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Review

Impact of SGLT2i on cardiovascular outcomes and heart failure in patients with type 2 diabetes

  • The concurrent management of type 2 diabetes mellitus and heart failure presents several challenges and unmet clinical needs. The sodium-glucose cotransporter 2 inhibitors (SGLT2i) are new generation of oral hypoglycemic agents, they inhibit renal glucose reabsorption and increase renal glucose excretion, thus lowering plasma glucose levels and contributing to a modest reduction in HbA1C. In two pivotal randomized clinical trial, SGLT2i have showed a clinically important reduction in cardiovascular mortality and hospitalization due to heart failure. However, also important adverse effects such as increased risk of bone fractures and lower limb amputations were found. Currently, physiological mechanisms leading to cardiovascular benefits with SGLT2i are not completely understood, but it seems accepted that some of these benefits are related to non-glycemic effects. In this review, we analyze the available clinical evidence focusing in cardiovascular outcomes and heart failure, physiological mechanism of action, and comment on future directions of research.

    Citation: Juan José Rodríguez, Luis Ortega-Paz, Salvatore Brugaletta, Manel Sabaté. Impact of SGLT2i on cardiovascular outcomes and heart failure in patients with type 2 diabetes[J]. AIMS Medical Science, 2018, 5(1): 67-79. doi: 10.3934/medsci.2018.1.67

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  • The concurrent management of type 2 diabetes mellitus and heart failure presents several challenges and unmet clinical needs. The sodium-glucose cotransporter 2 inhibitors (SGLT2i) are new generation of oral hypoglycemic agents, they inhibit renal glucose reabsorption and increase renal glucose excretion, thus lowering plasma glucose levels and contributing to a modest reduction in HbA1C. In two pivotal randomized clinical trial, SGLT2i have showed a clinically important reduction in cardiovascular mortality and hospitalization due to heart failure. However, also important adverse effects such as increased risk of bone fractures and lower limb amputations were found. Currently, physiological mechanisms leading to cardiovascular benefits with SGLT2i are not completely understood, but it seems accepted that some of these benefits are related to non-glycemic effects. In this review, we analyze the available clinical evidence focusing in cardiovascular outcomes and heart failure, physiological mechanism of action, and comment on future directions of research.


    In this paper, we consider the following Kirchhoff-type elliptic problem:

    $ {(a+bΩ|u|2dx)Δu=λ|u|q2uln|u|2+μ|u|2u,xΩ,u(x)=0,xΩ, $ (1.1)

    where $ \Omega\subset \mathbb{R}^{4} $ is a bounded domain with smooth boundary $ \partial\Omega $, $ 2 < q < 4 $, $ a $, $ b $, $ \lambda $, and $ \mu $ are positive parameters.

    As a natural generalization of (1.1), we obtain the following Kirchhoff-type elliptic problem:

    $ {(a+bΩ|u|2dx)Δu=f(x,u),xΩ,u(x)=0,xΩ. $ (1.2)

    When the space dimension $ N = 1 $, the equation in (1.2) is closely related to the stationary version of the following wave equation:

    $ ρ2ut2(P0h+E2LL0|ux|2dx)2ux2=f(x,u), $ (1.3)

    which was proposed by Kirchhoff [1] to describe the transversal oscillations of a stretched string. Here $ \rho > 0 $ is the mass per unit length, $ P_0 $ is the base tension, $ E $ is the Young modulus, $ h $ is the area of the cross section, and $ L $ is the initial length of the string. Such problems are widely applied in engineering, physics, and other applied sciences (see [2,3,4]). A remarkable feature of problem (1.2) is the presence of the nonlocal term, which brings essential difficulties when looking for weak solutions to it in the framework of variational methods since, in general, one cannot deduce from $ u_n\rightharpoonup u $ weakly in $ H_0^1(\Omega) $ the convergence $ \int_{\Omega}|\nabla u_n|^2\mathrm{d}x\rightarrow \int_{\Omega}|\nabla u|^2\mathrm{d}x $.

    In recent years, various techniques, such as the mountain pass lemma, the Nehari manifold approach, genus theory, Morse theory, etc., have been used to study the existence and multiplicity of weak solutions to Kirchhoff problems with different kinds of nonlinearities in the general dimension. We refer the interested reader to [5,6,7,8,9,10] and the references therein. In particular, when dealing with (1.2) by using variational methods, $ f $ is usually required to satisfy the following Aimbrosetti–Rabinowitz condition: i.e., for some $ \nu > 4 $ and $ R > 0 $, there holds

    $ 0<νF(x,t)tf(x,t), |t|>R,xΩ, $

    which implies that $ f $ is $ 4 $-superlinear about $ t $ at infinity, that is,

    $ limt+F(x,t)t4=+, $ (1.4)

    where $ F(x, t) = \int_{0}^{t}f(x, \tau)\mathrm{d}\tau $. This guarantees the boundedness of any $ (PS) $ sequence of the corresponding energy functional in $ H_0^1(\Omega) $. In addition, assume that $ f $ satisfies the subcritical growth condition

    $ |f(x,t)|C(|t|q1+1), tR, xΩ, $ (1.5)

    where $ C > 0 $, $ 2 < q < 2^*: = \frac{2N}{N-2} $. Then it follows from [11, Lemma 1] that the functional satisfies the compactness condition. Combining (1.4) with (1.5), one has $ q > 4 $, which, together with $ q < 2^* $, implies $ N < 4 $. Hence, problem (1.2) is usually studied in dimension three or less. For example, Chen et al. [12] studied problem (1.2) with $ N\leq3 $ and $ f(x, u) = \lambda h(x)|u|^{q-2}u+g(x)|u|^{p-2}u $, where $ a, \ b, \ \lambda > 0 $, $ 1 < q < 2 < p < 2^{*} $, and $ h, g \in C(\overline{\Omega}) $ are sign-changing functions. They obtained the existence of multiple positive solutions with the help of Nehari manifolds and fibering maps. Silva [13] considered the existence and multiplicity of weak solutions to problem (1.2) in a bounded smooth domain $ \Omega\subset \mathbb{R}^3 $ with $ f(x, u) = |u|^{\gamma-2}u $ and $ \gamma\in(2.4) $ by using fibering maps and the mountain pass lemma. Later, the main results in [13] were extended to the parallel $ p $-Kirchhoff problem in a previous work of ours [14].

    For the critical problem (1.2) with $ N\geq4 $, it was shown in [15] that when $ a $ and $ b $ satisfy appropriate constraints, the interaction between the Kirchhoff operator and the critical term makes some useful variational properties of the energy functional valid, such as the weak lower semi-continuity and the Palais–Smale properties. Naimen [16] considered problem (1.2) with $ f(x, u) = \lambda u^{q}+\mu u^{2^*-1}(1\leq q < 2^*-1) $ when $ N = 4 $. By applying the variational method and the concentration compactness argument, he proved the existence of solutions to problem (1.2). Later, Naimen and Shibata [17] considered the same problem with $ N = 5 $, and the existence of two solutions was obtained by using the variational method. Faraci and Silva [18] considered problem (1.2) with $ f(x, u) = \lambda g(x, u)+ |u|^{2^*-2}u $ in $ \Omega\subset \mathbb{R}^{N} (N > 4) $. By using variational properties and the fiber maps of the energy functional associated with the problem, the existence, nonexistence, and multiplicity of weak solutions were obtained under some assumptions on $ a $, $ b $, $ \lambda $, and $ g(x, u) $. Li et al. [19] considered a Kirchhoff-type problem without a compactness condition in the whole space $ \mathbb{R}^{N} (N\geq 3) $. By introducing an appropriate truncation on the nonlocal coefficient, they showed that the problem admits at least one positive solution.

