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The mechanism of Parkinson oscillation in the cortex: Possible evidence in a feedback model projecting from the globus pallidus to the cortex


  • The origin, location and cause of Parkinson's oscillation are not clear at present. In this paper, we establish a new cortex-basal ganglia model to study the origin mechanism of Parkinson beta oscillation. Unlike many previous models, this model includes two direct inhibitory projections from the globus pallidus external (GPe) segment to the cortex. We first obtain the critical calculation formula of Parkinson's oscillation by using the method of Quasilinear analysis. Different from previous studies, the formula obtained in this paper can include the self-feedback connection of GPe. Then, we use the bifurcation analysis method to systematically explain the influence of some key parameters on the oscillation. We find that the bifurcation principle of different cortical nuclei is different. In general, the increase of the discharge capacity of the nuclei will cause oscillation. In some special cases, the sharp reduction of the discharge rate of the nuclei will also cause oscillation. The direction of bifurcation simulation is consistent with the critical condition curve. Finally, we discuss the characteristics of oscillation amplitude. At the beginning of the oscillation, the amplitude is relatively small; with the evolution of oscillation, the amplitude will gradually strengthen. This is consistent with the experimental phenomenon. In most cases, the amplitude of cortical inhibitory nuclei (CIN) is greater than that of cortical excitatory nuclei (CEX), and the two direct inhibitory projections feedback from GPe can significantly reduce the amplitude gap between them. We calculate the main frequency of the oscillation generated in this model, which basically falls between 13 and 30 Hz, belonging to the typical beta frequency band oscillation. Some new results obtained in this paper can help to better understand the origin mechanism of Parkinson's disease and have guiding significance for the development of experiments.

    Citation: Minbo Xu, Bing Hu, Weiting Zhou, Zhizhi Wang, Luyao Zhu, Jiahui Lin, Dingjiang Wang. The mechanism of Parkinson oscillation in the cortex: Possible evidence in a feedback model projecting from the globus pallidus to the cortex[J]. Mathematical Biosciences and Engineering, 2023, 20(4): 6517-6550. doi: 10.3934/mbe.2023281

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  • The origin, location and cause of Parkinson's oscillation are not clear at present. In this paper, we establish a new cortex-basal ganglia model to study the origin mechanism of Parkinson beta oscillation. Unlike many previous models, this model includes two direct inhibitory projections from the globus pallidus external (GPe) segment to the cortex. We first obtain the critical calculation formula of Parkinson's oscillation by using the method of Quasilinear analysis. Different from previous studies, the formula obtained in this paper can include the self-feedback connection of GPe. Then, we use the bifurcation analysis method to systematically explain the influence of some key parameters on the oscillation. We find that the bifurcation principle of different cortical nuclei is different. In general, the increase of the discharge capacity of the nuclei will cause oscillation. In some special cases, the sharp reduction of the discharge rate of the nuclei will also cause oscillation. The direction of bifurcation simulation is consistent with the critical condition curve. Finally, we discuss the characteristics of oscillation amplitude. At the beginning of the oscillation, the amplitude is relatively small; with the evolution of oscillation, the amplitude will gradually strengthen. This is consistent with the experimental phenomenon. In most cases, the amplitude of cortical inhibitory nuclei (CIN) is greater than that of cortical excitatory nuclei (CEX), and the two direct inhibitory projections feedback from GPe can significantly reduce the amplitude gap between them. We calculate the main frequency of the oscillation generated in this model, which basically falls between 13 and 30 Hz, belonging to the typical beta frequency band oscillation. Some new results obtained in this paper can help to better understand the origin mechanism of Parkinson's disease and have guiding significance for the development of experiments.



