Loading [MathJax]/jax/output/SVG/jax.js
Review Topical Sections

The role of epinephrine in anaphylaxis at all stages of management in pediatric populations

  • Anaphylaxis is a severe and generalized form of hypersensitivity or allergic reaction. It can be life-threatening and requires rapid management. Cases of anaphylaxis are growing worldwide. The first line treatment in anaphylaxis is epinephrine. However, despite guidelines emphasizing the importance of this drug, studies show that use of epinephrine in anaphylaxis is suboptimal. In this article we describe the practical approach to recognizing and managing anaphylaxis in various settings.

    Citation: Maria Wołos, Jan Stachurski. The role of epinephrine in anaphylaxis at all stages of management in pediatric populations[J]. AIMS Medical Science, 2021, 8(2): 80-86. doi: 10.3934/medsci.2021009

    Related Papers:

    [1] Meshari Alesemi . Innovative approaches of a time-fractional system of Boussinesq equations within a Mohand transform. AIMS Mathematics, 2024, 9(10): 29269-29295. doi: 10.3934/math.20241419
    [2] Azzh Saad Alshehry, Humaira Yasmin, Ali M. Mahnashi . Analyzing fractional PDE system with the Caputo operator and Mohand transform techniques. AIMS Mathematics, 2024, 9(11): 32157-32181. doi: 10.3934/math.20241544
    [3] Aisha Abdullah Alderremy, Rasool Shah, Nehad Ali Shah, Shaban Aly, Kamsing Nonlaopon . Comparison of two modified analytical approaches for the systems of time fractional partial differential equations. AIMS Mathematics, 2023, 8(3): 7142-7162. doi: 10.3934/math.2023360
    [4] Musawa Yahya Almusawa, Hassan Almusawa . Numerical analysis of the fractional nonlinear waves of fifth-order KdV and Kawahara equations under Caputo operator. AIMS Mathematics, 2024, 9(11): 31898-31925. doi: 10.3934/math.20241533
    [5] M. Mossa Al-Sawalha, Khalil Hadi Hakami, Mohammad Alqudah, Qasem M. Tawhari, Hussain Gissy . Novel Laplace-integrated least square methods for solving the fractional nonlinear damped Burgers' equation. AIMS Mathematics, 2025, 10(3): 7099-7126. doi: 10.3934/math.2025324
    [6] Aslı Alkan, Halil Anaç . The novel numerical solutions for time-fractional Fornberg-Whitham equation by using fractional natural transform decomposition method. AIMS Mathematics, 2024, 9(9): 25333-25359. doi: 10.3934/math.20241237
    [7] Reetika Chawla, Komal Deswal, Devendra Kumar, Dumitru Baleanu . A novel finite difference based numerical approach for Modified Atangana- Baleanu Caputo derivative. AIMS Mathematics, 2022, 7(9): 17252-17268. doi: 10.3934/math.2022950
    [8] Emad Salah, Ahmad Qazza, Rania Saadeh, Ahmad El-Ajou . A hybrid analytical technique for solving multi-dimensional time-fractional Navier-Stokes system. AIMS Mathematics, 2023, 8(1): 1713-1736. doi: 10.3934/math.2023088
    [9] Qasem M. Tawhari . Advanced analytical techniques for fractional Schrödinger and Korteweg-de Vries equations. AIMS Mathematics, 2025, 10(5): 11708-11731. doi: 10.3934/math.2025530
    [10] Ritu Agarwal, Mahaveer Prasad Yadav, Dumitru Baleanu, S. D. Purohit . Existence and uniqueness of miscible flow equation through porous media with a non singular fractional derivative. AIMS Mathematics, 2020, 5(2): 1062-1073. doi: 10.3934/math.2020074
  • Anaphylaxis is a severe and generalized form of hypersensitivity or allergic reaction. It can be life-threatening and requires rapid management. Cases of anaphylaxis are growing worldwide. The first line treatment in anaphylaxis is epinephrine. However, despite guidelines emphasizing the importance of this drug, studies show that use of epinephrine in anaphylaxis is suboptimal. In this article we describe the practical approach to recognizing and managing anaphylaxis in various settings.



