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Current and future biocompatibility aspects of biomaterials for hip prosthesis

Department of Mechanical Engineering, Malaviya National Institute of Technology, Malaviya Nagar, JLN Marg, Jaipur, Rajasthan-302017, India

The field of biomaterials has turn into an electrifying area because these materials improve the quality and longevity of human life. The first and foremost necessity for the selection of the biomaterial is the acceptability by human body. However, the materials used in hip implants are designed to sustain the load bearing function of human bones for the start of the patient’s life. The most common classes of biomaterials used are metals, polymers, ceramics, composites and apatite. These five classes are used individually or in combination with other materials to form most of the implantation devices in recent years. Numerous current and promising new biomaterials i.e. metallic, ceramic, polymeric and composite are discussed to highlight their merits and their frailties in terms of mechanical and metallurgical properties in this review. It is concluded that current materials have their confines and there is a need for more refined multi-functional materials to be developed in order to match the biocompatibility, metallurgical and mechanical complexity of the hip prosthesis.
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1.Ramakrishna S, Mayer J, Wintermantel E, et al. (2001) Biomedical applications of polymer-composite materials: a review. Compos Sci Technol 61: 1189–1224.    

2.Wise D (2000) Biomaterials engineering and devices. Berlin: Humana Press, 205–319.

3.Park JB, Bronzino JD (2003) Biomaterials: principles and applications. Boca Rator, FL: CRC Press, 1–241.

4.Available from: http: //www.datamonitor.com/healthcare.html.

5.Ma W, Ruys A, Mason R, et al. (2007) DLC coatings: Effects of physical and chemical properties on biological response. Biomaterials 28: 1620–1628.    

6.Baker D (2001) Macro-and Microscopic Evaluation of Fatigue in Medical Grade Ultrahigh Molecular Weight Polyethylene. [PhD Theses] University of California: Berkeley: 1–223.

7.Zinger O, Anselme K, Denzer A, et al. (2004) Time-dependent morphology and adhesion of osteoblastic cells on titanium model surfaces featuring scale-resolved topography. Biomaterials 25: 2695–2711.    

8.Jayaraman M, Meyer U, Buhner M, et al. (2004) Influence of titanium surfaces on attachment of osteoblast-like cells in vitro Biomaterials 25: 625–631.

9.Wiles P (1958) The surgery of the osteoarthritic hip. Br J Surg 45: 488–497.    

10.Haboush EJ (1953) A new operation for arthroplasty of the hip based on biomechanics, photoelasticity, fast-setting dental acrylic, and other considerations. Bull Hosp Joint Disease 14: 242–277.

11.Robert S, Derkash MD (1997) History of the Association of Bone and Joint Surgeons. Clin Orthop Relat Res 337: 306–309.    

12.Walker PS, Gold BL (1971) The tribology (friction, lubrication and wear) of all-metal artificial hip joints. Wear 17: 285–299.    

13.Charnley J (1961) Arthroplasty of the hip. A new operation. Lancet 1: 1129–1132.

14.Charnley J (1982) Long-term results of low-friction arthroplasty. Hip: 42–49.

15.Williams DF (2008) On the mechanisms of biocompatibility. Biomaterials 29: 2941–2953.    

16.Chevalier J (2006) What future for zirconia as a biomaterial. Biomaterials 27: 535–543.    

17.Bizot P, Nizard R, Lerouge S, et al. (2000) Ceramic/ceramic total hip arthroplasty. J Orthop Sci 5: 622–627.    

18.Cales B (2000) Zirconia as a sliding material-Histologic, laboratory, and clinical data. Clin Orthop Relat Res 94–112.

19.Long M, Rack H (1998) Titanium alloys in total joint replacement-a materials science perspective. Biomaterials 19: 1621–1639.    

20.Holzwarth U, Cotogno G (2012) Total Hip Arthroplasty: State of the art, prospects and challenges JRC Scientific and policy reports.

21.Katz J (1980) Anisotropy of Young’s modulus of bone. Nature: 283: 106–107.    

22.Gutwein L, Webster T (2004) Increased viable osteoblast density in the presence of nanophase compared to conventional alumina and titania particles. Biomaterials 25: 4175–4183.    

23.Williams DF (1987) Review: Tissue-biomaterial interactions. J Mat Sci 22: 3421–3445.    

24.Geetha M, Singh AK, Asokamani R, et al. (2009) Ti based biomaterials, the ultimate choice for orthopaedic implants-A review. Prog Mater Sci 54: 397–425.    

