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Research article

Impact of grape polyphenols on Akkermansia muciniphila and the gut barrier

  • A healthy gastrointestinal tract functions as a highly selective barrier, allowing the absorption of nutrients and metabolites while preventing gut bacteria and other xenobiotic compounds from entering host circulation and tissues. The intestinal epithelium and intestinal mucus provide a physical first line of defense against resident microbes, pathogens and xenotoxic compounds. Prior studies have indicated that the gut microbe Akkermansia muciniphila, a mucin-metabolizer, can stimulate intestinal mucin thickness to improve gut barrier integrity. Grape polyphenol (GP) extracts rich in B-type proanthocyanidin (PAC) compounds have been found to increase the relative abundance of A. muciniphila, suggesting that PACs alter the gut microbiota to support a healthy gut barrier. To further investigate the effect of GPs on the gut barrier and A. muciniphila, male C57BL/6 mice were fed a high-fat diet (HFD) or low-fat diet (LFD) with or without 1% GPs (HFD-GP, LFD-GP) for 12 weeks. Compared to the mice fed unsupplemented diets, GP-supplemented mice showed increased relative abundance of fecal and cecal A. muciniphila, a reduction in total bacteria, a diminished colon mucus layer and increased fecal mucus content. GP supplementation also reduced the presence of goblet cells regardless of dietary fat. Compared to the HFD group, ileal gene expression of lipopolysaccharide (LPS)-binding protein (Lbp), an acute-phase protein that promotes pro-inflammatory cytokine expression, was reduced in the HFD-GP group, suggesting reduced LPS in circulation. Despite depletion of the colonic mucus layer, markers of inflammation (Ifng, Il1b, Tnfa, and Nos2) were similar among the four groups, with the exception that ileal Il6 mRNA levels were lower in the LFD-GP group compared to the LFD group. Our findings suggest that the GP-induced increase in A. muciniphila promotes redistribution of the intestinal mucus layer to the intestinal lumen, and that the GP-induced decrease in total bacteria results in a less inflammatory intestinal milieu.

    20230105144039.jpg

    Citation: Esther Mezhibovsky, Yue Wu, Fiona G. Bawagan, Kevin M. Tveter, Samantha Szeto, Diana Roopchand. Impact of grape polyphenols on Akkermansia muciniphila and the gut barrier[J]. AIMS Microbiology, 2022, 8(4): 544-565. doi: 10.3934/microbiol.2022035

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  • A healthy gastrointestinal tract functions as a highly selective barrier, allowing the absorption of nutrients and metabolites while preventing gut bacteria and other xenobiotic compounds from entering host circulation and tissues. The intestinal epithelium and intestinal mucus provide a physical first line of defense against resident microbes, pathogens and xenotoxic compounds. Prior studies have indicated that the gut microbe Akkermansia muciniphila, a mucin-metabolizer, can stimulate intestinal mucin thickness to improve gut barrier integrity. Grape polyphenol (GP) extracts rich in B-type proanthocyanidin (PAC) compounds have been found to increase the relative abundance of A. muciniphila, suggesting that PACs alter the gut microbiota to support a healthy gut barrier. To further investigate the effect of GPs on the gut barrier and A. muciniphila, male C57BL/6 mice were fed a high-fat diet (HFD) or low-fat diet (LFD) with or without 1% GPs (HFD-GP, LFD-GP) for 12 weeks. Compared to the mice fed unsupplemented diets, GP-supplemented mice showed increased relative abundance of fecal and cecal A. muciniphila, a reduction in total bacteria, a diminished colon mucus layer and increased fecal mucus content. GP supplementation also reduced the presence of goblet cells regardless of dietary fat. Compared to the HFD group, ileal gene expression of lipopolysaccharide (LPS)-binding protein (Lbp), an acute-phase protein that promotes pro-inflammatory cytokine expression, was reduced in the HFD-GP group, suggesting reduced LPS in circulation. Despite depletion of the colonic mucus layer, markers of inflammation (Ifng, Il1b, Tnfa, and Nos2) were similar among the four groups, with the exception that ileal Il6 mRNA levels were lower in the LFD-GP group compared to the LFD group. Our findings suggest that the GP-induced increase in A. muciniphila promotes redistribution of the intestinal mucus layer to the intestinal lumen, and that the GP-induced decrease in total bacteria results in a less inflammatory intestinal milieu.

    20230105144039.jpg



    The mathematical models with uncertainty properties take the forms fuzzy differential equations (FDEs), fuzzy integral equations (FIEs), or fuzzy integro-differential equations (FIDEs). Therefore, the solution of integro-differential equations (IDEs) that have been considered the main core of some physical systems play a significant role in science and engineering [1,2,3,4,5,6]. Some of these systems are linear and nonlinear Fredholm IDEs, and their solutions are continuously growing in many physical problems that arise naturally under uncertainty properties. The study of FDEs and fuzzy integral equations is currently the focus of much research. The starting point of fuzzy sets was first introduced by Zadeh [7]. The fuzzy integral equations were previously derived by Kaleva and Seikkala [8,9]. Lately, a lot of academics have focused on this topic and produced a ton of studies that are published in the literature [10]. As a result, fuzzy models constrained by FSIDEs behave more like the actual process because the after effect is incorporated into it by using the concepts of fuzzy derivatives and fuzzy integrals [11,12], which have several benefits, including the ability to incorporate additional conditions into the problem structure and the ability to structure realistic problems. However, the idea of Hukuhara derivatives that FDEs were developed [13]. FDEs and FIEs were extended to FIDEs, which first appeared in 1999 [14]. That study paved the way for future research on FSIDEs by applying principles from fuzzy sets theory to the analysis of FDEs and FIEs.

    Typically, it is difficult and limiting to obtain the exact analytical solutions for linear FIDEs. Unfortunately, there isn't an analytical solution for the majority of the intricate physical phenomena that can be explained by nonlinear FSIDEs [15]. Analytical solutions are not found in many cases. However, there is always a need for the solutions to these equations because of their practical applications, such as the fuzzy Riccati differential equation [16]. Therefore, in order to handle such fuzzy situations, it is frequently important to suggest effective approximate techniques. In the meantime, the approximate-analytic class of methods under the approximation techniques can directly evaluate the solution accuracy for the systems involving high-order FIDEs. In addition to being applicable to nonlinear systems of FIDEs without the need for linearization or discretization as numerical approximate techniques [17]. Although some numerical class techniques and approximate analytical class techniques are employed and analyzed to obtain the approximate solution of a system of second-kind Fredholm-integro differential equations in the crisp domain [8,9,10,11,12], also in the fuzzy domain, the learning algorithm approximate method (LAM) is used to obtain the solution of these systems in 2017 [12].

