Biological properties of mesenchymal stem cells derived from adipose tissue, umbilical cord tissue and bone marrow

Ruhma Mahmood; Mahmood Shaukat; Mahmood S Choudhery; Ruhma Mahmood; Mahmood Shaukat; Mahmood S Choudhery

doi:10.3934/celltissue.2018.2.78

AIMS Cell and Tissue Engineering

2018, Volume 2, Issue 2: 78-90. doi: 10.3934/celltissue.2018.2.78

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Biological properties of mesenchymal stem cells derived from adipose tissue, umbilical cord tissue and bone marrow

1.
Stem Cell Laboratory, Allama Iqbal Medical College, University of Health Sciences, Lahore, Pakistan
2.
Tissue Engineering and Regenerative Medicine Laboratory, Department of Biomedical Sciences, King Edward Medical University, Lahore, Pakistan

Regenerative medicine employs stem cells to repair or to restore the function of damaged tissues. Major sources of stem cells are embryonic as well as adult tissues; however, adult stem cells are preferred for cell based regenerative therapies. Mesenchymal stem cells (MSCs) are a type of adult stem cells and they hold great promise for regenerative therapeutics. Beside other sources adipose tissue, bone marrow and cord tissue are common sources of MSCs. Significant biological differences may exist in MSCs derived from different sources due to which cells from some sources may be favoured over others for clinical use. MSC origin may be an important consideration to determine biological activity and potential use in regenerative medicine. Therefore, it is important to consider the biological characteristics of MSCs isolated from these sources. The current study briefly discusses essential characteristics (such as isolation procedures, identification, proliferative capacity and differentiation potential) of MSCs derived from umbilical cord tissue, adipose tissue and bone marrow.
- mesenchymal stem cells,
- adipose tissue,
- bone marrow,
- cord tissue,
- proliferation,
- differentiation
Citation: Ruhma Mahmood, Mahmood Shaukat, Mahmood S Choudhery. Biological properties of mesenchymal stem cells derived from adipose tissue, umbilical cord tissue and bone marrow[J]. AIMS Cell and Tissue Engineering, 2018, 2(2): 78-90. doi: 10.3934/celltissue.2018.2.78

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Abstract

Regenerative medicine employs stem cells to repair or to restore the function of damaged tissues. Major sources of stem cells are embryonic as well as adult tissues; however, adult stem cells are preferred for cell based regenerative therapies. Mesenchymal stem cells (MSCs) are a type of adult stem cells and they hold great promise for regenerative therapeutics. Beside other sources adipose tissue, bone marrow and cord tissue are common sources of MSCs. Significant biological differences may exist in MSCs derived from different sources due to which cells from some sources may be favoured over others for clinical use. MSC origin may be an important consideration to determine biological activity and potential use in regenerative medicine. Therefore, it is important to consider the biological characteristics of MSCs isolated from these sources. The current study briefly discusses essential characteristics (such as isolation procedures, identification, proliferative capacity and differentiation potential) of MSCs derived from umbilical cord tissue, adipose tissue and bone marrow.