    The purpose of this paper is to study the global behavior of the following max-type system of difference equations of the second order with four variables and period-two parameters

    {xn=max{An,zn1yn2},yn=max{Bn,wn1xn2},zn=max{Cn,xn1wn2},wn=max{Dn,yn1zn2},  nN0{0,1,2,}, (1.1)

    where An,Bn,Cn,DnR+(0,+) are periodic sequences with period 2 and the initial values xi,yi,zi,wiR+ (1i2). To do this we will use some methods and ideas which stems from [1,2]. For a more complex variant of the method, see [3]. A solution {(xn,yn,zn,wn)}+n=2 of (1.1) is called an eventually periodic solution with period T if there exists mN such that (xn,yn,zn,wn)=(xn+T,yn+T,zn+T,wn+T) holds for all nm.

    When xn=yn and zn=wn and A0=A1=B0=B1=α and C0=C1=D0=D1=β, (1.1) reduces to following max-type system of difference equations

    {xn=max{α,zn1xn2},zn=max{β,xn1zn2},  nN0. (1.2)

    Fotiades and Papaschinopoulos in [4] investigated the global behavior of (1.2) and showed that every positive solution of (1.2) is eventually periodic.

    When xn=zn and yn=wn and An=Cn and Bn=Dn, (1.1) reduces to following max-type system of difference equations

    {xn=max{An,yn1xn2},yn=max{Bn,xn1yn2},  nN0. (1.3)

    Su et al. in [5] investigated the periodicity of (1.3) and showed that every solution of (1.3) is eventually periodic.

    In 2020, Su et al. [6] studied the global behavior of positive solutions of the following max-type system of difference equations

    {xn=max{A,yntxns},yn=max{B,xntyns},  nN0,

    where A,BR+.

    In 2015, Yazlik et al. [7] studied the periodicity of positive solutions of the max-type system of difference equations

    {xn=max{1xn1,min{1,pyn1}},yn=max{1yn1,min{1,pxn1}}, nN0, (1.4)

    where pR+ and obtained in an elegant way the general solution of (1.4).

    In 2016, Sun and Xi [8], inspired by the research in [5], studied the following more general system

    {xn=max{1xnm,min{1,pynr}},yn=max{1ynm,min{1,qxnt}},  nN0, (1.5)

    where p,qR+, m,r,tN{1,2,} and the initial conditions xi,yiR+ (1is) with s=max{m,r,t} and showed that every positive solution of (1.5) is eventually periodic with period 2m.

    In [9], Stević studied the boundedness character and global attractivity of the following symmetric max-type system of difference equations

    {xn=max{B,ypn1xpn2},yn=max{B,xpn1ypn2},  nN0,

    where B,pR+ and the initial conditions xi,yiR+ (1i2).

    In 2014, motivated by results in [9], Stević [10] further study the behavior of the following max-type system of difference equations

    {xn=max{B,ypn1zpn2},yn=max{B,zpn1xpn2},zn=max{B,xpn1ypn2}.  nN0, (1.6)

    where B,pR+ and the initial conditions xi,yi,ziR+ (1i2), and showed that system (1.6) is permanent when p(0,4).

    For more many results for global behavior, eventual periodicity and the boundedness character of positive solutions of max-type difference equations and systems, please readers refer to [11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30] and the related references therein.

    In this section, we study the global behavior of system (1.1). For any n1, write

    {x2n=A2nXn,y2n=B2nYn,z2n=C2nZn,w2n=D2nWn,x2n+1=A2n+1Xn,y2n+1=B2n+1Yn,z2n+1=C2n+1Zn,w2n+1=D2n+1Wn.