    In various fields of science, nonlinear evolution equations practically model many natural, biological and engineering processes. For example, PDEs are very popular and are used in physics to study traveling wave solutions. They have played a crucial role in illustrating the nature of nonlinear problems. PDEs are collected to control the diffusion of chemical reactions. In biology, they play a fundamental role in describing various phenomena, such as population growth. In addition, natural phenomena such as fluid dynamics, plasma physics, optics and optical fibers, electromagnetism, quantum mechanics, ocean waves, and others are studied using PDEs. The qualitative and quantitative characteristics of these phenomena can be identified from the behaviors and shapes of their solutions. Therefore, finding the analytic solutions to such phenomena is a fundamental topic in mathematics. Scientists have developed sparse fundamental approaches to find analytic solutions for nonlinear PDEs. Among these techniques, I present integration methods from [1] and [2], the modified F-expansion and Generalized Algebraic methods, respectively. Bekir and Unsal [3] proposed the first integral method to find the analytical solution of nonlinear equations. Kumar, Seadawy and Joardar [4] used the improved Kudryashov technique to extract fractional differential equations. Adomian [5] proposed the Adomian decomposition technique to find the solution of frontier problems of physics. [6] uses an exploratory method to find explicit solutions of non-linear PDEs. Many different methods of solving equations arising from natural phenomena and some of their analytic solutions, such as dark and light solitons, non-local rogue waves, an occasional wave and mixed soliton solutions, are exhibited and can be found in [7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39,40].

    The Novikov-Veselov (NV) system [41,42] is given by

    Ψt+αΓxxy+βΦxyy+γΓyΦ+γ(Ψ22)y+λΓΦx+λ(Ψ22)x=0,Γy=Ψx,Ψy=Φx, (1.1)

    where α,β,γ and λ are constants. Barman [42] declared that Eq (1.1) is involved to represent tidal and tsunami waves, electro-magnetic waves in communication cables and magneto-sound and ion waves in plasma. In [42], the generalized Kudryashov method was utilized to have traveling wave solutions for Eq (1.1). According to Croke [43], the Novikov-Veselov system is generalized from the KdV equations which were examined by Novikov and Veselov. Croke [43] used several approaches, (the extended mapping, the Hirota and the extended tanh-function approaches) in the proposed system to achieve numerous soliton solutions, such as breathers, and constrained analytic solutions. Boiti, Leon, and Manna [44] applied the inverse dispersion technique to solve (1.1) for a particular type of initial value. Numerical solutions and a study of the stability of solutions for the proposed equation were presented by Kazeykina and Klein [45]. The Nizhnik-Novikov-Veselov system for two dimensions was also solved using the Kansa technique to find the numerical results [46]. To the best of my knowledge, the stability and error analysis of the numerical scheme presented here has not yet been discussed for system (1.1). Therefore, this has motivated me enormously to do so. The primary purpose is to obtain multiple analytic solutions to system (1.1) by using both the modified F-expansion and Generalized Algebraic methods. In connection with the numerical solution, the method of finite differences is utilized to achieve numerical results for the studied system. I graphically and analytically compare the traveling wave solutions and numerical results. Undoubtedly, the presented results strongly contribute to describing physical problems in practice.

    The outline of this article is provided in this paragraph. Section 2 summarizes the employed methods. All the analytic solutions are extracted in Section 3. The shooting and BVP results for the proposed system are presented in Section 4. In addition, I examine the numerical solution of the system (1.1) in Section 5. Sections 6 and 7 study the stability and error analysis of the numerical scheme, respectively. Section 8 presents the results and discussion.

    Considering the development equation with physical fields Ψ(x,y,t), Φ(x,y,t) and Γ(x,y,t) in the variables x, y and t is given in the following form:

    Q1(Ψ,Ψt,Ψx,Ψy,Γ,Γy,Γxxy,Φ,Φxyy,Φx,)=0. (2.1)

    Step 1. We extract the traveling-wave solutions of System (1.1) that are formed as follows:

    Φ(x,y,t)=ϕ(η),η=x+ywt,Ψ(x,y,t)=ψ(η),Γ(x,y,t)=Θ(η), (2.2)

    where w is the wave speed.

    Step 2. The nonlinear evolution (2.1) is reduced to the following ODE:

    Q2(ψ,ψη,Θ,Θη,Θηηη,ϕ,ϕηηη,ϕη,)=0, (2.3)

    where Q2 is a polynomial in ψ(η),ϕ(η), Θ(η) and their total derivatives.

    According to the modified F-expansion method, the solutions of (2.3) are given by the form

    ψ(η)=ρ0+Nk=1(ρkF(η)k+qkF(η)k), (2.4)

    and F(η) is a solution of the following differential equation:

    F(η)=μ0+μ1F(η)+μ2F(η)2, (2.5)

    where μ0, μ1, μ2, are given in Table 1 [1], and ρk, qk are to be determined later.