References

[1]	Mao AS, Mooney DJ (2015) Regenerative medicine. Current therapies and future directions. Proc Natl Acad Sci USA 112: 14452–14459. doi: 10.1073/pnas.1508520112
[2]	Fuchs E, Chen T (2013) A matter of life and death: self-renewal in stem cells. EMBO Rep 14: 39–48. doi: 10.1038/embor.2012.197
[3]	Lin YT, Hufton PG, Lee EJ, et al. (2018) A stochastic and dynamical view of pluripotency in mouse embryonic stem cells. PLoS Comput Biol 14: e1006000. doi: 10.1371/journal.pcbi.1006000
[4]	Thomson M, Liu SJ, Zou LN, et al. (2011) Pluripotency factors in embryonic stem cells regulate differentiation into germ layers. Cell 145: 875–889. doi: 10.1016/j.cell.2011.05.017
[5]	Knoepfler PS (2009) Deconstructing Stem Cell Tumorigenicity: A Roadmap to Safe Regenerative Medicine. Stem Cell 27: 1050–1056. doi: 10.1002/stem.37
[6]	Takahashi K, Tanabe K, Ohnuki M, et al. (2007) Induction of pluripotent stem cells from adult human fibroblasts by defined factors. Cell 131: 861–872. doi: 10.1016/j.cell.2007.11.019
[7]	Yu J, Vodyanik MA, Smuga-Otto K, et al. (2007) Induced pluripotent stem cell lines derived from human somatic cells. Science 318: 1917–1920. doi: 10.1126/science.1151526
[8]	Takahashi K, Yamanaka S (2006) Induction of pluripotent stem cells from mouse embryonic and adult fibroblast cultures by defined factors. Cell 126: 663–676.
[9]	Okita K, Matsumura Y, Sato Y, et al. (2011) A more efficient method to generate integration-free human iPS cells. Nat Methods 8: 409–412. doi: 10.1038/nmeth.1591
[10]	Kim C (2015) iPSC technology-Powerful hand for disease modeling and therapeutic screen. BMB Rep 48: 256–265. doi: 10.5483/BMBRep.2015.48.5.100
[11]	Youssef AA, GyangRoss E, Bolli R, et al. (2016) The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications. JACC Basic Transl Sci 1: 510–523. doi: 10.1016/j.jacbts.2016.06.010
[12]	Behfar A, Terzic A (2008) Mesenchymal stem cells: engineering regeneration. Clin Translation Sci 1: 34–35. doi: 10.1111/j.1752-8062.2008.00024.x
[13]	Nelson TJ, Behfar A, Satsuki Y, et al. (2009) Stem Cell Platforms for Regenerative Medicine. Clin Transl Sci 2: 222–227.
[14]	Ullah I, Subbarao RB, Rho GJ (2015) Human mesenchymal stem cells - current trends and future prospective. Biosci Rep 35: e00191.
[15]	Zhao Q, Ren H, Han Z (2016) Mesenchymal stem cells: immunomodulatory capability and clinical potential in immune diseases. J Cell Immunother 2: 3–20. doi: 10.1016/j.jocit.2014.12.001
[16]	Majka M, Sułkowski M, Badyra B, et al. (2017) Concise Review: Mesenchymal Stem Cells in Cardiovascular Regeneration: Emerging Research Directions and Clinical Applications. Stem Cells Transl Med 6: 1859–1867. doi: 10.1002/sctm.16-0484
[17]	Lo Furno D, Mannino G, Giuffrida R (2017) Functional role of mesenchymal stem cells in the treatment of chronic neurodegenerative diseases. J Cell Physiol 233: 3982–3999
[18]	Peired AJ, Sisti A, Romagnani P (2016) Mesenchymal Stem Cell-Based Therapy for Kidney Disease: A Review of Clinical Evidence. Stem Cells Int 2016: 4798639.
[19]	Mangır N, Türkeri L (2017) Stem cell therapies in post-prostatectomy erectile dysfunction: A critical review. Can J Urol 24: 8609–8619.
[20]	Berardis S, Sattwika PD, Najimi M, et al. (2015) Use of mesenchymal stem cells to treat liver fibrosis: Current situation and future prospects. World J Gastroenterol 21: 742–758. doi: 10.3748/wjg.v21.i3.742
[21]	Amorin B, Alegretti AP, Valim V, et al. (2014) Mesenchymal stem cell therapy and acute graft-versus-host disease: A review. Hum Cell 27: 137–150. doi: 10.1007/s13577-014-0095-x
