
Citation: Xi Lu, Zejun You, Miaomiao Sun, Jing Wu, Zhihong Zhang. Breast cancer mitotic cell detection using cascade convolutional neural network with U-Net[J]. Mathematical Biosciences and Engineering, 2021, 18(1): 673-695. doi: 10.3934/mbe.2021036
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[3] | Xiaojun Zhou, Yue Dai . A spectral collocation method for the coupled system of nonlinear fractional differential equations. AIMS Mathematics, 2022, 7(4): 5670-5689. doi: 10.3934/math.2022314 |
[4] | Yuanqiang Chen, Jihui Zheng, Jing An . A Legendre spectral method based on a hybrid format and its error estimation for fourth-order eigenvalue problems. AIMS Mathematics, 2024, 9(3): 7570-7588. doi: 10.3934/math.2024367 |
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It is well known that the spectral method has high-order accuracy for smooth problems. The spectral method together with the difference method and the finite element method has become an important method for the numerical solution of partial differential equations (PDEs), and has been successfully applied to solve many practical problems. In recent years, with regard to the differential equations of time evolution, the high-order discrete scheme in time has received widespread attention and has become one of the hot spots in the field of numerical computing. The discontinuous Galerkin method in time is constantly developing, and a better higher-order discrete scheme in time is established [1,2,3]. The explicit, implicit and implicit-explicit Runge-Kutta methods have also made great progress: a local discontinuous Galerkin method with implicit-explicit time-marching is used to solve the multi-dimensional convection-diffusion problems and time-dependent incompressible fluid flow in [4,5,6]. In [7,8,9], the spectral method in time and the time multi-interval spectral method are also proposed. The single interval and multi-interval Legendre spectral methods in time are established for the parabolic equations, in which the L2-optimal error estimate in space is obtained in [10].
The Maxwell equation is a set of important PDEs that describes electromagnetic field phenomena, and some effective numerical methods have been established for the Maxwell equation by scholars [11,12,13]. The finite-difference time-domain method (also called Yee's scheme) for the Maxwell equation is proposed in [14]. In [15,16], an energy-conserved splitting spectral method for solving the Maxwell equation is given. For the 2-D Maxwell equation, a Legendre-Galerkin method in space and the energy-conserved splitting spectral method in time is constructed [17]. In previous work, the different method is used in the time direction. For the 1-D Maxwell equation of inhomogeneous media with discontinuous solutions, the multidomain Legendre-Galerkin and the multidomain Legendre-tau method are established in [18,19], and the optimal error estimates of the semi-discrete schemes are given.
Consider the following 1-D Maxwell equation [20]
{ϵ∂tEz=∂xHy,(x,t)∈Ω,μ∂tHy=∂xEz,(x,t)∈Ω,Ez(−1,t)=Ez(1,t)=0,t∈It,Ez(x,0)=Ez0(x),Hy(x,0)=Hy0(x),x∈Ix, | (1.1) |
where Ix=(−1,1), It=(0,T], and Ω=Ix×It. Ez and Hy stand for the electric field and the magnetic field, respectively. The positive constants ϵ and μ stand for the electric permeability and the magnetic permeability, respectively.
In [21,22], an h-p version of the Petrov-Galerkin time stepping method is used to solve the nonlinear initial value problems by transforming the second-order problem into a first-order system. For the linear second-order wave equation, it is often transformed into the first-order system similar to equation (1.1) by using the substitution v=∂u∂t,w=∂u∂x [23]. It is interesting to note that some methods use the derivative as the main unknown function, and u is expressed as the integral of w.
In this paper, a Legendre-tau space-time (LT-ST) spectral method is developed to solve the 1-D Maxwell equation (1.1) and a time multi-interval Legendre-tau spectral method is considered. The scheme is based on the Legendre-tau method, which uses polynomials of different degrees are used to approximate the electric field Ez and magnetic field Hy, respectively, so that they can be decoupled in computation. After decoupling, it is an equation only about Ez, which can be solved by the method in [10]. The method is also applied to the numerical solutions of the 1-D nonlinear Maxwell equation.
The paper is organized as follows. In Section 2, a Legendre-tau space-time spectral method for (1.1) is presented, and stability analysis and error estimate are given. In Section 3, a time multi-interval Legendre-tau spectral method is developed, and its error estimate is also obtained. Some numerical results are given in Section 4. Finally, the method is applied to the numerical solution of the 1-D nonlinear Maxwell equation in Section 5.
In this section, a Legendre-tau space-time spectral method is presented for the problem (1.1). Moreover, the stability and the error estimate of this method are given.
Let (⋅,⋅)Q and ‖⋅‖Q be the inner product and the norm of L2(Q), where Q stands for Ω, Ix and It, respectively. For a nonnegative integer m, let ‖⋅‖m,I and |⋅|m,I be the norm and the semi-norm of the classical Sobolev space Hm(I), where I stands for Ix or It, respectively. Define
H10(I)={v∈H1(I):v(−1)=v(1)=0}. |
For a pair of positive integers N and M, define L=(N,M). Let PN(Ix) be the space of polynomials of degree at most N on Ix. Define the polynomial space
VN={v∈PN(Ix)}, |
and the approximation space in space
V0N=H10(Ix)∩VN,VN−1={v∈PN−1(Ix)}. | (2.1) |
Let PM(It) be the space of polynomials of degree at most M on It, we define the approximation space in time
VM={v∈PM(It)},VM−1={v∈PM−1(It)}. | (2.2) |
Let xCj and ωCj(0≤j≤N) be the Chebyshev-Gauss-Lobatto (CGL) points and the corresponding weights on Ix. We define the CGL interpolation operator ICNv∈VN:
ICNv(xCj)=v(xCj),0≤j≤N. |
Similarly, let xLj and ωLj(0≤j≤N) be the Legendre-Gauss-Lobatto (LGL) points and the corresponding weights on Ix. ILNv∈VN denotes the LGL interpolation operator, and
ILNv(xLj)=v(xLj),0≤j≤N. |
We denote by PN:L2(Ix)→VN the L2(Ix)-Legendre projection operator and define P1N:H1(Ix)→VN by
P1Nu(x)=u(−1)+∫x−1PN−1∂xu(y)dy,x∈Ix. | (2.3) |
It is easy to see that
P1Nu(−1)=u(−1),P1Nu(1)=u(1), | (2.4) |
(∂xP1Nu−∂xu,v)=(PN−1∂xu−∂xu,v)=0,∀v∈VN−1. | (2.5) |
Let C be a generic positive constant independent of N, and the following approximation results can be found in [10,24].
Lemma 2.1. If u∈Hr(Ix), then
‖PNu−u‖Ix≤CN−r|u|r,Ix,r≥0,‖ILNu−u‖Ix≤CNl−r|u|r,Ix,r≥1,l=0,1.|P1Nu−u|l,Ix≤CNl−r|u|r,Ix,r≥1,l=0,1. |
Let tCj and ωCj(0≤j≤M) be the CGL points and the corresponding weights on It, and let tLj and ωLj(0≤j≤M) be the LGL points and the corresponding weights on It. We denote by PM:L2(It)→VM the L2(It)-Legendre projection operator and define P1M:H1(It)→VM as
P1Mv(t)=v(0)+∫t0PM−1∂tv(s)ds,t∈It. | (2.6) |
It is easy to find that
P1Mu(−1)=u(−1),P1Mu(1)=u(1), | (2.7) |
(∂tP1Mu−∂tu,v)=(PM−1∂tu−∂tu,v)=0,∀v∈VM−1. | (2.8) |
The following approximation result can be found in [10].
Lemma 2.2. If u∈Hσ(It) and σ≥1, then
|P1Mv−v|l,It≤CMl−σ|v|σ,It,l=0,1, |
where C is a positive constant independent of M.