    Nevertheless, the series solution's convergence cannot be guaranteed by some current approximate-analytical techniques. However, perturbation-based methods such as the standard fuzzy HAM approach [17] exist to solve fuzzy problems and have the capacity to control convergence. The idea of HAM first appeared in Liao PhD thesis 1992 [18] to deal with approximate solutions for linear and nonlinear mathematical engineering models. It was found that the HAM provides a solution in series form with a degree of polynomial function HAM that converges to the close form solution; otherwise, the solution is approximated to some degree of accuracy to the open form solution [17,19]. Also, the basic idea of HAM provides a great technique to rate the solution convergence through the convergence control parameter. The standard HAM has been modified and used to solve a variety of mathematical problems in the fuzzy domain, such as fuzzy FDEs [19], fuzzy partial differential equations [20], fuzzy fractional differential equations [21,22], fuzzy integral equations [17], and fuzzy integro-differential equations [23]. According to the aforementioned survey, the majority of the research that used numerical and approximation analytical techniques was applied on crisp system Fredholm IDEs, with only one implementation on FFSIDEs. As a result, we believe it is vital to propose new approximation analytical techniques to overcome such challenges, as we will demonstrate in the next sections. HAMFF, would give significant contribution toward overcoming obstacles of existing methods such as the Variational iteration method (VIM), the Adomian decomposition method (ADM) etc for example the proposed methods will help us to simplify the complexity of the uncertain nonlocal derivative when solving FFSIDEs. Furthermore, unlike all existing methods HAMFF provides the convergence parameter to control the accuracy of the solution, thus ensuring the convergence of the approximate series solutions. Also, the series solutions provided by the HAMFF have the ability to show the graphical designs of the solutions. Consequently, the goal of this research is to create a new convergence-controlled approximate analytical technique, HAMFF, for solving problems that are subject to boundary and initial conditions. The formulation and analysis of this study involving a theoretical framework and methodology relies on some well-known concepts of fuzzy sets theory that have been used to help build our recommended technique to solve FFSIDEs. These concepts include properties of fuzzy numbers [24], fuzzy extension principles [25], the α-cuts [26], fuzzy function [27], fuzzy differentiations, and the context of fuzzy integration [28,29,30].

    The following terms must be defined in order to analyze the suggested system in this work.

    Definition 2.1. [24] A triangular fuzzy number is a fuzzy set ˜A=(s1,s2,s3)that, satisfies the membership function,

    Tri˜A(x)={0ifx<s1(xs1)/(s2s1)ifs1xs2(s3x)/(s3s2)ifs2xs30ifx>s3,

    where the crisp interval can be defined by α-cut operation where α[0,1], such that,

    ˜Aα=[s1(α),s3(α)]=[(s2s1)α+s1,(s3s2)α+a3]

    where at α=1 the lower and upper bound of ˜Aα are equal and this is the original crisp number.

    Moreover, according to [24] the triangular fuzzy number satisfies the following properties:

    (1) It is convex (the line by α-cut is continuous and the α-cut interval satisfies for Aα=[s1(α),s3(α)], if there is two different s1<s2s1(α1)s1(α2) and s3(α1)s3(α2)).

    (2) It is normalized (the maximum membership value is 1, xR,μA(x)=1).

    (3) Its membership function is piecewise continuous.

    (4) It is defined in the real number.

    Definition 2.2. [28] The integral of the fuzzy function ˜f in [a,b] is the fuzzy number with α-levels denoted by,

    [ba˜f(x)dx]α=[baf_(x;α)dx,baˉf(x;α)dx]

    where baf_(x;α)dx and baˉf(x;α)dx are the Riemann integrals of the real functions f_(x;α), f_(x;α)in the interval [a,b].

    Now, the general form of the fuzzy system of Fredholm integro-differential equations (FSFIDEs) of the second kind [10] is defined as

    ˜u(n)i(x,α)=˜fi(x,α)+2j=1˜λij(α)ba˜kij(x,t,˜ui(t,α)),i=1,2 (1)

    the initial conditions

    ˜ui(0,α)=(a_i(α),ˉai(α)),˜ui(0,α)=(a_i(α),ˉai(α)),,˜ui(n1)(0,α)=(a_i(n1)(α),ˉai(n1)(α))

    where 0α1, ˜λij are positive fuzzy parameters, ˜kij is an arbitrary fuzzy function called the kernal of integral and ˜fi(x,α) is the given fuzzy function of x[a,b] with ˜ui(x,α) as the unknown fuzzy functions

    ˜ui(x,α)=[u_i(x,α),ˉui(x,α)],˜fi(x,α)=[f_i(x,α),ˉfi(x,α)],

    then we can write Eq (1) as

    u_(n)i(x,α)=f_i(x,α)+2j=1λ_ij(α)bak_ij(x,t,u_i(t,α))dt,ˉu(n)i(x,α)=ˉfi(x,α)+2j=1ˉλij(α)baˉkij(x,t,ˉui(t,α))dt.

    For the analysis of HAM in [18], we can have the substantive of the solution of Eq (1) for all α-level sets values where α[0,1] is the following process.

    The zeroth-order deformation is

    (1q)L[˜ui(x,q,α)˜fi(x,α)]q˜hH(t)Ni[˜ui(x,q,α)], (2)

    and by taking q=0 and q=1 we get.

    ˜ui(x,0,α)=˜fi(x,α)˜ui(x,1,α)=˜ui(x,α)}. (3)

    From Eq (2), the fuzzy initial guess˜ui,0(x,α)can be determined from˜fi(x,α), then the taylor series ofqfor ˜ui(x,q,α)is

    ˜ui(x,q,α)=˜ui(x,0,α)+m=1˜ui,m(x,α,˜h(x))m!qm, (4)

    where

    ˜ui,m(x,α,˜h(α))=1m!˜ui,m(x,α,q,˜h(α))qm|q=0 (5)

    the m-th order deformation f or q=1 in Eq (4) is as follows;

    L[˜ui,m(x,α)χm˜ui,m1(x,α)]=˜h(α)[Ri,m(˜ui,m1)],
    Ri,m(˜ui,m1)=˜uni,m1(1χm)˜fi(x,α)2j=1˜λij(α)ba˜Fij(˜ui,m1(t,α))dt,

    and the series solution of Eq (1) takes the following forms

    {u_i,0(x,α)+m=1u_i,m(x,α,h_(α))ˉui,0(x,α)+m=1ˉui,m(x,α,ˉh(α)). (6)

    A convenient selecting of ˜h(α) obtains the convergence of Eq (6) therefore, the solution in series form (homotopy solution).

    The approximate solution of Eq (1) is convergence based on best values of the parameter ˜h(α) therefore, ˜h(α) should be discussed to supply enough accuracy for ascertain order of the HAMFF series solution. Therefore, an accurate convergent solution is guaranteed when the convergence parameter is chosen appropriately. Finding the approximate solution with the least amount of residual error is one common method for choosing ˜h(α). Assume that the residual of Eq (6) is denoted by ~RE=[RE_,¯RE], then defined the following residual form

    ~RE1(x,α,˜h1(α))=˜u(n)(x,α,˜h1(α))˜f1(x,α)˜λ1(x)ba˜k1(x,t,˜u(t,α,˜h1(x)),~RE2(x,α,˜h2(α))=˜v(n)(x,α,˜h2(α))˜f2(x,α)˜λ2(α)ba˜k2(x,t,˜v(t,α,˜h2(α)),

    the mean square residual error (MSRE) of Eq (6) is define in the following form:

    ~MSREi(x,α,˜hi(α))=10j=0(~REi(x,0.1j,˜hi(α))210+1,i=1,2,0<α1, (7)

    by using the least square method to optimize the values of ˜hi(α) such that

    Ji(x,α,˜hi(α))=(10~MSREi(x,α,˜hi(α)))2dx,i=1,2 (8)

    and the nonlinear equation coming from Eq. (8) for any α(0,1] is derived such that

    ˜Ji(x,α,˜hi(α))˜hi(α)=0{J_i(x,α,hi(α))hi(x)=0,ˉJi(x,α,ˉhi(α))ˉh'i(α)=0.

    Finally, the equation is solved for ˜hi(α) in each α-level set to obtain the best value of ˜h by plotting curves called h-curves such that horizontal line segment with respect to ˜u(n)i(x,α) to illustrate the best region of the ˜h(α)values, which are the for x0<x<X. It is familiar in the fuzzy environment to display the contract h-curves, and to find the optimal value ˜h(α) for eachα[0,1]. The choice the best value of ˜h(α)provides the best accurate solution of the FFSIDEs with its corresponding fuzzy level set ˜α=[α_,¯α], and then applied α_ for each lower level set gets the best lower approximate solution. A similar step is applied to ¯α to determine the best upper solution. The following algorithm is summarizing the dynamic convergence of HAMFF:

    Step 1: Set ˜ui,0(x,α)=˜ui,0,(˜ui,0={u_i,0,ˉui,0}),˜ui(0,α)=(a_i(α),ˉai(α)),.,˜ui(n1)(0,α)=(a_i(n1)(α),ˉai(n1)(α)).

