Critical function of Siah2 in tumorigenesis

Kazunobu Baba; Tadaaki Miyazaki; Kazunobu Baba; Tadaaki Miyazaki

doi:10.3934/molsci.2017.4.415

AIMS Molecular Science

2017, Volume 4, Issue 4: 415-423. doi: 10.3934/molsci.2017.4.415

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Review

Critical function of Siah2 in tumorigenesis

Kazunobu Baba ,
Tadaaki Miyazaki ^,

Department of Probiotics Immunology, Institute for Genetic Medicine, Hokkaido University, North 15 West 7, Kita-ku, Sapporo City, Hokkaido, Japan

Received: 31 July 2017 Accepted: 21 September 2017 Published: 11 October 2017

The seven in absentia homolog (Siah) family proteins are components of E3 RING zinc finger ubiquitin ligase complexes that catalyze the ubiquitination of proteins. Siah proteins target their substrates for proteasomal degradation. Evidence is growing that Siah proteins are implicated in the progression of various cancer cells and play a critical role in angiogenesis and tumorigenesis, particularly through Ras, p53, estrogen, and hypoxia inducible factor (HIF)-mediated signaling pathways in response to DNA damage or hypoxia.
- Siah2,
- Nrf2,
- ROS metabolism,
- Hypoxia
Citation: Kazunobu Baba, Tadaaki Miyazaki. Critical function of Siah2 in tumorigenesis[J]. AIMS Molecular Science, 2017, 4(4): 415-423. doi: 10.3934/molsci.2017.4.415

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Abstract

The seven in absentia homolog (Siah) family proteins are components of E3 RING zinc finger ubiquitin ligase complexes that catalyze the ubiquitination of proteins. Siah proteins target their substrates for proteasomal degradation. Evidence is growing that Siah proteins are implicated in the progression of various cancer cells and play a critical role in angiogenesis and tumorigenesis, particularly through Ras, p53, estrogen, and hypoxia inducible factor (HIF)-mediated signaling pathways in response to DNA damage or hypoxia.

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