Research article Special Issues

Expression and role of cystatin C in hyperthermia-induced brain injury in rats


  • Received: 24 August 2022 Revised: 18 October 2022 Accepted: 31 October 2022 Published: 28 November 2022
  • Cystatin C, the full name of cystatin C, is one of the most potent cathepsin inhibitors currently known, which can strongly inhibit cathepsin in lysosomes and regulate the level of intracellular proteolysis. Cystatin C plays a very broad role in the body. High temperature-induced brain injury leads to very serious damage to brain tissue, such as cell inactivation, brain tissue edema, etc. At this time, cystatin C can play a crucial role. Based on the research on the expression and role of cystatin C in high temperature-induced brain injury in rats, this paper draws the following conclusions: high temperature can cause very serious damage to the brain tissue of rats, which can seriously lead to death. Cystatin C has a protective effect on brain cells and cerebral nerves. When the brain is damaged by high temperature, cystatin C can relieve the damage of high temperature to the brain and protect brain tissue. In this paper, a detection method for cystatin C with more outstanding performance is proposed, and compared with the traditional detection method, the detection method in this paper is verified to have more accurate accuracy and excellent stability through comparative experiments. Compared with traditional detection methods, it is more worthwhile to use and is a better detection method.

    Citation: Haiqiang Liu, Feifei Shen, Hewei Zhang, Weikai Zhang. Expression and role of cystatin C in hyperthermia-induced brain injury in rats[J]. Mathematical Biosciences and Engineering, 2023, 20(2): 2716-2731. doi: 10.3934/mbe.2023127

    Related Papers:

  • Cystatin C, the full name of cystatin C, is one of the most potent cathepsin inhibitors currently known, which can strongly inhibit cathepsin in lysosomes and regulate the level of intracellular proteolysis. Cystatin C plays a very broad role in the body. High temperature-induced brain injury leads to very serious damage to brain tissue, such as cell inactivation, brain tissue edema, etc. At this time, cystatin C can play a crucial role. Based on the research on the expression and role of cystatin C in high temperature-induced brain injury in rats, this paper draws the following conclusions: high temperature can cause very serious damage to the brain tissue of rats, which can seriously lead to death. Cystatin C has a protective effect on brain cells and cerebral nerves. When the brain is damaged by high temperature, cystatin C can relieve the damage of high temperature to the brain and protect brain tissue. In this paper, a detection method for cystatin C with more outstanding performance is proposed, and compared with the traditional detection method, the detection method in this paper is verified to have more accurate accuracy and excellent stability through comparative experiments. Compared with traditional detection methods, it is more worthwhile to use and is a better detection method.