    Table 1.  The relations among μ0, μ1, μ2 and the function F(η).
    μ0 μ1 μ2 F(η)
    μ0=0, μ1=1, μ2=1, F(η)=12+12tanh(12η).
    μ0=0, μ1=1, μ2=1, F(η)=1212coth(12η).
    μ0=12, μ1=0, μ2=12, F(η)=coth(η)±csch(η), tanh(η)±sech(η).
    μ0=1, μ1=0, μ2=1, F(η)=tanh(η), coth(η).
    μ0=12, μ1=0, μ2=12, F(η)=sec(η)+tan(η), csc(η)cot(η).
    μ0=12, μ1=0, μ2=12, F(η)=sec(η)tan(η), csc(η)+cot(η).
    μ0=±1, μ1=0, μ2=±1, F(η)=tan(η), cot(η).

     | Show Table
    DownLoad: CSV

    According to the generalized direct algebraic method, the solutions of (2.3) are given by

    ψ(η)=ν0+Nk=1(νkG(η)k+rkG(η)k), (2.6)

    and G(η) is a solution of the following differential equation:

    G(η)=ε4k=0δkGk(η), (2.7)

    where νk, and rk are to be determined, and N is an integer number obtained by the highest degree of the nonlinear terms and the highest order of the derivatives. ε is user-specified, usually taken with ε=±1, and δk, k=0,1,2,3,4, are given in Table 2 [2].

    Table 2.  The relations among δk, k=0,1,2,3,4, and the function G(η).
    δ0 δ1 δ2 δ3 δ4 G(η)
    δ0=0, δ1=0, δ2>0, δ3=0, δ4<0, G(η)=ε δ2δ4sech(δ2η).
    δ0=δ224c4, δ1=0, δ2<0, δ3=0, δ4>0, G(η)=εδ22δ4tanh(δ22η).
    δ0=0, δ1=0, δ2<0, δ3=0, δ4>0, G(η)=ε δ2δ4 sec (δ2η).
    δ0=δ224δ4, δ1=0, δ2>0, δ3=0, δ4>0, G(η)=ε δ22δ4tan(δ22η).
    δ0=0, δ1=0, δ2=0, δ3=0, δ4>0, G(η)=εδ4η.
    δ0=0, δ1=0, δ2>0, δ30, δ4=0, G(η)=δ2δ3.sech2(δ22η).

     | Show Table
    DownLoad: CSV

    Consider the Novikov-Veselov (NV) system

    Ψt+αΓxxy+βΦxyy+γΓyΦ+γ(Ψ22)y+λΓΦx+λ(Ψ22)x=0,Γy=Ψx,Ψy=Φx, (3.1)

    a system of PDEs in the unknown functions Ψ=Ψ(x,y,t),Φ=Φ(x,y,t), Γ=Γ(x,y,t) and their partial derivatives. I plug the transformations

    Φ(x,y,t)=ϕ(η),η=x+ywt,Ψ(x,y,t)=ψ(η),Γ(x,y,t)=Θ(η), (3.2)

    into Eq (3.1) to reduce it to a system of ODEs given by

    wψη+αΘηηη+βϕηηη+γΘηϕ+γ(ψ22)η+λΘϕη+λ(ψ22)η=0,Θη=ψη,ψη=ϕη. (3.3)

    Integrating Θη=ψη and ϕη=ψη yields

    Θ=ψ,and ϕ=ψ. (3.4)

    Substituting (3.4) into the first equation of (3.3) and integrating once with respect to η yields

    wψ+(α+β)ψηη+(γ+λ)ψ2=0. (3.5)

    Balancing ψηη with ψ2 in (3.5) calculates the value of N=2.

    According to the modified F-expansion method with N=2, the solutions of (3.5) are

    ψ(η)=ρ0+ρ1F(η)+q1F(η)+ρ2F(η)2+q2F(η)2, (3.6)

    and F(η) is a solution of the following differential equation:

    F(η)=μ0+μ1F(η)+μ2F(η)2, (3.7)

    where μ0, μ1, μ2 are given in Table 1. To explore the analytic solutions to (3.5), I ought to follow the subsequent steps.