    On the other hand, equations with logarithmic nonlinearity have also been receiving increasing attention recently, due to their wide application in describing many phenomena in physics and other applied sciences such as viscoelastic mechanics and quantum mechanics theory ([20,21,22,23]). The logarithmic nonlinearity is sign-changing and satisfies neither the monotonicity condition nor the Ambrosetti–Rabinowitz condition, which makes the study of problems with logarithmic nonlinearity more interesting and challenging. Therefore, much effort has also been made in this direction during the past few years. For example, Shuai [24] considered problem (1.2) with $ a > 0 $, $ b = 0 $, and $ f(x, u) = a(x)u\ln |u| $, where $ a(x)\in C(\overline{\Omega}) $ can be positive, negative, or sign-changing in $ \overline{\Omega} $. Among many interesting results, he proved, by the use of the Nehari manifold, the symmetric mountain pass lemma and Clark's Theorem, that the problem possesses two sequences of solutions when $ a(x) $ is sign-changing. Later, the first two authors of this paper and their co-author [25] investigated the following critical biharmonic elliptic problem:

    $ {Δ2u=λu+μulnu2+|u|22u,xΩ,u=uν=0,xΩ, $ (1.6)

    where $ 2^{**}: = \frac{2N}{N-4} $ is the critical Sobolev exponent for the embedding $ H_0^2(\Omega)\hookrightarrow L^{2^{**}}(\Omega) $. Both the cases $ \mu > 0 $ and $ \mu < 0 $ are considered in [25], and the existence of nontrivial solutions was derived by combing the variational methods with careful estimates on the logarithmic term. It is worth mentioning that the result with $ \mu > 0 $ implies that the logarithmic term plays a positive role in problem (1.6) to admit a nontrivial solution. Later, Zhang et al. [26] not only weakened the existence condition in [25], but also specified the types and the energy levels of solutions by using Brézis–Lieb's lemma and Ekeland's variational principle.

    Inspired mainly by the above-mentioned literature, we consider a critical Kirchhoff problem with a logarithmic perturbation and investigate the combined effect of the nonlocal term, the critical term, and the logarithmic term on the existence of weak solutions to problem (1.1). We think that at least the following three essential difficulties make the study of such a problem far from trivial. The first one is that since the power corresponding to the critical term is equal to that corresponding to the nonlocal term in the energy functional $ I(u) $ (see (2.2)), it is very difficult to obtain the boundedness of the $ (PS) $ sequences for $ I(u) $. The second one is the lack of compactness of the Sobolev embedding $ H_0^1(\Omega)\hookrightarrow L^4(\Omega) $, which prevents us from directly establishing the $ (PS) $ condition for $ I(u) $. The third one is caused by the logarithmic nonlinearity, which we have mentioned above.

    To overcome these difficulties and to investigate the existence of weak solutions to problem (1.1), we first consider a sequence of approximation problems (see problem (2.7) in Section 2) and obtain a bounded $ (PS) $ sequence for each approximation problem based on a result by Jeanjean [27]. Then, with the help of some delicate estimates on the truncated Talenti functions and Brézis–Lieb's lemma, we prove that the $ (PS) $ sequence has a strongly convergent subsequence. Then we obtain a solution $ u_{n} $ to problem (2.7) for almost every $ \nu_{n}\in(\sigma, 1] $. Finally, we show that the original problem admits a mountain pass type solution if the sequence of the approximation solution $ \{u_{n}\} $ is bounded by the mountain pass lemma.

    The organization of this paper is as follows: In Section 2, some notations, definitions, and necessary lemmas are introduced. The main results of this paper are also stated in this section. In Section 3, we give detailed proof of the main results.

    We start by introducing some notations and definitions that will be used throughout the paper. In what follows, we denote by $ \|\cdot\|_{p} $ the $ L^p(\Omega) $ norm for $ 1\leq p\leq \infty $. The Sobolev space $ H_0^1(\Omega) $ will be equipped with the norm $ \|u\|: = \|u\|_{H_0^1(\Omega)} = \|\nabla u\|_2 $, which is equivalent to the full one due to Poincaré's inequality. The dual space of $ H_0^1(\Omega) $ is denoted by $ H^{-1}(\Omega) $. We use $ \rightarrow $ and $ \rightharpoonup $ to denote the strong and weak convergence in each Banach space, respectively, and use $ C $, $ C_1 $, $ C_2 $, $... $ to denote (possibly different) positive constants. $ B_R(x_0) $ is a ball of radius $ R $ centered at $ x_0 $. We use $ \omega_{4} $ to denote the area of the unit sphere in $ \mathbb{R}^{4} $. For all $ t > 0 $, $ O(t) $ denotes the quantity satisfying $ |\frac{O(t)}{t}|\leq C $, $ O_1(t) $ means there exist two positive constants $ C_1 $ and $ C_2 $ such that $ C_1t\leq O_1(t)\leq C_2t $, $ o(t) $ means $ |\frac{o(t)}{t}|\rightarrow0 $ as $ t\rightarrow0 $, and $ o_{n}(1) $ is an infinitesimal as $ n\rightarrow \infty $. We use $ S > 0 $ to denote the best embedding constant from $ H_{0}^{1}(\Omega) $ to $ L^4(\Omega) $, i.e.,

    $ u4S12u,  uH10(Ω). $ (2.1)

    In this paper, we consider weak solutions to problem (1.1) in the following sense:

    Definition 2.1. (weak solution) A function $ u\in H_{0}^{1}(\Omega) $ is called a weak solution to problem (1.1) if for every $ \varphi\in H_{0}^{1}(\Omega) $, there holds

    $ aΩuφdx+bu2ΩuφdxλΩ|u|q2uφlnu2dxμΩ|u|2uφdx=0. $

    Define the energy functional associated with problem (1.1) by

    $ I(u)=a2u2+b4u4+2λq2uqqλqΩ|u|qlnu2dxμ4u44,  uH10(Ω). $ (2.2)

    From $ 2 < q < 4 $, one can see that $ I(u) $ is well defined and is a $ C^1 $ functional in $ H_{0}^{1}(\Omega) $ (see [18]). Moreover, each critical point of $ I $ is also a weak solution to problem (1.1).

    We introduce a definition of a local compactness condition, usually called the $ (PS)_c $ condition.