    Then, (1.1) reduces to the following system

    {Xn=max{1,C2n1Zn1A2nB2nYn1},Yn=max{1,D2n1Wn1B2nA2nXn1},Zn=max{1,A2nXnC2n+1D2n+1Wn1},Wn=max{1,B2nYnD2n+1C2n+1Zn1},Zn=max{1,A2n1Xn1C2nD2nWn1},Wn=max{1,B2n1Yn1D2nC2nZn1},Xn=max{1,C2nZnA2n+1B2n+1Yn1},Yn=max{1,D2nWnB2n+1A2n+1Xn1},  nN0. (2.1)

    From (2.1) we see that it suffices to consider the global behavior of positive solutions of the following system

    {un=max{1,bvn1aAUn1},Un=max{1,BVn1aAun1},vn=max{1,aunbBVn1},Vn=max{1,AUnbBvn1},  nN0, (2.2)

    where a,b,A,BR+, the initial conditions u1,U1,v1,V1R+. If (un,Un,vn,Vn,a,A,b,B)=(Xn,Yn,Zn,Wn,A2n,B2n,C2n1,D2n1), then (2.2) is the first four equations of (2.1). If (un,Un,vn,Vn,a,A,b,B)=(Zn,Wn,Xn,Yn,C2n,D2n,A2n1,B2n1), then (2.2) is the next four equations of (2.1). In the following without loss of generality we assume aA and bB. Let {(un,Un,vn,Vn)}n=1 be a positive solution of (2.2).

    Proposition 2.1. If ab<1, then there exists a solution {(un,Un,vn,Vn)}n=1 of (2.2) such that un=vn=1 for any n1 and limnUn=limnVn=.

    Proof. Let u1=v1=1 and U1=V1=max{baA,aAB,abB}+1. Then, from (2.2) we have

    {u0=max{1,bv1aAU1}=1,U0=max{1,BV1aAu1}=BV1aA,v0=max{1,au0bBV1}=1,V0=max{1,AU0bBv1}=V1ab,

    and

    {u1=max{1,bv0aAU0}=max{1,bBV1}=1,U1=max{1,BV0aAu0}=max{1,BV1aAab}=BV1aAab,v1=max{1,au1bBV0}=max{1,aabbBV1}=1,V1=max{1,AU1bBv0}=max{1,V1(ab)2}=V1(ab)2.

    Suppose that for some kN, we have

    {uk=1,Uk=BV1aA(ab)k,vk=1,Vk=V1(ab)k+1.

    Then,

    {uk+1=max{1,bvkaAUk}=max{1,b(ab)kBV1}=1,Uk+1=max{1,BVkaAuk}=max{1,BV1aA(ab)k+1}=BV1aA(ab)k+1,vk+1=max{1,auk+1bBVk}=max{1,a(ab)k+1bBV1}=1,Vk+1=max{1,AUk+1bBvk}=max{1,V1(ab)k+2}=V1(ab)k+2.

    By mathematical induction, we can obtain the conclusion of Proposition 2.1. The proof is complete.

    Now, we assume that ab1. Then, from (2.2) it follows that

    {un=max{1,bvn1aAUn1},Un=max{1,BVn1aAun1},vn=max{1,abBVn1,vn1ABUn1Vn1},Vn=max{1,AbBvn1,Vn1abun1vn1},  nN0. (2.3)

    Lemma 2.1. The following statements hold:

    (1) For any nN0,

    un, Un, vn, Vn[1,+). (2.4)

    (2) If ab1, then for any kN and nk+2,

    {un=max{1,baAUn1,bvkaA(AB)nk1Un1Un2Vn2UkVk},Un=max{1,BaAun1,BVkaA(ab)nk1un1un2vn2ukvk},vn=max{1,abBVn1,vk(AB)nkUn1Vn1UkVk},Vn=max{1,AbBvn1,Vk(ab)nkun1vn1ukvk}. (2.5)

    (3) If ab1, then for any kN and nk+4,

    {1vnvn2,1VnAaVn2,1unmax{1,bBun2,bvkaA(AB)nk1},1Unmax{1,BbUn2,BVkaA(ab)nk1}. (2.6)

    Proof. (1) It follows from (2.2).