    Step 2: Set ˜λ(α)=[λ_(α),ˉλ(α)].

    Step 3: Set m=1,2,3,,n.

    Step 4: Set m=m+1 and for m=1 to m<n evaluate

    ˜xi,m(x,α)=˜xni,m1(x,α)+˜h(α)[˜xni,m1(x,α)ba˜kij(x,t,˜xim1(x,α,˜h(α))dt(1χm)˜fi(x,α)].

    Step 5: Compute

    ˜xi,m(x,α,˜h(α))=˜x0,m1(x,α)+nk=1˜xk,m1(x,α),i=1,2.

    Step 6: Set the value of α0[0,1],x[a,b] and evaluate

    ˜h(α0)=˜x(x,α0,˜h(α0))˜h(α0),

    then plot the h-curve.

    Step 7: Define the residual form in Eqs (6)–(8) and substitute the ˜h(α0) in Eq (9) to compute the optimal value of ˜h(α0).

    Step 8: Replace-again the optimal values of ˜h(α) for the lower and upper levels in Eq (10).

    In this section, the HAMFF is applied to achieve an approximate-exact solution for FSFIDEs in three problems. We defined the maximum errors as follows to demonstrate the high accuracy of the solution when compared with the exact solution.

    =˜uE(x,α)˜u(x,α),

    where:

    ˜uE(x,α): Fuzzy exact solution,

    ˜u(x,α): Fuzzy approximate solution (HAM).

    Moreover, giving the residual error (RE), the computation associated with the problem were performed using the Maple 18 package with a precision of 30 digits.

    Problem 1. Consider the following the crisp second kind linear SFIDEs [10]

    u(x)xv(x)u(x)=(x2)sinx+10x[costu(t)sintv(t)]dt,v(x)2xu(x)+v(x)=2xcosx+10sinx[costu(t)sin tv(t)]dt. (9)

    Subject to initial conditions (ICs).

    u(0)=0,u(0)=1,˜v(0)=1,v(0,α)=0. (10)

    Since this problem is crisp SFIDEs, we will first present fuzzification of the equation. In this study, the fuzzy version of system (9) is created. Such that from Definition 2.2 the fuzzy version of the integral operator is follows:

    10x[cost˜u(t,α)sint˜v(t,α)]dt={10x[costu_(t,α)sintv_(t,α)]dt10x[cost¯u(t,α)sint¯v(t,α)]dt
    10sinx[cost˜u(t,α)sin t˜v(t,α)]dt={10sinx[costu_(t,α)sin tv_(t,α)]dt10sinx[cost¯u(t,α)sin t¯v(t,α)]dt.

    Now according to the fuzzy analysis in [17] the fuzzy version of system (9) is as follows:

    ˜u(x,α)x˜v(x,α)˜u(x,α)=(x2)sinx+10x[cost˜u(t,α)sint˜v(t,α)]dt,˜v(x,α)2x~u(x,α)+˜v(x,α)=2xcosx+10sinx[cost˜u(t,α)sin t˜v(t,α)]dt. (11)

    From the Definition 2.1 of the triangular fuzzy numbers, we can defuzzify the ICs. Let [˜0]α and [˜1]αbe triangular fuzzy numbers corresponding with the ICs (10) for all α[0,1] such that

    ˜u(0,α)=[˜0]α=(1,0,1),˜u(0,α)=[˜1]α=(3,4,5)
    ˜v(0,α)=[˜1]α=(14,34,74),˜v(0,α)=[˜0]α=(12,0,12).

    According to the α-cut of triangular fuzzy number in Definition 2.1 the following fuzzy ICs of system (11) are defined as follows

    ˜u(0,α)=(α1,1α),˜u(0,α)=(4α3,54α),˜v(0,α)=(34α+14,7434α),˜v(0,α)=(12α12,1212α), (12)

    where ˜f1(x,α)=[f_1(x,α),¯f1(x,α)] and ˜f2(x,α)=[f_2(x,α),¯f2(x,α)] are given by

    f_1(x,α)=(0.708073418x3.sin(x)+3.5sin(x)x)α0.708073418x+sin(x)2.5sin (x)x,
    f_2(x,α)=(0.708073418sin(x)3.0cos(x)x)α0.708073418sin(x)+cos(x)x,
    ¯f1(x,α)=(0.708073418x+3.sin(x)3.5sin(x)x)α+0.708073418x5.0sin(x)+4.5sin(x)x,
    ¯f2(x,α)=(0.708073418sin(x)+3.0cos(x)x)α+0.708073418sin(x)5.0cos(x)x.

    The exact solutions of the system (11) are

    ˜uE(x,α)=[αx16αx3+1120αx5,(2α)x(1316α)x3+(1601120α)x5],˜vE(x,α)=[(2α1)12αx2+124αx4,(32α)(112α)x2+(112124α)x4]. (14)

    To solve the fuzzy system (11) according to the ICs (12) by means of the HAMFF to obtain the initial approximations. from section 3, the iterations of HAMFF are determined in the following recursive way:

    ˜u0(x,α)=˜u(0,α)+x˜u(0,α),˜v0(x,α)=˜v(0,α)+x˜v(0,α), (15)

    and choosing the linear operators

    L[˜u(x,q,α)]=2˜u(x,q,α)2x,L[˜v(x,q,α)]=2˜v(x,q,α)2x,L1=x0x0()dtdt, (16)

    with the property L[c1+c2x]=0, where c1 and c2 are constants. Furthermore, formulation of system (9) according to HAMFF in Section 3 involved the embedding parameter q[0,1] and the parameter can be defined with the nonlinear operators as follows:

    {N1[˜u(x,q;α),˜v(x,q;α)]=2˜u(x,q;α)2xx˜v(x,q;α)˜u(x,q;α)˜f1(x,α)10x[(cost)˜u(t,q;α)(sint)˜v(t,q;α)]dt,N2[˜u(x,q;α),˜v(x,q;α)]=2˜v(x,q,α)2x2x˜u(x,q;α)+˜v(x,q;α)+˜f2(x,α)10sinx[(cost)˜u(t,q;α)(sint)˜v(t,q;α)]dt. (17)

    Using the above definition, with the assumption H(x)=1 we construct the zeroth-order deformation equation

    {(1q)L[˜u(x,q,α)˜u0(x,α)]=qhH(x)N1[˜u(x,q;α),˜v(x,q;α)],(1q)L[˜v(x,q,α)˜v0(x,α)]=qhH(x)N2[˜u(x,q;α),˜v(x,q;α)]. (18)

    Obviously, when q=0 and q=1

    ˜u(x,0,α)=˜u0(x,α),˜u(x,1,α)=˜u(x,α),
    ˜v(x,0,α)=˜v0(x,α),˜v(x,1,α)=˜v(x,α).