    Definition 2.2. ($ (PS)_c $ condition [28]) Assume that $ X $ is a real Banach space, $ I:X\rightarrow \mathbb{R} $ is a $ C^1 $ functional, and $ c\in \mathbb{R} $. Let $ \{u_n\}\subset X $ be a $ (PS)_c $ sequence of $ I(u) $, i.e.,

    $ I(un)c and I(un)0 in X1(Ω) as n, $

    where $ X^{-1} $ is the dual space of $ X $. We say that $ I $ satisfies the $ (PS)_c $ condition if any $ (PS)_c $ sequence has a strongly convergent subsequence.

    The following three lemmas will play crucial roles in proving our main results. The first one is the mountain pass lemma, the second one is Brézis–Lieb's lemma, and the third one will be used to deal with the logarithmic term.

    Lemma 2.1. (mountain pass lemma [28]) Assume that $ (X, \|\cdot\|_X) $ is a real Banach space, $ I:X\rightarrow \mathbb{R} $ is a $ C^1 $ functional, and there exist $ \beta > 0 $ and $ r > 0 $ such that $ I $ satisfies the following mountain pass geometry:

    (i) $ I(u)\geq \beta > 0 $ if $ \|u\|_X = r $;

    (ii) There exists a $ \overline{u}\in X $ such that $ \|\overline{u}\|_X > r $ and $ I(\overline{u}) < 0 $.

    Then there exists a $ (PS)_{c_*} $ sequence such that

    $ c:=infγΓmaxt[0,1]I(γ(t))β, $

    where

    $ Γ={γC([0,1],X):γ(0)=0,γ(1)=¯u}. $

    $ c_* $ is called the mountain level. Furthermore, $ c_* $ is a critical value of $ I $ if $ I $ satisfies the $ (PS)_{c_*} $ condition.

    Lemma 2.2. (Brézis–Lieb's lemma [29]) Let $ p\in(0, \infty) $. Suppose that $ \{u_n\} $ is a bounded sequence in $ L^p(\Omega) $ and $ u_n\rightarrow u $ a.e. on $ \Omega $. Then

    $ limn(unppunupp)=upp. $

    Lemma 2.3. $ (1) $ For all $ t\in(0, 1] $, there holds

    $ |tlnt|1e. $ (2.3)

    $ (2) $ For any $ \alpha, \delta > 0 $, there exists a positive constant $ C_{\alpha, \delta} $ such that

    $ |lnt|Cα,δ(tα+tδ), t>0. $ (2.4)

    $ (3) $ For any $ \delta > 0 $, there holds

    $ lnttδ1δe, t>0. $ (2.5)

    $ (4) $ For any $ q\in \mathbb{R}\backslash\{0\} $, there holds

    $ 2tqqtqlnt22, t>0. $ (2.6)

    Proof. $ (1) $ Let $ k_{1}(t): = t\ln t $, $ t\in(0, 1] $. Then simple analysis shows that $ k_{1}(t) $ is decreasing in $ (0, \frac{1}{e}) $, increasing in $ (\frac{1}{e}, 1) $, and attaining its minimum at $ t_{k_{1}} = \frac{1}{e} $ with $ k_{1}(t_{k_{1}}) = -\frac{1}{e} $. Moreover, $ k_{1}(t)\leq 0 $ for all $ t\in(0, 1] $. Consequently, $ |k_{1}(t)|\leq \dfrac{1}{e} $, $ t\in(0, 1] $.

    $ (2) $ For any $ \alpha, \ \delta > 0 $, from

    $ \lim\limits_{t\rightarrow 0^{+}}\frac{\ln t}{t^{-\delta}} = 0 \ \ \text{and} \ \ \lim\limits_{t\rightarrow +\infty}\frac{\ln t}{t^{\alpha}} = 0, $

    one sees that there exist constants $ C_{\delta}, C_{\alpha} > 0 $ and $ 0 < M_{1} < M_2 < +\infty $ such that $ |\ln t|\leq C_{\delta} t^{-\delta} $ when $ t\in(0, M_{1}) $ and $ |\ln t|\leq C_{\alpha} t^{\alpha} $ when $ t\in(M_{2}, \infty) $. Moreover, it is obvious that there exists $ C_{\alpha}' > 0 $ such that $ |\ln t|\leq C_{\alpha}'t^{\alpha} $ when $ t\in[M_1, M_2] $. Therefore,

    $ |\ln t|\leq (C_{\alpha}'+C_{\alpha})t^{\alpha}+C_{\delta} t^{-\delta} \leq C_{\alpha, \delta}(t^{\alpha}+t^{-\delta}), \quad \forall\ t > 0, $

    where $ C_{\alpha, \delta} = \max\{ C_{\delta}, C_{\alpha}'+C_{\alpha}\} $.

    $ (3) $ For any $ \delta > 0 $, set $ k_{2}(t): = \dfrac{\ln t}{t^{\delta}} $, $ t > 0 $. Then direct computation shows that $ k'_{2}(t) > 0 $ in $ (0, e^{\frac{1}{\delta}}) $, $ k'_{2}(t) < 0 $ in $ (e^{\frac{1}{\delta}}, +\infty) $, and $ k_{2}(t) $ attain their maximum at $ t_{k_{2}} = e^{\frac{1}{\delta}} $. Therefore, $ k_{2}(t) \leq k_{2}(e^{\frac{1}{\delta}}) = \frac{1}{\delta e} $, $ t > 0 $.

    $ (4) $ Let $ k_{3}(t): = 2t^q-qt^q\ln t^2 $, $ t > 0 $, where $ q\in \mathbb{R}\backslash\{0\} $. From

    $ k'_{3}(t) = -q^{2}t^{q-1} \ln t^{2}, \ \ t > 0, $

    we know that $ k_{3}(t) $ has a unique critical point, $ t_{k_{3}} = 1 $ in $ (0, +\infty) $. Moreover, $ k'_{3}(t) > 0 $ in $ (0, 1) $, $ k'_{3}(t) < 0 $ in $ (1, +\infty) $, and $ k_{3}(t) $ attain their maximum at $ t_{k_{3}} $. Consequently, $ k_{3}(t) \leq k_{3}(1) = 2 $. The proof is complete.

    Following the ideas of [16], we consider the following approximation problem:

    $ {(a+bΩ|u|2dx)Δu=λ|u|q2uln|u|2+νμ|u|2u,xΩ,u(x)=0,xΩ, $ (2.7)

    where $ \nu\in(\sigma, 1] $ for some $ \sigma\in(\frac{1}{2}, 1) $. Associated functionals are defined by

    $ Iν(u)=a2u2+b4u4+2λq2uqqλqΩ|u|qlnu2dx14νμu44,  uH10(Ω). $

    Noticing that $ I_\nu(u) = I_\nu(|u|) $ and $ I(u) = I(|u|) $, we may assume that $ u\geq0 $ in the sequel.

    To obtain the boundedness of the $ (PS) $ sequences for $ I_\nu $, we need the following result by Jeanjean: [27].