[22]	Choudhery MS, Badowski M, Muise A, et al. (2013) Comparison of Human Adipose and Cord Tissue Derived Mesenchymal Stem Cells. Cytotherapy 15: 330–343. doi: 10.1016/j.jcyt.2012.11.010
[23]	Mehmood R, Choudhery MS, Mehmood A, et al. (2015) In Vitro differentiation potential of Placenta Derived Cells into Skin-Like Cells. Stem Cells Int 2015: 841062.
[24]	Friedenstein AJ, Piatetzky-Shapiro II, Petrakova KV (1966) Osteogenesis in transplants of bone marrow cells. J Embryol Exp Morphol 16: 381–390.
[25]	Bajpai VK, Mistriotis P, Andreadis ST (2012) Clonal multipotency and effect of long-term in vitro expansion on differentiation potential of human hair follicle derived mesenchymal stem cells. Stem Cell Res 8: 74–84.
[26]	Campagnoli C, Roberts IA, Kumar S, et al. (2001) Identification of mesenchymal stem/progenitor cells in human first-trimester fetal blood, liver, and bone marrow. Blood 98: 2396–2402.
[27]	In 't Anker PS, Scherjon SA, Kleijburg-van dKC, et al. (2004) Isolation of mesenchymal stem cells of fetral or maternal origin from human placenta. Stem Cells 22: 1338–1345. doi: 10.1634/stemcells.2004-0058
[28]	Ryu KH, Cho KA, Park HS, et al. (2012) Tonsil-derived mesenchymal stromal cells: Evaluation of biologic, immunologic and genetic factors for successful banking. Cytotherapy 14: 1193–1202. doi: 10.3109/14653249.2012.706708
[29]	Toma JG, Akhavan M, Fernandes KJ, et al. (2001) Isolation of multipotent adult stem cells from the dermis of mammalian skin. Nat Cell Biol 3: 778–784. doi: 10.1038/ncb0901-778
[30]	Hass R, Kasper C, Böhm S, et al. (2001) Different populations and sources of human mesenchymal stem cells (MSC): A comparison of adult and neonatal tissue-derived MSC. Cell Commun Signal 9: 12.
[31]	Arutyunyan I,Elchaninov A,Makarov A, et al. (2016) Umbilical Cord as Prospective Source for Mesenchymal Stem Cell-Based Therapy. Stem Cells Int 2016: 6901286.
[32]	Strioga M, Viswanathan S, Darinskas A, et al. (2012) Same or not the same? Comparison of adipose tissue-derived versus bone marrow-derived mesenchymal stem and stromal cells. Stem Cells Dev 21: 2724–2752.
[33]	Bosch J, Houben AP, Radke TF, et al. (2012) Distinct differentiation potential of "MSC" derived from cord blood and umbilical cord: are cord-derived cells true mesenchymal stromal cells? Stem Cells Dev 21: 1977e88.
[34]	Elahi KC, Klein G, Avci-Adali M, et al. (2016) Human mesenchymal stromal cells from different sources diverge in their expression of cell surface proteins and display distinct differentiation patterns. Stem Cells Int 2016: 5646384.
[35]	Maridas DE, Rendina-Ruedy E, Le PT, et al. (2018) Isolation, Culture, and Differentiation of Bone Marrow Stromal Cells and Osteoclast Progenitors from Mice. J Vis Exp (131): e56750.
[36]	Bai C, Hou L, Ma Y, et al. (2013) Isolation and characterization of mesenchymal stem cells from chicken bone marrow. Cell Tissue Bank 14: 437–451.
[37]	Juneja SC, Viswanathan S, Ganguly M, et al. (2016) A Simplified Method for the Aspiration of Bone Marrow from Patients Undergoing Hip and KneeJoint Replacement for Isolating Mesenchymal Stem Cells and In Vitro Chondrogenesis. Bone Marrow Res 2016: 3152065.
[38]	Xia CS, Zuo AJ, Wang CY, et al. (2013) Isolation of rabbit bone marrow mesenchymal stem cells using density gradient centrifugation and adherence screening methods. Minerva Med 104: 519–525.
[39]	Marquez-Curtis LA, Janowska-Wieczorek A, McGann LE, et al. (2015) Mesenchymal stromal cells derived from various tissues: Biological, clinical and cryopreservation aspects. Cryobiology 71: 181–197. doi: 10.1016/j.cryobiol.2015.07.003