The problem (1.1) is expressed in a weak form: Find Ez∈H10(Ix)⊗H1(It) and Hy∈L2(Ix)⊗H1(It) such that
{(ϵ∂tEz,v)Ω+(Hy,∂xv)Ω=0,∀v∈H10(Ix)⊗L2(It),(μ∂tHy,w)Ω−(∂xEz,w)Ω=0,∀w∈L2(Ix)⊗L2(It),Ez(x,0)=Ez0(x),Hy(x,0)=Hy0(x),∀x∈Ix. | (2.9) |
The LT-ST scheme to the problem (1.1) is: Find EzL∈V0N⊗VM and HyL∈VN−1⊗VM such that
{(ϵ∂tEzL,v)Ω+(HyL,∂xv)Ω=0,∀v∈V0N⊗VM−1,(μ∂tHyL,w)Ω−(∂xEzL,w)Ω=0,∀w∈VN−1⊗VM−1,EzL(x,0)=ILNEz0(x),HyL(x,0)=PN−1ILNHy0(x),∀x∈Ix. | (2.10) |
In the following section, the stability analysis of (2.10) is considered. Suppose that there are perturbations ˜fi(i=1,2) on the right-hand side. For simplicity, the original notations EzL and HyL are used to represent the solutions to the perturbation problem, which satisfies the following perturbation equation:
{(ϵ∂tEzL,v)Ω+(HyL,∂xv)Ω=(˜f1,v)Ω,∀v∈V0N⊗VM−1,(μ∂tHyL,w)Ω−(∂xEzL,w)Ω=(˜f2,w)Ω,∀w∈VN−1⊗VM−1,EzL(x,0)=0,HyL(x,0)=0,∀x∈Ix. | (2.11) |
Theorem 2.1. Let EzL and HyL are the solutions to (2.11). Suppose that ˜fi(i=1,2) are perturbations on the right-hand side, such that
‖√ϵEzL‖2Ω+‖√μHyL‖2Ω+T(‖√ϵEzL(T)‖2Ix+‖√μHyL(T)‖2Ix)≤CT2(‖~f1‖2Ω+‖~f2‖2Ω). | (2.12) |
Proof. Taking v=˜EzL:=t−1EzL∈V0N⊗VM−1 and w=˜HyL:=t−1HyL∈VN−1⊗VM−1 in (2.11), we get
{(ϵ∂t(t˜EzL),˜EzL)Ω+(t˜HyL,∂x˜EzL)Ω=(˜f1,˜EzL)Ω,(μ∂t(t˜HyL),˜HyL)Ω−(t∂x˜EzL,˜HyL)Ω=(˜f2,˜HyL)Ω, | (2.13) |
which leads to
(ϵ∂t(t˜EzL),˜EzL)Ω+(μ∂t(t˜HyL),˜HyL)Ω=(˜f1,˜EzL)Ω+(˜f2,˜HyL)Ω. | (2.14) |
By integration by parts,
(ϵ∂t(t˜EzL),˜EzL)Ω=(ϵ˜EzL,˜EzL)Ω+(ϵt∂t˜EzL,˜EzL)Ω=‖√ϵ˜EzL‖2Ω+12T‖√ϵ˜EzL(T)‖2Ix−12‖√ϵ˜EzL‖2Ω=12(‖√ϵ˜EzL‖2Ω+T‖√ϵ˜EzL(T)‖2Ix),(μ∂t(t˜HzL),˜HzL)Ω=(μ˜HzL,˜HzL)Ω+(μt∂t˜HzL,˜HzL)Ω=12(‖√μ˜HzL‖2Ω+T‖√μ˜HzL(T)‖2Ix), | (2.15) |
and using the Cauchy-Schwarz inequality
|(~f1,˜EzL)Ω+(~f2,˜HyL)Ω|≤‖~f1‖Ω‖˜EzL‖Ω+‖~f2‖Ω‖˜HyL‖Ω≤14(‖√ϵ˜EzL‖2Ω+‖√μ˜HzL‖2Ω)+1ϵ‖~f1‖2Ω+1μ‖~f2‖2Ω, | (2.16) |
where ˜EzL(T) = ˜EzL(x,T) and ˜HyL(T) = ˜HyL(x,T). Substituting (2.15)-(2.16) into (2.14),
14(‖√ϵ˜EzL‖2Ω+‖√μ˜HzL‖2Ω)+T2(‖√ϵ˜EzL(T)‖2Ix+‖√μ˜HzL(T)‖2Ix)≤1ϵ‖~f1‖2Ω+1μ‖~f2‖2Ω. | (2.17) |
and noting that ‖EzL‖Ω≤T‖˜EzL‖Ω,‖HyL‖Ω≤T‖˜HyL‖Ω, we get the result of (2.12).
In the following section, the error estimate of (2.10) is given. In order to deal with the error of the initial value, the following auxiliary problem is considered [25]
{ϵ∂tE=∂xH,(x,t)∈Ω,μ∂tH=∂xE,(x,t)∈Ω,E(−1,t)=E(1,t)=0,t∈It,E(x,0)=ILNEz0(x),H(x,0)=PN−1ILNHy0(x),x∈Ix. | (2.18) |
Firstly, the estimate between the two solutions to (2.10) and (2.18) is considered. We define
Ea=P1NP1ME,Ha=PN−1P1MH. | (2.19) |
By (2.5) and (2.8), we have
(∂tP1ME,v)It=(∂tE,v)It,∀v∈VM−1,(∂xP1NE,w)Ix=(∂xE,w)Ix,∀w∈VN−1, |
and
{(ϵ∂tEa,v)Ω+(Ha,∂xv)Ω=(ϵP1N∂tE,v)Ω−(P1M∂xH,v)Ω,∀v∈V0N⊗VM−1,(μ∂tHa,w)Ω−(∂xEa,w)Ω=(μ∂tH,w)Ω−(P1M∂xE,w)Ω,∀w∈VN−1⊗VM−1. | (2.20) |
Let ez=EzL−Ea and ey=HyL−Ha. By (2.10) and (2.20), the following error equation is obtained
{(ϵ∂tez,v)Ω+(ey,∂xv)Ω=(f1,v)Ω,∀v∈V0N⊗VM−1,(μ∂tey,w)Ω−(∂xez,w)Ω=(f2,w)Ω,∀w∈VN−1⊗VM−1,ez(x,0)=0,ey(x,0)=0,∀x∈Ix. | (2.21) |
Due to (2.18), we have ϵ∂tE=∂xH, μ∂tH=∂xE, and
f1=ϵ(P1M−I)∂tE+(I−P1N)∂xH,f2=μ(P1M−I)∂tH. |
Similar to the proof of Theorem 2.1, we obtain the following error estimate.
Theorem 2.2. Let Ea and Ha be the projections (2.19) of E and H (2.18), respectively. Let EzL and HyL be the solutions to (2.10), respectively. Assuming that σ≥1, r≥2, E,H∈C([0,T];Hr(Ix))∩L2(Ix;Hσ(It)), and then there exists a positive constant C such that
‖√ϵ(EzL−Ea)‖2Ω+‖√μ(HyL−Ha)‖2Ω+T(‖√ϵ(EzL−Ea)(T)‖2Ix+‖√μ(HyL−Ha)(T)‖2Ix)≤CT2[M2(1−σ)(‖∂σtE‖2Ω+‖∂σtH‖2Ω)+N2(1−r)‖∂rxH‖2Ω] | (2.22) |
Proof. By (2.12) and (2.21), we have
‖√ϵez‖2Ω+‖√μey‖2Ω+T(‖√ϵez(T)‖2Ix+‖√μey(T)‖2Ix)≤CT2(‖f1‖2Ω+‖ f2‖2Ω). | (2.23) |
According to Lemma 2.1 and 2.2, it follows that
‖f1‖2Ω≤C(M2(1−σ)‖∂σtE‖2Ω+N2(1−r)‖∂rxH‖2Ω), | (2.24) |
‖f2‖2Ω≤CM2(1−σ)‖∂σtH‖2Ω. | (2.25) |
Substituting (2.24)-(2.25) into (2.23), the error estimate (2.22) is obtained.
Next, the error estimate between the solutions to (2.10) and (1.1) is considered.