    Thus, we obtain the mthorder deformation equations for m1 which are

    {L[˜um(x,α)χm˜um1(x,α)]=h[R1,m(˜um1,˜vm1)],L[˜vm(x,α)χm˜vm1(x,α)]=h[R2,m(˜um1,˜vm1)], (19)

    where

    R1,m(˜um1,˜vm1)=˜um1(x,α)x˜vm1(x,α)˜um1(x,α)(1χm)˜f1(x,α)λ110x[cost˜um1(t,α)sint˜vm1(t,α)]dt,R2,m(˜um1,˜vm1)=˜vm1(x,α)2x˜um1(x,α)+˜vm1(x,α)+(1χm)˜f2(x,α)λ210sinx[cost˜um1(t,α)sint˜vm1(t,α)]dt. (20)

    Now, for m1, the solutions of the mth-order deformation Eq (17) are

    {˜um(x,α)=χm˜um1(x,α)+hL1[R1,m(˜um1,˜vm1)],˜vm(x,α)=χm˜vm1(x,α)+hL1[R2,m(˜um1,˜vm1)]. (21)

    Thus, the approximate solutions in a series form are given by

    ˜u(x,α)=˜u0(x,α)+6k=1˜uk(x,α),˜v(x,α)=˜v0(x,α)+6k=1˜vk(x,α). (22)

    From Section 4, the residual function with respect to this solution for the system (9) is obtained by the substitution of the series solution (19) into the original system (9) such that

    ~RE1(x,α)=˜u(x,α)x˜v(x,α)˜u(x,α)˜f1(x,α)10x[(cost)˜u(t,α)(sint)˜v(t,α)]dt,~RE2(x,α)=˜v(x,α)2x~u(x,α)+˜v(x,α)+˜f2(x,α)10sinx[(cost)˜u(t,α)(sint)˜v(t,α)]dt. (23)

    The ˜hi(α)-curves of sixth-order HAMFF upper and lower bound solutions ˜u(x,α) and ˜v(x,α) at x=0.3 and α=0.5 for system (9) are shown in the following Tables 1 and 2 and Figures 14.

    Table 1.  Best values of the convergence control parameter of sixth-order HAMFF solution ˜u(x,α) of system (11) at x=0.3 and α=0.5, where * denoted to the optimal value of ˜h1.
    h_11* -0.993770765902976 h_12 -0.940282902800624 h_13 -0.913774159351708
    ¯h11* -0.995692236847504 ¯h12 -0.937399868820798 ¯h13 -0.908804197021662

     | Show Table
    DownLoad: CSV
    Table 2.  Best values of the convergence control parameter of sixth-order HAMFF solution ˜v(x,α) of system (11) at x=0.3 and α=0.5, where * denoted to the optimal value of ˜h2.
    h_21* -0.997396591174385 h_22 -0.943482345592162 h_23 -0.911405157147745
    ¯h21* -0.999232447779833 ¯h22 -0.940161255064283 ¯h23 -0.906821208973723

     | Show Table
    DownLoad: CSV
    Figure 1.  The h-curve representation of sixth-order HAMFF lower solution for system (9) of u_(0.3;0.5;h).
    Figure 2.  The h-curve representation of sixth-order HAMFF upper solution for system (11) of ¯u(0.3;0.5;h).
    Figure 3.  The h-curve representation of sixth-order HAMFF lower solution for system (11) of v_(0.3;0.5;h).
    Figure 4.  The h-curve representation of sixth-order HAMFF upper solution for system (9) of ¯v(0.3;0.5;h).

    By comparing the Tables 36, we can see how the results improve after the minimization process.

    Tables 3 and 4 show a comparison of the absolute errors applying the HAMFF (m=6) with the exact solutions (11) within the interval 0α1 at x=0.5 with best values of the convergence control parameter ˜hi after minimization which are listed in the following tables (see Tables 5 and 6).

    In the following Figures 510 shows the exact solutions (˜uE(x,α), ˜vE(x,α)) and the fuzzy approximate solutions by HAM (˜u(x,α), ˜v(x,α)) of the system (11) are in the form of fuzzy numbers for any 0α1 at x=0.3 and ˜hi=1.

    Table 3.  Solution and accuracy sixth-order HAMFF for system (9) of ˜u(x,α) at x=0.5 and ˜hi=1 with 0α1.
    α u_E(x,α) u_(x,α) |u_E(x,α)u_(x,α)| ¯uE(x,α) ¯u(x,α) |¯uE(x,α)¯u(x,α)|
    0.0 -0.239712769 -0.239712815 4.628E-08 1.198563846 1.198563912 6.571E-08
    0.2 -0.095885107 -0.095885142 3.508E-08 1.054736184 1.054736239 5.451E-08
    0.4 0.047942553 0.047942529 2.388E-08 0.910908523 0.910908566 4.331E-08
    0.6 0.191770215 0.191770202 1.268E-08 0.767080861 0.767080893 3.211E-08
    0.8 0.335597877 0.335597875 1.485E-09 0.623253200 0.623253221 2.091E-08
    1.0 0.479425538 0.479425548 9.714E-09 0.479425538 0.479425548 9.714E-09

     | Show Table
    DownLoad: CSV
    Table 4.  Solution and accuracy sixth-order HAMFF for system (11) of˜v(x,α) at x=0.5 and ˜hi=1 with 0α1.
    α v_E(x,α) v_(x,α) |v_E(x,α)v_(x,α)| ¯vE(x,α) ¯v(x,α) |¯vE(x,α)¯v(x,α)|
    0.0 -2.193956404 -2.193956432 2.793E-08 3.949121528 3.949121561 3.340E-08
    0.2 -1.579648611 -1.579648633 2.180E-08 3.334813735 3.334813762 2.726E-08
    0.4 -0.965340818 -0.965340833 1.566E-08 2.720505941 2.720505962 2.113E-08
    0.6 -0.351033024 -0.351033034 9.535E-09 2.106198148 2.106198163 1.499E-08
    0.8 0.263274768 0.263274765 3.401E-09 1.491890355 1.491890364 8.865E-09
    1.0 0.877582561 0.877582564 2.731E-09 0.877582561 0.877582564 2.731E-09

     | Show Table
    DownLoad: CSV
    Table 5.  Solution and accuracy sixth-order HAMFF for system (11) of ˜u(x,α) at =0.3, ˜hi=h_11,˜hi=¯h11 and 0α1.
    α u_E(x,α) u_(x,α) |u_E(x,α)u_(x,α)| ¯uE(x,α) ¯u(x,α) |¯uE(x,α)¯u(x,α)|
    0.0 -0.239712769 -0.239712775 5.966E-09 1.198563846 1.198563860 1.350E-08
    0.2 -0.095885107 -0.095885113 6.133E-09 1.054736184 1.054736195 1.040E-08
    0.4 0.047942553 0.047942547 6.300E-09 0.910908523 0.910908530 7.315E-09
    0.6 0.191770215 0.191770208 6.467E-09 0.767080861 0.767080865 4.221E-09
    0.8 0.335597877 0.335597870 6.634E-09 0.623253200 0.623253201 1.128E-09
    1.0 0.479425538 0.479425531 6.800E-09 0.479425538 0.479425536 1.964E-09

     | Show Table
    DownLoad: CSV
    Table 6.  Solution and accuracy sixth-order HAMFF for system (11) of˜v(x,α) at x=0.3, ˜hi=h_21,˜hi=¯h21 and 0α1.
    α v_E(x,α) v_(x,α) |v_E(x,α)v_(x,α)| ¯vE(x,α) ¯v(x,α) |¯vE(x,α)¯v(x,α)|
    0.0 -2.193956404 -2.193956416 1.186E-08 3.949121528 3.949121552 2.445E-08
    0.2 -1.579648611 -1.579648621 1.028E-08 3.334813735 3.334813754 1.970E-08
    0.4 -0.965340818 -0.965340826 8.700E-09 2.720505941 2.720505956 1.496E-08
    0.6 -0.351033024 -0.351033031 7.118E-09 2.106198148 2.106198158 1.021E-08
    0.8 0.263274768 0.263274763 5.536E-09 1.491890355 1.491890360 5.463E-09
    1.0 0.877582561 0.877582557 3.954E-09 0.877582561 0.877582562 7.146E-10

     | Show Table
    DownLoad: CSV
    Figure 5.  The exact and HAMFF lower and upper solutions of system (11) ˜uE(x,α) and ˜u(x,α) for all α[0,1].
    Figure 6.  The exact and HAMFF lower and upper solutions of system (11) ˜vE(x,α) and ˜v(x,α) for all α[0,1].
    Figure 7.  The exact lower and upper solutions of system (11) ˜uE(x,α) for all x,α[0,1].
    Figure 8.  The HAMFF lower and upper solutions of system (11) and ˜u(x,α) for all x,α[0,1].
    Figure 9.  The exact lower and upper solutions of system (11) ˜vE(x,α) for all x,α[0,1].
    Figure 10.  The HAMFF lower and upper solutions of system (9) and ˜v(x,α) for all x,α[0,1].