    (2) Since ABab1, it follows from (2.2) and (2.3) that for any kN and nk+2,

    un=max{1,bvn1aAUn1}=max{1,baAUn1max{1,abBVn2,vn2ABUn2Vn2}}=max{1,baAUn1,bvn2ABaAUn1Un2Vn2}=max{1,baAUn1,bABaAUn1Un2Vn2max{1,abBVn1,vn3ABUn3Vn3}}=max{1,baAUn1,bvn3(AB)2aAUn1Un2Vn2Un3Vn3}=max{1,baAUn1,bvkaA(AB)nk1Un1Un2Vn2UkVk}.

    In a similar way, also we can obtain the other three formulas.

    (3) By (2.5) one has that for any kN and nk+2,

    {unbaAUn1,UnBaAun1,vnabBVn1,VnAbBvn1,

    from which and (2.4) it follows that for any nk+4,

    {1unmax{1,bBun2,bvkaA(AB)nk1},1Unmax{1,BbUn2,BVkaA(ab)nk1},1vnmax{1,avn2A,vn2}=vn2,1Vnmax{1,AVn2a,Vn2}=AVn2a.

    The proof is complete.

    Proposition 2.2. If ab=AB=1, then {(un,Un,vn,Vn)}+n=1 is eventually periodic with period 2.

    Proof. By the assumption we see a=A and b=B. By (2.5) we see that for any kN and nk+2,

    {un=max{1,b3Un1,b3vkUn1Un2Vn2UkVk},Un=max{1,b3un1,b3Vkun1un2vn2ukvk},vn=max{1,a3Vn1,vkUn1Vn1UkVk},Vn=max{1,a3vn1,Vkun1vn1ukvk}. (2.7)

    (1) If a=b=1, then it follows from (2.7) and (2.4) that for any nk+4,

    {un=max{1,vkUn1Un2Vn2UkVk}max{1,vkUn2Un3Vn3UkVk}=un1,Un=max{1,Vkun1un2vn2ukvk}Un1,vn=max{1,vkUn1Vn1UkVk}vn1,Vn=max{1,Vkun1vn1ukvk}Vn1. (2.8)

    We claim that vn=1 for any n6 or Vn=1 for any n6. Indeed, if vn>1 for some n6 and Vm>1 for some m6, then

    vn=v1Un1Vn1U1V1>1,  Vm=V1um1vm1u1v1>1,

    which implies

    1v1Un1Vn1U1V1V1um1vm1u1v1=Vmvn>1.

    A contradiction.

    If vn=1 for any n6, then by (2.8) we see un=1 for any n10, which implies Un=Vn=V10.

    If Vn=1 for any n6, then by (2.8) we see Un=1 for any n10, which implies vn=un=v10.

    Then, {(un,Un,vn,Vn)}+n=1 is eventually periodic with period 2.

    (2) If a<1<b, then it follows from (2.7) that for any nk+4,

    {un=max{1,b3Un1,b3vkUn1Un2Vn2UkVk},Un=max{1,b3un1,b3Vkun1un2vn2ukvk},vn=max{1,vkUn1Vn1UkVk}vn1,Vn=max{1,Vkun1vn1ukvk}Vn1. (2.9)

    It is easy to verify vn=1 for any n6 or Vn=1 for any n6.

    If Vn=vn=1 eventually, then by (2.9) we have

    {1vkUn1Vn1UkVk eventually,1Vkun1vn1ukvk eventually.

    Since Unb3un1 and unb3Un1, we see

    {un=max{1,b3Un1,b3vkUn1Un2Vn2UkVk}=max{1,b3Un1}un2 eventually,Un=max{1,b3un1,b3Vkun1un2vn2ukvk}=max{1,b3un1}Un2 eventually,

    which implies

    {un2un=max{1,b3Un1}max{1,b3Un3}=un2 eventually,Un2Un=max{1,b3un1}max{1,b3un3}=Un2 eventually.

    If Vn>1=vn eventually, then by (2.9) we have

    {1vkUn1Vn1UkVk eventually,Vn=Vkun1vn1ukvk>1 eventually.

    Thus,

    {un=max{1,b3Un1,b3vkUn1Un2Vn2UkVk}=max{1,b3Un1}un2 eventually,Un=max{1,b3un1,b3Vkun1un2vn2ukvk}=max{1,b3Vkun1un2vn2ukvk}Un2 eventually,

    which implies

    {un2un=max{1,b3Un1}max{1,b3Un3}=un2 eventually,Un=1 eventually  or  b3Vk eventually.

