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Mathematical Biosciences and Engineering

2015, Volume 12, Issue 6: 1289-1302. doi: 10.3934/mbe.2015.12.1289
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Algebraic and topological indices of molecular pathway networks in human cancers

  • 1.
    Department of Mathematical Sciences, University of Wisconsin – Milwaukee, P.O. Box 413, Milwaukee, WI 53201-0413
  • 2.
    Newman-Lakka Institute, Tufts University School of Medicine, Boston, MA 02111
  • 3.
    Cross Cancer Institute, University of Alberta, Edmonton, T6G 2E1
  • 4.
    Cross Cancer Institute and Department of Physics, University of Alberta, Edmonton, T6G 2E1
  • Received: 01 October 2014 Accepted: 29 June 2018 Published: 01 August 2015

  • MSC : Primary: 92C42; Secondary: 94C15.

  • Protein-protein interaction networks associated with diseases have gained prominence as an area of research.We investigate algebraic and topological indices for protein-protein interaction networks of 11 human cancers derived from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. We find a strong correlationbetween relative automorphism group sizes and topological network complexities on the one hand and five year survival probabilities on the other hand. Moreover, we identify several protein families (e.g. PIK, ITG, AKT families) that are repeated motifs in many of the cancer pathways. Interestingly, these sources of symmetry are often central rather than peripheral. Our results can aide in identification of promising targets for anti-cancer drugs. Beyond that, we provide a unifying framework to study protein-protein interaction networks of families of related diseases (e.g. neurodegenerative diseases, viral diseases, substance abuse disorders).

    Citation: Peter Hinow, Edward A. Rietman, Sara Ibrahim Omar, Jack A. Tuszyński. Algebraic and topological indices of molecular pathway networks in human cancers[J]. Mathematical Biosciences and Engineering, 2015, 12(6): 1289-1302. doi: 10.3934/mbe.2015.12.1289

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  • Protein-protein interaction networks associated with diseases have gained prominence as an area of research.We investigate algebraic and topological indices for protein-protein interaction networks of 11 human cancers derived from the Kyoto Encyclopedia of Genes and Genomes (KEGG) database. We find a strong correlationbetween relative automorphism group sizes and topological network complexities on the one hand and five year survival probabilities on the other hand. Moreover, we identify several protein families (e.g. PIK, ITG, AKT families) that are repeated motifs in many of the cancer pathways. Interestingly, these sources of symmetry are often central rather than peripheral. Our results can aide in identification of promising targets for anti-cancer drugs. Beyond that, we provide a unifying framework to study protein-protein interaction networks of families of related diseases (e.g. neurodegenerative diseases, viral diseases, substance abuse disorders).


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  • © 2015 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
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