Theorem 2.3. Let Ez, Hy, EzL, and HyL be the solutions to (1.1) and (2.10), respectively. Assume that σ≥1, r≥2, E,H∈C([0,T];Hr(Ix))∩L2(Ix;Hσ(It)), and then there exists a positive constant C such that
‖√ϵ(EzL−Ez)‖2Ω+‖√μ(HyL−Hy)‖2Ω+T(‖√ϵ(EzL−Ez)(T)‖2Ix+‖√μ(HyL−Hy)(T)‖2Ix)≤CT2[M2(1−σ)(‖∂σtE‖2Ω+‖∂σtH‖2Ω)+N2(1−r)‖∂rxH‖2Ω]+CTN−2r(‖Ez‖2L∞(0,T;Hr(Ix))+‖Hy‖2L∞(0,T;Hr(Ix))) | (2.26) |
Proof. Firstly, the error between the solutions to (2.18) and (1.1) is estimated. Let ez=E−Ez and ey=H−Hy. By (1.1) and (2.18), we get the following error equation
{ϵ∂tez=∂xey,(x,t)∈Ω,μ∂tey=∂xez,(x,t)∈Ω. | (2.27) |
Then, we consider the inner product on Ix
{(ϵ∂tez,ez)Ix=−(ey,∂xez)Ix,(μ∂tey,ey)Ix=(∂xez,ey)Ix, | (2.28) |
which leads to
‖√ϵez(t)‖2Ix+‖√μey(t)‖2Ix=‖√ϵez(0)‖2Ix+‖√μey(0)‖2Ix,∀t>0. | (2.29) |
Next, integrating over t
‖√ϵez‖2Ω+‖√μey‖2Ω=T(‖√ϵez(0)‖2Ix+‖√μey(0)‖2Ix), | (2.30) |
and taking t=T, we have
‖√ϵez(T)‖2Ix+‖√μey(T)‖2Ix=‖√ϵez(0)‖2Ix+‖√μey(0)‖2Ix. | (2.31) |
According to Lemma 2.1, it follows that
‖ez(0)‖Ix=‖Ez0−ILNEz0‖Ix≤CN−r|Ez0|r,Ix,‖ey(0)‖Ix=‖Hy0−PN−1ILNHy0‖Ix≤‖Hy0−PN−1Hy0‖Ix+‖PN−1(Hy0−ILNHy0)‖Ix≤CN−r|Hy0|r,Ix. | (2.32) |
Substituting (2.32) into (2.30)-(2.31), we obtain
‖√ϵ(E−Ez)‖2Ω+‖√μ(H−Hy)‖2Ω+T(‖√ϵ(E−Ez)(T)‖2Ix+‖√μ(H−Hy)(T)‖2Ix)≤CTN−2r(|Ez|2r,Ix+|Hy0|2r,Ix). | (2.33) |
On the other hand, by Lemmas 2.1-2.2, we have
‖√ϵ(Ea−E)‖2Ω+‖√μ(Ha−H)‖2Ω+T(‖√ϵ(Ea−E)(T)‖2Ix+‖√μ(Ha−H)(T)‖2Ix)≤CTN−2r(|Ez02r,Ix+|Hy0|2r,Ix). | (2.34) |
From (2.22) and (2.33)-(2.34), the error estimate (2.26) is obtained.
In this section, a time multi-interval Legendre-tau spectral scheme is developed and its error estimate is obtained.
Let K be a positive integer and a partition of the computational interval It is given as
It=K⋃k=1Ik,Ik=(ak−1,ak),τk=ak−ak−1,1≤k≤K, | (3.1) |
where
0=a0<a1<⋅⋅⋅<ak<⋅⋅⋅<aK=T. |
Let M=(M1,⋯,MK) and L=(N,M). We define the space of approximate functions in time as
XM=WM∩H1(It),WM={v:v|Ik∈PMk(Ik),1≤k≤K}, | (3.2) |
where PMk(Ik) denotes the space of polynomials of degree at most Mk on Ik. We define the space of the test functions in time as
WM−1={v:v|Ik∈PMk−1(Ik),1≤k≤K}, | (3.3) |
where M−1=(M1−1,⋯,MK−1).
Let ˆI=(−1,1) be a reference interval, ˆtkj and ˆωkj(0≤j≤Mk) be the LGL points and the corresponding weights on ˆI. We denote by {ˆtkj} and {ˆωkj} be the LGL points and the corresponding weights on Ik. Next, we define
IkM={tkj:tkj=τkˆtkj+ak−1+ak2,0≤j≤Mk,1≤k≤K}, |
where τk=ak−ak−1.
Letting vk≡v|Ik, for any u,v∈C(ˉI) and ωkj=12τkˆωkj, we define
(u,v)M,Ik=Mk∑j=0uk(tkj)vk(tkj)ωkj,(u,v)M=K∑k=1(u,v)M,Ik. |
Similarly, we denote ˆtk,Cj and ˆωk,Cj be the CGL points and the corresponding weights on ˆI. Let {ˆtk,Cj} and {ˆωk,Cj} be the CGL points and the corresponding weights on Ik.
We define LGL interpolation operator ILM:C(ˉI)→WM by
ILMu(tkj)=u(tkj),0≤Mk,1≤k≤K. |
Similarly, for the CGL interpolation operator ILM:C(ˉI)→WM, which satisfies
ICMu(tk,Cj)=u(tk,Cj),0≤Mk,1≤k≤K. |
Define the following relation
v(t)=ˆv(ˆt),t=12(τkˆt+ak−1+ak),ak−1≤t≤ak. |
Let ˆPMk−1:L2(ˆI)→PMk−1 the L2-Legendre projection operator by PM−1:L2(It)→WM−1 such that
(PM−1v)|Ik(t)=ˆPMk−1^(v|Ik)(ˆt). |
Let ˆP1,Mk:H1(ˆI)→PMk be the Legendre projection operator, which satisfies
ˆP1,Mkˆv(ˆt)=ˆv(−1)+∫ˆt−1ˆPMk−1∂ˆtˆv(s)ds, |
and P1,M be generated by P1,Mk:H1(Ik)→PMk(Ik) such that
(P1,Mv)|Ik(t)≡P1,Mkv|Ik(t)=ˆP1,Mk^(v|Ik)(ˆt). | (3.4) |
The following approximation results can be found in [10].
Lemma 3.1. If v∈Hσ(It) and σ≥1, then
|P1Mv−v|l,It≤C(K∑k=1(τ−1kMk)2(l−σ)|v|2σ,Ik)12,l=0,1, |
where C is a generic positive constant independent of τk, Mk.
The time multi-interval Legendre-tau spectral method for the problem (1.1) is : Find EkzN∈V0N⊗WM and HkyN∈VN−1⊗WM such that
{(ϵ∂tEKzL,v)Ω+(HKyL,∂xv)Ω=0,∀v∈V0N⊗WM−1,(μ∂tHKyL,w)Ω−(∂xEKzL,w)Ω=0,∀w∈VN−1⊗WM−1,EKzL(x,0)=ILNEz0(x),HKyL(x,0)=PN−1ILNHy0(x),∀x∈Ix. | (3.5) |
We set
vk(x,t)=v(x,t+ak−1),t∈ˆIk=(0,τk),1≤k≤K. |
Let Ωk=Ix׈Ik, and (3.5) can be written as: For 1≤k≤K, find EkzL∈V0N⊗PMk(ˆIk) and HkyL∈VN−1⊗PMk(ˆIk) such that
{(ϵ∂tEkzL,vk)Ωk+(HkyL,∂xvk)Ωk=0,∀vk∈V0N⊗PMk−1(ˆIk),(μ∂tHkyL,wk)Ωk−(∂xEkzL,wk)Ωk=0,∀wk∈VN−1⊗PMk−1(ˆIk),EkzL(x,0)=Ek−1zL(x,τk−1),HkyL(x,0)=Hk−1yN(x,τk−1),x∈Ix, | (3.6) |
where E0zL(x,τ0)=ILNEz0(x),H0yL(x,τ0)=PN−1ILNHy0(x) when k=1.