[40]	Dominici M, Le Blanc K, Mueller I, et al. (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8: 315–317.
[41]	Zuk PA, Zhu M, Mizuno H, et al. (2001) Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng 7: 211–228. doi: 10.1089/107632701300062859
[42]	Gimble J, Guilak F (2003) Adipose-derived adult stem cells: isolation, characterization, and differentiation potential. Cytotherapy 5: 362–369.
[43]	Carvalho PP, Gimble JM, Dias IR, et al. (2012) Xenofree enzymatic products for the isolation of human adipose-derived stromal/stem cells. Tissue Eng Part C Meth 19: 473–478.
[44]	Patrikoski M, Juntunen M, Boucher S, et al. (2013) Development of fully defined xeno-free culture system for the preparation and propagation of cell therapy-compliant human adipose stem cells. Stem Cell Res Ther 4: 27. doi: 10.1186/scrt175
[45]	Aguena M, Fanganiello RD, Tissiani LA, et al. (2012) Optimization of parameters for a more efficient use of adipose-derived stem cells in regenerative medicine therapies. Stem Cells Int 2012: 303610.
[46]	Yang XF, He X, He J, et al. (2011) High efficient isolation and systematic identification of human adipose-derived mesenchymal stem cells. J Biomed Sci 18: 59. doi: 10.1186/1423-0127-18-59
[47]	Markarian CF, Frey GZ, Silveira MD, et al. (2014) Isolation of adipose-derived stem cells: a comparison among different methods. Biotechnol Lett 36: 693–702. doi: 10.1007/s10529-013-1425-x
[48]	Philips BJ, Marra KG, Rubin JP (2012) Adipose stem cell-based soft tissue regeneration.Expert Opin Biol Ther 12: 155–163.
[49]	Thirumala S, Gimble JM, Devireddy RV (2010) Cryopreservation of stromal vascular fraction of adipose tissue in a serum-free freezing medium. J Tissue Eng Regen Med 4: 224–232. doi: 10.1002/term.232
[50]	Kolaparthy KL, Sanivarapu S, Moogla S, et al. (2015) Adipose Tissue - Adequate, Accessible Regenerative Material. Int J Stem Cells 8: 121–127.
[51]	Bunnell BA, Flaat M, Gagliardi C, et al. (2008) Adipose-derived stem cells ;isolation, expansion and differentiation. Methods 45: 115–120. doi: 10.1016/j.ymeth.2008.03.006
[52]	Bourin P, Bunnell BA, Casteilla L, et al. (2013) Stromal cells from the adipose tissue-derived stromal vascular fraction and culture expanded adipose tissue-derived stromal/stem cells: a joint statement of the International Federation for Adipose Therapeutics and Science (IFATS) and the International Society for Cellular Therapy (ISCT). Cytotherapy 15: 641–648. doi: 10.1016/j.jcyt.2013.02.006
[53]	Church C, Berry R, Rodeheffer MS (2014) Isolation and Study of Adipocyte Precursors. Methods Enzymol 537: 31–46. doi: 10.1016/B978-0-12-411619-1.00003-3
[54]	Oberbauer E, Steffenhagen C, Wurzer C, et al. (2015) Enzymatic and non-enzymatic isolation systems for adipose tissue-derived cells: current state of the art. Cell Regen 4: 7.
[55]	Bellei B, Migliano E, Tedesco M, et al. (2017) Maximizing non-enzymatic methods for harvesting adipose-derived stem from lipoaspirate: technical considerations and clinical implications for regenerative surgery. Sci Rep 7: 10015.
[56]	Shah FS, Wu X, Dietrich M, et al. (2013) A non-enzymatic method for isolating human adipose tissue-derived stromal stem cells. Cytotherapy 15: 979–985. doi: 10.1016/j.jcyt.2013.04.001
[57]	Amirkhani MA, Mohseni R, Soleimani M, et al. (2016) A rapid sonication based method for preparation of stromal vascular fraction and mesenchymal stem cells from fat tissue. Bioimpacts 6: 99. doi: 10.15171/bi.2016.14
[58]	Han YF, Tao R, Sun TJ, et al. (2013) Optimization of Human umbilical cord mesenchymal stem cellsisolation and culture methods. Cytotechnology 65: 819–827. doi: 10.1007/s10616-012-9528-0