    According to Figures 510, one can summarize that the sixth-order HAMFF solutions of system (9) satisfied the fuzzy solution in triangular fuzzy number forms. To show HAMFF accuracy of Eq (11) crisp version was solved via the Euler polynomials (EP) [10] and Laguerre polynomials methods [11] (MLP), comparison between sixth-order HAMFF solution EP with N=6 iterations MLP [11] with N=5 iterations can be made whenα=1 which is equivalent to the crisp version of Eq (11) at the same values ofx[0,1] that illustrated in Tables 7 and 8 and are displayed in Table 9 below.

    Table 7.  Accuracy of sixth-order HAMFF solution for system (11) at α=1 and hi=1.
    x uE(x,1) u(x,1) |uE(x,1)u(x,1)| vE(x,1) v(x,1) |vE(x,1)v(x,1)|
    0.0 0.0 0.0 0.0 1.0 1.0 0.0
    0.2 0.198669330 0.198669332 1.832E-09 0.980066577 0.980066579 1.758E-09
    0.4 0.389418342 0.389418351 8.876E-09 0.921060994 0.921061000 6.568E-09
    0.6 0.564642473 0.564642474 7.133E-10 0.825335614 0.825335599 1.523E-08
    0.8 0.717356090 0.717355970 1.199E-07 0.696706709 0.696706666 4.290E-08
    1.0 0.841470984 0.841470265 7.190E-07 0.540302305 0.540305187 2.881E-06

     | Show Table
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    Table 8.  Control parameters at α=1, where hi is the ideal expression.
    h11* -0.997358653933643 h12 -0.934546746098124 h13 -0.905342473297271
    h21* -1.000822093275177 h22 -0.937048072427569 h23 -0.903768109332694

     | Show Table
    DownLoad: CSV
    Table 9.  Accuracy of sixth-order HAMFF solution with EP [10] and MLP [11] for system (11) at α=1 and hi with optimal values of h1=h_11,h2=¯h21.
    |uE(x,1)u(x,1)| [10] [11] |vE(x,1)v(x,1)| [10] [11]
    3.309E-07 5.801E-05 1.568E-06 2.941E-06 1.016E-04 5.780E-06

     | Show Table
    DownLoad: CSV

    Indeed, the sixth- order HAMFF solution system (9) obtained better solution in terms of accuracy over EP [10] and MLP [11] at α=1 as illustrated in Table 9 above.

    Problem 2. Consider the fuzzy version following second kind linear FSFIDEs as follows:

    ˜u(x,α)x˜v(x,α)+2x˜u(x,α)=2+32066x3712x2+2x3+10xt[x˜u(t,α)t˜v(t,α)]dt,˜v(x,α)2x˜u(x,α)+˜v(x,α)=110930x5x2+10xt[˜u(t,α)+t2˜v(t,α)]dt, (24)

    with the boundary conditions (BCs)

    ˜u(0,α)=(2α+1,52α),˜u(1,α)=(3α1,53α),˜v(0,α)=(2α1,32α),˜v(1,α)=(6α5,76α). (25)

    System (24) was derived utilizing the same fuzzy analysis in problem 1 from the crisp version SFIDEs in [11],

    where

    ˜f1(x,α)=[f_1(x,α),¯f1(x,α)] and ˜f2(x,α)=[f_2(x,α),¯f2(x,α)] are given by

    f_1(x,α)=(9130x7912x2+2+2x3)α+4720x+72x2,
    f_2(x,α)=235αx2930x+3α43αx22x2,
    ¯f1(x,α)=(9130x+7912x222x3)α293x2+10112x+4+4x3,
    ¯f2(x,α)=(235x3+3x2)α+24730x8x2+2.

    The exact solutions of the system (24) are

    ˜uE(x,α)=[αx_22αx_+2α+1,(2α)¯x2(42α)¯x+(52α)],
    ˜vE(x,α)=[(α2)x_2+(2α1)x_+α,α¯x2+(32α)¯x+(2α)].

    To solve system (24) approximately, the HAMFF is applied to system (24) such that the method iterations are determined in the following recursive way:

    ˜u0(x,α)=˜u(0,α)+x˜u(0,α),˜v0(x,α)=˜v(0,α)+x˜v(0,α), (26)

    where ˜u(0,α)=˜C1, and ˜v(0,α)=˜C2, calculated from the BCs (25).

    Choosing the linear operators

    L[˜u(x,q,α)]=2˜u(x,q,α)2x,L[˜v(x,q,α)]=2˜v(x,q,α)2x,L1=x0x0()dtdt, (27)

    with the property L[c1+c2x]=0, where c1 and c2 are constants.

    C_1=2.7581×1091.999999995α,¯C1=3.999999989+1.999999995α,C_2=1.000000009+2.000000001α,¯C2=2.999999992  2.000000001α.

    As in Problem 1, nonlinear operators of system (21) are defined as follows

    {N1[˜u(x,q,α),˜v(x,q,α)]=2˜φ1(x,q,α)2xx~v(x,q,α)+(2x)˜u(x,q,α)˜f1(x,α)10xt[x˜u(x,q,α)t˜v(x,q,α)]dt,N2[˜u(x,q,α),˜v(x,q,α)]=2˜v(x,q,α)2x2x~u(x,q,α)+˜v(x,q,α)+˜f2(x,α)10(xt)[˜u(x,q,α)+t2˜v(x,q,α)]dt. (28)

    Using the above definition, with the assumption H(x)=1 we construct the zeroth-order deformation equation

    {(1q)L[˜u(x,q,α)˜u0(x,α)]=qhH(x)N1[˜u(x,q,α),˜v(x,q,α)],(1q)L[˜v(x,q,α)˜v0(x,α)]=qhH(x)N2[˜u(x,q,α),˜v(x,q,α)]. (29)

    Obviously, when q=0 and q=1

    ˜u(x,0,α)=˜u0(x,α),˜u(x,1,α)=˜u(x,α),
    ˜v(x,0,α)=˜v0(x,α),˜v(x,1,α)=˜v(x,α).