In the following, we present the error estimate. In order to deal with the error of the initial value, we consider the following auxiliary problems on Ωk,1≤k≤K,
{ϵ∂tEk=∂xHk,(x,t)∈Ωk,μ∂tHk=∂xEk,(x,t)∈Ωk,Ek(x,0)=EkzL(x,0),Hk(x,0)=HkyL(x,0),x∈Ix. | (3.7) |
Similar to the process of the single-interval, we define Eka=P1NP1MkEk, Hka=PN−1P1MkHk, and denote
fk1=ϵ(P1Mk−I)∂tEk+(I−P1N)∂xHk,fk2=μ(P1Mk−I)∂tHk. |
Let ekz=EkzL−Eka and eky=HkyL−Hka, the following error equation is obtained
{(ϵ∂tekz,vk)Ωk+(eky,∂xvk)Ωk=(fk1,vk)Ωk,∀vk∈V0N⊗PMk−1,(μ∂teky,w)Ωk−(∂xekz,wk)Ωk=(fk2,wk)Ωk,∀wk∈VN−1⊗PMk−1,ekz(x,0)=0,eky(x,0)=0,∀x∈Ix. | (3.8) |
For each subinterval in the multi-interval, using Theorem 2.2 and Lemma 3.1, the error estimate between the solution to (3.6) and the projection of the solution to (3.7) is obtained
‖√ϵ(EkzL−Eka)‖2Ωk+‖√μ(HkyL−Hka)‖2Ωk+τk(‖√ϵ(EkzL−Eka)(τk)‖2Ix+‖√μ(HkyL−Hka)(τk)‖2Ix)≤Cτ2k[(τ−1kMk)2(1−σ)(‖∂σtEk‖2Ωk+‖∂σtHk‖2Ωk)+N2(1−r)‖∂rxHk‖2Ωk]. | (3.9) |
Let ekz=Ek−Ekz and eky=Hk−Hky, the results are similar to (2.30)-(2.31) for the multi-interval case,
‖√ϵekz‖2Ωk+‖√μeky‖2Ωk=τk(‖√ϵekz(0)‖2Ix+‖√μeky(0)‖2Ix), | (3.10) |
‖√ϵekz(τk)‖2Ix+‖√μeky(τk)‖2Ix=‖√ϵekz(0)‖2Ix+‖√μeky(0)‖2Ix. | (3.11) |
Using the triangle inequality, we get
√‖√ϵekz(0)‖2xx+‖√μeky(0)‖2Ix=√‖√ϵ(Ek−1zL−Ek−1z)(τk−1)‖2Ix+‖√μ(Hk−1yL−Hk−1y)(τk−1)‖2Ix≤√‖√ϵ(Ek−1zL−Ek−1)(τk−1)‖2Lx+‖√μ(Hk−1yL−Hk−1)(τk−1)‖2lx+√‖√ϵek−1z(τk−1)‖2Ix+‖√μek−1y(τk−1)‖2Ix=√‖√ϵ(Ek−1zL−Ek−1)(τk−1)‖2Ix+‖√μ(Hk−1yL−Hk−1)(τk−1)‖2Ix+√‖√ϵek−1z(0)‖2Ix+‖√μek−1y(0)‖2Ix |
which leads to
√‖√ϵekz(0)‖2Ix+‖√μeky(0)‖2Ix≤k−1∑m=1√‖√ϵ(EmzL−Em)(τm)‖2Ix+‖√μ(HmyL−Hm)(τm)‖2Ix+√‖√ϵe1z(0)‖2Ix+‖√μe1y(0)‖2Ix,∀k≥2 | (3.12) |
By the Cauchy-Schwarz inequality, ∑k−1m=1τm=ak−1, and (3.9), we derive
√‖√ϵekz(0)‖2Ix+‖√μeky(0)‖2Ix≤k−1∑m=1√‖√ϵ(EmzL−Em)(τm)‖2Ix+‖√μ(HmyL−Hm)(τm)‖2Ix+√‖√ϵe1z(0)‖2Ix+‖√μe1y(0)‖2Ix,∀k≥2 | (3.13) |
According to (2.7) and Lemma 2.1, it follows that
(k−1∑m=1√‖√ϵ(Ema−Em)(τm)‖2Ix+‖√μ(Hma−Hm)(τm)‖2Ix)2=(k−1∑m=1√‖√ϵ(P1N−I)Em(τm)‖2Ix+‖√μ(PN−1−I)Hm(τm)‖2Ix)2≤Cak−1k−1∑m=1τ−1mN−2r(|Em(τm)|2r,Ix+|Hm(τm)|2r,Ix) | (3.14) |
As (2.32), we have
‖√ϵe1z(0)‖2Ix+‖√μe1y(0)‖2Ix≤CN−2r(|Ez0|2r,Ix+|Hy0|2r,Ix). |
Substituting the above estimation results into (3.10)-(3.11), we obtain
‖√ϵ(Ek−Ekz)‖2Ωk+‖√μ(Hk−Hky)‖2Ωk+τk(‖√ϵ(Ek−Ekz)(τk)‖2Ix+‖√μ(Hk−Hky)(τk)‖2Ix)≤Cak−1τkk−1∑m=1[(τ−1mMm)2(1−σ)(‖∂σtEm‖2Ωm+‖∂σtHm‖2Ωm)+N2(1−r)‖∂rxHm‖2Ωm]+Cak−1τkk−1∑m=1τ−1mN−2r(|Em(τm)|2r,Ix+|Hm(τm)|2r,Ix)+CτkN−2r(|Ez0|2r,Ix+|Hy0|2r,Ix) | (3.15) |
By (2.7), Lemma 2.1 and 2, we get
‖√ϵ(Eka−Ek)‖2Ωk+‖√μ(Hka−Hk)‖2Ωk+τk(‖√ϵ(Eka−Ek)(τk)‖2Ix+‖√μ(Hka−Hk)(τk)‖2Ix)≤C[(τ−1kMk)−2σ(‖∂σtEk‖2Ωk+‖∂σtHk‖2Ωk)+N−2r(‖∂rxEk‖2Ωk+∂rxHk‖2Ωk)]+CτkN−2r(|Ek(τk)|2r,Ix+|Hk(τk)|2r,Ix). | (3.16) |
If τk≡τ,Mk≡M for simplicity, and combining (3.9) and (3.15)-(3.16), we get the following error estimate.
Theorem 3.1. Let Ez and Hy be solutions to (1.1), respectively. Let EKzL and HKyL be solutions to (3.5), respectively. Let Ek and Hk be solutions to (3.7), respectively. Assuming that σ≥1, r≥2, Ez,Hy∈C([0,T];Hr(Ix))∩L2(Ix;Hσ(It)), Ek,Hk∈C([0,τk];Hr(Ix))∩L2(Ix;Hσ(ˆIk)), and then there exists a positive constant C such that
‖√ϵ(EKzL−Ez)‖2Ω+‖√μ(HKyL−Hy)‖2Ω+K∑k=1τk(‖√ϵ(EkzL−Ekz)(τk)‖2Ix+‖√μ(HkyL−Hky)(τk)‖2Ix)≤C[(τ−1M)2(1−σ)+N2(1−r)+τ−2N−2r] | (3.17) |
In this section, some numerical results are presented. We define
E∞(Ez)=max0≤j≤N|EzL(xCj,t)−Ez(xCj,t)|,E∞(Hy)=max0≤j≤N|HyL(xCj,t)−Hy(xCj,t)|. |
Example 4.1. The LT-ST spectral method for the 1-D Maxwell equation
Consider the problem (1.1) with Ix=(0,1), It=(0,1), Ω=Ix×It, ϵ=1, and μ=1. The solution is as
{Ez(x,t)=cos(3πt)sin(3πx),(x,t)∈Ω,Hy(x,t)=sin(3πt)cos(3πx),(x,t)∈Ω. | (4.1) |
In Figure 1, the values of log10 E∞(Ez) and log10 E∞(Hy) is obtained when t=1. It can be seen from Figure 1 that the LT-ST method has spectral accuracy both in the time and space, which is consistent with the results of theoretical analysis.
To check the high accuracy, we compare the numerical errors of our scheme (2.10) with the Legendre-tau spectral method in space and the leapfrog-Crank-Nicolson method in time (LT-LFCN) [19]. For convenience of notation, let (N,τ) be the degree of the polynomial in the space approximation and the time step for the LT-LFCN method.
The L∞-error of the LT-LFCN scheme and our method (2.10) at t=1 are listed in Table 1. It can be seen from Table 1 that on the same PC machine, the proposed method takes shorter time than the LT-LFCN method.
