=12[111111102], G_τ=[d1d1d1d1d1d1d1d1d1], ¯Gτ=18[d1d1d1d1d1d1d1d1d1]=Gτ,
    F_τ=18[d2d2d2d2d2d2d2d2d2], ¯Fτ=18[d2d2d2d2d2d2d2d2d2]=Fτ,

    where d1>0, d2>0. We identify the norm in Lemma 2.4 in the following manner.

    T2(G)=2∥∣(G)TG+GTG2=8.1883=T2(F)=2∥∣(F)TF+FTF2.

    We exhibit the results of Theorem 3.1 for the upper bound T2, we obtain

    Ψ1i=1.08330.51180.0404d22=0.57150.0404d22.

    Since Ψ1i>0,i=1,2,3. Therefore, d22<14.1460.

    Ω1j=1.08330.51180.0404d21=0.57150.0404d21.

    Since Ω1j>0,j=1,2,3. Therefore, d21<14.1460. Similarly, we exhibit the results of Theorem 3.2 for the upper bound T2, we obtain

    Ψ2i=2.13891.02360.0176d21=1.11530.0176d21.

    Since Ψ2i>0, i=1,2,3. Therefore, d21<63.3693.

    Ω2j=2.13891.02360.0176d22=1.11530.0176d22.

    Since Ω2j>0, j=1,2,3. Therefore, d22<63.3693.

    For this example, the Matlab simulation results from non-linear activation functions under the initial conditions ˇx(0)= [0.5,0.5,0.2]T and ˇu(0)=[0.3,0.3,0.1]T. The activation function used is a piecewise linear functions f(ˇx)=0.5×(|ˇx+1||ˇx1|) and g(ˇu)=0.5×(|ˇu+1||ˇu1|), which bounds neuron activations, ensuring stability. The state response graph shows the evolution of neuron activations over time for each layer (ˇx and ˇu), influenced by time-delayed interactions. The responses converge smoothly to zero due to the damping effect in Figure 1.

    Remark 4.1. For Ψ2i and Ω2j,i,j=1,2,3, d21 and d22 respectively, are valid in the domain, 12.5869<d2q<49.6193, q=1,2 whereas Ψ1i and Ω1j, i,j=1,2,3 are not valid in that domain. This is because of the new upper bound value T2 norm and the sufficient conditions in 3.1 and 3.2. Hence, our new sufficient conditions in 3.2 will give better results when comparing 3.1 with the proposed BAM NNs.

    Remark 4.2. In this example, we apply the existing norm in the literature as stated in Lemma 2.6, then T2(G)=(G2+G2)2=(F2+F2)2=T2(F)=8.3284>8.1883 =2∥∣(G)TG+GTG2 =2∥∣(F)TF+FTF2. Therefore, the proposed results will give better domain of region as compared with their existing results. Hence, our results are efficient when compared with the existing results for this network parameters.

    Example 4.2. Take into account the network parameters for the specified BAM NNs (2.1) that adhere to (2.2).

    l1=l2=l3=l4=14, h1=h2=h3=h4=14, γ=15, δ=15,
    A_=A=¯A=[10000010000010000010]=B_=B=¯B, G_=F_=125[0000000000006000],¯G=¯F=125[66666666666600012],  G=F=125[3333333333333006],
    G=F=125[3333333333333006], G_τ=15[e1e1e1e1e1e1e1e1e1e1e1e1e1e1e1e1], ¯Gτ=15[e1e1e1e1e1e1e1e1e1e1e1e1e1e1e1e1],
    F_τ=15[e2e2e2e2e2e2e2e2e2e2e2e2e2e2e2e2],¯Fτ=15[e2e2e2e2e2e2e2e2e2e2e2e2e2e2e2e2].

    where e1>0, e2>0. We identify the norm in Lemma 2.4 in the following manner.

    T2(G)=T2(F)=0.7778.
    Figure 1.  Response of ˇx, ˇu among the different initial states.

    We exhibit the results of Theorem 3.1 for the upper bound T2, we obtain

    Ψ1i=1.60.03560.256e22=1.56440.256e22.

    Since Ψ1i>0,i=1,2,3,4. Therefore, e22<6.2576.

    Ω1j=1.60.03560.256e21=1.56440.256e21.

    Since Ω1j>0,j=1,2,3,4. Therefore, e21<6.2576. Similarly, we exhibit the results of Theorem 3.2 for the upper bounds T2, we obtain

    Ψ2i=3.13600.03890.0320e21=3.09710.0320e21.

    Since Ψ2i>0, i=1,2,3,4. Therefore, e21<96.7844.