    If Vn=1<vn eventually, then by (2.9) we have Un2=Un eventually and un=un1 eventually. By the above we see that {(un,Un,vn,Vn)}+n=1 is eventually periodic with period 2.

    (3) If b<1<a, then for any kN and nk+2,

    {un=max{1,b3vkUn1Un2Vn2UkVk}un1,Un=max{1,b3Vkun1un2vn2ukvk}Un1,vn=max{1,a3Vn1,vkUn1Vn1UkVk},Vn=max{1,a3vn1,Vkun1vn1ukvk}. (2.10)

    It is easy to verify un=1 for any n3 or Un=1 for any n3.

    If un=Un=1 eventually, then

    {1b3vkUn1Un2Vn2UkVk eventually,1b3Vkun1un2vn2ukvk eventually.

    Thus, by (2.6) we have

    {vn2vn=max{1,a3Vn1,vkUn1Vn1UkVk}=max{1,a3Vn1}vn2 eventually,Vn2Vn=max{1,a3vn1,Vkun1vn1ukvk}=max{1,a3vn1}Vn2 eventually.

    If un=1<Un eventually, then

    {1b3vkUn1Un2Vn2UkVk eventually,1<b3Vkun1un2vn2ukvk=Un eventually.

    Thus,

    {vn2vn=max{1,a3Vn1,vkUn1Vn1UkVk}=max{1,a3Vn1}vn2 eventually,Vn=max{1,a3vn1,Vkun1vn1ukvk}=max{1,Vkun1vn1ukvk}=1 eventually or Vk eventually.

    If un>1=Un eventually, then we have Vn=Vn2 eventually and vn=1 eventually or vn=vk eventually.

    By the above we see that {(un,Un,vn,Vn)}+n=1 is eventually periodic with period 2.

    Proposition 2.3. If ab=1<AB, then {(un,Un,vn,Vn)}+n=1 is eventually periodic with period 2.

    Proof. Note that UnBaAun1 and VnAbBvn1. By (2.5) we see that there exists NN such that for any nN,

    {un=max{1,b2AUn1}un2,Un=max{1,BaAun1,BVkaAun1un2vn2ukvk},vn=max{1,a2BVn1}vn2,Vn=max{1,AbBvn1,Vkun1vn1ukvk}. (2.11)

    It is easy to verify that un=1 for any nN+1 or vn=1 for any nN+1.

    If un=vn=1 eventually, then by (2.11) we see that Un=Un1 eventually and Vn=Vn1 eventually.

    If uM+2n>1=vn eventually for some MN, then by (2.11) and (2.4) we see that

    {uM+2n=b2AUM+2n1>1 eventually,UM+2n+1=max{1,BbUM+2n1,BVkaAuM+2nuM+2n1vM+2n1ukvk}BbUM+2n1 eventually,vn=max{1,a2BVn1}=1 eventually,Vn=max{1,AbBvn1,Vkun1vn1ukvk}Vn1 eventually.

    By (2.11) we see that Un is bounded, which implies B=b.

    If UM+2n1BVkaAuM+2nuM+2n1vM+2n1ukvk eventually, then

    UM+2n+1=BVkaAuM+2nuM+2n1vM+2n1ukvkUM+2n1 eventually.

    Thus, UM+2n+1=UM+2n1 eventually and uM+2n=uM+2n2 eventually. Otherwise, we have UM+2n+1=UM+2n1 eventually and uM+2n=uM+2n2 eventually. Thus, Vn=Vn1=max{1,AbB} eventually since limnVkun1vn1ukvk=0. By (2.2) it follows UM+2n=UM+2n2 eventually and uM+2n+1=uM+2n1 eventually.

    If vM+2n>1=un eventually for some MN, then we may show that {(un,Un,vn,Vn)}+n=1 is eventually periodic with period 2. The proof is complete.

    Proposition 2.4. If ab>1, then {(un,Un,vn,Vn)}+n=1 is eventually periodic with period 2.

