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Long non-coding RNA XIST is down-regulated and correlated to better prognosis in ovarian cancer

1 Department of Oncology, Jingzhou Central Hospital, Jingzhou 434000, China
2 Department of Obstetrics and Gynecology, Jingzhou Central Hospital, Jingzhou 434000, China
3 Department of neurosurgery, Jingzhou Central Hospital, Jingzhou 434000, China

These two authors contributed equally.

Special Issues: Advanced Big Data Analysis for Precision Medicine

Ovarian cancer (OC) is one of the most common gynecological malignant tumors. Understanding the molecular mechanisms involved in the development of ovarian cancer is helpful for the diagnosis and treatment of OC. In this study, we found that lncRNA XIST was significantly overexpressed in normal ovarian tissues and down-regulated in OC. Moreover, we showed XIST was associated with the development of OC and down-regulated in advanced stage OC compared to early-stage OC samples. Overexpression of XIST was significantly associated with longer survival in patients with OC. Also, our analysis also showed that lncRNA XIST was closely related to biological processes such as transcription, protein phosphorylation, transport, protein ubiquitination, and DNA repair. To further reveal the function and role of XIST in OC, we constructed a protein-protein interaction network and an endogenous competitive RNA network. The present study provided a theoretical basis for the diagnosis and treatment of OC.
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Keywords long-chain non-coding RNA; XIST; ovarian cancer; biological processes; prognostic markers

Citation: Yue Hu, Xiaoqin Mei, Dong Tang. Long non-coding RNA XIST is down-regulated and correlated to better prognosis in ovarian cancer. Mathematical Biosciences and Engineering, 2020, 17(3): 2070-2081. doi: 10.3934/mbe.2020110


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