Algebraic and topological indices of molecular pathway networks in human cancers

  • Received: 01 October 2014 Accepted: 29 June 2018 Published: 01 August 2015
  • MSC : Primary: 92C42; Secondary: 94C15.

  • Protein-protein interaction networks associated with diseases have gained prominence as an area of research.We investigate algebraic and topological indices for protein-protein interaction networks of 11 human cancers derived from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. We find a strong correlationbetween relative automorphism group sizes and topological network complexities on the one hand and five year survival probabilities on the other hand. Moreover, we identify several protein families (e.g. PIK, ITG, AKT families) that are repeated motifs in many of the cancer pathways. Interestingly, these sources of symmetry are often central rather than peripheral. Our results can aide in identification of promising targets for anti-cancer drugs. Beyond that, we provide a unifying framework to study protein-protein interaction networks of families of related diseases (e.g. neurodegenerative diseases, viral diseases, substance abuse disorders).

    Citation: Peter Hinow, Edward A. Rietman, Sara Ibrahim Omar, Jack A. Tuszyński. Algebraic and topological indices of molecular pathway networks in human cancers[J]. Mathematical Biosciences and Engineering, 2015, 12(6): 1289-1302. doi: 10.3934/mbe.2015.12.1289

    Related Papers:

  • Protein-protein interaction networks associated with diseases have gained prominence as an area of research.We investigate algebraic and topological indices for protein-protein interaction networks of 11 human cancers derived from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. We find a strong correlationbetween relative automorphism group sizes and topological network complexities on the one hand and five year survival probabilities on the other hand. Moreover, we identify several protein families (e.g. PIK, ITG, AKT families) that are repeated motifs in many of the cancer pathways. Interestingly, these sources of symmetry are often central rather than peripheral. Our results can aide in identification of promising targets for anti-cancer drugs. Beyond that, we provide a unifying framework to study protein-protein interaction networks of families of related diseases (e.g. neurodegenerative diseases, viral diseases, substance abuse disorders).


    加载中
    [1] Nature, 406 (2000), 378-382.
    [2] Pharmacy and Therapeutics, 36 (2011), 225-227.
    [3] Algorithmica, 40 (2004), 51-62.
    [4] Cambridge University Press, Cambridge, 2001.
    [5] Proc. Natl. Acad. Sci. USA, 109 (2012), 9209-9212.
    [6] Expert Opin. Drug Discov., 8 (2013), 7-20.
    [7] Pharmacol. Therapeut., 138 (2013), 333-408.
    [8] Symmetry, 2 (2010), 1683-1709, arXiv:1006.3923.
    [9] Nat. Rev. Drug Discov., 10 (2011), 563-564.
    [10] Nucleic Acid Res., 37 (2009), 1-13.
    [11] Nature Protocols, 4 (2009), 44-57, http://david.abcc.ncifcrf.gov/
    [12] John Wiley & Sons, Hoboken, NJ, 2008.
    [13] Nucleic Acid Res., 28 (2000), 23-30, http://www.genome.jp/kegg/.
    [14] Nucleic Acid Res., 32 (2004), D277-D280.
    [15] In A Voronkov, editor, The Alan Turing Centenary, pages 181-195. EasyChair, 2012,http://vlsicad.eecs.umich.edu/BK/SAUCY/.
    [16] Computer Science Review, 3 (2009), 199-243.
    [17] Landes Bioscience, Austin, TX, 2006.
    [18] Springer Verlag, Dordrecht, Heidelberg, New York, London, 2012.
    [19] Discr. Appl. Math., 156 (2008), 3525-3531.
    [20] http://seer.cancer.gov/.
    [21] Theor. Biol. Med. Model., 8 (2011), p21.
    [22] Genome Res., 13 (2003), 2498-2504. http://cytoscape.org.
    [23] BioSystems, 113 (2013), 149-154.
    [24] University of St Andrews, St Andrews, United Kingdom, 2013. http://www.gap-system.org.
    [25] BMC Syst. Biol., 7 (2013), p90.
    [26] Phys. Rev. E, 78 (2008), 046102, arXiv:0802.4318.
    [27] Bioinformatics, 25 (2009), 1470-1471, http://bioconductor.org.
  • Reader Comments
  • © 2015 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Metrics

Article views(1827) PDF downloads(493) Cited by(9)

Article outline

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return

Catalog