    Step 1. Placing (3.6) along with (3.7) into Eq (3.5) and gathering the coefficients of F(η)j, j = 4,3,2,1,0,1,2,3,4, to zeros gives a system of equations for ρ0,ρk,qk, k=1,2.

    Step 2. Solve the resulting system using mathematical software: for example, Mathematica or Maple.

    Step 3. Choosing the values of μ0,μ1 and μ2 and the function F(η) from Table 1 and substituting them along with ρ0,ρk,qk, k=1,2, in (3.6) produces a set of trigonometric function and rational solutions to (3.5).

    Applying the above steps, I determine the values of ρ0,ρ1,ρ2,q1,q2 and w as follows:

    (1). When μ0=0, μ1=1 and μ2=1, I have two cases.

    Case 1.

    ρ0=0,ρ1=6(α+β)γ+λ,ρ2=6(α+β)γ+λ,q1=q2=0,andw=α+β. (3.8)

    The solution is given by

    Ψ1(x,y,t)=3(α+β)2(γ+λ)sech2(12(x+y(α+β)t+x0)). (3.9)

    Case 2.

    ρ0=α+βγ+λ,ρ1=6(α+β)γ+λ,ρ2=6(α+β)γ+λ,q1=q2=0,andw=(α+β). (3.10)

    The solution is given by

    Ψ2(x,y,t)=(α+β)2(γ+λ)(3tanh2(12(x+y+t(α+β))+x0)1). (3.11)

    Figure 1 presents the time evolution of the analytic solutions (a) Ψ1 and (b) Ψ2 with t=0,10,20. The parameter values are x0=20, α=0.50,β=0.6, γ=1.5, and λ=1. Figure 2 presents the wave behavior by changing a certain parameter value and fixing the values of the others. Figure 2(a,b) presents the behavior of Ψ1 when I change the values of (a) α or β and (b) γ or λ. In Figure 2(a) it can also be seen that the value of α or β affects the direction and amplitude of the wave, such that a negative value always makes the wave negative, its amplitude decreases when α,β0, and its amplitude increases when α,β. In Figure 2(b) the value of γ or λ affects the direction and amplitude of the wave, such that a negative value always makes the wave negative, and its amplitude decreases when the value of γ or λ increases. In Figure 2, (c) and (d) present the wave behavior of Ψ2.

    Figure 1.  Time evolution of the analytic solutions (a) Ψ1 and (b) Ψ2 with t=0,10,20. The parameter are given by x0=20, α=0.50,β=0.6, γ=1.5, and λ=1.
    Figure 2.  This figure present the wave behavior when changing a certain parameter value and fixing the values of the others. (a) presents the behavior when I change the value of α or β, and (b) presents when I change the value of γ or λ for the solution Ψ1. (c) and (d) are for Ψ2.

    (2). When μ0=0, μ1=1, and μ2=1, I have two cases.

    Case 3. The solution is given by

    Ψ3(x,y,t)=3(α+β)2(γ+λ)csch2(12(x+y(α+β)t)). (3.12)

    Case 4. The solution is given by

    Ψ4(x,y,t)=(α+β)2(γ+λ)(3coth2(12(x+y+t(α+β)))1). (3.13)

    (3). When μ0=1, μ1=0, and μ2=1, I have

    Case 5. The solution is given by

    Ψ5(x,y,t)=8(α+β)γ+λ(cosh(4(16t(α+β)+x+y))+2)csch2(2(16t(α+β)+x+y)). (3.14)

    (4). When μ0=±1, μ1=0, and μ2=±1, I have one case.

    Case 6. The solution is given by

    Ψ6(x,y,t)=24(α+β)γ+λcsc2(2(16t(α+β)+x+y)). (3.15)

    According to the generalized algebraic method, the solutions of (3.5) are given by the form

    ψ(η)=ν0+ν1G(η)+ν2G(η)2+r1G(η)+r2G(η)2, (3.16)

    where νk, rk are to be determined later. G(η) is a solution of the following differential equation:

    G(η)=ε4k=0δkGk(η), (3.17)

    where δk, k=0,1,3,4, are given in Table 2. In all the cases mentioned above and the subsequent solutions, I used the mathematical software Mathematica to find the values of the constants ν0,ν1,ν2,r1,r2 and w. Thus, the analytic solutions to (3.5) using the generalized algebraic method will be presented here with different values of the constants δk, k=0,1,3,4.