    Thus, we obtain the mthorder deformation equations for m1 which are

    {L[˜um(x,α)χm˜um1(x,α)]=h[R1,m(˜um1,˜vm1)],L[˜vm(x,α)χm˜vm1(x,α)]=h[R2,m(˜um1,˜vm1)], (30)

    where

    R1,m(˜um1,˜vm1)=˜vm1(x,α)x˜vm1(x,α)+2x˜um1(x,α)(1χm)˜f1(x,α)10xt[x˜um1(t,α)t˜vm1(t,α)]dt,R2,m(˜um1,˜vm1)=+˜vm1(x,α)2x˜um1(x,α)+˜vm1(x,α)+(1χm)˜f2(x,α)10xt[˜um1(t,α)+t2˜vm1(t,α)]dt. (31)

    Now, for m1, the solutions of the mth-order deformation system (24) are

    {˜um(x,α)=χm˜um1(x,α)+hL1[R1,m(˜um1,˜vm1)],˜vm(x,α)=χm˜vm1(x,α)+hL1[R2,m(˜um1,˜vm1)]. (32)

    Thus, the approximate solutions in a series form are given by

    ˜u(x,α)=˜u0(x,α)+9k=1˜uk(x,α),˜v(x,α)=˜v0(x,α)+9k=1˜vk(x,α). (33)

    The residual error function with respect to this solution for the system (21) is

    ~RE1(x,α)=˜u(x,α)x˜v(x,α)+2x˜u(x,α)˜f1(x,α)10xt[x˜u(t,α)t˜v(t,α)]dt,~RE2(x,α)=˜v(x,α)2x~u(x,α)+˜v(x,α)˜f2(x,α)10xt[˜u(t,α)+t2˜v(t,α)]dt. (34)

    The ˜hi(α)-curves of ninth-order HAMFF upper and lower bound solutions ˜u(x,α) and ˜v(x,α) at x=0.1 and α=0.5 for system (21) are shown in the following Tables 10 and 11 and Figures 1114.

    Table 10.  Best values of the convergence control parameter of ninth-order fuzzy HAMFF solution ˜u(x,α) of system (24) at x=0.1 and α=0.5, where * denoted to the optimal value of ˜h1.
    h_11* -0.994760367994695203
    ¯h11* -0.991888973708002525

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    Table 11.  Best values of the convergence control parameter of ninth-order HAMFF solution ˜v(x,α)of system (24) at x=0.1 and α=0.5, where * denoted to the optimal value of ˜h2.
    h_21* -0.994874792763616010
    ¯h21* -0.985659503042079665

     | Show Table
    DownLoad: CSV
    Figure 11.  The h-curve representation of ninth-order HAMFF lower solution for system (24) of u_(0.1;0.5;h).
    Figure 12.  The h-curve representation of ninth-order HAMFF upper solution for system (24) of ¯u(0.1;0.5;h).
    Figure 13.  The h-curve representation of ninth-order HAMFF lower solution for system (24) of v_(0.1;0.5;h).
    Figure 14.  The h-curve representation of ninth-order HAMFF upper solution for system (24) of ¯v(0.1;0.5;h).

    By comparing the Tables 1215, we can see how the results improve after the minimization process.

    Tables 12 and 13 show a comparison of the absolute errors applying the HAMFF (m=9) with the exact solutions within the interval 0α1 at x=0.5 with best values of the convergence control parameter ˜hi after minimization which are listed in the following tables (see Tables 14 and 15).

    The values of ˜C1, and ˜C2, at x=1 for 0α1 with optimal values of ˜hi calculated from the BCs (25) are as follows

    C_1=2.2133×109 1.999999995α,¯C1=3.999999995+1.999999995α,C_2=1.000000005 + 2.000000005α,¯C2=3.0000000232.000000015        α.

    In the following Figures 1520 shows that the exact solutions (˜uE(x,α), ˜vE(x,α)) and the fuzzy approximate solutions by HAMFF (˜u(x,α), ˜v(x,α)) of the system (24) are in the form of fuzzy numbers for any 0α1 at x=0.1 and ˜hi=1.

    Table 12.  Solution and accuracy of ninth-order HAMFF for system (24) of˜u(x,α) at x=0.5 and ˜hi=1 with 0α1.
    α u_E(x,α) u_(x,α) |u_E(x,α)u_(x,α)| ¯uE(x,α) ¯u(x,α) |¯uE(x,α)¯u(x,α)|
    0.0 1.000 1.000000001 1.382E-09 3.500 3.500000005 5.577E-09
    0.2 1.250 1.250000001 1.801E-09 3.250 3.250000005 5.157E-09
    0.4 1.500 1.500000002 2.221E-09 3.000 3.000000004 4.738E-09
    0.6 1.750 1.750000002 2.640E-09 2.750 2.750000004 4.318E-09
    0.8 2.000 2.000000003 3.060E-09 2.500 2.500000003 3.899E-09
    1.0 2.250 2.250000003 3.479E-09 2.250 2.250000003 3.479E-09

     | Show Table
    DownLoad: CSV
    Table 13.  Solution and accuracy ninth-order HAMFF for system (24) of ˜v(x,α) at x=0.5 and ˜hi=1 with 0α1.
    α v_E(x,α) v_(x,α) |v_E(x,α)v_(x,α)| ¯vE(x,α) ¯v(x,α) |¯vE(x,α)¯v(x,α)|
    0.0 -1.000 -1.000000004 4.770E-09 3.500 3.499999996 3.408E-09
    0.2 -0.550 -0.550000004 4.634E-09 3.050 3.049999996 3.544E-09
    0.4 -0.100 -0.100000004 4.498E-09 2.600 2.599999996 3.681E-09
    0.6 0.350 0.349999995 4.362E-09 2.150 2.149999996 3.817E-09
    0.8 0.800 0.799999995 4.225E-09 1.700 1.699999996 3.953E-09
    1.0 1.250 1.249999995 4.089E-09 1.250 1.249999995 4.089E-09

     | Show Table
    DownLoad: CSV
    Table 14.  Solution and accuracy ninth-order HAMFF for system (24) of ˜u(x,α) at x=0.1 and ˜hi=h_11,˜hi=¯h11with 0α1.
    α u_E(x,α) u_(x,α) |u_E(x,α)u_(x,α)| ¯uE(x,α) ¯u(x,α) |¯uE(x,α)¯u(x,α)|
    0.0 1.0 0.999999998 1.112E-09 3.50 3.500000002 2.503E-09
    0.2 1.250 1.249999999 6.640E-10 3.250 3.250000002 2.042E-09
    0.4 1.500 1.499999999 2.154E-10 3.000 3.000000001 1.581E-09
    0.6 1.750 1.750000000 2.331E-10 2.750 2.750000001 1.120E-09
    0.8 2.000 2.000000000 6.817E-10 2.500 2.500000000 6.599E-10
    1.0 2.250 2.250000001 1.130E-09 2.250 2.250000000 1.990E-10

     | Show Table
    DownLoad: CSV
    Table 15.  Solution and accuracy ninth-order HAMFF for system (24) of ˜v(x,α) at x=0.1 and ˜hi=h_21,˜hi=¯h21with 0α1.
    α v_E(x,α) v_(x,α) |v_E(x,α)v_(x,α)| ¯vE(x,α) ¯v(x,α) |¯vE(x,α)¯v(x,α)|
    0.0 -1.000 -1.000000002 2.752E-09 3.500 3.500000011 1.140E-08
    0.2 -0.550 -0.550000002 2.194E-09 3.050 3.050000009 9.896E-09
    0.4 -0.100 -0.100000001 1.636E-09 2.600 2.600000008 8.389E-09
    0.6 0.350 0.349999998 1.078E-09 2.150 2.150000006 6.882E-09
    0.8 0.800 0.799999999 5.201E-10 1.700 1.700000005 5.375E-09
    1.0 1.250 1.250000000 3.791E-11 1.250 1.250000003 3.868E-09

     | Show Table
    DownLoad: CSV
    Figure 15.  The exact and HAMFF lower and upper solutions of system (24) ˜uE(x,α) and ˜u(x,α) for all α[0,1].
    Figure 16.  The exact and HAMFF lower and upper solutions of system (24) ˜vE(x,α) and ˜v(x,α) for all α[0,1].
    Figure 17.  The exact lower and upper solutions of system (24) ˜uE(x,α) for all x,α[0,1].
    Figure 18.  The HAMFF lower and upper solutions of system (24) and ˜u(x,α) for all x,α[0,1].
    Figure 19.  The exact lower and upper solutions of system (24) ˜vE(x,α) for all x,α[0,1].
    Figure 20.  The HAMFF lower and upper solutions of system (24) and ˜v(x,α) for all x,α[0,1].