    Ω2j=3.13600.03890.0320e22=3.09710.0320e22.

    Since Ω2j>0, j=1,2,3,4. Therefore, e22<96.7844.

    For this example, the Matlab simulation results from non-linear activation functions under the initial conditions ˇx(0)= [0.5,0.5,0.3,0.4]T and ˇu(0)=[0.3,0.3,0.2,0.4]T. The activation function used is a piecewise linear function f(ˇx)=0.5×(|ˇx+1||ˇx1|) and g(ˇu)=0.5×(|ˇu+1||ˇu1|), which bounds neuron activations, ensuring stability. The state response graph shows the evolution of neuron activations over time for each layer (ˇx and ˇu), influenced by time-delayed interactions. The responses converge smoothly to zero due to the damping effect in Figure 2.

    Remark 4.3. For Ψ2i and Ω2j,i,j=1,2,3,4, e21 and e22, respectively, are valid in the domain, 6.1035<e2q<96.7186, q=1,2 whereas Ψ1i and Ω1j, i,j=1,2,3,4 are not valid in that domain. This is because of the new upper bound value T2 norm and the sufficient conditions in 3.1 and 3.2. Hence, our new sufficient conditions in 3.2 will give better results for the proposed BAM NNs. Moreover, Theorem 3.2 provides better results and is more robust compared to Theorem 3.1. It offers a significantly larger stability region e21,e22<96.7186, while Theorem 3.1 is limited to e21,e22< 6.1035.

    Remark 4.4. In this example, we apply the existing norm as stated in Lemma 2.6, then T2(G)=(G2+G2)2=(F2+F2)2=T2(F)=0.7811 >0.7778=2∥∣(G)TG+GTG2=2∥∣(F)TF+FTF2. Therefore, the proposed results will give better domain of region as compared with the existing results. Hence, our results are efficient when compared with the existing results for these network parameters.

    Remark 4.5. The constant multiple time delays are employed in a range of real-time applications, such as network communication, and control systems, particularly in industrial processes, telecommunication operating systems, signal processing, and also gravitational lensing in astrophysics. The novel global asymptotic stability and dissipativity criteria of BAM NNs with delays have been discussed in [34]. The fractional-order uncertain BAM NNs with mixed time delays are discussed in [35]. Some new criteria on the stability of fractional-order BAM NNs with time delay is discussed in [36]. The concept of global the exponential stability via inequality technique for inertial BAM NNs with time delays is discussed in [37]. Also, the proposed results can be applied to the time-varying delay parameters of BAM NNs. Since we can find multiple constant time delays as the upper bounds for the time-varying delay parameters. The proposed results can be utilized for the GARS of time-varying delayed BAM NNs, and it will give better results for these network parameters.

    Figure 2.  Response of ˇx, ˇu among the different initial states.

    This research looks into the GARS of hybrid BAM NNs that deal with time delays and unknown parameters in great detail. We have defined the relevant conditions to ensure GARS in these hybrid BAM NNs. Also, the results for the GARS of these BAM NNs are given in 3.1 and 3.2. The proposed research work confers the following advantages: (1) The results stated in both 3.1 and 3.2 are different sufficient conditions. (2) From the numerical examples, it is clear that the results in 3.2 are valid in the larger domain, while the sufficient conditions in 3.1 are enforceable only in the smaller domain. (3) The domain of validity for the results in 3.2 is much larger compared to the larger network parameters given in 2. The new results stated in 3.1 and 3.2 are derived using the new upper bound and the suitable LKF. Our research has shown greater efficacy compared to some earlier findings. The two numerical instances demonstrate how our novel conditions yield effective outcomes. This suggested research could be expanded in further studies to incorporate complex-valued diffusion BAM NNs and the impulsive fractional-order quaternion-valued BAM NNs with real-time applications.

    N. Mohamed Thoiyab: Writing-review & editing, writing-original draft, conceptualization; Mostafa Fazly: Writing-review & editing, visualization, investigation, funding acquisition; R. Vadivel: Writing-review & editing, methodology, validation; Nallappan Gunasekaran: Methodology, formal analysis, software, supervision. All authors have read and approved the final version of the manuscript for publication.

    The authors declare they have not used Artificial Intelligence (AI) tools in the creation of this article.

    The authors claim that they have no conflicts of interest in publishing this work.

    Prof. Mostafa Fazly is the Guest Editor of special issue "Nonlinear Systems and Applications" for AIMS Mathematics. Prof. Mostafa Fazly was not involved in the editorial review and the decision to publish this article.



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