    加载中


    [1] R. Janowski, M. Kozak, E. Jankowska, Z. Grzonka, A. Grubb, M. Abrahamson, et al., Human cystatin C, an amyloidogenic protein, dimerizes through three-dimensional domain swapping, Nat. Struct. Biol., 8 (2001), 316–320. https://doi.org/10.1038/86188 doi: 10.1038/86188
    [2] M. G. Shlipak, M. J. Sarnak, R. Katz, L. F. Fried, S. L. Seliger, A. B. Newman, et al., Cystatin C and the risk of death and cardiovascular events among elderly persons, N. Engl. J. Med., 352 (2005), 2049–2060. https://doi.org/10.1056/NEJMoa043161 doi: 10.1056/NEJMoa043161
    [3] O. Tenstad, A. B. Roald, A. Grubb, Renal handling of radiolabelled human cystatin C in the rat, Scand. J. Clin. Lab. Invest., 56 (1996), 409–414. https://doi.org/10.3109/00365519609088795 doi: 10.3109/00365519609088795
    [4] L. Kou, Y. Shi, L. Zhang, D. Liu, Q. Yang, A lightweight three-factor user authentication protocol for the information perception of IoT, CMC-Comput. Mater. Continua, 58 (2019), 545–565. https://doi.org/10.32604/cmc.2019.03760 doi: 10.32604/cmc.2019.03760
    [5] J. Zhang, Y. Xie, W. Liu, X. Gong, Table recognition for sensitive data perception in an IoT vision environment, Appl. Sci., 9 (2019), 4162. https://doi.org/10.3390/app9194162 doi: 10.3390/app9194162
    [6] C. Wan, J. Jiang, H. Mao, J. Cao, X. Wu, G. Cui, Involvement of upregulated p53-induced death domain protein (PIDD) in neuronal apoptosis after rat traumatic brain injury, J. Mol. Neurosci., 51 (2013), 695–702. https://doi.org/10.1007/s12031-013-0050-4 doi: 10.1007/s12031-013-0050-4
    [7] H. S. Sharma, J. Westman, J. Cervós-Navarro, F. Nyberg, Role of neurochemicals in brain edema and cell changes following hyperthermic brain injury in the rat, in Brain Edema X, Springer, Vienna, 70 (1997), 269–274. https://doi.org/10.1007/978-3-7091-6837-0_84
    [8] M. Nieto-Sampedro, M. A. Berman, Interleukin‐1‐like activity in rat brain: Sources, targets, and effects of injury, J. Neurosci. Res., 17 (2010), 214–219. https://doi.org/10.1002/jnr.490170303 doi: 10.1002/jnr.490170303
    [9] S. M. Cutler, M. Cekic, D. M. Miller, B. Wali, J. W. VanLandingham, D. G. Stein, Progesterone improves acute recovery after traumatic brain injury in the aged rat, J. Neurotrauma, 24 (2007), 1475–1486. https://doi.org/10.1089/neu.2007.0294 doi: 10.1089/neu.2007.0294
    [10] L. Zhang, K. Tanabe, F. Yanagidate, Y. Kawasaki, G. Chen, S. Dohi, et al., Different effects of local anesthetics on extracellular signal-regulated kinase phosphorylation in rat dorsal horn neurons, Eur. J. Pharmacol., 734 (2014), 132–136. https://doi.org/10.1016/j.ejphar.2014.03.048 doi: 10.1016/j.ejphar.2014.03.048
    [11] T. D. Sharkey, S. M. Schrader, High temperature stress, in Physiology and Molecular Biology of Stress Tolerance in Plants, Springer, (2006), 101–129. https://doi.org/10.1007/1-4020-4225-6_4
    [12] Y. Fan, G. Zhao, C. K. Li, B. Zhang, G. Tan, X. Sun, et al., SNPL: One scheme of securing nodes in iot perception layer, Sensors, 20 (2020), 1090. https://doi.org/10.3390/s20041090 doi: 10.3390/s20041090
    [13] A. Kogut, D. N. Spergel, C. Barnes, C. L. Bennett, M. Halpern, G. Hinshaw, et al., First-year wilkinson microwave anisotropy probe (WMAP) observations: temperature-polarization correlation, Astrophys. J. Suppl. Ser., 2003, 148 (2003), 161. https://doi.org/10.1086/377219 doi: 10.1086/377219
    [14] R. G. Ahmed, The relation between biological consequences and high temperature in mammals, Int. J. Zool. Res., 2 (2006), 48–59. https://doi.org/10.3923/ijzr.2006.48.59 doi: 10.3923/ijzr.2006.48.59
    [15] M. Kurioka, Studies on the ascorbic acid metabolism of animals in high temperature environment: (Ⅰ) on the ascorbic acid content of animal tissues suddenly exposed to hot environment, Vitamins, 16 (1959), 415–421. https://doi.org/10.20632/vso.16.0_415 doi: 10.20632/vso.16.0_415
  • Reader Comments
  • © 2023 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Metrics

Article views(1636) PDF downloads(77) Cited by(0)

Article outline

Figures and Tables

Figures(8)  /  Tables(5)

Other Articles By Authors

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return

Catalog