    Lemma 2.4. Assume that $ (X, \|\cdot\|_X) $ is a real Banach space, and let $ J\subset \mathbb{R}^+ $ be an interval. We consider a family $ (I_\nu)_{\nu\in J} $ of $ C^1 $-functionals on $ X $ of the form

    $ I_\nu(u) = A(u)-\nu B(u), \ \nu\in J, $

    where $ B(u)\geq0 $ for all $ u\in X $ and either $ A(u)\rightarrow +\infty $ or $ B(u)\rightarrow +\infty $ as $ \|u\|_{X}\rightarrow \infty $. Assume, in addition, that there are two points $ e_1, e_2 $ in $ X $ such that for all $ \nu\in J $, there holds

    $ cν:=infγΓmaxt[0,1]Iν(γ(t))max{Iν(e1),Iν(e2)}, $

    where

    $  Γ={γC([0,1],X):γ(0)=e1,γ(1)=e2}. $

    Then, for almost every $ \nu\in J $, there is a sequence $ \{u_n\} \subset X $ such that

    $ (i)\ \{u_n\}\ is\ bounded, \ \ (ii)\ I_\nu(u_n)\rightarrow c_v, \ as \ n\rightarrow \infty, \ \ (iii)\ I_\nu'(u_{n})\rightarrow 0\ in \ X^{-1}(\Omega)\ as \ n\rightarrow \infty, $

    where $ X^{-1} $ is the dual space of $ X $.

    At the end of this section, we state the main results of this paper, which can be summarized into the following theorem:

    Theorem 2.1. Let $ b, \mu > 0 $ satisfy $ bS^2 < \mu < 2bS^2 $, and take $ \frac{1}{2} < \sigma < 1 $ such that $ \frac{bS^2}{\sigma} < \mu $. Assume one of the following $ (C_1) $, $ (C_2) $, or $ (C_3) $ holds.

    $ (C_1) $ $ a > 0 $, and $ \lambda > 0 $ is small enough.

    $ (C_2) $ $ \lambda > 0 $, and $ a > 0 $ is large enough.

    $ (C_3) $ $ a > 0 $, $ \lambda > 0 $, and $ b < \frac{\mu}{S^2} $ is sufficiently close to $ \frac{\mu}{S^2} $.

    Then problem (2.7) has a solution for almost every $ \nu\in(\sigma, 1] $. In addition, we can find an increasing sequence $ \nu_n\in(\sigma, 1] $ such that $ \nu_n\rightarrow1 $ as $ n \rightarrow \infty $ and denote by $ u_n $ the corresponding solution to problem (2.7). Then either (i) or (ii) below holds.

    $ (i) $ $ \lim\limits_{n \rightarrow \infty}\|u_n\|_{H^1_0 (\Omega)} = \infty $;

    $ (ii) $ $ \{u_n\} $ is bounded in $ H^1 _0 (\Omega) $ and consequently, problem (1.1) has a nontrivial weak solution.

    In particular, if $ \Omega\subset \mathbb{R}^{4} $ is strictly star-shaped, then problem (1.1) has a nontrivial weak solution.

    We are going to show that there exists a bounded $ (PS) $ sequence of the energy functional $ I_\nu $ for almost every $ \nu\in(\sigma, 1] $. For this, let us introduce the Talenti functions (see [16]). For any $ \varepsilon > 0 $, define

    $ Uε(x)=812εε2+|x|2, xR4. $

    Then $ U_\varepsilon(x) $ is a solution to the critical problem

    $ Δu=u3,xR4,   $ (3.1)

    and it satisfies $ \|U_\varepsilon\|^2 = \|U_\varepsilon\|_{4}^{4} = S^2 $, where $ S = \inf\limits_{u\in H_0^1(\Omega)\backslash\{0\}}\dfrac{\|u\|^2}{\|u\|_{4}^{2}} = \dfrac{\|U_\varepsilon\|^2}{\|U_\varepsilon\|_{4}^{2}} $ (an equivalent characterization of $ S $ defined in (2.1)).

    Lemma 3.1. Let $ \tau\in C_0^\infty(\Omega) $ be a cut-off function such that $ 0\leq\tau(x)\leq1 $ in $ \Omega $ with $ \tau(x) = 1 $ if $ |x| < R $ and $ \tau(x) = 0 $ if $ |x| > 2R $, where $ R > 0 $ is a constant such that $ B_{2R}(0)\subset\Omega $ (Here we assume, without loss of generality, that $ 0\in\Omega $). Set $ u_\varepsilon(x) = \tau(x)U_\varepsilon(x) $. Then we have

    $ uε2=S2+O(ε2),uε44=S2+O(ε4),uεqq=O1(ε4q)+O(εq), $ (3.2)

    and

    $ Ωuqεlnu2εdx=O1(ε4qln(1ε))+O(εqlnε)+O(ε4q), $ (3.3)

    where $ q\in(2, 4) $.

    Set $ v_\varepsilon(x) = \dfrac{u_\varepsilon(x)}{\|u_\varepsilon\|_4} $. Then, as $ \varepsilon\rightarrow0 $,

    $ vε2=S+O(ε2),vε44=1,vεqq=O1(ε4q)+O(εq), $

    and

    $ Ωvqεlnv2εdx=O1(ε4qln(1ε))+O(εqlnε)+O(ε4q). $

    Proof. We only prove (3.2) and (3.3). The proof of other results is similar and can be referred to [30]. Using the properties of the cut-off function $ \tau $, one has

    $    Ωuqεdx=CB2R(0)τqεq(ε2+|x|2)qdx=CBR(0)εq(ε2+|x|2)qdx+CB2R(0)BR(0)τqεq(ε2+|x|2)qdx:=J1+J2. $

    By changing the variable and applying the polar coordinate transformation, we can estimate $ J_1 $ as follows:

    $ J1=CBRε(0)εqε4(1+|y|2)qε2qdy=Cε4qBRε(0)1(1+|y|2)qdy=Cω4ε4qRε0r3(1+r2)qdr=C1ε4q(+0r3(1+r2)qdr+Rεr3(1+r2)qdr)=C2ε4q+O(εq), $ (3.4)

    where we have used the fact that

    $ |+Rεr3(1+r2)qdr|+Rεr32qdr=O(ε2q4), $

    and

    $ +0r3(1+r2)qdrC. $

    On the other hand,

    $ |J2|CεqB2R(0)BR(0)1|x|2qdx=O(εq). $ (3.5)

    Hence, (3.2) follows from (3.4) and (3.5).