LT-LFCN | LT-ST | ||||||
(N,τ) | E∞(Ez) | E∞(Hy) | time | (N,M) | E∞(Ez) | E∞(Hy) | time |
(8, 1e-02) | 5.14e-04 | 6.85e-03 | 0.19s | (8, 8) | 4.04e-03 | 1.99e-02 | 0.08s |
(12, 1e-03) | 4.35e-06 | 6.97e-06 | 0.49s | (12, 12) | 9.38e-06 | 3.99e-05 | 0.10s |
(16, 1e-04) | 1.29e-09 | 6.96e-07 | 4.94s | (16, 16) | 6.57e-09 | 3.34e-08 | 0.10s |
(20, 1e-05) | 1.03e-13 | 6.98e-09 | 52.81s | (20, 20) | 1.38e-12 | 7.86e-12 | 0.10s |
(24, 1e-06) | 2.83e-14 | 6.97e-11 | 598.48s | (24, 24) | 1.69e-15 | 2.99e-15 | 0.11s |
Example 4.2. The time multi-interval Legendre-tau spectral method for the 1-D Maxwell equation
Further, the method (3.6) is used to solve Example 1 of N=Mk=24 and 0≤t≤5, and the numerical results are shown in Table 2.
t | E∞(Ez) | E∞(Hy) | time |
1.00 | 1.69e-15 | 2.99e-15 | 0.11s |
2.00 | 3.10e-15 | 3.44e-15 | 0.12s |
3.00 | 3.38e-15 | 3.44e-15 | 0.13s |
4.00 | 5.82e-15 | 7.10e-15 | 0.16s |
5.00 | 9.49e-15 | 7.71e-15 | 0.19s |
In this section, the proposed method is applied to the numerical solution of the 1-D nonlinear Maxwell equation. The approximating of the nonlinear term is calculated by interpolation at the CGL point, and implemented with the help of Fast Legendre transformation.
Now, we apply the LT-ST method to solve the 1-D nonlinear Maxwell equation as [26]
{ϵ∂tEz+J(Ez)−∂xHy=0,(x,t)∈Ω,μ∂tHy−∂xEz=0,(x,t)∈Ω,Ez(−1,t)=Ez(1,t)=0,t∈It,Ez(x,0)=Ez0(x),Hy(x,0)=Hy0(x),x∈Ix, | (5.1) |
where the nonlinear function J(Ez)=σ(|Ez|)Ez with σ(s) is a real valued function representing the electric conductivity.
The problem (5.1) can be written in a weak form: Find Ez∈H10(Ix)⊗H1(It) and Hy∈L2(Ix)⊗H1(It) such that
{(ϵ∂tEz,v)Ω+(J(Ez),v)Ω+(Hy,∂xv)Ω=0,∀v∈H10(Ix)⊗L2(It),(μ∂tHy,w)Ω−(∂xEz,w)Ω=0,∀w∈L2(Ix)⊗L2(It),Ez(x,0)=Ez0(x),Hy(x,0)=Hy0(x),∀x∈Ix. | (5.2) |
Combining the interpolation operator both in space and time, a 2-D interpolation is defined as IL(N,M). The LT-ST method to the problem (5.1) is: Find EzL∈V0N⊗VM and HyL∈VN−1⊗VM such that
{(ϵ∂tEzL,v)Ω+(IC(N,M)J(EzL),v)Ω+(HyL,∂xv)Ω=0,∀v∈V0N⊗VM−1,(μ∂tHyL,w)Ω−(∂xEzL,w)Ω=0,∀w∈VN−1⊗VM−1,EzL(x,0)=ILNEz0(x),HyL(x,0)=PN−1ILNHy0(x),∀x∈Ix, | (5.3) |
We briefly describe the implementation of scheme (5.3). For simplicity, taking Ω=[−1,1]×[−1,1]. Let Lk be the Legendre polynomial of degree k, and the basis functions in space are
Φ(x)=(1−x2,1+x2,ϕ2(x),...,ϕN(x)), |
Φ0(x)=(ϕ2(x),...,ϕN(x)),L(x)=(L0(x),L1(x),...,LN−1(x)), |
where ϕk(x)=Lk(x)−Lk−2(x).
The basis functions in time are
Ψ(t)=(1,1+t,ϕ2(t),...,ϕM(t)),L(t)=(L0(t),L1(t),...,LM−1(t)), |
where ϕk(t)=Lk(t)−Lk−2(t).
The approximate solutions and the test functions are expressed as
EzL(x,t)=Ψ(t)ˆEΦT(x),HyL(x,t)=Ψ(t)ˆHLT(x)v(x,t)=L(t)ˆvΦT0(x),w(x,t)=L(t)ˆwLT(x) |
The interpolation polynomial of the nonlinear term can be expressed as IC(N,M)J(EzL)=Ψ(t)ˆJΦT(x). The following algebraic equation is obtained from (5.3)
{ϵ(∂tΨ,L)ItˆE(Φ0,Φ)Ix+(Ψ,L)ItˆJ(Φ0,Φ)Ix+(Ψ,L)ItˆH(∂xΦ0,L)Ix=0,μ(∂tΨ,L)ItˆH(L,L)Ix−(Ψ,L)ItˆE(L,∂xΦ)Ix=0, | (5.4) |
where ˆE and ˆH are matrices composed of coefficients of approximate solutions EzL and HyL, respectively. For simplicity, (5.4) can be rewritten in matrix form as
{ϵKtˆEMx+MtˆJMx+MtˆHKx0=0,μKtˆHD−MtˆEKxT=0. | (5.5) |
A simple implicit-explicit iteration method is used to solve (5.5). In order to separate the initial conditions from the coefficient matrix, ˆE, ˆH, Mt is divided into the following forms as
ˆE=[ˆEiˆE0],ˆH=[ˆHiˆH0],Mt=[MtiMt0], | (5.6) |
where ^Ei and ^Hi are the first rows of the coefficient matrix ˆE and ˆH respectively, corresponding to the initial value, Mti is the first column of Mt. By the properties of the basis function and the orthogonality of Legendre polynomials show that both Kt and D are diagonal matrices, and the elements on the diagonal of Kt are 2 except that the first element is zero. Thus, (5.5) can be expressed as
4ϵμˆE0Mx+(Mt0)2ˆE0Kxx=−2μMtˆJMx−2μMti^HiKx0−Mt0Mti^EiKxx, | (5.7) |
2μˆH0=Mt0ˆE0KxTD−1+Mti^EiKxTD−1. | (5.8) |
Let
G=−2μMti^HiKx0−Mt0Mti^EiKxx, |
In computations. We use the following simple explicit-implicit iteration scheme for (5.7),
4ϵμˆE[k+1]0Mx+(Mt0)2ˆE[k+1]0Kxx=−2μMtˆJ[k]Mx+G,k=0,1,⋯, | (5.9) |
when k=0, using the initial information of EzL in (5.3), and taking E[0]zL(t)≡EzL(0) as the initial guess of the iteration. The iterative scheme (5.9) is a linear equation of ˆE[k+1]0, which can be solved by the method in [10].
Combining the interpolation operator in space and the multi-interval interpolation operator in time in Section 3, a 2-D interpolation is defined as IL(N,M). The time multi-interval Legendre-tau spectral method for (5.1) is: Find EkzN∈V0N⊗WM and HkyN∈VN−1⊗WM such that
{(ϵ∂tEKzL,v)Ω+(IL(N,M)J(EKzL),v)Ω+(HKyL,∂xv)Ω=0,∀v∈V0N⊗WM−1,(μ∂tHKyL,w)Ω−(∂xEKzL,w)Ω=0,∀w∈VN−1⊗WM−1,EKzL(x,0)=ILNEz0(x),HKyL(x,0)=PN−1ILNHy0(x),∀x∈Ix, | (5.10) |
In computation, the interval is shifted to ˆIk=(0,τk). Let Ωk=Ix׈Ik, and then (5.10) can be written as: Find EkzL∈V0N⊗PMk(ˆIk) and HkyL∈VN−1⊗PMk(ˆIk),1≤k≤K, such that
{(ϵ∂tEkzL,vk)Ωk+(IL(N,Mk)J(EkzL),vk)Ωk+(HkyL,∂xvk)Ωk=0,∀vk∈V0N⊗PMk−1(ˆIk),(μ∂tHkyL,wk)Ωk−(∂xEkzL,wk)Ωk=0,∀wk∈VN−1⊗PMk−1(ˆIk),EkzL(x,0)=Ek−1zL(x,τk−1),HkyL(x,0)=Hk−1yN(x,τk−1),x∈Ix, | (5.11) |
where E0zL(x,τ0)=ILNEz0(x) and H0yL(x,τ0)=PN−1ILNHy0(x) when k=1.