    Proof. By (2.5) we see that there exists NN such that for any nN,

    {un=max{1,baAUn1},Un=max{1,BaAun1},vn=max{1,abBVn1},Vn=max{1,AbBvn1}. (2.12)

    If a<A, then for n2k+N with kN,

    vn=max{1,abBVn1}max{1,aAvn2}max{1,(aA)kvn2k},

    which implies vn=1 eventually and Vn=max{1,AbB} eventually.

    If a=A, then

    {vn=max{1,abBVn1}vn2 eventually,Vn=max{1,AbBvn1}Vn2 eventually.

    Which implies

    {vn2vn=max{1,abBVn1}max{1,abBVn3}=vn2 eventually,Vn2Vn=max{1,AbBvn1}max{1,AbBvn3}=Vn2 eventually.

    Thus, Vn,vn are eventually periodic with period 2. In a similar way, we also may show that Un,un are eventually periodic with period 2. The proof is complete.

    From (2.1), (2.2), Proposition 2.1, Proposition 2.2, Proposition 2.3 and Proposition 2.4 one has the following theorem.

    Theorem 2.1. (1) If min{A0C1,B0D1,A1C0,B1D0}<1, then system (1.1) has unbounded solutions.

    (2) If min{A0C1,B0D1,A1C0,B1D0}1, then every solution of system (1.1) is eventually periodic with period 4.

    In this paper, we study the eventual periodicity of max-type system of difference equations of the second order with four variables and period-two parameters (1.1) and obtain characteristic conditions of the coefficients under which every positive solution of (1.1) is eventually periodic or not. For further research, we plan to study the eventual periodicity of more general max-type system of difference equations by the proof methods used in this paper.

    The authors declare they have not used Artificial Intelligence (AI) tools in the creation of this article.

    Project supported by NSF of Guangxi (2022GXNSFAA035552) and Guangxi First-class Discipline SCPF(2022SXZD01, 2022SXYB07) and Guangxi Key Laboratory BDFE(FED2204) and Guangxi University of Finance and Economics LSEICIC(2022YB12).

    There are no conflict of interest in this article.



    Conflict of interest



    The authors declare no conflict of interest.