    Next, we shall prove (3.3). According to the definition of $ u_\varepsilon $, we obtain

    $ Ωuqεlnu2εdx=ΩτqUqεln(U2ετ2)dx=ΩτqUqεlnτ2dx+ΩτqUqεlnU2εdx:=J3+J4. $

    By direct computation, we have

    $ |J3|=|B2R(0)BR(0)τqUqεlnτ2dx|CB2R(0)BR(0)Uqεdx=O(εq). $

    Rewrite $ J_4 $ as follows:

    $ J4=BR(0)UqεlnU2εdx+B2R(0)BR(0)τqUqεlnU2εdx:=J41+J42. $

    By using inequality (2.4) with $ \alpha_{1} = \delta_{1} < 4-q $, one has

    $ |J42|CB2R(0)BR(0)(Uqδ1ε+Uq+δ1ε)dx=O(εqδ1)+O(εq+δ1)=O(εqδ1), $

    where

    $ B2R(0)BR(0)Uqδ1εdx=CB2R(0)BR(0)εqδ1(ε2+|x|2)qδ1dxCB2R(0)BR(0)εqδ1|x|2q2δ1dx=O(εqδ1), $

    and

    $ B2R(0)BR(0)Uq+δ1εdx=CB2R(0)BR(0)εq+δ1(ε2+|x|2)q+δ1dxCB2R(0)BR(0)εq+δ1|x|2q2δ1dx=O(εq+δ1). $

    In addition,

    $ J41=CBR(0)εq(ε2+|x|2)qln(Cεε2+|x|2)dx=Cε4BRε(0)εqε2q(1+|y|2)qln(Cεε2(1+|y|2))dy=Cε4qBRε(0)1(1+|y|2)qln(C1ε(1+|y|2))dy=Cε4qln(1ε)BRε(0)1(1+|y|2)qdy+Cε4qBRε(0)1(1+|y|2)qln(C1+|y|2)dy=Cε4qln(1ε)(R41(1+|y|2)qdyBcRε(0)1(1+|y|2)qdy)   +Cε4qBRε(0)1(1+|y|2)qln(C1+|y|2)dy=C1ε4qln(1ε)Cε4qln(1ε)BcRε(0)1(1+|y|2)qdy   +Cε4qBRε(0)1(1+|y|2)qln(C1+|y|2)dy. $ (3.6)

    By direct computation, one obtains

    $ |BcRε(0)1(1+|y|2)qdy|=|ω4+Rεr3(1+r2)qdr|C+Rεr32qdr=O(ε2q4), $ (3.7)

    and

    $ BRε(0)1(1+|y|2)qln(C1+|y|2)dy=R41(1+|y|2)qln(C1+|y|2)dyBcRε(0)1(1+|y|2)qln(C1+|y|2)dyC+|BcRε(0)1(1+|y|2)qln(C1+|y|2)dy|C+O(ε2q42δ2), $ (3.8)

    where we have used the fact that

    $ |BcRε(0)1(1+|y|2)qln(C1+|y|2)dy|CBcRε(0)(1(1+|y|2)qδ2+1(1+|y|2)q+δ2)dy=Cω4+Rεr3(1(1+r2)qδ2+1(1+r2)q+δ2)drC1+Rε(r32q+2δ2+r32q2δ2)dr=O(ε2q42δ2), $

    by recalling (2.4) with $ \alpha_{2} = \delta_{2} < q-2 $. Substituting (3.7) and (3.8) into (3.6), one arrives at

    $ J41=C1ε4qln(1ε)Cε4qln(1ε)O(ε2q4)+Cε4q(C+O(ε2q42δ2))=C1ε4qln(1ε)+O(εqlnε)+O(ε4q)+O(εq2δ2). $

    Putting the estimates on $ J_3 $, $ J_{41} $, and $ J_{42} $ together, one obtains

    $ Ωuqεlnu2εdx=O(εq)+O(εqδ1)+C1ε4qln(1ε)+O(εqlnε)+O(ε4q)+O(εq2δ2). $

    Therefore, (3.3) follows by taking $ \delta_{1} $ and $ \delta_{2} $ suitably small. The proof is complete.

    With the help of Lemma 3.1, the existence of bounded $ (PS) $ sequences of $ I_{\nu} $ can be derived.

    Lemma 3.2. Let $ b > 0 $, $ \mu > 0 $ satisfy $ bS^2 < \mu $ and take $ \sigma < 1 $ such that $ \dfrac{bS^2}{\sigma} < \mu $. Then there exists a bounded (PS) sequence of the energy functional $ I_\nu $ for almost every $ \nu\in(\sigma, 1] $.

    Proof. Applying (2.5) with $ \delta < 4-q $, using the Sobolev embedding inequality, and noticing that $ \nu\leq1 $, one has

    $ Iν(u)=a2u2+b4u4+2q2λuqqλqΩuqlnu2dx14νμu44a2u2λqΩuqlnu2dx14μu44a2u2Cuq+δ14μS2u4=u2(a2Cuq+δ214μS2u4). $

    Hence, there exist positive constants $ \beta $ and $ \rho $ such that

    $ Iν(u)β for all u=ρ. $

    On the other hand, from (2.6), one has $ t^q\ln t^2\geq\dfrac{2}{q}(t^q-1) $ for $ t > 0 $. Let $ v_\varepsilon $ be given in Lemma 3.1. Then, as $ \varepsilon\rightarrow 0 $, we have, for all $ t > 0 $,

    $ Iν(tvε)=a2t2vε2+b4t4vε4+2q2λtqvεqqλqtqΩvqεln(tvε)2dx14νμt4vε44a2t2vε2+b4t4vε4+2q2λtqvεqq2q2λΩ((tvε)q1)dx14νμt4vε44=a2t2vε2+b4t4vε4+2q2λ|Ω|14νμt4vε44=a2t2(S+O(ε2))+b4t4(S+O(ε2))2+2q2λ|Ω|14νμt4=a2St214(νμbS2)t4+2q2λ|Ω|+O(ε2), $

    which ensures that

    $ Iν(tvε)a2St214(σμbS2)t4+2q2λ|Ω|+1, $

    for all sufficiently small $ \varepsilon > 0 $. Fix such an $ \varepsilon $ and denote it by $ \varepsilon_0 $. Then it follows from $ \dfrac{bS^2}{\sigma} < \mu $ and the above inequality that

    $ limtIν(tvε0)= $ (3.9)

    uniformly for $ \nu\in(\sigma, 1] $, which implies that there exists a $ t^* > 0 $ such that $ \|t^*v_{\varepsilon_0}\| > \rho $ and $ I_\nu(t^*v_{\varepsilon_0}) < 0 $ for all $ \nu\in(\sigma, 1] $. Thus, $ I_\nu $ satisfies the mountain pass geometry around $ 0 $, which is determined independently of $ \nu\in(\sigma, 1] $. Now define

    $ cν:=infγΓmaxt[0,1]Iν(γ(t)) and Γ={γC([0,1],H10(Ω)):γ(0)=0,γ(1)=tvε0}. $

    Then, following the mountain pass lemma, we have

    $ cνβ>max{Iν(γ(0)),Iν(γ(1))}, $ (3.10)

    for all $ \nu\in(\sigma, 1] $. Set

    $ Iν(u)=A(u)νB(u),  uH10(Ω), $

    where $ B(u): = \dfrac{1}{4}\mu\|u\|_4^{4} $ and $ A(u): = \dfrac{a}{2}\|u\|^2+\dfrac{b}{4}\|u\|^{4}+\dfrac{2}{q^2}\lambda\|u\|_q^{q} -\dfrac{\lambda}{q}\int_{\Omega}u^{q}\ln u^2\mathrm{d}x. $ By a simple analysis, one has

    $ B(u)0 for all uH10(Ω), and A(u)+, as u. $ (3.11)

    In view of (3.10), (3.11), and according to Lemma 2.4, there exists a bounded $ (PS)_{c_\nu} $ sequence of $ I_\nu $ for almost every $ \nu\in(\sigma, 1] $. The proof is complete.

