Textured soybean protein improved level of glycated albumin, LDL–Cholesterol, and protein intake in prediabetes postmenopausal overweight women

Diah Mulyawati Utari; Indri Kartiko-Sari; Mitsutaka Kohno; Shigeru Yamamoto; Diah Mulyawati Utari; Indri Kartiko-Sari; Mitsutaka Kohno; Shigeru Yamamoto

doi:10.3934/agrfood.2022021

AIMS Agriculture and Food

2022, Volume 7, Issue 2: 326-340. doi: 10.3934/agrfood.2022021

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Research article Topical Sections

Textured soybean protein improved level of glycated albumin, LDL–Cholesterol, and protein intake in prediabetes postmenopausal overweight women

1.
Department of Public Health Nutrition, Faculty of Public Health, Universitas Indonesia, Indonesia
2.
Asian Nutrition and Food Culture Research Center–Jumonji University, Japan
3.
Fuji Science Innovation Center, Japan

Received: 28 November 2021 Revised: 04 May 2022 Accepted: 10 May 2022 Published: 01 June 2022

Background
Indonesia has been increasing in health issues such as obesity, diabetes mellitus (DM), cardiovascular diseases (CVD), stroke and others. Healthy lifestyle of improving dietary habit with food consumption is considered effective to prevent these health issues. Soybean-based food is considered as food-alternative for plant-based protein and its ability to push down global warming rate.
Objective
This study aims to test the effect of Textured Soybean Protein (TSP) on level of Glycated Albumin (GA) and lipid profiles in prediabetes overweight postmenopausal women.
Methods
A parallel study design consisted of two groups: intervention group provided with TSP contains 30 grams protein and control group, with study duration of 21 days. Each group consists of 26 postmenopausal women with criteria of overweight with fasting blood sugar level of 120–200 mg/dL (prediabetes). The data was analyzed by unpaired and paired t-test.
Results
TSP has significant influence on the change of GA level (3.4% reduction, p < 0.05) and LDL Cholesterol (LDL-C) (6.0% reduction, p < 0.05). TSP also improve the protein consumption of 18.1%.
Conclusions
The provision of TSP for 21 days could improve GA and LDL-C significantly. In longer term, TSP is expected to improve of lipid profiles, insulin resistance and controlling weight and BMI.
- soybean proteins,
- prediabetes,
- postmenopausal,
- overweight,
- protein intake,
- macronutrient intakes,
- glycated albumin,
- lipid profile,
- LDL Cholesterol,
- sustainability
Citation: Diah Mulyawati Utari, Indri Kartiko-Sari, Mitsutaka Kohno, Shigeru Yamamoto. Textured soybean protein improved level of glycated albumin, LDL–Cholesterol, and protein intake in prediabetes postmenopausal overweight women[J]. AIMS Agriculture and Food, 2022, 7(2): 326-340. doi: 10.3934/agrfood.2022021

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Abstract

Background

Indonesia has been increasing in health issues such as obesity, diabetes mellitus (DM), cardiovascular diseases (CVD), stroke and others. Healthy lifestyle of improving dietary habit with food consumption is considered effective to prevent these health issues. Soybean-based food is considered as food-alternative for plant-based protein and its ability to push down global warming rate.

Objective

This study aims to test the effect of Textured Soybean Protein (TSP) on level of Glycated Albumin (GA) and lipid profiles in prediabetes overweight postmenopausal women.

Methods

A parallel study design consisted of two groups: intervention group provided with TSP contains 30 grams protein and control group, with study duration of 21 days. Each group consists of 26 postmenopausal women with criteria of overweight with fasting blood sugar level of 120–200 mg/dL (prediabetes). The data was analyzed by unpaired and paired t-test.

Results

TSP has significant influence on the change of GA level (3.4% reduction, p < 0.05) and LDL Cholesterol (LDL-C) (6.0% reduction, p < 0.05). TSP also improve the protein consumption of 18.1%.

Conclusions

The provision of TSP for 21 days could improve GA and LDL-C significantly. In longer term, TSP is expected to improve of lipid profiles, insulin resistance and controlling weight and BMI.