25.Hallab NJ, Anderson S, Stafford T, et al. (2005) Lymphocyte responses in patients with total hip arthroplasty. Orthop Res 23: 384–391.    

26.Sargeant A, Goswami T (2006) Mater Des 27: 287–307.

27.Viceconti M, Muccini R, Bernakiewicz M, et al. (2000) Large-sliding contact elements accurately predict levels of bone-implant micromotion relevant to osseointegration. J Biomech 33: 1611–1618.    

28.Nasab M, Hassan M (2010) Metallic biomaterials of knee and hip - a review, Trends Biomater Artif Organs 24: 69–82.

29.Niinomi M (2002) Recent metallic materials for biomedical applications. Metal Mater Transac A. 33 A: 477–486.

30.Pilliar R (2009) Metallic biomaterials, in Biomedical Materials (R. Narayan, ed.), Springer US: 41–81.

31.Kshang D, Lu J, Yao C, et al. (2008) The role of nanometer and sub-micron surface features on vascular and bone cell adhesion on titanium. Biomaterials 29: 970–983.    

32.Budzynski P, Youssef A, Sielanko J (2006) Surface modification of Ti–6Al–4V alloy by nitrogen ion implantation. Wear 261: 1271–1276.    

33.Viceconti M, Muccini R, Bernakiewicz M, et al. (2000) Large-sliding contact elements accurately predict levels of bone-implant micromotion relevant to osseointegration. J Biomech 33: 1611–1618.    

34.Cigada A, Rondelli G, Vicentini B, et al. (1989) Duplex stainless steels for osteosynthesis devices. J Biomed Mater Res 462: 1087–1095.

35.Thomann U, Uggowitzer P (2000) Wear-corrosion behavior of biocompatible austenitic stainless steels. Wear 239: 48–58.    

36.Mirhosseini N, Crouse P, Schmidth M, et al. (2007) Laser surface micro-texturing of Ti–6Al–4V substrates for improved cell integration. Appl Surf Sci 253: 7738–7743.    

37.Fini M, Giavaresi G, Torricelli P, et al. (2004) Osteoporosis and biomaterial osteointegration. Biomed Pharmacother 58: 487–493.    

38.Davis JR (2003) Metallic Materials, Chapter 3, Handbook of Materials for Medical Devices, Ohio: ASM International.

39.Alvarado J, Maldonado R, Marxuach J, et al. (2003) Biomechanics of Hip and Knee Prostheses. Applications of Engineering Mechanics in Medicine, GED – University of Puerto Rico Mayaguez: 6–22.

40.Yildiz H, Chang FK, Goodman S (1998) Composite hip prosthesis design II. Simulation. J Biomed Mater Res 39: 102–119

41.Ramsden J, David A, Stephenson D, et al, (2007) The Design and Manufacture of Biomedical Surfaces. CIRP Ann-Manuf Techn 56: p. 687–711.

42.Available from: http: //users.ox.ac.uk/~exet0249/biomaterials.html#biomat

43.Chevalier J, Gremillard L (2009) Ceramics for medical applications: a picture for the next 20 years. J Eur Ceram Soc 29: 1245–1255.    

44.Hench L (1998) Bioceramics. Am Ceram Soc 81: 1705–1728.

45.Lee B, Lee C, Kim D, et al. (2008) Effect of surface structure on biomechanical properties and osseointegration. Mater Sci Eng C 28: 1448–1461.    

46.Imam M, Fraker A, Harris J, et al. (1983) Influence of heat treatment on the fatigue lives of Ti-6Al-4V and Ti-4.5Al-5Mo-1.5CR. Titanium Alloys is surgical implants, luckey, H.A. and Kubli, F.E. Eds Philadelphia, PA: ASTM special technical publication 796: 105–119.

47.Navarro M, Michiardi A, Castano O, et al. (2008) Biomaterials in orthopaedics. J R Soc Interface 5: 1137–1158.    

48.Noiri F, Hoshi H, Murakami K, et al. (2002) Fol Ophthalmol Jpn 53: 476–480.

49.Oonishi H (1992) Bioceramic in orthopaedic surgery–our clinical experiences. In: Bioceramic, J.E. Hulbert and S.F. Hulbert (Eds.) 3: 31–42.

50.Yamada K, Nakamura S, Suchiya T, et al. (2002) Key Engineering Materials. 216: 149–152.

51.Hentrich R, Graves G, Stein H, et al. (1971) An evaluation of inert and resorabable ceramics for future clinical applications. J Biomed Mater Res 5: 25–51.    