    According to Figures 1520, one can summarize that the ninth-order HAMFF solutions of system (24) satisfied the fuzzy solution in triangular fuzzy number forms are illustrated in Tables 16 and 17. Next, a comparison between ninth-order HAMFF solution and the MLP [11] are displayed in Table 18 in terms of accuracy at different values of x[0,1] and α=1.

    Table 16.  Accuracy of ninth-order HAMFF solution for system (24) at α=1 and hi=1.
    x uE(x,1) u(x,1) |uE(x,1)u(x,1)| vE(x,1) v(x,1) |vE(x,1)v(x,1)|
    0.0 3.0 3.0 0.0 1.0 1.0 0.0
    0.2 2.64 2.640000001 1.357E-09 1.16 1.159999998 1.652E-09
    0.4 2.36 2.360000002 2.732E-09 1.24 1.239999996 3.240E-09
    0.6 2.16 2.160000004 4.374E-09 1.24 1.239999994 5.138E-09
    0.8 2.04 2.040000006 6.953E-09 1.16 1.159999991 8.385E-09
    1.0 2.00 1.999999999 0.0 1.00 0.999999999 0.0

     | Show Table
    DownLoad: CSV
    Table 17.  Control parameters at α=1, where hi is the ideal expression.
    h11* -0.989174220493120112
    h21* -0.988661974289768555

     | Show Table
    DownLoad: CSV
    Table 18.  Accuracy of ninth-order HAMFF solution and MLP [11] for system (24) at α=1 and hi with optimal values of h1=h_11,h2=¯h21.
    x uE(x,1) u(x,1) |uE(x,1)u(x,1)| vE(x,1) v(x,1) |vE(x,1)v(x,1)|
    0.0 3.0 3.0 0.0 1.0 1.0 0.0
    0.2 2.64 2.639999999 1.799E-10 1.16 1.160000001 1.300E-09
    0.4 2.36 2.359999999 2.774E-10 1.24 1.240000002 2.510E-09
    0.6 2.16 2.159999999 1.135E-10 1.24 1.240000003 3.377E-09
    0.8 2.04 2.040000001 1.026E-09 1.16 1.160000002 2.664E-09
    1.0 2.00 2.000000000 0.0 1.00 0.999999999 0.0

     | Show Table
    DownLoad: CSV

    The values of C1, and C2, at x=1 for α=1 calculated from the BCs (22) are as follows

    C1=1.999999993,C2=0.999999991.

    The values of C1, and C2, at x=1 for α=1 with optimal values of hicalculated from the BCs (22) as follows

    C1=2.000000000,C2=1.000000006.

    From Table 18, the ninth-order HAMFF solution system (9) obtained better solution in terms of accuracy MLP [11] at

    α=1 at different values of x.

    Problem 3. From [4] the fuzzy version of second kind linear SFIDEs is defined as below:

    ˜u(x,α)=˜f1(x,α)+10[xt2˜u(t,α)x˜v(t,α)]dt,˜v(x,α)=˜f2(x,α)+10[x2˜u(t,α)x2t2˜v(t,α)]dt, (35)

    with the ICs

    ˜u(0,α)=(α1,1α),˜v(0,α)=(1α,α1), (36)

    where

    ˜f1(x,α)=[f_1(x,α),¯f1(x,α)]=[716αx,(981116α)x],

    and

    ˜f2(x,α)=[f_2(x,α),¯f2(x,α)]=[16930αx2,(2513016460α)x2].

    Section 3 of the HAMFF analysis of system (35) states the following:

    ˜u0(x,α)=˜u(0,α),˜v0(x,α)=˜v(0,α), (37)

    and choosing the linear operators

    L[˜u(x,q,α)]=˜u(x,q,α)x,L[˜v(x,q,α)]=˜v(x,q,α)x,L1=x0()dt,

    with the property L[c1]=0, where c1 is a constant. Furthermore, the system (35) suggests that we define the nonlinear operators as

    {N1[˜u(x,q,α),˜v(x,q,α)]=˜u(x,q,α)x˜f1(x,α)10[xt2˜u(x,q,α)+x˜v(x,q,α)]dt,N2[˜u(x,q,α),˜v(x,q,α)]=˜v(x,q,α)x˜f2(x,α)10[x2˜v(x,q,α)+x2t2˜u(x,q,α)]dt. (38)

    Using the above definition, with the assumption H(x)=1,we construct the zeroth-order deformation equation

    {(1q)L[˜u(x,q,α)˜u0(x,α)]=qhH(x)N1[˜u(x,q,α),˜v(x,q,α)],(1q)L[˜v(x,q,α)˜v0(x,α)]=qhH(x)N2[˜u(x,q,α),˜v(x,q,α)]. (39)

    Obviously, when q=0 and q=1

    ˜u(x,0,α)=˜u0(x,α),˜u(x,1,α)=˜u(x,α),
    ˜v(x,0,α)=˜v0(x,α),˜v(x,1,α)=˜v(x,α),

    Thus, we obtain the mthorder deformation equations for m1 which are

    {L[˜um(x,α)χm˜um1(x,α)]=h[R1,m(˜um1,˜vm1)],L[˜vm(x,α)χm˜vm1(x,α)]=h[R2,m(˜um1,˜vm1)], (40)

    where

    R1,m(˜um1,˜vm1)=˜um1(x,α)(1χm)˜f1(x,α)10[xt2˜um1(t,α)+x˜vm1(t,α)]dt,R2,m(˜um1,˜vm1)=˜vm1(x,α)(1χm)˜f2(x,α)10[x2˜um1(t,α)+x2t2˜vm1(t,α)]dt. (41)

    Now, for m1, the solutions of the mth-order deformation system (35) are

    {˜um(x,α)=χm˜um1(x,α)+hL1[R1,m(˜um1,˜vm1)],˜vm(x,α)=χm˜vm1(x,α)+hL1[R2,m(˜um1,˜vm1)]. (42)

    Thus, the approximate solutions in a series form are given by

    ˜u(x,α)=˜u0(x,α)+9k=1˜uk(x,α),˜v(x,α)=˜v0(x,α)+9k=1˜vk(x,α). (43)

    The residual error function with respect to this solution for the system (32) is

    ~RE1(x,α)=˜u(x,α)˜f1(x,α)10[xt2˜u(t,α)+x˜v(t,α)]dt,~RE2(x,α)=˜v(x,α)˜f2(x,α)10[x2˜u(t,α)+x2t2˜v(t,α)]dt. (44)

    The ˜hi(α)-curves of ninth-order HAMFF upper and lower bound solutions ˜u(x,α) and ˜v(x,α) at x=0.5 and α=0.5 for system (35) are shown in the following Tables 19 and 20 and Figures 2124.

    Table 19.  Best values of the convergence control parameter of ninth-order HAMFF solution ˜u(x,α) of system (35) at x=0.5 and α=0.5, where * denoted to the optimal value of ˜h1.
    h_11* -1.05007026461221104226628591648
    ¯h11* -1.05090002060914472244868635790

     | Show Table
    DownLoad: CSV
    Table 20.  Best values of the convergence control parameter of ninth-order HAMFF solution ˜v(x,α) of system (35) at x=0.5 and α=0.5, where * denoted to the optimal value of ˜h2.
    h_21* -1.05012728339193604133371209084
    ¯h21* -1.05086285144053136204330440090

     | Show Table
    DownLoad: CSV
    Figure 21.  The h-curve representation of ninth-order HAMFF lower solution for system (35) of u_(0.5;0.5;h).
    Figure 22.  The h-curve representation of ninth-order HAMFF upper solution for system (35) of ¯u(0.5;0.5;h).
    Figure 23.  The h-curve representation of ninth-order HAMFF lower solution for system (35) of v_(0.5;0.5;h).
    Figure 24.  The h-curve representation of ninth-order HAMFF upper solution for system (35) of ¯v(0.5;0.5;h).