    (5). When δ0=δ224δ4, δ1=δ3=0, δ2<0, δ4>0, and ε=±1,

    ν0=±4δ22ε4(α+β)2(γ+λ)23δ2ε4(α+β)2(γ+λ)22δ2ε2(α+β)(γ+λ)(γ+λ)2,ν2=6δ4ε2(α+β)(γ+λ),ν1=r1=r2=0,ε=±1.w=±2(4δ223δ2)ε4(α+β)2(γ+λ)2(γ+λ). (3.18)

    Case 7. The solution is given by

    Ψ7(x,y,t)=1(γ+λ)2(3δ2ε4(α+β)(γ+λ)tanh2(δ2(2tδ2(4δ23)ε4(α+β)2(γ+λ)2γ+λ+x+y)2)+2δ2ε2(α+β)(γ+λ)+δ2(4δ23)ε4(α+β)2(γ+λ)2). (3.19)

    Figure 3 shows the time evolution of the analytic solutions. Figure 3(a) shows Ψ7 with t = 0:2:6. The parameter values are δ2=1, δ4=1, ϵ=1, α=0.50, β=0.6, γ=1.5, λ=1.8 and x0=10. Figure 3(b) shows Ψ8 with t=0:2:8. The parameter values are δ2=1, δ4=1, ϵ=1, α=0.50, β=0.6, γ=1.5, λ=1.8 and x0=10. Figures 46 present the 3D time evolution of the analytic solutions Ψ2 (left) and the numerical solutions (right) obtained employing the scheme 5.1 with t=5,15,25, Mx=1600, Ny=100, x=060 and y=01.

    Figure 3.  Time evolution of the analytic solutions. (a) Ψ7 with t=0:2:6. The parameter values are δ2=1, δ4=1, ϵ=1, α=0.50, β=0.6, γ=1.5, λ=1.8 and x0=10. (b) Ψ8 with t=0:2:8. The parameter values are δ2=1, δ4=1, ϵ=1, α=0.50, β=0.6, γ=1.5, λ=1.8 and x0=10.
    Figure 4.  3D graphs presenting the analytic (left) and the numerical (right) solutions of Ψ2(x,y,t) at t=5. The figures present the strength of agreement between analytic and numerical solutions.
    Figure 5.  3D graphs presenting the analytic (left) and the numerical (right) solutions of Ψ2(x,y,t) at t=15. The figures present the strength of agreement between analytic and numerical solutions.
    Figure 6.  3D graphs presenting the analytic (left) and the numerical (right) solutions of Ψ2(x,y,t) at t=25. The figures present the strength of agreement between analytic and numerical solutions.

    (6). When δ0=0, δ1=δ3=0, δ2>0, δ4<0, and ε=±1,

    ν2=6δ4ε2(α+β)γ+λ,ν1=ν0=r1=r2=0,w=4δ2ε2(α+β). (3.20)

    Case 8. The solution is given by

    Ψ8(x,y,t)=6δ2ϵ4(α+β)sech2(δ2(4δ2ϵ2t(α+β)+x+y))γ+λ (3.21)

    (7). When δ0=0, δ1=δ4=0, δ30, δ2>0, ε=±1

    Set 1.ν1=3δ3ε2(α+β)2(γ+λ),ν0=ν2=r1=r2=0,w=δ2ε2(α+β).Set 2.ν0=δ2ε2(α+β)(γ+λ),ν1=3δ3ε2(α+β)2(γ+λ),ν2=r1=r2=0,w=δ2ε2(α+β). (3.22)

    Case 9.The solution is given by

    Ψ9(x,y,t)=3δ2(α+β)sech2(12δ2(δ2t((α+β))+x+y))2(γ+λ). (3.23)

    Case 10. The solution is given by

    Ψ10(x,y,t)=3δ2(α+β)sech2(12δ2(δ2t(α+β)+x+y))2(γ+λ)δ2(α+β)γ+λ. (3.24)

