A therapy inactivating the tumor angiogenic factors

doi:10.3934/mbe.2013.10.185

Mathematical Biosciences and Engineering, 2013, 10(1): 185-198. doi: 10.3934/mbe.2013.10.185. Primary: 92C17; Secondary: 35K57, 92C50.

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A therapy inactivating the tumor angiogenic factors

1. Departamento de Ecuaciones Diferenciales y Análisis Numérico, Facultad de Matemáticas, Universidad de Sevilla, Calle Tara s/n, 41012-Seville

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This paper is devoted to a nonlinear system of partial differential equations modeling the effect of an anti-angiogenic therapy based on an agent that binds to the tumor angiogenic factors. The main feature of the model under consideration is a nonlinear flux production of tumor angiogenic factors at the boundary of the tumor. It is proved the global existence for the nonlinear system and the effect in the large time behavior of the system for high doses of the therapeutic agent.

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Keywords: Chemotaxis; anti-angiogenic therapy.

Citation: Cristian Morales-Rodrigo. A therapy inactivating the tumor angiogenic factors. Mathematical Biosciences and Engineering, 2013, 10(1): 185-198. doi: 10.3934/mbe.2013.10.185

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This article has been cited by:

1. CRISTIAN MORALES-RODRIGO, J. IGNACIO TELLO, GLOBAL EXISTENCE AND ASYMPTOTIC BEHAVIOR OF A TUMOR ANGIOGENESIS MODEL WITH CHEMOTAXIS AND HAPTOTAXIS, Mathematical Models and Methods in Applied Sciences, 2014, 24, 03, 427, 10.1142/S0218202513500553

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