    In order to validate the ninth-order HAMFF solution of system (32), a comparative analysis with the learning algorithm iteration (LAI) [4] corresponding with 200 iteration is displayed in Tables 21 and 22 in terms of residual errors (~RE1) and (~RE2) respectively for different values of 0α1 at x=0.5.

    Table 21.  Show a comparison of the REs (~RE1) applying the HAMFF (m=9) and LAI [4] within the interval 0α1 at x=0.5 and ˜hi=1.
    α u_(x,α) RE_1(x,α) LAI [4] ¯u(x,α) ¯RE1(x,α) LAI [4]
    0.0 0.0 0.0 0.0 0.249999946 1.770E-07 8.72E-06
    0.2 0.024999993 2.205E-08 1.30E-07 0.224999950 1.636E-07 6.50E-07
    0.4 0.049999986 4.411E-08 3.30E-07 0.199999954 1.503E-07 6.30E-07
    0.6 0.074999980 6.617E-08 2.60E-07 0.174999958 1.369E-07 4.50E-07
    0.8 0.099999973 8.823E-08 1.40E-07 0.149999962 1.236E-07 4, 70E-07
    1.0 0.124999966 1.102E-07 1.40E-07 0.124999966 1.102E-07 1.40E-07

     | Show Table
    DownLoad: CSV
    Table 22.  Show a comparison of the REs (~RE2) applying the HAMFF (m=9) and LAI [4] within the interval 0α1 at x=0.5 and ˜hi=1.
    α v_(x,α) RE_2(x,α) LAI [4] ¯v(x,α) ¯RE2(x,α) LAI [4]
    0.0 0.0 0.0 0.0 0.374999977 1.105E-07 3.01E-06
    0.2 0.049999997 1.377E-08 3.50E-07 0.349999979 1.022E-07 2.20E-06
    0.4 0.099999994 2.755E-08 4.40E-07 0.324999981 9.389E-08 2.13E-06
    0.6 0.149999991 4.132E-08 6.60E-07 0.299999982 8.555E-08 2.10E-06
    0.8 0.199999988 5.510E-08 2.40E-07 0.274999984 7.721E-08 1.32E-06
    1.0 0.249999986 6.887E-08 1.12E-06 0.249999986 6.887E-08 1.24E-06

     | Show Table
    DownLoad: CSV

    By comparing the Tables 2123, we can see how the results improve after the minimization process. A comparison between ninth-order HAM solution and the fuzzy neural network [4] with 200 numerical iterations is given.

    Tables 21 and 22 show a comparison of the REs applying the HAMFF (m=9) with the errors [4] within the interval 0α1 at x=0.5 with best values of the convergence control parameter ˜hi after minimization which are listed in the following tables (see Table 23).

    In the following Figures 2528 show that the fuzzy approximate solutions by HAMFF (˜u(x,α), ˜v(x,α)) of the system (32) are in the form of fuzzy numbers for any 0α1 at x=0.5 and ˜hi=1.

    Table 23.  REs applying the HAMFF (m=9) at x=0.5 and ˜hi are optimal values of ˜hij.
    α u_(x,α) RE_1(x,α) ¯u(x,α) ¯RE1(x,α) v_(x,α) RE_2(x,α) ¯v(x,α) ¯RE2(x,α)
    0.0 0.0 0.0 0.249999994 2.190E-08 0.0 0.0 0.374999999 4.495E-10
    0.2 0.024999999 2.928E-09 0.224999994 2.045E-08 0.049999999 1.234E-13 0.349999999 2.552E-10
    0.4 0.049999998 5.856E-09 0.199999994 1.900E-08 0.099999999 2.468E-13 0.324999999 6.091E-11
    0.6 0.074999997 8.784E-09 0.174999995 1.755E-08 0.149999999 3.703E-13 0.299999999 1.333E-10
    0.8 0.099999996 1.171E-08 0.149999995 1.610E-08 0.199999999 4.937E-13 0.274999999 3.276E-10
    1.0 0.124999996 1.464E-08 0.124999996 1.464E-08 0.249999999 6.171E-13 0.249999999 5.220E-10

     | Show Table
    DownLoad: CSV
    Figure 25.  The HAM lower and upper solutions of system (35) ˜u(x,α) for all α[0,1].
    Figure 26.  The HAM lower and upper solutions of system (35) ˜v(x,α) for all α[0,1].
    Figure 27.  The HAMFF lower and upper solutions of system (35) and ˜u(x,α) for all x,α[0,1].
    Figure 28.  The HAMFF lower and upper solutions of system (35) and ˜v(x,α) for all x,α[0,1].

    The fuzzy solution in triangular fuzzy number forms was satisfied by the ninth-order HAMFF solutions of system (35) as shown in Figures 2528.

    The method of approximate analytical class for solving FSIDEs, known as HAMFF, is the main topic of this work. Using the HAMFF technique, the convergence of the series solution can be efficiently managed by selecting the best convergence parameter for each fuzzy level set. In this study, the FSFIDEs were proposed as utilized as an experimental study to demonstrate the HAMFF technique's precision in solving linear systems with initial conditions. The technique was found to produce a polynomial series solution in close-analytical form that converges to the exact solution as the series order increases. The novelty of HAMFF derived from basic concepts of the standard HAM and some popular definitions and properties of fuzzy sets theory. The study also used the HAMFF to find the series solution in nonlinear terms and suggested a new fuzzy version of FSFIDEs. The HAMFF technique was discovered to offer the series solution FSFIDEs subject to boundary conditions. The optimal convergence parameters for the suggested problems were also ascertained by utilizing the HAMFF's convergence behavior in fuzzy environments to increase the accuracy of the technique. A comparison analysis between the HAMFF and other approximate techniques is presented, showing that the HAMFF obtained a better solution in terms of accuracy. It is noteworthy to note that all the problems in this study that were solved with HAMFF obtained the series solution in the triangular fuzzy numbers.

    Zena Talal Yassin: Conceptualization, validation, investigation, writing original draft preparation; Waleed Al-Hayani: Conceptualization, validation, investigation, writing original draft preparation; Ala Amourah: methodology, validation, writing review and editing; Ali F. Jameel: methodology, for-mal analysis, writing review and editing; Nidal Anakira: methodology, investigation, supervision; All authors have read and agreed to the published version of the manuscript.

    The authors declare they have not used Artificial Intelligence (AI) tools in the creation of this article.

    The authors declare no conflict of interest.


    Acknowledgments



    This work was supported by a Robert T. Rosen Memorial scholarship to E.M. and the NIH-NCCIH grant R01 AT010242 to D.E.R. KMT was supported by NIH-NCCIH grant F31AT010981. We thank Madeline Bandomer, Shikha Ranka, Kim Knowles and Rocio Duran for assistance with animal work, as well as Marianne Polunas from Rutgers Research Pathology Services for slide preparation.

    Conflict of interest



    DER has equity in Nutrasorb, LLC. The funders had no role in the design of the study; in the collection, analyses or interpretation of data; in the writing of the manuscript nor in the decision to publish the results.

    Author contributions



    EM, FB and KMT performed data acquisition. EM, YW, FB, SS and KMT performed data analysis. EM and YW drafted the manuscript. DER provided oversight for the project and edits and wrote the final manuscript.

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