    In this section I extract numerical solutions to the resulting ODE system (3.5) using several numerical methods. The purpose of this procedure is to guarantee the accuracy of the analytic solutions. I picked one of the analytic solutions above to be a sample, (3.11). The nonlinear shooting and BVP methods, at t=0, are used by taking the value of ψ at the right endpoint of the domain η=0 with guessing the initial value for ψη. The new target is to obtain the second boundary condition of ψ at the left endpoint of a particular domain. Once the numerical result is obtained, I compare it with the analytic solution (3.11). The MATLAB solver ODE15s and FSOLVE [47] are used to get the numerical solution. The resulting ODE (3.5) is discretized as

    f(ψ)=0,f(ψi)=wψi+α+βΔη(ψi+12ψi+ψi1)+γ+λ2Δη(ψ2i+1ψ2i1), (4.1)

    for the BVP method and

    ψηη=1α+β(wψ(γ+λ)ψ2), (4.2)

    for the shooting method. Figure 7 presents the comparison between the numerical solutions obtained using the above numerical methods and the analytic solution. Figure 7 shows that the solutions are identical to the analytic solution.

    Figure 7.  Comparing the numerical solutions resulting from the shooting and BVP methods with the analytic solution (3.11) at t=0. The parameter values are taken as α=0.50, β=0.6, γ=1.5,λ=1.8, with N=600.

    Thus, it is possible to verify the correctness of the analytic solution. I also accept the obtained numerical solution as an initial condition for the numerical scheme in the next section.

    In this section, I use the finite-difference method to obtain the numerical results of system (1.1) over the domain [a,b]×[c,d]. Here, a,b,c and d represent the endpoints of the rectangular domain in the x and y directions, respectively, and Tf is a certain time. The domain [a,b]×[c,d] is split into (Mx+1)×(Ny+1) mesh points:

    xm=a+mΔx,m=0,1,2,,Mx,yn=c+nΔy,n=0,1,2,,Ny,

    where Δx and Δy are the step-sizes of the x and y domains, respectively. The system (1.1) is converted to an ODE system by discretizing the space derivatives while keeping the time derivative continuous. Completing this yields

    Ψt|km,n+α2ΔyΔ2xδ2x(Γk+1m,n+1Γk+1m,n1)+β2ΔxΔ2yδ2y(Φk+1m+1,nΦk+1m1,n)γ4Δy((Φk+1m,n+1+Φk+1m,n)Γk+1m,n+1(Φk+1m,n+Φk+1m,n1)Γk+1m,n1)λ4Δx((Γk+1m+1,n+Γk+1m,n)Φk+1m+1,n(Γk+1m,n+Γk+1m1,n)Φk+1m1,n)+γ4Δy((Ψk+1m,n+1)2(Ψk+1m,n1)2)+λ4Δx((Ψk+1m+1,n)2(Ψk+1m1,n)2)=0,12Δy(Γk+1m,n+1Γk+1m,n1)=12Δx(Ψk+1m+1,nΨk+1m1,n),12Δy(Ψk+1m,n+1Ψk+1m,n1)=12Δx(Φk+1m+1,nΦk+1m1,n), (5.1)

    where

    δ2xΓk+1m,n=(Γk+1m+1,n2Γk+1m,n+Γk+1m1,n),δ2yΦk+1m,n=(Φk+1m,n+12Φk+1m,n+Φk+1m,n1),

    subject to the boundary conditions:

    Ψx(a,y,t)=Ψx(b,y,t)=0,y[c,d],Ψy(x,c,t)=Ψy(x,d,t)=0,x[a,b]. (5.2)

    Equation (5.2) permits us to use fictitious points in estimating the space derivatives at the domain's endpoints. The initial conditions are generated by

    Ψ2(x,y,0)=(α+β)2(γ+λ)(3tanh2(12(x+y+x0)1), (5.3)

    where α,β,γ and λ are user-defined parameters. In all the numerical results shown in this section, the parameter values are fixed as α=0.50,β=0.6,γ=1.50,λ=1.80,x0=45.0, y=01, x=060 and t=025. The above system is solved by using an ODE solver in FORTRAN called the DDASPK solver [48]. This solver used a backward differentiation formula. Since I do not have the initial conditions for the space derivatives, I approximate the Jacobian matrix of the linearized system by using LU-Factorization. The obtained numerical results are acceptable. This can be observed from the Figures 8 and 9.