References

[1]	Ministry of Health Republic of Indonesia Research and Development Board (2019) National report of basic health research 2018, Jakarta: Ministry of Health.
[2]	Ministry of Health Republic of Indonesia (2017) Penyakit jantung penyebab kematian tertinggi, kemenkes ingatkan cerdik (Indonesian). Available from: http://sehatnegeriku.kemkes.go.id/baca/umum/20170801/2521890/penyakit-jantung-penyebab-kematian-tertinggi-kemenkes-ingatkan-cerdik-2/#:~:text=Penyakit%20Jantung%20Penyebab%20Kematian%20Tertinggi%2C%20Kemenkes%20Ingatkan%20CERDIK,-0&text=Survei%20Sample%20Regristration%20System%20(SRS,yakni%20sebesar%2012%2C9%25.
[3]	International Diabetes Federation (2017) IDF diabetes atlas-8th edition, Brussels: International Diabetes Federation.
[4]	Anderson JW, Johnstone BM, Cook-Newell ME (1995) Meta-analysis of the effects of soy protein intake on serum lipids. N Engl J Med 333: 276–282. https://doi.org/10.1056/NEJM199508033330502 doi: 10.1056/NEJM199508033330502
[5]	Zhan SY, Ho SC (2005) Meta-analysis of the effects of soy protein containing isoflavones on the lipid profile. Am J Clin Nutr 81: 397–408. https://doi.org/10.1093/ajcn.81.2.397 doi: 10.1093/ajcn.81.2.397
[6]	Sathyapalan T, Rigby AS, Bhasin S, et al. (2017) Effect of soy in men with type 2 diabetes mellitus and subclinical hypogonadism: A randomized controlled study. J Clin Endocrinol Metab 102: 425–433. https://doi.org/10.1210/jc.2016-2875 doi: 10.1210/jc.2016-2875
[7]	Sathyapalan T, Javed Z, Rigby AS, et al. (2017) Soy protein improves cardiovascular risk in subclinical hypothyroidism: A randomized double-blinded crossover study. J Endocr Soc 1: 423–430. https://doi.org/10.1210/js.2016-1068 doi: 10.1210/js.2016-1068
[8]	Jayagopal V, Albertazzi P, Kilpatrick ES, et al. (2002) Beneficial effects of soy phytoestrogen intake in postmenopausal women with type 2 diabetes. Diabetes Care 25: 1709–1714. https://doi.org/10.2337/diacare.25.10.1709 doi: 10.2337/diacare.25.10.1709
[9]	Ciaccio M (2019) Introduction of glycated albumin in clinical practice. J Lab Precis Med 4: 28. https://doi.org/10.21037/jlpm.2019.08.02 doi: 10.21037/jlpm.2019.08.02
[10]	Sari IK, Utari DM, Kohno M, et al. (2020) Acceptance of textured soybean protein in Indonesian dishes and its effects on energy in overweight women. Asian J Diet 4: 171–177.
[11]	Hughes GJ, Ryan DJ, Mukherjea R, et al. (2011) Protein digestibility-corrected amino acid scores (PDCAAS) for soy protein isolates and concentrate: Criteria for evaluation. J Agric Food Chem 59: 12707–12712. https://doi.org/10.1021/jf203220v doi: 10.1021/jf203220v
[12]	Rutherfurd SM, Fanning AC, Miller BJ, et al. (2015) Protein digestibility-corrected amino acid scores and digestible indispensable amino acid scores differentially describe protein quality in growing male rats. J Nutr 145: 372–379. https://doi.org/10.3945/jn.114.195438 doi: 10.3945/jn.114.195438
[13]	Das D, Kabir MD, Sarkar S, et al. (2022) Antidiabetic potential of soy protein/peptide: A therapeutic insight. Int J Biol Macromol 194: 276–288. https://doi.org/10.1016/j.ijbiomac.2021.11.131 doi: 10.1016/j.ijbiomac.2021.11.131
[14]	Hadi A, Arab A, Moradi S, et al. (2019) The effect of l-arginine supplementation on lipid profile: a systematic review and meta-analysis of randomised controlled trials. Br J Nutr 122: 1021–1032. https://doi.org/10.1017/S0007114519001855 doi: 10.1017/S0007114519001855
[15]	Utari DM, Rimbawan, Riyadi H, et al. (2011) Efek intervensi tempe terhadap profil lipid, superoksida dismutase, LDL teroksidasi dan malondialdehyde pada wanita menopause. Avaliable from: https://repository.ipb.ac.id/handle/123456789/51547.
[16]	Feinman RD, Pogozelski WK, Astrup A, et al. (2015) Dietary carbohydrate restriction as the first approach in diabetes management: Critical review and evidence base. Nutrition 31: 1–13. https://doi.org/10.1016/j.nut.2014.06.011 doi: 10.1016/j.nut.2014.06.011
