Numerical evaluation of high-intensity focused ultrasound- induced thermal lesions in atherosclerotic plaques

Weirui Lei; Jiwen Hu; Yatao Liu; Wenyi Liu; Xuekun Chen; Weirui Lei; Jiwen Hu; Yatao Liu; Wenyi Liu; Xuekun Chen

doi:10.3934/mbe.2021062

Mathematical Biosciences and Engineering

2021, Volume 18, Issue 2: 1154-1168. doi: 10.3934/mbe.2021062

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Research article

Numerical evaluation of high-intensity focused ultrasound- induced thermal lesions in atherosclerotic plaques

College of Mathematics and Physics, University of South China, Hengyang, 421001, China

Received: 22 June 2020 Accepted: 22 December 2020 Published: 12 January 2021

The aim of this study is to estimate the effects of some acoustic parameters on thermal lesions of atherosclerotic plaques in high-intensity focused ultrasound (HIFU) fields. A fluid-solid thermal coupling model is presented for describing the temperature elevation and thermal ablation of atherosclerotic plaque. A finite element approach is used to solve the coupling equations in cylindrical coordinates. The model considers the effect of the wall thickness of large arteries. The extent of the tissue lesion is determined by the accumulated thermal lesion with Arrhenius integral equation at each location. The results show the lesion size of atherosclerotic plaque is positively correlated to the excited frequency and acoustic output power with heating time. The computational model indicates HIFU may present a novel option for thermal ablation of atherosclerotic plaques with a completely non-invasive treatment paradigm.
- atherosclerosis plaque,
- multi-physics field model,
- thermal lesions,
- HIFU,
- finite element method
Citation: Weirui Lei, Jiwen Hu, Yatao Liu, Wenyi Liu, Xuekun Chen. Numerical evaluation of high-intensity focused ultrasound- induced thermal lesions in atherosclerotic plaques[J]. Mathematical Biosciences and Engineering, 2021, 18(2): 1154-1168. doi: 10.3934/mbe.2021062

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Abstract

The aim of this study is to estimate the effects of some acoustic parameters on thermal lesions of atherosclerotic plaques in high-intensity focused ultrasound (HIFU) fields. A fluid-solid thermal coupling model is presented for describing the temperature elevation and thermal ablation of atherosclerotic plaque. A finite element approach is used to solve the coupling equations in cylindrical coordinates. The model considers the effect of the wall thickness of large arteries. The extent of the tissue lesion is determined by the accumulated thermal lesion with Arrhenius integral equation at each location. The results show the lesion size of atherosclerotic plaque is positively correlated to the excited frequency and acoustic output power with heating time. The computational model indicates HIFU may present a novel option for thermal ablation of atherosclerotic plaques with a completely non-invasive treatment paradigm.

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