    Figure 8.  Time change for the numerical results while holding y=0.5 and Mx=1600 at t=0:5:25. The wave at t=25 illustrates that the numerical and the analytic solutions are quite identical.
    Figure 9.  The convergence histories of the scheme with the fixation of both y=0.5 and Mx=1600 at t=5.

    The von Neumann analysis is used to examine the stability of the scheme (5.1). The von Neumann analysis is occasionally called Fourier analysis and is utilized exclusively when the scheme is linear. Hence, I suppose that the linear version is given by

    Ψt+αΓxxy+βΦxyy+s0Γy+s1Ψy+s2Φx+s3Ψx=0,Γy=Ψx,Ψy=Φx, (6.1)

    where s0=γΦ, s1=γΨ, s2=λΓ, s3=λΨ are constants. Since Γy=Ψx, and Ψy=Φx, the first equation of (6.1) is given by

    Ψt+αΨxxx+βΨyyy+s0Ψy+s1Ψy+s2Ψx+s3Ψx=0, (6.2)

    where α,β,γ,λ,s0,s1,s2,s3,l4 are constants. I set directly

    Ψkm,n=μkexp(ιπξ0nΔx)exp(ιπξ1mΔy), (6.3)

    and also I can have

    Ψk+1m,n=μΨkm,n,Ψkm+1,n=exp(ιπξ0Δx)Ψkm,n,Ψkm,n+1=exp(ιπξ1Δy)Ψkm,n,Ψkm1,n=exp(ιπξ0Δx)Ψkm,n,Ψkm,n1=exp(ιπξ1Δy)Ψkm,n,m=1,2,,Nx1,n=1,2,,Ny1.

    Substituting (6.3) into (6.2) and doing some operations, I have

    1=μ(1ιΔt(sin(ξ0πΔx)Δx(4αΔ2xsin2(ξ0πΔx2)s2s3)+sin(ξ1πΔy)Δy(4βΔ2ysin2(ξ1πΔy2)s0s1))).

    Hence,

    μ=11aι, (6.4)

    where

    a=Δt(sin(ξ0πΔx)Δx(4αΔ2xsin2(ξ0πΔx2)s2s3)+sin(ξ1πΔy)Δy(4βΔ2ysin2(ξ1πΔy2)s0s1)).

    Thus,

    |μ|2=11+a21. (6.5)

    The stability condition of the von Neumann analysis is fulfilled. Consequently, from Eq (6.5), the scheme is unconditionally stable.

    To examine the accuracy of the numerical scheme (5.1), I study the truncation error utilizing Taylor expansions. Suppose that the error is

    ek+1m,n=Ψk+1m,nΨ(xm,yn,tk+1), (7.1)

    where Ψ(xm,yn,tk+1) and Ψk+1m,n are the analytic solution and an approximate solution, respectively. Substituting (7.1) into (5.1) gives

    ek+1j,kekj,kΔt=Tk+1m,n(α12Δ3xδ2x(ek+1m+1,nek+1m1,n)+β12Δ3yδ2y(ek+1m,n+1ek+1m,n1)+s2+s32Δx(ek+1m+1,nek+1m1,n)+s0+s12Δy(ek+1m,n+1ek+1m,n1)),

    where

    Tk+1m,n=α2Δ3xδ2x(Ψ(xm+1,yn,tk+1)Ψ(xm1,yn,tk+1))+β2Δ3yδ2y(Ψ(xm,yn+1,tk+1)Ψ(xm,yn1,tk+1))+s2+s32Δx(Ψ(xm+1,yn,tk+1)Ψ(xm1,yn,tk+1))+s0+s12Δy(Ψ(xm,yn+1,tk+1)Ψ(xm,yn1,tk+1)).

    Hence,

    Tk+1m,nΔt22Ψ(xm,yn,ξk+1)t2Δ2x25Ψ(ζm,yn,tk+1)x5Δ2y25Ψ(xm,ηn,tk+1)x5Δ2y63Ψ(xm,ηn,tk+1)x3Δ2x63Ψ(ζm,yn,tk+1)x3.

    Accordingly, the truncation error of the numerical scheme is

    Tk+1m,n=O(Δt,Δ2x,Δ2y).