Example 5.1. The LT-ST method for the 1-D nonlinear Maxwell equation
Consider the problem (5.1), and set the right-hand function of the first equation to f(x,t). According to [26], the nonlinear term is given as
J(Ez)=(|Ez|2−|Ez|4)Ez, |
where Ix=(0,1), It=(0,1), Ω=Ix×It, and ϵ=μ=1. The solution is
{Ez(x,t)=cos(3πt)sin(3πx),(x,t)∈Ω,Hy(x,t)=sin(3πt)cos(3πx),(x,t)∈Ω, | (5.12) |
and the right-hand side of the first equation is
f(x,t)=cos(3πt)3sin(3πx)3−cos(3πt)5sin(3πx)5,(x,t)∈Ω. | (5.13) |
The scheme (5.3) is used to solve Example 5.1, and the values of log10 E∞(Ez) and log10 E∞(Hy) are obtained when t=1. It can be seen from Figure 2 that the method has high accuracy both in time and space.
ItNum represents the number of iterations. Further, the method (5.11) is used to solve Example 5.1 in the case of N=Mk=24 and 0≤t≤5, the numerical results are shown in Table 3.
t | E∞(Ez) | E∞(Hy) | time | ItNum |
1.00 | 1.72e-15 | 2.83e-15 | 0.17s | 10 |
2.00 | 3.72e-15 | 3.44e-15 | 0.32s | 10 |
3.00 | 4.11e-15 | 4.10e-15 | 0.49s | 10 |
4.00 | 6.30e-15 | 6.55e-15 | 0.65s | 10 |
5.00 | 1.04e-14 | 8.93e-15 | 0.81s | 10 |
Example 5.2. Comparison of the LT-ST method of 1-D nonlinear Maxwell equation and related computation results
Consider the same problem as in Example 5.1, but the nonlinear is given as [26]
J(Ez)=|Ez|12Ez. |
Taking the same solution (5.12), the right-hand function of the first equation is
f(x,t)=cos(3πt)sin(3πx)√|cos(3πt)sin(3πx)|,(x,t)∈Ω. | (5.14) |
The Scheme (5.3) is applied to Example 5.1, and the values of log10 E∞(Ez) and log10 E∞(Hy) is obtained when t=1. Computational results are given in Figure 3 to show that the LT-ST method has high accuracy both in time and space.
In order to compare the accuracy with the LT-LFCN method, we use it and the LT-ST method to computate Example 5.2, respectively. The LT-LFCN method is as follows:
Let τ be the time step, tk=kτ(k=0,1,⋅⋅⋅,nT;T=nTτ). Denote uk(x):=u(x,kτ), and we define
ukˆt=uk+1−uk−12τ,uˉk=uk+1+uk−12. |
The LT-LFCN scheme to the problem (5.1) is: For 1≤k≤nT−1, find EkzN∈V0N and HkyN∈VN−1 such that
{(ϵEkzNˆt,v)+(HˉkyN,∂xv)+(INJ(EkzN),v)=0,∀v∈V0N,(μHkyNˆt,w)−(∂xEˉkzN,w)=0,∀w∈VN−1E0zN=ILNEz0,E1zN=ILN[Ez0+τ∂tEz(0)],H0yN=PLN−1INHy0,H1yN=PLN−1IN[Hy0+τ∂tHy(0)]. | (5.15) |
The L∞-error of the LT-LFCN method (5.15) and the proposed method (5.3) at t=1 are shown in Table 4. The results in Table 4 demonstrate that on the same PC machine, the proposed method provides more accurate results using less time than the LT-LFCN method.
LT-LFCN | LT-ST | ||||||
(N,τ) | E∞(Ez) | E∞(Hy) | time | (N,M) | E∞(Ez) | E∞(Hy) | time |
(8, 1e-02) | 1.86e-03 | 1.98e-02 | 0.21s | (8, 8) | 4.13e-03 | 1.99e-02 | 0.16s |
(12, 1e-03) | 2.22e-05 | 1.46e-04 | 0.71s | (12, 12) | 9.41e-06 | 3.98e-05 | 0.17s |
(16, 1e-04) | 1.65e-07 | 1.56e-06 | 7.86s | (16, 16) | 6.55e-09 | 3.33e-08 | 0.18s |
(20, 1e-05) | 1.50e-09 | 1.56e-08 | 82.99s | (20, 20) | 1.37e-12 | 7.86e-12 | 0.18s |
(24, 1e-06) | 1.59e-11 | 1.58e-10 | 863.42s | (24, 24) | 1.77e-15 | 2.77e-15 | 0.19s |
The scheme (5.11) is also used to solve Example 5.2 for long-time computation. Numerical results are given in Table 5 with N=Mk=24 and 0≤t≤5 to show the effectiveness of the LT-ST method.
t | L∞(Ez) | L∞(Hy) | time | ItNum |
1.00 | 1.77e-15 | 2.77e-15 | 0.19s | 12 |
2.00 | 3.33e-15 | 4.88e-15 | 0.36s | 11 |
3.00 | 3.77e-15 | 4.21e-15 | 0.55s | 12 |
4.00 | 6.77e-15 | 7.21e-15 | 0.73s | 11 |
5.00 | 9.85e-15 | 9.35e-15 | 0.91s | 11 |
In this paper, the LT-ST method is investigated for the 1-D Maxwell equation and the time multi-interval Legendre-tau spectral method is considered. Error estimates for the method of single and multidomain are given, respectively. Numerical results are consistent with the theoretical analysis. Compared with the LT-LFCN method, the proposed method has advantages in accuracy and computation time. Moreover, the space-time spectral method is developed for the numerical solutions of the 1-D nonlinear Maxwell equation. In the future, the multidomain spectral method in space will be developed to solve the case of inhomogeneous media.
The research was supported by the National Natural Science Foundation of China (Grants No. 11971016).
The authors declare no conflict of interest.