    [1] Cardona V, Ansotegui IJ, Ebisawa M, et al. (2020) World allergy organization anaphylaxis guidance 2020. World Allergy Organ J 13: 100472. doi: 10.1016/j.waojou.2020.100472
    [2] Sicherer SH, Simons FER (2017) Epinephrine for first-aid management of anaphylaxis. Pediatrics 139: e20164006. doi: 10.1542/peds.2016-4006
    [3] Rudders SA, Banerji A, Clark S, et al. (2011) Age-related differences in the clinical presentation of food-induced anaphylaxis. J Pediatr 158: 326-328. doi: 10.1016/j.jpeds.2010.10.017
    [4] Simons FE, Sampson HA (2015) Anaphylaxis: unique aspects of clinical diagnosis and management in infants (birth to age 2 years). J Allergy Clin Immunol 135: 1125-1131. doi: 10.1016/j.jaci.2014.09.014
    [5] Turner PJ, Jerschow E, Umasunthar T, et al. (2017) Fatal anaphylaxis: mortality rate and risk factors. J Allergy Clin Immunol Pract 5: 1169-1178. doi: 10.1016/j.jaip.2017.06.031
    [6] Turner PJ, Gowland MH, Sharma V, et al. (2015) Increase in anaphylaxis-related hospitalizations but no increase in fatalities: an analysis of United Kingdom national anaphylaxis data, 1992–2012. J Allergy Clin Immunol 135: 956-963.e1. doi: 10.1016/j.jaci.2014.10.021
    [7] Motosue MS, Bellolio MF, Van Houten HK, et al. (2018) Outcomes of emergency department anaphylaxis visits from 2005 to 2014. J Allergy Clin Immunol Pract 6: 1002-1009.e2. doi: 10.1016/j.jaip.2017.07.041
    [8]  Emergency treatment of anaphylactic reactions: guidelines for healthcare providers Working Group of the Resuscitation Council (UK) (2016) .Available from: https://www.resus.org.uk/sites/default/files/2020-06/EmergencyTreatmentOfAnaphylacticReactions%20%281%29.pdf.
    [9] Brown JC, Simons E, Rudders SA (2020) Epinephrine in the management of anaphylaxis. J Allergy Clin Immunol Pract 8: 1186-1195. doi: 10.1016/j.jaip.2019.12.015
    [10] Fleming JT, Clark S, Camargo CA, et al. (2015) Early treatment of food-induced anaphylaxis with epinephrine is associated with a lower risk of hospitalization. J Allergy Clin Immunol Pract 3: 57-62. doi: 10.1016/j.jaip.2014.07.004
    [11] Cardona V, Ferré-Ybarz L, Guilarte M, et al. (2017) Safety of adrenaline use in anaphylaxis: a multicentre register. Int Arch Allergy Immunol 173: 171-177. doi: 10.1159/000477566
    [12] Anagnostou K (2018) Anaphylaxis in children: epidemiology, risk factors and management. Curr Pediatr Rev 14: 180-186. doi: 10.2174/1573396314666180507115115
    [13] Grabenhenrich LB, Dölle S, Ruëff F, et al. (2018) Epinephrine in severe allergic reactions: the european anaphylaxis register. J Allergy Clin Immunol Pract 6: 1898-1906.e1. doi: 10.1016/j.jaip.2018.02.026
    [14] Brown JC (2018) Epinephrine, auto-injectors, and anaphylaxis: challenges of dose, depth, and device. Ann Allergy Asthma Immunol 121: 53-60. doi: 10.1016/j.anai.2018.05.001
    [15] Edwards E, Kessler C, Cherne N, et al. (2018) Human factors engineering validation study for a novel 0.1-mg epinephrine auto-injector. Allergy Asthma Proc 39: 461-465. doi: 10.2500/aap.2018.39.4171
    [16] Lieberman P, Nicklas RA, Randolph C, et al. (2015) Anaphylaxis-a practice parameter update 2015. Ann Allergy Asthma Immunol 115: 341-384. doi: 10.1016/j.anai.2015.07.019
    [17] Simons KJ, Simons FE (2010) Epinephrine and its use in anaphylaxis: current issues. Curr Opin Allergy Clin Immunol 10: 354-361. doi: 10.1097/ACI.0b013e32833bc670
    [18] Choi YJ, Kim J, Jung JY (2019) Underuse of epinephrine for pediatric anaphylaxis victims in the emergency department: a population-based study. Allergy Asthma Immunol Res 11: 529-537. doi: 10.4168/aair.2019.11.4.529
    [19] Prince BT, Mikhail I, Stukus DR (2018) Underuse of epinephrine for the treatment of anaphylaxis: missed opportunities. J Asthma Allergy 11: 143-151. doi: 10.2147/JAA.S159400
    [20] Cristiano LM, Hiestand B, Caldwell JW, et al. (2018) Prehospital administration of epinephrine in pediatric anaphylaxis—a statewide perspective. Prehosp Emerg Care 22: 452-456. doi: 10.1080/10903127.2017.1399184
    [21] Carrillo E, Hern HG, Barger J (2016) Prehospital administration of epinephrine in pediatric anaphylaxis. Prehosp Emerg Care 20: 239-244. doi: 10.3109/10903127.2015.1086843
    [22] Dubus JC, Lê MS, Vitte J, et al. (2019) Use of epinephrine in emergency department depends on anaphylaxis severity in children. Eur J Pediatr 178: 69-75. doi: 10.1007/s00431-018-3246-3
    [23] Song TT, Brown D, Karjalainen M, et al. (2018) Value of a second dose of epinephrine during anaphylaxis: a patient/caregiver survey. J Allergy Clin Immunol Pract 6: 1559-1567. doi: 10.1016/j.jaip.2018.01.019
  • Reader Comments
  • © 2021 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Metrics

Article views(2917) PDF downloads(179) Cited by(1)

Other Articles By Authors

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return

Catalog