52.Brook R (1991) Concise Encyclopedia of Advanced Ceramic Materials. Oxford: Pergamon Press. 525–528.

53.Bokras J, LaGrange L, Schoen F (1992) Control of structure of carbon for use in bioengineering, Chem Phys Carbon 9: 103–107.

54.Lewandow-Szumiei M, Komender J, Gorecki A, et al. (1997) Fixation of carbon fibre-reinforced carbon composite implanted into bone. J Mater Sci-Mater M 8: 485–488.    

55.Shi H, Shimizu K (1998) On-line metabolic pathway analysis based on metabolic signal flow diagram.Biotechnol Bioeng 58: 139–148.

56.Hoeland W, Vogel W, Waumann K, et al. (1985) Interface reactions between machinable bioactive glass-ceramics and bone. J Biomed Mater Res 19: 303–312.    

57.Yamamuro T, Hench L L, Wilson J (1990) Handbook of Bioactive Ceramics I and II. Boca Raton: CRC Press.

58.Wilson J, Pigott G, Schoen F, et al. (1982) Toxicology and biocompatibility of bioglass. J Biomed Mater Res 15: 805–817.

59.lrie K, Oohashi N (1995) Japan Kokai Tokkyo Koho; JP 7 41, 459.

60.Rodrigues C, Serricella P, Linhares A, et al. (2003) Characterization of a bovine collagen-hydroxyapatite composite scaffold for bone tissue engineering. Biomaterials 24: 4987–4997.    

61.Ruan J, Grant M (2001) Biocompatibility evaluation in vitro. Part I: Morphology expression and proliferation of human and rat osteoblasts on the biomaterials J. J Cent South Univ T 8: 1–8.

62.Thian E, Loh N, Khor K (2002) In vitro behavior of sintered powder injection molded Ti-6Al-4V/HA. J Biomed Mater Res 63(2): 79–87.

63.Piattelli A, Trisi P (1994) A light and laser scanning microscopy study of bone/hydroxyapatite-coated titanium implants interface: histochemical evidence of un-mineralized material in humans. J Biomed Mater Res 28: 529–536.    

64.Bajpai P, Fuchs C (1985) Development of a hydroxyapatite bone grout. Proceedings of the first annual scientific session of the academy of surgical research. San Antonio, Texas. C.W. Hall (Ed.). New York: Pergamon press. 50–54,

65.Ramakrishna S, Mayer J, Wintermantel E, et al. (2001) Biomedical applications of polymer-composite materials: a review. Compos Sci Technol61: 1189–1224.

66.Davidson J, Georgette F (1987) State-of-the-art materials for orthopaedic prosthetic devices: On implant manufacturing and material technology. P Soc Manufact Eng EM87–122: 122–126.

67.Costa L, Brach de Prever E (2000) UHMWPE for arthroplasty. Torino: Edizioni Minerva Medica.

68.Kelly J (2002) Ultra-high molecular weight polyethylene, J Macromol Sci-Pol R 42: 355–371.

69.Endo M, Barbour P, Barton D, et al. (2001) Comparative wear and wear debris under three different counterface conditions of crosslinked and non-crosslinked ultra high molecular weight polyethylene, Biomed Mater Eng 11: 23–35.

70.Baker D, Bellare A, Pruitt L (2003) The effects of degree of crosslinking on the fatigue crack initiation and propagation resistance of orthopedic-grade polyethylene. J Biomed Mater Res A 66: 146–154.

71.Gomoll A, Wanich T, Bellare A (2002) J-integral fracture toughness and tearing modulus measurement of radiation cross-linked UHMWPE. J Orthop Res 20: 1152–1156.    

72.Champion A, Li S, Saum K, et al. (1994) The effect of crystallinity on the physical properties of UHMWPE. Transact Orthop Res Soc 19: 585–589.

73.Simis K, Bistolfi A, Bellare A, et al. (2006) The combined effects of crosslinking and high crystallinity on the microstructural and mechanical properties of ultra high molecular weight polyethylene. Biomaterials, 27: 1688–1694.    

74.Hermawan H, Ramdan D, Djuansjah J (2011) Biomedical Engineering — From Theory to Applications. Reza Fazel-Rezai, editor. Metals for Biomedical Applications. Rijeka: InTech. 411–430.

75.Manivasagam G, Dhinasekaran D, Rajamanickam A (2010) Biomedical Implants: Corrosion and its Prevention - A Review. Recent Pat Corros Sci 2: 40–54.    

76.Zhang L, Feng X, Liu H, et al. (2004) Hydroxyapatite/collagen composite materials formation in simulated body fluid environment. Mater Lett 58: 719–722.    

