Mathematical Biosciences and Engineering, 2013, 10(1): 263-278. doi: 10.3934/mbe.2013.10.263.

Primary: 35R35, 35Q92; Secondary: 92C37.

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On a mathematical model of tumor growth based on cancer stem cells

1. Departamento de Matemática Aplicada, EUI Informática, Universidad Politécnica de Madrid, 28031 Madrid

We consider a simple mathematical model of tumor growth based on cancer stem cells. The model consists of four hyperbolic equations of first order to describe the evolution ofdifferent subpopulations of cells: cancer stem cells, progenitor cells, differentiated cells and dead cells. A fifth equation is introduced to model the evolution of the moving boundary. The system includes non-local terms of integral type in the coefficients. Under some restrictions in the parameters we show thatthere exists a unique homogeneous steady state which is stable.
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Keywords free boundary problems; stability.; Cancer steam cells

Citation: J. Ignacio Tello. On a mathematical model of tumor growth based on cancer stem cells. Mathematical Biosciences and Engineering, 2013, 10(1): 263-278. doi: 10.3934/mbe.2013.10.263


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