[59]	Semenova E, Machaj EK, Oldak T (2017) Comparison of Characteristics of Mesenchymal Stem Cells Obtained Mechanically and Enzymatically from Placenta and Umbilical Cord. JCEST 8: 262.
[60]	Marmotti A, Mattia S, Bruzzone M, et al. (2012) Minced umbilical cord fragments as a source of cells for orthopaedic tissue engineering: an in vitro study. Stem Cells Int 2012: 326813.
[61]	Hassan G, Kasem I, Soukkarieh C, et al. (2017) A simple method to isolate and expand human umbilical cord derived mesenchymal stem cells: using explant method and umbilical cord blood serum. Int J Stem Cells 10: 184–192. doi: 10.15283/ijsc17028
[62]	Hassan G, Bahjat M, Kasem I, et al. (2018) Platelet lysate induces chondrogenic differentiation of umbilical cord-derived mesenchymal stem cells. Cell Mol Biol Lett 23: 11. doi: 10.1186/s11658-018-0080-6
[63]	Majore I, Moretti P, Stahl F, et al. (2011) Growth and differentiation properties of mesenchymal stromal cell populations derived from whole human umbilical cord. Stem Cell Rev 7: 17–31.
[64]	Choudhery MS, Badowski M, Muise A, et al. (2013) Utility of cryopreserved umbilical cord tissue for regenerative medicine. Curr Stem Cell Res Ther 8: 370–380. doi: 10.2174/1574888X11308050004
[65]	Hendijani F, Sadeghi-Aliabadi H, Haghjooy Javanmard S (2014) Comparison of human mesenchymal stem cells isolated by explant culture method from entire umbilical cord and Wharton's jelly matrix. Cell Tissue Bank 15: 555–565.
[66]	Capelli C, Gotti E, Morigi M, et al. (2011) Minimally manipulated whole human umbilical cord is a rich source of clinical-grade human mesenchymal stromal cells expanded in human platelet lysate. Cytotherapy 13: 786–801.
[67]	Mennan C, Wright K, Bhattacharjee A, et al. (2013) Isolation and characterisation of mesenchymal stem cells from different regions of the human umbilical cord. Biomed Res Int 2013: 916136.
[68]	Kern S, Eichler H, Stoeve J, et al. (2006) Comparative analysis of mesenchymal stem cells from bone marrow, umbilical cord blood, or adipose tissue. Stem Cells 24: 1294–1301. doi: 10.1634/stemcells.2005-0342
[69]	Li CY, Wu XY, Tong JB, et al. (2015) Comparative analysis of human mesenchyal stem cells from bone marrow and adipose tissue under xeno-free conditions for cell therapy. Stem Cell Res Ther 6: 55. doi: 10.1186/s13287-015-0066-5
[70]	Dmitrieva RI, Minullina IR, Bilibina AA, et al. (2012) Bone marrow- and subcutaneous adipose tissuederived mesenchymal stem cells: Differences and similarities. Cell Cycle 11: 377–383. doi: 10.4161/cc.11.2.18858
[71]	Vidal MA, Walker NJ, Napoli E, et al. (2012) Evaluation of Senescence in Mesenchymal Stem Cells Isolated from Equine Bone Marrow, Adipose Tissue, and Umbilical Cord Tissue. Stem Cells Dev 21: 273–283. doi: 10.1089/scd.2010.0589
[72]	Minguell JJ, Erices A, Conget P, et al. (2001) Mesenchymal stem cells. Exp Biol Med (Maywood) 226: 507–520. doi: 10.1177/153537020122600603
[73]	Heo JS, Choi Y, Kim H, et al. (2016)Comparison of molecular profiles of human mesenchymal stem cells derived from bone marrow, umbilical cord blood, placenta and adipose tissue. Int J Mol Med 37: 115–125.
[74]	Dominici M, Le Blanc K, Mueller I, et al. (2006) Minimal criteria for defining multipotent mesenchymal stromal cells. The International Society for Cellular Therapy position statement. Cytotherapy 8: 315–317.
[75]	Chen JY, Mou XZ, Du ZC, et al. (2015) Comparative analysis of biological characteristics of adult mesenchymal stem cells with different tissue origins. Asian Pac J Trop Med 8: 739–746.