77.Au A, James Raso V, Liggins AB, et al. (2007) Contribution of loading conditions and material properties to stress shielding near the tibial component of total knee replacements. J Biomech 40(6): 1410–1416.

78.Skinner HB (1998) Composite technology for total hip anthroplasty. Clinothop 235: 224–36.

79.De Santis R, Ambrosio L, Nicolais L (2000) Polymer-based composites hip prostheses. J Inorg Biochem 79: 97–102    

80.Kaddick C, Ascherl R, Siebels W, et al. (1996) Mechanical stability of hip joint endoprosthesis shafts of carbon fiber composite materials. Z Ortho Ihre Grenzgeb 134: 111–6.    

81.Yildiz H, Ha SK, Chang F (1998) Composite hip prosthesis design I. Analysis. J Biomed Mater Res 39: 92–101.

82.Simoes JA, Marques AT, Jeronimidis G. (2000) Design of a controlled-stiffness composite proximal femoral prosthesis. Compos Sci T echnol 60: 559–567.    

83.Srinivasan S, de Andrade JR, Biggers SB Jr, et al. (2000) Structural response and relative strength of a laminated composite hip prosthesis: effect of functional activity. Biomaterials 21: 1929–40.    

84.Available from: http: //imeulia.blogspot.com/2011/08/classes-and-characteristics-of.html

85.Chang M, Ikonama T, Kikuchi M, et al. (2001) The cross linkage effect of hydroxyapatite/collagen nanocompositess on a self organization phenomenon. J Mater Sci Mater Med 13: 993

86.Lewis G (1990) Selection of Engineering Materials, Adapted by permission of Prentice Hall: 189

87.American society for testing and materials. (1992) Annual Book of ASTM standards, Medical Devices and Services, American Society for testing and materials, Philadelphia, PA: 13.

88.Vallet-Regí M (2001) Ceramics for medical applications. J Chem Soc Dalton 2: 97–108.

89.Jong S, Tsai Y, Hsieh Y (2014) Polysiloxane resin composition, US8637603 B2, 2014 Jan 28.

90.Swab J, Halbig M, Mathur S (2012) Advances in Ceramic Armor VIII: Ceramic Engineering and Science Proceedings 33: 246.

91.Du C, Cui F, Zhang W (2000) Formation of calcium phosphate/collagen composites through mineralization of collagen matrix. J Biomed Mater Res 50: 518–527.

92.Wahl D, Czernuszka J (2006) Collagen-hydroxyapatite composites for hard tissue repair. Eur Cell Mater 11: 43–56.

93.Galego N, Rozsa C, Sanchez R, et al. (2000) Characterization and application of poly(β-hydroxyalkanoates) family ascomposite biomaterials. Polym Test 19: 485–492.    

94.Katti K, Turlapati P, Verma D, et al. (2008) Static and dynamic mechanical behavior of hydroxyapatite-polyacrylicacidcomposites under simulated body fluid. Am J Biochem Biotechnol 2: 73–79.

95.Roy Chowdhury S, Kulkarni A, Basak A, et al. (2007) Wear characteristic and biocompatibility of some hydroxyapatite-collagen composite acetabular cups. Wear 262: 1387–1398.    

96.Verma D, Katti K, Katti D, et al. (2007) Mechanical response and multi-level structure of biomimetic hydroxyapatite/polygalacturonic/chitosannano-composites. Mat Sci Eng C-Mater 28: 399–405.

97.Zhang L, Li Y, Zhou G, et al. (2007) Preparation and characterization of chitosan/nanohydroxyapatite composite used as bone substitute material. High Technol Lett 13: 31–35.

98.Lu X, Zheng B, Chen N, et al. (2007) Preparation and evaluation of self-hardening bone-rehabilitative composite with natural hydroxyapatite/chitosan. Key Eng Mater 334–335 II: 1197–1200.

99.Wang M, Bonfield W (2001) Chemically coupled hydroxyapatite-polyethylene composites: structure and properties. Biomaterials 22: 1311–1320.    

100.Bleach N, Nazhat S, Tanner K, et al. (2002) Effect of filler content on mechanical and dynamic mechanical properties of particulate biphasic calcium phosphate-polylactide composites. Biomaterials 23: 1579–1585.    

101.Ignjatovic N, Plavsic M, Miljkovic M, et al. (1999a) Microstructural characteristic of Ca-hydroxyapatite/poly-L-lactide based composites. J Microsc 196: 23.

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