[1] |
C. W. Elston, I. O. Ellis, Pathological prognostic factors in breast cancer. I. The value of histological grade in breast cancer: Experience from a large study with long-term follow-up, Histopathology, 19 (1991), 403–410. doi: 10.1111/j.1365-2559.1991.tb00229.x
![]() |
[2] | G. Jiménez, D. Racoceanu, Deep learning for semantic segmentation vs. classification in computational pathology: Application to mitosis analysis in breast cancer grading, Front. Bioeng. Biotechnol., (2019), 7–145. |
[3] | Mitosis Detection Contest[EB/OL], http://ipal.cnrs.fr/ICPR2012/. |
[4] | MITOS-ATYPIA-14 Contest[EB/OL], https://mitos-atypia-14.grand-challenge.org/home/. |
[5] | C. Sommer, L. Fiaschi, F. A. Hamprecht, D. W. Gerlich, Learning-based mitotic cell detection in histopathological images, Proc. 21st Int. Conf. Pattern Recognit., (2012), 2306–2309. |
[6] | S. Berg, D. Kutra, T. Kroeger, C. N. Straehle, B. X. Kausler, C. Haubold, et al., Ilastik: Interactive machine learning for (bio)image analysis, Nat. Methods, (2019), 1226–1232. |
[7] | C. H. Huang, H. K. Lee, Automated mitosis detection based on exclusive independent component analysis, Proc. 21st Int. Conf. Pattern Recognit., (2012), 1856–1859. |
[8] | A. M. Khan, H. El-Daly, N. M. Rajpoot, A gamma-gaussian mixture model for detection of mitotic cells in breast cancer histopathology images, Proc. 21st Int. Conf. Pattern Recognit., (2012), 149–152. |
[9] | H. Irshad, Automated mitosis detection in histopathology using morphological and multi-channel statistics features, J. Pathol. Inf., 4 (2013), 10. |
[10] | A. Tashk, M. S. Helfroush, H. Danyali, M. Akbarzadeh-jahromi, Automatic detection of breast cancer mitotic cells based on the combination of textural, statistical and innovative mathematical features, Appl. Math. Modell., 39 (2015), 6165–6182. |
[11] | F. Pourakpour, H. Ghassemian, Automated mitosis detection based on combination of effective textural and morphological features from breast cancer histology slide images, Biomed. Eng. IEEE, 39 (2016), 214–223. |
[12] | H. Wang, A. Cruzroa, A. Basavanhally, H. Gilmore, N. Shih, M. Feldman, et al., Mitosis detection in breast cancer pathology images by combining handcrafted and convolutional neural network features, J. Med. Imag., 1 (2014), 034003. |
[13] | T. Kausar, M. Wang, B. Wu, M. Idrees, B. Kanwal, Multi-scale deep neural network for mitosis detection in histological images, Proc. Int. Conf. Intell. Informat. Biomed. Sci., (2018), 47–51. |
[14] | D. C. Cireşan, A. Giusti, L. M. Gambardella, J. Schmidhuber, Mitosis detection in breast cancer histology images with deep neural networks, Int. Conf Med. Image Comput. Comput. Assisted Intervention, (2013), 411–418. |
[15] | H. Chen, Q. Dou, X. Wang, J. Qin, P. A. Heng, Mitosis detection in breast cancer histology images via deep cascaded networks, Proc. 30th AAAI Conf. Artif. Intell., (2016), 1160–1166. |
[16] | M. Ma, Y. Shi, W. Li, Y. Gao, J. Xu, A novel two-stage deep method for mitosis detection in breast cancer histology images, Proc. 24th Int. Conf. Pattern Recognit., (2018), 3892–3897. |
[17] | N. Maroof, A. Khan, S. A. Qureshi, A. Rehman, R. K. Khalil, S. Shim, Mitosis detection in breast cancer histopathology images using hybrid feature space, Photodiagn. Photodyn. Ther., (2020), 101885. |
[18] | Y. Zhang, J. Chen, X. Pan, Multi-feature fusion of deep networks for mitosis segmentation in histological images, Int. J. Imag. Syst. Technol., (2020), 1–13. |
[19] | M. Hwang, D. Wang, C. Wu, W. C. Jiang, X. X. Kong, K. Hwang, et al., A fuzzy segmentation method to learn classification of mitosis, Int. J. Fuzzy Syst., (2020), 1653–1664. |
[20] | C. Li, X. Wang, W. Liu, L. J. Latecki, DeepMitosis: Mitosis detection via deep detection, verification and segmentation networks, Med. Image Anal., (2018), 121–133. |
[21] | S. Ren, K. He, R. Girshick, J. Sun, Faster R-CNN: Towards real-time object detection with region proposal networks, IEEE Trans. Pattern Anal. Mach. Intell. (2017), 1137–1149. |
[22] | K. He, X. Zhang, S. Ren, J. Sun, Deep residual learning for image recognition, Proceed. IEEE Conf. Comput. Vision Pattern Recognit., (2016), 770–778. |
[23] | H. Lei, S. Liu, H. Xie, J. Y. Kuo, B. Lei, An improved object detection method for mitosis detection, Proc. 41st Annu. Int. Conf. IEEE Eng. Med. Biol. Soc., (2019), 130–133. |
[24] | A. Sengupta, Y. Ye, R. Wang, C. Liu, K. Roy, Going deeper in spiking neural networks: VGG and residual architectures, Front. Neurosci., (2019), 1–10 |
[25] | C. Li, X. Wang, W. Liu, L. J. Latecki, B. Wang, J. Huang, Weakly supervised mitosis detection in breast histopathology images using concentric loss, Med. Image Anal. (2019), 165–178. |
[26] | K. He, G. Gkioxari, P. Dollár, R. Girshick, Mask R-CNN, Proceed. IEEE Int. Conf. Comput. Vision, (2017), 2980–2988. |
[27] | V. Dodballapur, Y. Song, H. Huang, M. Chen, W. Chrzanowski, W. Cai, Mask-driven mitosis detection in histopathology images, Proceed. IEEE 16th Int. Symp. Biomed. Imaging, (2019), 1855–1859. |
[28] | D. Cai, X. Sun, N. Zhou, X. Han, J. Yao, Efficient mitosis detection in breast cancer histology images by RCNN, Proceed. IEEE 16th Int. Symp. Biomed. Imaging, (2019), 919–922. |
[29] | Y. Li, E. Mercan, S. Knezevitch, J. G. Elmore, L. G. Shapiro, Efficient and accurate mitosis detection, a lightweight RCNN approach, Proceed. 7th Int. Conf Pattern Recognit. Appl. Methods, (2018), 69–77. |
[30] | H. J. Lei, S. M. Liu, A. Elazab, X. H. Gong, B. Y. Lei, Attention-guided multi-branch convolutional neural network for mitosis detection from histopathological images, J. Biomed. Health Inf., (2020), 2168–2194. |
[31] | T. Mahmood, M. Arsalan, M. Owais, M. B. Lee, K. R. Park, Artificial intelligence-based mitosis detection in breast cancer histopathology images using faster R-CNN and deep CNNs, J. Clin. Med., (2020), 749 |
[32] | S. Meriem, T. Wang, S. A. Al-Fadhli, PartMitosis: A partially supervised deep learning framework for mitosis detection in breast cancer histopathology images, IEEE Access, (2020), 1–1. |
[33] | S. Meriem, X. Wang, T. Wang, MaskMitosis: A deep learning framework for fully supervised, weakly supervised, and unsupervised mitosis detection in histopathology images, Med. Biol. Eng. Comput., (2020) 1603–1623. |
[34] |
N. Kumar, R. Verma, S. Sharma, S. Bhargava, A. Vahadane, A. Sethi, A dataset and a technique for generalized nuclear segmentation for computational pathology, IEEE Trans. Med. Imaging, 36 (2017), 1550–1560. doi: 10.1109/TMI.2017.2677499
![]() |