    Next, we prove the local compactness for $ I_{\nu}(u) $, which will play a fundamental role in proving the main results.

    Lemma 3.3. Let $ b > 0 $, $ \mu > 0 $ satisfy $ bS^2 < \mu < 2bS^2 $ and take $ \dfrac{1}{2} < \sigma < 1 $ such that $ \dfrac{bS^2}{\sigma} < \mu $. Suppose that one of the following $ (C_1) $, $ (C_2) $, or $ (C_3) $ holds.

    $ (C_1) $ $ a > 0 $, and $ \lambda > 0 $ is small enough.

    $ (C_2) $ $ \lambda > 0 $, and $ a > 0 $ is large enough.

    $ (C_3) $ $ a > 0 $, $ \lambda > 0 $, and $ b < \dfrac{\mu}{S^2} $ is close enough to $ \dfrac{\mu}{S_2} $.

    Let $ \{u_{n}\}\subset H_0^1(\Omega) $ be a bounded $ (PS) $ sequence for $ I_\nu(u) $ with $ \nu\in (\sigma, 1] $ at the level $ c $ with $ c < c(K) $, where $ c(K): = \dfrac{a^2S^2}{4(\nu\mu -bS^2)} = \dfrac{1}{2}aK+\dfrac{1}{4}b K^2-\nu\mu\dfrac{K^2}{4S^2} > 0 $ and $ K: = \dfrac{aS^2}{\mu\nu-bS^2} $, that is, $ I_\nu(u_{n})\rightarrow c $ and $ I_\nu'(u_{n})\rightarrow 0 $ in $ H^{-1}(\Omega) $ as $ n\rightarrow \infty $. Then there exists a subsequence of $ \{u_{n}\} $ (still denoted by $ \{u_{n}\} $ itself) and a $ u\in H_0^1(\Omega) $ such that $ u_{n}\rightarrow u $ in $ H_0^1(\Omega) $ as $ n\rightarrow \infty $.

    Proof. By the boundedness of $ \{u_n\} $ in $ H_0^1(\Omega) $ and the Sobolev embedding, one sees that there is a subsequence of $ \{u_{n}\} $ (which we still denote by $ \{u_{n}\} $) such that, as $ n\rightarrow \infty $,

    $ unu in H10(Ω),unu in Ls(Ω), 1s<4,unu a.e. in Ω. $ (3.12)

    It follows from $ u_n\rightarrow u $ a.e. in $ \Omega $ as $ n\rightarrow \infty $ that

    $ uqnlnu2nuqlnu2 a.e. in Ω as n. $ (3.13)

    Moreover, by virtue of (2.4) with $ \alpha = \delta < 4-q $, we get

    $ |uqnlnu2n|Cδ,δ(uqδn+uq+δn)Cδ,δ(uqδ+uq+δ) in L1(Ω) as n. $ (3.14)

    With the help of (3.13), (3.14), and Lebesgue's dominating convergence theorem, we obtain

    $ limnΩuqnlnu2ndx=Ωuqlnu2dx. $ (3.15)

    Similarly, we have

    $ limnΩuq1nulnu2ndx=Ωuqlnu2dx. $ (3.16)

    To prove $ u_n\rightarrow u \ in \ H_0^1(\Omega) $ as $ n\rightarrow \infty $, set $ w_n = u_n-u $. Then $ \{w_n\} $ is also a bounded sequence in $ H_0^1(\Omega) $. So there exists a subsequence of $ \{w_{n}\} $ (which we still denote by $ \{w_{n}\} $) such that $ \lim\limits_{n\rightarrow \infty}\|w_n\|^2 = l\geq0 $. We claim that $ l = 0 $. Otherwise, according to (3.12) and Brézis–Lieb's lemma, we see that, as $ n\rightarrow \infty $,

    $ un2=wn2+u2+on(1),un44=wn44+u44+on(1). $ (3.17)

    It follows from (3.12), (3.16), and (3.17) that

    $ on(1)=Iν(un),u=au2+bun2u2λΩuqlnu2dxνμu44+on(1)=au2+bwn2u2+bu4λΩuqlnu2dxνμu44+on(1), as n. $ (3.18)

    By (3.12), (3.15), (3.17), and (3.18), the boundedness of $ \{u_n\} $ in $ H_0^1(\Omega) $ and the Sobolev embedding, we obtain

    $ on(1)=Iν(un),un=au2+awn2+2bwn2u2+bwn4+bu4 λΩuqlnu2dxνμu44νμwn44+on(1)=Iν(un),u+awn2+bwn4+bwn2u2νμwn44+on(1)=awn2+bwn4+bwn2u2νμwn44+on(1)awn2+bwn4+bwn2u2νμS2wn4+on(1)=[(a+bu2)(νμbS2)S2wn2]wn2+on(1), as n. $ (3.19)

    Then, we have

    $ limnwn2=l(a+bu2)S2νμbS2. $ (3.20)

    It follows from $ I_\nu(u_{n})\rightarrow c $, (3.12), (3.15), and (3.17) that, as $ n\rightarrow \infty $,

    $ c+on(1)=Iν(un)=a2un2+b4un4+2q2λunqqλqΩuqnlnu2ndx14νμun44=a2wn2+b4wn4+b4wn2u214νμwn44+on(1)    +a2u2+b4u4+b4wn2u2+2q2λuqqλqΩuqlnu2dx14νμu44:=I1+I2, $

    where

    $ I1=a2wn2+b4wn4+b4wn2u214νμwn44+on(1),I2=a2u2+b4u4+b4wn2u2+2q2λuqqλqΩuqlnu2dx14νμu44+on(1). $

    By (3.19) and (3.20), we have, as $ n\rightarrow \infty $,

    $ I1+on(1)=I114Iν(un),un=a4wn2a4(a+bu2)S2νμbS2=a2S24(νμbS2)+abS24(νμbS2)u2. $ (3.21)

    Applying (2.5) with $ \delta < 4-q $, from (3.20) and the Sobolev embedding, one has, as $ n\rightarrow \infty $,

    $ I2a2u2+b4u4+b4wn2u2λqCuq+δ14νμS2u4+on(1)a2u2+b4u4+b4(a+bu2)S2νμbS2u2λqCuq+δ14νμS2u4+on(1)=(12+bS24(νμbS2))au2+14(b+b2S2νμbS2νμS2)u4λqCuq+δ+on(1)=2νμbS24(νμbS2)au2+νμ(2bS2νμ)4S2(νμbS2)u4λqCuq+δ+on(1). $ (3.22)

    In view of (3.21), (3.22), and the assumption of $ \nu\in (\sigma, 1] $, we obtain, as $ n\rightarrow \infty $,