[17]	Blasbalg TL, Hibbeln JR, Ramsden CE, et al. (2011) Changes in consumption of omega-3 and omega-6 fatty acids in the United States during the 20th century. Am J Cli Nutr 93: 950–962. https://doi.org/10.3945/ajcn.110.006643 doi: 10.3945/ajcn.110.006643
[18]	World Health Organization (2007) Protein requirements of adults, including older people, and women during pregnancy and lactation, In: Protein and amino acid requirements in human nutrition: Report of a joint WHO/FAO/UNU expert consultation (WHO technical report series 935), Geneva: WHO Press, 103–160.
[19]	Hsu P, Ai M, Kanda E, et al. (2015) A comparison of glycated albumin and glycosylated hemoglobin for the screening of diabetes mellitus in Taiwan. Atherosclerosis 242: 327–333. https://doi.org/10.1016/j.atherosclerosis.2015.07.037 doi: 10.1016/j.atherosclerosis.2015.07.037
[20]	Danese E, Montagnana M, Nouvenne A, et al. (2015) Advantages and pitfalls of fructosamine and glycated albumin in the diagnosis and treatment of diabetes. J Diabetes Sci Technol 9: 169–176. https://doi.org/10.1177%2F1932296814567227
[21]	Freitas PAC, Ehlert LR, Camargo JL (2017) Glycated albumin: A potential biomarker in diabetes. Arch Endocrinol Metab 61: 296–304. https://doi.org/10.1590/2359-3997000000272 doi: 10.1590/2359-3997000000272
[22]	Selvin E, Rawlings AM, Grams M, et al. (2014) Prognostic utility of fructosamine and glycated albumin for incident diabetes and microvascular complications. Lancet Diabetes Endocrinol 2: 279–288. https://doi.org/10.1016%2FS2213-8587(13)70199-2
[23]	Selvin E, Rawlings AM, Lutsey PL, et al. (2015) Fructosamine and glycated albumin and the risk of cardiovascular outcomes and death. Circulation 132: 269–277. https://doi.org/10.1161/CIRCULATIONAHA.115.015415 doi: 10.1161/CIRCULATIONAHA.115.015415
[24]	Kisugi R, Kouzuma T, Yamamoto T, et al. (2007) Structural and glycation site changes of albumin in diabetic patient with very high glycated albumin. Clin Chem Acta 382: 59–64. https://doi.org/10.1016/j.cca.2007.04.001 doi: 10.1016/j.cca.2007.04.001
[25]	Azadbakht L, Atabak S, Esmaillzadeh A (2008) Soy protein intake, cardiorenal indices, and C-reactive protein in type 2 diabetes with nephropathy. Diabetes Care 31: 648–654. http://doi.org/10.2337/dc07-2065 doi: 10.2337/dc07-2065
[26]	Yoon HJ, Lee YH, Kim KJ, et al. (2015) Glycated albumin levels in patients with type 2 diabetes increase relative to HbA1c with time. Biomed Res Int 2015: 1–8. https://doi.org/10.1155/2015/576306 doi: 10.1155/2015/576306
[27]	Koga M (2014) Glycated albumin; clinical usefulness. Clin Chem Acta 433: 96–104. https://doi.org/10.1016/j.cca.2014.03.001 doi: 10.1016/j.cca.2014.03.001
[28]	Masumoto N, Otsuki H, Iwakawa S, et al. (2016) Usefulness of glycated albumin in decisions regarding the discontinuation of a diabetes drug and factors associated with poor glycemic control following discontinuation in patients with type 2 diabetes mellitus. Diabetol Int 8: 39–44. https://doi.org/10.1007/s13340-016-0274-y doi: 10.1007/s13340-016-0274-y
[29]	Yang B, Chen Y, Xu TC, et al. (2011) Systematic review and meta-analysis of soy products consumption in patients with type 2 diabetes mellitus. Asia Pac J Clin Nutr 20: 593–602.
[30]	Lu JM, Ji LN, Li YF, et al. (2016) Glycated albumin is superior to glycated hemoglobin for glycemic control assessment at an early stage of diabetes treatment: A multicenter, prospective study. J Diabetes Complications 30: 1609–1613. https://doi.org/10.1016/j.jdiacomp.2016.07.007 doi: 10.1016/j.jdiacomp.2016.07.007
[31]	Food and Drug Administration (1999) Food labeling: Health claims; soy protein and coronary heart disease. Fed Regist 64: 57700–57733.
[32]	Liu ZP, Li WX, Sun J, Liu C, et al. (2004) Intake of soy foods and soy isoflavones by rural adult women in China. Asia Pac J Clin Nutr 13: 204–209.
[33]	Ouellet V, Marois J, Weisnagel SJ, et al. (2007) Dietary cod protein improves insulin sensitivity in insulin resistant men and women: A randomized controlled trial. Diabetes Care 30: 2816–2821. https://doi.org/10.2337/dc07-0273 doi: 10.2337/dc07-0273