[76]	Choudhery MS, Badowski M, Muise A, et al. (2014) Cryopreservation of whole adipose tissue for future use in regenerative medicine. J Surg Res 187: 24–35. doi: 10.1016/j.jss.2013.09.027
[77]	De Ugarte DA, Alfonso Z, Zuk PA, et al. (2003) Differential expression of stem cell mobilizationassociated molecules on multi-lineage cells from adipose tissue and bone marrow. ImmunolLett 89: 267–270.
[78]	Quirici N, Scavullo C, De GL, et al. (2010) Anti-L-NGFR and -CD34 monoclonal antibodies identify multipotent mesenchymal stem cells in human adipose tissue. Stem Cells 19: 915–925.
[79]	LV FJ, Tuan RS, Cheung KMC, et al. (2014) Concise Review: The Surface Markers and Identity of Human Mesenchymal Stem Cells. Stem Cells 32: 1408–1419. doi: 10.1002/stem.1681
[80]	Bühring HJ, Battula VL, Treml S, et al. (2007) Novel markers for the prospective isolation of human MSC. Ann NY Acad Sci 1106: 262–271.
[81]	Meyerrose TE, De Ugarte DA, Hofling AA, et al. (2007) In vivo distribution of human adipose-derived mesenchymal stem cells in novel xenotransplantation models. Stem Cells 25: 220–227.
[82]	Álvarez-Viejo M, Menéndez-Menéndez Y, Otero-Hernández J (2015) CD271 as a marker to identify mesenchymal stem cells from diverse sources before culture. World J Stem Cells 7: 470–476. doi: 10.4252/wjsc.v7.i2.470
[83]	Watson JT, Foo T, Wu J, et al. (2013) CD271 as a marker for mesenchymal stem cells in bone marrow versus umbilical cord blood. Cells Tissues Organs 197: 496–504.
[84]	Choudhery MS, Khan M, Mahmood R, et al. (2012) Bone marrow derived mesenchymal stem cells from aged mice have reduced wound healing, angiogenesis, proliferation and anti-apoptosis capabilities. Cell Biol Int 36: 747–753. doi: 10.1042/CBI20110183
[85]	Peng L, Jia Z, Yin X, et al. (2008) Comparative analysis of mesenchymal stem cells from bone marrow, cartilage, and adipose tissue. Stem Cells Dev 17: 761–773. doi: 10.1089/scd.2007.0217
[86]	Van Harmelen V, Röhrig K, Hauner H, et al. (2004) Comparison of proliferation and differentiation capacity of human adipocyte precursor cells from the omental and subcutaneous adipose tissue depot of obese subjects. Metabolism 53: 632–637. doi: 10.1016/j.metabol.2003.11.012
[87]	Zhu X, Shi W, Tai W, et al. (2012) The comparition of biological characteristics and multilineage differentiation of bone marrow and adipose derived Mesenchymal stem cells. Cell Tissue Res 350: 277–287. doi: 10.1007/s00441-012-1453-1
[88]	Shen X, Pan B, Zhou H, et al. (2017) Differentiation of mesenchymal stem cells into cardiomyocytes is regulated by miRNA-1-2 via WNT signaling pathway. J Biomed Sci 24: 29.
[89]	Ji R, Zhang N, You N, et al. (2012) The differentiation of MSCs into functional hepatocyte-like cells in a liver biomatrix scaffold and their transplantation into liver-fibrotic mice. Biomaterials 33: 8995–9008. doi: 10.1016/j.biomaterials.2012.08.058
[90]	Yang B, Zheng JH, Zhang YY (2013) Myogenic differentiation of mesenchymal stem cells for muscle regeneration in urinary tract. Chin Med J (Engl) 126: 2952–2959.
[91]	Feng Y (2014) Differentiation of mesenchymal stem cells into neuronal cells on fetal bovine acellular dermal matrix as a tissue engineered nerve scaffold. Neural Regen Res 9: 1968–1978.
[92]	Sakaguchi Y, Sekiya I, Yagishita K, et al. (2005) Comparison of human stem cells derived from various mesenchymal tissues: superiority of synovium as a cell source. Arthritis Rheum 52: 2521–2529.
[93]	Hu L, Hu J, Zhao J, et al. (2013) Side-by-side comparison of the biological characteristics of human umbilical cord and adipose tissue-derived mesenchymal stem cells. BioMed Res Int 2013: 438243.

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