    $      c+on(1)=Iν(un)=I1+I2a2S24(νμbS2)+abS24(νμbS2)u2+2νμbS24(νμbS2)au2   +νμ(2bS2νμ)4S2(νμbS2)u4λqCuq+δ=a2S24(νμbS2)+νμa2(νμbS2)u2+νμ(2bS2νμ)4S2(νμbS2)u4λqCuq+δ=a2S24(νμbS2)+μa2(μbS2ν1)u2+μ(2bS2νμ)4S2(μbS2ν1)u4λqCuq+δa2S24(νμbS2)+μa2(μbS2)u2+μ(2bS2μ)4S2(μbS2)u4λqCuq+δ:=a2S24(νμbS2)+h(u), $ (3.23)

    where

    $ h(t)=μa2(μbS2)t2+μ(2bS2μ)4S2(μbS2)t41qλCtq+δ, for t>0. $

    By a simple analysis, $ (C_1) $, $ (C_2) $, or $ (C_3) $ imply that

    $ h(t)>0, for t>0. $ (3.24)

    Indeed, if the parameters satisfy $ (C_{1}) $, then, for any $ a > 0 $, set

    $ g_{1}(t): = \dfrac{\mu aq}{2C(\mu-b S^{2})}t^{2-q-\delta} +\dfrac{\mu (2bS^{2}-\mu)q}{4CS^{2}(\mu-b S^{2})}t^{4-q-\delta}, \ t > 0. $

    From

    $ g_{1}'(t) = \left(\frac{\mu q(2bS^{2}-\mu)(4-q-\delta)}{4CS^{2}(\mu-bS^{2})}t^{2}-\frac{\mu a q (q+\delta-2)}{2C(\mu-bS^{2})}\right)t^{1-q-\delta}, \ t > 0, $

    we know that $ g_{1}(t) $ has a unique critical point

    $ t_{1} = \left( \frac{2aS^{2}(q+\delta-2)}{(4-q-\delta)(2bS^{2}-\mu)}\right)^{\frac{1}{2}} $

    in $ (0, +\infty) $. Moreover, $ g_{1}'(t) < 0 $ in $ (0, t_{1}) $, $ g_{1}'(t) > 0 $ in $ (t_{1}, +\infty) $ and $ g_{1}(t) $ attain their minimum at $ t_{1} $. Consequently,

    $ g1(t)g1(t1)=μaq2C(μbS2)(2aS2(q+δ2)(4qδ)(2bS2μ))q+δ22+μq(2bS2μ)4CS2(μbS2)(2aS2(q+δ2)(4qδ)(2bS2μ))4qδ2>0. $

    Consequently, for $ \lambda > 0 $ small enough, we have $ g_{1}(t) > \lambda $ for $ t\in(0, +\infty) $. This implies (3.24). By applying a similar argument, one can show that (3.24) is also true if $ (C_{2}) $ or $ (C_{3}) $ hold. It then follows from (3.23) and (3.24) that $ c\geq c(K): = \frac{a^2S^2}{4(\nu\mu -bS^2)} $, a contradiction. Thus $ l = 0 $, i.e., $ u_{n} $ converges strongly to $ u $ in $ H_0^1(\Omega) $. The proof is complete.

    With the help of the Talenti functions given in Lemma 3.1, we show that the mountain pass level of $ I_{\nu}(u) $ around $ 0 $ is smaller than $ c(K) $.

    Lemma 3.4. Let $ b, \mu > 0 $ satisfy $ bS^2 < \mu $ and take $ \sigma < 1 $ such that $ \dfrac{bS^2}{\sigma} < \mu $. Suppose that $ \nu\in (\sigma, 1] $. Then there exists a $ u^* > 0 $ such that

    $ supt0Iν(tu)<c(K), $ (3.25)

    where $ c(K) $ is the positive constant given in Lemma 3.3.

    Proof. Let $ v_\varepsilon $ be given in Lemma 3.1. According to the definition of $ I_\nu $, one sees that $ \lim\limits_{t\rightarrow0}I_\nu(tv_\varepsilon) = 0 $ and $ \lim\limits_{t\rightarrow +\infty}I_\nu(tv_\varepsilon) = -\infty $ uniformly for $ \varepsilon\in(0, \varepsilon_1) $, where $ \varepsilon_1 $ is a sufficiently small but fixed number. Therefore, there exists $ 0 < t_1 < t_2 < +\infty $, independent of $ \varepsilon $, such that

    $ Iν(tvε)<c(K),  t(0,t1][t2,+). $ (3.26)

    For $ t\in[t_1, t_2] $, it follows from Lemma 3.1 that, as $ n\rightarrow \infty $,

    $ Iν(tvε)=a2t2vε2+b4t4vε4+2q2λtqvεqqλqtqΩvqεln(tvε)2dx14νμt4vε44=a2t2(S+O(ε2))+b4t4(S+O(ε2))2+O1(ε4q)+O(εq)   [O1(ε4qln(1ε))+O(εqlnε)+O(ε4q)]14νμt4=a2St214(νμbS2)t4+O(ε2)+O1(ε4q)+O(εq)   O1(ε4qln(1ε))+O(εqlnε)+O(ε4q):=g(t)O1(ε4qln(1ε))+O(ε4q), $

    where $ g(t): = \dfrac{a}{2}St^2-\dfrac{1}{4}(\nu\mu -bS^2)t^4 $. According to the positivity of $ g(t) $ for $ t > 0 $, suitably small, and the fact that $ \lim\limits_{t\rightarrow \infty}g(t) = -\infty $, there exists a $ t_0 > 0 $ such that $ \max\limits_{t > 0}g(t) = g(t_0) $. So, one has $ g'(t_0) = t_0[aS- (\nu\mu -bS^2)t_0^2] = 0 $, that is,

    $ t20=aSνμbS2. $

    It follows from the definition of $ g(t) $ that

    $ maxt>0g(t)=g(t0)=a2S24(νμbS2). $ (3.27)

    Then, for $ t\in[t_1, t_2] $, one sees

    $ Iν(tvε)maxt[t1,t2]g(t)O1(ε4qln(1ε))+O(ε4q)maxt>0g(t)O1(ε4qln(1ε))+O(ε4q), as ε0. $ (3.28)

    From

    $ limε0ε4qε4qln1ε=0, $

    we have

    $ O1(ε4qln(1ε))+O(ε4q)<0, $ (3.29)

    for suitably small $ \varepsilon $. Fix such an $ \varepsilon > 0 $. It then follows from (3.27), (3.28), and (3.29) that

    $ Iν(tvε)<c(K), t[t1,t2]. $ (3.30)

    Take $ u^*\equiv v_\varepsilon $, and we obtain (3.25) by combining (3.26) with (3.30). The proof is complete.

    On the basis of the above lemmas, we can now prove Theorem 2.1.