[34]	Harland JI, Haffner TA (2008) Systematic review, meta-analysis and regression of randomised controlled trials reporting an association between an intake of circa 25 g soya protein per day and blood cholesterol. Atherosclerosis 200: 13–27. https://doi.org/10.1016/j.atherosclerosis.2008.04.006 doi: 10.1016/j.atherosclerosis.2008.04.006
[35]	Padhi EM, Blewett HJ, Duncan AM, et al. (2015) Whole soy flour incorporated into a muffin and consumed at 2 doses of soy protein does not lower LDL cholesterol in a randomized, double-blind controlled trial of hypercholesterolemic adults. J Nutr 145: 2665–2674. https://doi.org/10.3945%2Fjn.115.219873
[36]	Nielen M, Feskens EJM, Rietman A, et al. (2014) Partly replacing meat protein with soy protein alters insulin resistance and blood lipids in postmenopausal women with abdominal obesity. J Nutr 144: 1423–1429. https://doi.org/10.3945/jn.114.193706 doi: 10.3945/jn.114.193706
[37]	Moghaddam AS, Entezari MH, Iraj B, et al. (2014) The effects of consumption of bread fortified with soybean flour on metabolic profile in type 2 diabetic women: A cross-over randomized controlled clinical trial. Int J Prev Med 5: 1529–1536.
[38]	Acharjee S, Zhou JR, Elajami TK, et al. (2015) Effect of soy nuts and equol status on blood pressure, lipids and inflammation in postmenopausal women stratified by metabolic syndrome status. Metabolism 64: 236–243. https://doi.org/10.1016/j.metabol.2014.09.005 doi: 10.1016/j.metabol.2014.09.005
[39]	Liu ZM, Ho SC, Chen YM, et al. (2014) Whole soy, but not purified daidzein, had a favorable effect on improvement of cardiovascular risks: A 6-month randomized, double-blind, and placebo-controlled trial in equol-producing postmenopausal women. Mol Nutr Food Res 58: 709–717. https://doi.org/10.1002/mnfr.201300499 doi: 10.1002/mnfr.201300499
[40]	Mullen E, Brown RM, Osborne TF, et al. (2004) Soy isoflavones affect sterol regulatory element binding proteins (SREBPs) and SREBP-regulated genes in HepG2 cells. J Nutr 134: 2942–2947. https://doi.org/10.1093/jn/134.11.2942 doi: 10.1093/jn/134.11.2942
[41]	Messina M, Nagata C, Wu AH (2006) Estimated Asian adult soy protein and isoflavone intakes. Nutr Cancer 55: 1–12.
[42]	Mezei O, Li Y, Mullen E, Ross-Viola JS, et al. (2006) Dietary isoflavone supplementation modulates lipid metabolism via PPARalpha-dependent and independent mechanisms. Physiol Genomics 26: 8–14. https://doi.org/10.1152/physiolgenomics.00155.2005 doi: 10.1152/physiolgenomics.00155.2005
[43]	Orgaard A, Jensen L (2008) The effects of soy isoflavones on obesity. Exp Biol Med 233: 1066–1080. https://doi.org/10.3181%2F0712-MR-347
[44]	Yeung J, Yu T (2003) Effects of isoflavones (soy phyto-estrogens) on serum lipids: A meta-analysis of randomized controlled trials. Nutr J 2: 1–8. https://doi.org/10.1186/1475-2891-2-15 doi: 10.1186/1475-2891-2-15
[45]	Matthan NR, Jalbert SM, Ausman LM, et al. (2007) Effect of soy protein from differently processed products on cardiovascular disease risk factors and vascular endothelial function in hypercholesterolemic subjects. Am J Clin Nutr 85: 960–966. https://doi.org/10.1093/ajcn/85.4.960 doi: 10.1093/ajcn/85.4.960
[46]	Potter SM (1995) Overview of proposed mechanism for hypocholesterolemic effect of soy. J Nutr 125: 606–614.
[47]	Duranti M, Lovati MR, Dani V, et al. (2004) The alpha' subunit from soybean 7S globulin lowers plasma lipids and upregulates liver beta-VLDL receptors in rats fed a hypercholesterolemic diet. J Nutr 134: 1334–1339. https://doi.org/10.1093/jn/134.6.1334 doi: 10.1093/jn/134.6.1334
[48]	Torres N, Torre-VilIalvazo I, Tovar AR (2006) Regulation of lipid metabolism by soy protein and its implication in diseases mediated by lipid disorders. J Nutr Biochem 17: 365–373. https://doi.org/10.1016/j.jnutbio.2005.11.005 doi: 10.1016/j.jnutbio.2005.11.005
[49]	Noordzij M, Tripepi G, Dekker F, et al. (2010) Sample size calculations: basic principles and common pitfalls. Nephrol Dial Transplant 25: 1388–1393. https://doi.org/10.1093/ndt/gfp732 doi: 10.1093/ndt/gfp732

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