    I have prosperously employed several analytical methods to extract the traveling wave solutions to the two-dimensional Novikov-Veselov system, confirming the solutions with numerical results obtained using the numerical scheme (5.1). The major highlights of the results are shown in Table 3 and Figures 810, which allow immediate comparison of the analytic solutions with the numerical results. Through these, I can notice that the solutions are identical to a large extent, and the error approaches zero whenever the value of Δx,Δy0. The numerical schemes are unconditionally stable for fixing the parameter values α=0.50,β=0.6,γ=1.50,λ=1.80,x0=45.0, y=01, x=060 and t=025.

    Table 3.  The relative error with L2 norm and CPU at t=20..
    Δx The Relative Error CPU
    0.6000 5.600×103 0.063×103m
    0.3000 2.100×103 0.1524×103s
    0.1500 6.700×104 0.3564×103s
    0.0750 2.100×104 0.8892×103s
    0.0375 6.610×105 1.7424×103s
    0.0187 2.310×105 4.0230×103s

     | Show Table
    DownLoad: CSV
    Figure 10.  The convergence histories measured utilizing the relative error with l2 norm as a function of Δx (see Table 3). Here, I picked a certain value of the variable y=0.5 at t=20 and x=060.

    Figure 1 presents the time evolution of the analytic solutions (a) Ψ1 and (b) Ψ2 with t=0,10,20. The parameter values are x0=20, α=0.50, β=0.6, γ=1.5, and λ=1. Figure 2 presents the wave behavior by changing a certain parameter value and fixing the values of the others. Figure 2(a,b) presents the behavior of Ψ1 when I change the values of (a) α or β and (b) γ or λ. In Figure 2(a) it can also be seen that the value of α or β affects the direction and amplitude of the wave, such that a negative value always makes the wave negative, its amplitude decreases when α,β0, and its amplitude increases when α,β. In Figure 2(b) the value of γ or λ affects the direction and amplitude of the wave, such that a negative value always makes the wave negative, and its amplitude decreases when the value of γ or λ increases. In Figure 2(c,d) present the wave behavior of Ψ2. Figure 3 shows the time evolution of the analytic solutions. Figure 3(a) shows Ψ7 with t=0:2:6. The parameter values are δ2=1, δ4=1, ϵ=1, α=0.50, β=0.6, γ=1.5, λ=1.8 and x0=10. Figure 3(b) shows Ψ8 with t=0:2:8. The parameter values are δ2=1, δ4=1, ϵ=1, α=0.50, β=0.6, γ=1.5, λ=1.8 and x0=10. Figures 46 present the 3D time evolution of the analytic solutions Ψ2 (left) and the numerical solutions (right) obtained employing the scheme 5.1 with t=5,15,25, Mx=1600, Ny=100, x=060 and y=01. These figures provide us with an adequate answer that the numerical and analytic solutions are quite identical. Barman et al. [42] accepted several traveling wave solutions for (1.1) as hyperbolic functions. The authors employed other parameters to develop new forms for the accepted solution. They proposed that Eq (1.1) describes tidal and tsunami waves, electromagnetic waves in transmission cables and magneto-sound and ion waves in plasma. In comparison, I have found numerous solutions also as hyperbolic functions. Furthermore, I obtained the numerical solutions to enhance the assurance that the solutions presented here are correct and accurate.

    I have successfully utilized the generalized algebraic and modified F-expansion methods to acquire the soliton solutions for the two-dimensional Novikov-Veselov system, verifying these solutions with numerical results obtained by employing the numerical scheme (5.1). The major highlights of the results shown in Figures 810 and Table 3, which allow immediate comparison of the analytic solutions with the numerical results. Through these, I can notice that the solutions are identical to a large extent, and the error approaches zero whenever the value of Δx,Δy0. The numerical schemes are unconditionally stable for fixing the parameter values α=0.50,β=0.6,γ=1.50,λ=1.80, x0=45.0, y=01, x=060 and t=025. The Jacobi elliptic functions have effectively deteriorated to hyperbolic functions. The applied numerical schemes have provided reliable numerical solutions when using a small value of Δx,Δy0.

    Ultimately, I can deduce that the methods used are valuable and applicable to extract soliton solutions for other nonlinear evolutionary systems found in chemistry, engineering, physics and other sciences.

    The author declares that he has no potential conflict of interest in this article.



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