    Proof of Theorem 2.1. From (3.10) and Lemma 3.4, we obtain

    $ 0<βcνmaxt[0,1]Iν(ttvε)supt0Iν(tvε)<c(K), $ (3.31)

    where $ c_\nu $ is defined in Lemma 3.2. This, together with Lemmas 3.2 and 3.3, shows that there exists a bounded $ (PS)_{c_\nu} $ sequence of the energy functional $ I_\nu $ for almost every $ \nu\in(\sigma, 1] $, which strongly converges to some nontrivial function in $ H^1_0(\Omega) $ up to subsequences. Thus, the approximation problem (2.7) has a nontrivial weak solution for almost every $ \nu\in(\sigma, 1] $. Take an increasing sequence $ \nu_n\in(\sigma, 1] $ such that $ \nu_n\rightarrow1 $ as $ n\rightarrow \infty $, and denote the corresponding solution by $ u_n $, which fulfills $ I_\nu(u_n) = c_{\nu_n}\geq \beta $. It is obvious that either $ \|u_n\|\rightarrow \infty $ as $ n\rightarrow \infty $ or $ \{u_n\}\subset H^1_0(\Omega) $ is bounded.

    To show that problem (1.1) admits a mountain pass-type solution for the latter case, we first prove

    $ cνnc1 as n. $ (3.32)

    Assume by contradiction that

    $ c1<limncνn, $

    where we have used the fact that $ c_{\nu} $ is nonincreasing in $ \nu $ since $ B(u) $ is nonnegative for all $ u\in H_{0}^{1}(\Omega) $. Let

    $ θ:=limncνnc1>0. $ (3.33)

    Following from the definition of $ c_{1} $, there exists a $ \gamma_{1}\in\Gamma $ such that

    $ maxt[0,1]I(γ1(t))<c1+14θ. $ (3.34)

    Then, in view of the fact that $ I_{\nu_{n}}(\gamma_{1}(t)) = I(\gamma_{1}(t))+\dfrac{1}{4}(1-\nu_{n})\mu \|\gamma_{1}(t)\|_{4}^{4} $ and (3.34), we have

    $ maxt[0,1]Iνn(γ1(t))<c1+14θ+14(1νn)μmaxt[0,1]γ1(t)44. $ (3.35)

    Since $ \mu\|\gamma_{1}(t)\|_{4}^{4} $ is continuous in $ t $, we deduce $ \mu\max\limits_{{t\in[0, 1]}}\|\gamma_{1}(t)\|_{4}^{4}\leq C $. From this and (3.35), one has

    $ \lim\limits_{n\rightarrow \infty}\max\limits_{t\in[0, 1]}I_{\nu_{n}}(\gamma_{1}(t)) \leq c_{1}+ \frac{1}{2}\theta. $

    On the other hand, by virtue of the definition of $ c_{\nu_n} $, we have

    $ \lim\limits_{n\rightarrow \infty}\max\limits_{t\in[0, 1]}I_{\nu_{n}}(\gamma_{1}(t)) \geq \lim\limits_{n\rightarrow \infty}c_{\nu_n}. $

    By using the above two inequalities, we obtain

    $ \lim\limits_{n\rightarrow \infty}c_{\nu_n}\leq c_{1}+ \frac{1}{2}\theta, $

    a contradiction with (3.33).

    Next, we claim that $ \{u_n\} $ is a $ (PS)_{c_1} $ sequence of $ I(u) $. Indeed, by (3.32), one has

    $     I(un)=a2un2+b4un4+2q2λunqqλqΩuqnlnu2ndx14μun44=a2un2+b4un4+2q2λunqqλqΩuqnlnu2ndx14νnμun44+14(νn1)μun44=Iνn(un)+14(νn1)μun44=c1+on(1), as n. $

    Similarly, for any $ \varphi\in H_0^1(\Omega) $,

    $     I(un),φ=aΩunφdx+bun2ΩunφdxλΩuq1nφlnu2ndxμΩu3nφdx=aΩunφdx+bun2ΩunφdxλΩuq1nφlnu2ndx   νnμΩu3nφdx+(νn1)μΩu3nφdx=Iνn(un),φ+(νn1)μΩu3nφdx=on(1), as n. $

    Hence, $ \{u_n\} $ is a bounded $ (PS)_{c_1} $ sequence for $ I $. It then follows from (3.31) and Lemma 3.3 that there exists a $ u\in H_0^1(\Omega) $ such that $ u_{n}\rightarrow u $ in $ H_0^1(\Omega) $ as $ n\rightarrow \infty $, and $ u $ is a mountain pass-type solution to problem (1.1).

    Finally, we prove the last part of Theorem 2.1. Take a sequence $ \{\nu_{n}\}\subset(\sigma, 1] $ such that $ \nu_n\rightarrow1 $ as $ n\rightarrow \infty $ and denote the corresponding solution to problem (2.7) by $ \{u_{n}\} $. We first show that $ \{u_{n}\} $ is bounded in $ H_{0}^{1}(\Omega) $. Assume by contradiction that $ \|u_{n}\|\rightarrow \infty $ as $ n\rightarrow \infty $. Set $ \widetilde{w}_{n}: = \dfrac{u_{n}}{\|u_{n}\|}\geq 0 $. Then $ \|\widetilde{w}_{n}\| = 1 $, and there is a subsequence of $ \{\widetilde{w}_{n}\} $ (which we still denote by $ \{\widetilde{w}_{n}\} $) such that $ \widetilde{w}_{n}\rightharpoonup \widetilde{w}_{0} $ in $ H_{0}^{1}(\Omega) $ as $ n\rightarrow \infty $. Notice that, for all $ \varphi\in H_{0}^{1}(\Omega) $, we have

    $ 0=Iνn(un),φ=aΩunφdx+bun2ΩunφdxλΩuq1nφlnu2ndxνnμΩu3nφdx=un3[(aun2+b)Ω˜wnφdxλunq4Ω˜wq1nφln˜w2ndx   λunq4lnun2Ω˜wq1nφdxνnμΩ˜w3nφdx], as n. $

    Letting $ n\rightarrow \infty $ in the above equality and recalling the assumptions that $ \nu_n\rightarrow1 $ and $ \|u_{n}\|\rightarrow \infty $ as $ n\rightarrow \infty $, one has

    $ bΩ˜w0φdx=μΩ˜w30φdx, φH10(Ω), $ (3.36)

    where we have used the fact that $ \lim\limits_{x\rightarrow \infty}x^{q-4}\ln x = 0 $ since $ q < 4 $. Since $ \Omega $ is strictly star-shaped, we know from Pohozaev's identity that $ \widetilde{w}_{0} = 0 $ (see [31]). Then, applying a similar argument to that of the proof of Theorem 1.6 in [16], one obtains $ \mu = bS^{2} $, a contradiction with $ bS^2 < \mu < 2bS^2 $. Therefore, $ \{u_{n}\} $ is bounded, and problem (1.1) has a nontrivial weak solution. The proof is complete.

    Qi Li, Yuzhu Han and Bin Guo: Methodology; Qi Li: Writing-original draft; Yuzhu Han and Bin Guo: Writing-review & editing.

    The authors declare they have not used Artificial Intelligence (AI) tools in the creation of this article.

    The authors wish to express their gratitude to the anonymous referee for giving a number of valuable comments and helpful suggestions, which improve the presentation of the manuscript significantly.

    This work is supported by the National Key Research and Development Program of China(grant no.2020YFA0714101).

    The authors declare there is no conflict of interest.

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