[35] | O. Ronneberger, P. Fischer, T. Brox, U-Net: Convolutional networks for biomedical image segmentation, Int. Conf Med. Image Comput. Comput. Assisted Intervention, (2015), 234–241. |
[36] | Z. W. Zhou, M. Mahfuzur, R. Siddiquee, N Tajbakhsh, J. M. Liang, UNet ++: A nested U-Net architecture for medical image segmentation, Dlmia, (2018), 1–7. |
[37] | C. Y. Lee, S. Xie, P. Gallagher, Z. Zhang, Z. W. Tu, Deeply-supervised nets, Proceed. 2015 18th Int. Conf. Artif. Int. Stat., (2015), 562–570. |
[38] | C. H. Sudre, W. Li, T. Vercauteren, S. Ourselin, M. J. Cardoso, Generalised dice overlap as a deep learning loss function for highly unbalanced segmentations, Comput. Vision Pattern Recogn., 2017. |
[39] | C. Yamauchi, T. Hasebe, M. Iwasaki, S. Imoto, N. Wada, M. Fukayama, et al., Accurate assessment of lymph vessel tumor emboli in invasive ductal carcinoma of the breast according to tumor areas, and their prognostic significance, Hum. Pathol., 38 (2007), 247–259. |
[40] | H. Wang, A. Cruz-Roa, A. Basavanhally, H. Gilmore, N. Shih, M. Feldman, et al., Cascaded ensemble of convolutional neural networks and handcrafted features for mitosis detection, Proc. SPIE, 9041 (2014). |
[41] | F. Milletari, N. Navab, S. Ahmadi, V-Net: Fully convolutional neural networks for volumetric medical image segmentation, proc. Int. Conf. 3D Vision, (2016), 565–571. |
[42] | K. He, X. Zhang, S. Ren, J. Sun, Deep residual learning for image recognition, Proc. IEEE Conf. Comput. Vis. Pattern Recognit., (2016), 770–778. |
[43] | P. Vamplew, R. Dazele, C. Foale, Softmax exploration strategies for multi-objective reinforcement learning, Neuro comput., (2017), 74–86. |
[44] | A. Vahadane, T. Peng, S. Albarqouni, M. Baust, K. Steiger, Structure-preserved color normalization for histological images, IEEE Int. Symp. Biomed. Imaging, (2015), 1012–1015. |
[45] | A. Krizhevsky, I. Sutskever, G. E. Hinton, ImageNet classification with deep convolutional neural networks, Int. Conf. Neural Inf. Process. Syst., (2012), 1097–1105. |
[46] |
N. Otsu, A threshold selection method from gray-level histograms, IEEE Trans. Syst. Man. Cybern., 9 (1979), 62–66. doi: 10.1109/TSMC.1979.4310076
![]() |
[47] | M. Veta, J. Pluim, Detecting mitotic figures in breast cancer histopathology images, SPIE Med. Imaging, 8676 (2013), 867607. |
[48] | C. D. Malon, C. Eric, Classification of mitotic figures with convolutional neural networks and seeded blob features, J. Pathol. Inf., 4 (2013), 9. |
[49] | M Veta, P. J. Diest, S. M. Willems, H. Wang, A. Madabhushi, A. Cruz-Roa, et al., Assessment of algorithms for mitosis detection in breast cancer histopathology images, Med. Image Anal., 20 (2015), 237–248. |
[50] | H. Chen, X. Wang, P. A. Heng, Automated mitosis detection with deep regression networks, 2016 IEEE 13th Int. Symp. Biomed. Imaging, 2016, 1945–8452. |
[51] | C. Li, X. Wang, W. Liu, L. J. Latecki, DeepMitosis: Mitosis detection via deep detection, verification and segmentation networks, Med. Image Anal., 45 (2018), 121–133. |
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LT-LFCN | LT-ST | ||||||
(N,τ) | E∞(Ez) | E∞(Hy) | time | (N,M) | E∞(Ez) | E∞(Hy) | time |
(8, 1e-02) | 5.14e-04 | 6.85e-03 | 0.19s | (8, 8) | 4.04e-03 | 1.99e-02 | 0.08s |
(12, 1e-03) | 4.35e-06 | 6.97e-06 | 0.49s | (12, 12) | 9.38e-06 | 3.99e-05 | 0.10s |
(16, 1e-04) | 1.29e-09 | 6.96e-07 | 4.94s | (16, 16) | 6.57e-09 | 3.34e-08 | 0.10s |
(20, 1e-05) | 1.03e-13 | 6.98e-09 | 52.81s | (20, 20) | 1.38e-12 | 7.86e-12 | 0.10s |
(24, 1e-06) | 2.83e-14 | 6.97e-11 | 598.48s | (24, 24) | 1.69e-15 | 2.99e-15 | 0.11s |
t | E∞(Ez) | E∞(Hy) | time |
1.00 | 1.69e-15 | 2.99e-15 | 0.11s |
2.00 | 3.10e-15 | 3.44e-15 | 0.12s |
3.00 | 3.38e-15 | 3.44e-15 | 0.13s |
4.00 | 5.82e-15 | 7.10e-15 | 0.16s |
5.00 | 9.49e-15 | 7.71e-15 | 0.19s |
t | E∞(Ez) | E∞(Hy) | time | ItNum |
1.00 | 1.72e-15 | 2.83e-15 | 0.17s | 10 |
2.00 | 3.72e-15 | 3.44e-15 | 0.32s | 10 |
3.00 | 4.11e-15 | 4.10e-15 | 0.49s | 10 |
4.00 | 6.30e-15 | 6.55e-15 | 0.65s | 10 |
5.00 | 1.04e-14 | 8.93e-15 | 0.81s | 10 |
LT-LFCN | LT-ST | ||||||
(N,τ) | E∞(Ez) | E∞(Hy) | time | (N,M) | E∞(Ez) | E∞(Hy) | time |
(8, 1e-02) | 1.86e-03 | 1.98e-02 | 0.21s | (8, 8) | 4.13e-03 | 1.99e-02 | 0.16s |
(12, 1e-03) | 2.22e-05 | 1.46e-04 | 0.71s | (12, 12) | 9.41e-06 | 3.98e-05 | 0.17s |
(16, 1e-04) | 1.65e-07 | 1.56e-06 | 7.86s | (16, 16) | 6.55e-09 | 3.33e-08 | 0.18s |
(20, 1e-05) | 1.50e-09 | 1.56e-08 | 82.99s | (20, 20) | 1.37e-12 | 7.86e-12 | 0.18s |
(24, 1e-06) | 1.59e-11 | 1.58e-10 | 863.42s | (24, 24) | 1.77e-15 | 2.77e-15 | 0.19s |
t | L∞(Ez) | L∞(Hy) | time | ItNum |
1.00 | 1.77e-15 | 2.77e-15 | 0.19s | 12 |
2.00 | 3.33e-15 | 4.88e-15 | 0.36s | 11 |
3.00 | 3.77e-15 | 4.21e-15 | 0.55s | 12 |
4.00 | 6.77e-15 | 7.21e-15 | 0.73s | 11 |
5.00 | 9.85e-15 | 9.35e-15 | 0.91s | 11 |
LT-LFCN | LT-ST | ||||||
(N,τ) | E∞(Ez) | E∞(Hy) | time | (N,M) | E∞(Ez) | E∞(Hy) | time |
(8, 1e-02) | 5.14e-04 | 6.85e-03 | 0.19s | (8, 8) | 4.04e-03 | 1.99e-02 | 0.08s |
(12, 1e-03) | 4.35e-06 | 6.97e-06 | 0.49s | (12, 12) | 9.38e-06 | 3.99e-05 | 0.10s |
(16, 1e-04) | 1.29e-09 | 6.96e-07 | 4.94s | (16, 16) | 6.57e-09 | 3.34e-08 | 0.10s |
(20, 1e-05) | 1.03e-13 | 6.98e-09 | 52.81s | (20, 20) | 1.38e-12 | 7.86e-12 | 0.10s |
(24, 1e-06) | 2.83e-14 | 6.97e-11 | 598.48s | (24, 24) | 1.69e-15 | 2.99e-15 | 0.11s |
t | E∞(Ez) | E∞(Hy) | time |
1.00 | 1.69e-15 | 2.99e-15 | 0.11s |
2.00 | 3.10e-15 | 3.44e-15 | 0.12s |
3.00 | 3.38e-15 | 3.44e-15 | 0.13s |
4.00 | 5.82e-15 | 7.10e-15 | 0.16s |
5.00 | 9.49e-15 | 7.71e-15 | 0.19s |
t | E∞(Ez) | E∞(Hy) | time | ItNum |
1.00 | 1.72e-15 | 2.83e-15 | 0.17s | 10 |
2.00 | 3.72e-15 | 3.44e-15 | 0.32s | 10 |
3.00 | 4.11e-15 | 4.10e-15 | 0.49s | 10 |
4.00 | 6.30e-15 | 6.55e-15 | 0.65s | 10 |
5.00 | 1.04e-14 | 8.93e-15 | 0.81s | 10 |
LT-LFCN | LT-ST | ||||||
(N,τ) | E∞(Ez) | E∞(Hy) | time | (N,M) | E∞(Ez) | E∞(Hy) | time |
(8, 1e-02) | 1.86e-03 | 1.98e-02 | 0.21s | (8, 8) | 4.13e-03 | 1.99e-02 | 0.16s |
(12, 1e-03) | 2.22e-05 | 1.46e-04 | 0.71s | (12, 12) | 9.41e-06 | 3.98e-05 | 0.17s |
(16, 1e-04) | 1.65e-07 | 1.56e-06 | 7.86s | (16, 16) | 6.55e-09 | 3.33e-08 | 0.18s |
(20, 1e-05) | 1.50e-09 | 1.56e-08 | 82.99s | (20, 20) | 1.37e-12 | 7.86e-12 | 0.18s |
(24, 1e-06) | 1.59e-11 | 1.58e-10 | 863.42s | (24, 24) | 1.77e-15 | 2.77e-15 | 0.19s |
t | L∞(Ez) | L∞(Hy) | time | ItNum |
1.00 | 1.77e-15 | 2.77e-15 | 0.19s | 12 |
2.00 | 3.33e-15 | 4.88e-15 | 0.36s | 11 |
3.00 | 3.77e-15 | 4.21e-15 | 0.55s | 12 |
4.00 | 6.77e-15 | 7.21e-15 | 0.73s | 11 |
5.00 | 9.85e-15 | 9.35e-15 | 0.91s | 11 |