Manuscript Topics

The modeling of complex systems, especially in biology and engineering, is a delicate issue considering that the different elements composing the system need a detailed analysis at different representation levels. Top-down and bottom-up approaches have been employed. Specifically in the top-down approach the behavior of the system is estimated at the macroscopic level (Ordinary Differential Equation (ODE) and Partial Differential Equation (PDE) based models); in the bottom-up approach the system is emphasized at the microscopic level (cellular automata and (multi)agent-based models).
This special issue focuses on the development and application of the recent top-down/bottom-up modeling approaches for the analysis and simulation of biological and engineering systems.
Original research articles as well as review articles are welcome.

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