Citation: Youyi Yang, Yongzhen Pei, Xiyin Liang, Yunfei Lv. An optimal scheme to boost immunity and suppress viruses for HIV by combining a phased immunotherapy with the sustaining antiviral therapy[J]. Mathematical Biosciences and Engineering, 2020, 17(5): 4578-4608. doi: 10.3934/mbe.2020253
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The classical beta function
B(δ1,δ2)=∞∫0tδ1−1(1−t)δ2−1dt,(ℜ(δ1)>0,ℜ(δ2)>0) | (1.1) |
and its relation with well known gamma function is given by
B(δ1,δ2)=Γ(δ1)Γ(δ2)Γ(δ1+δ2),ℜ(δ1)>0,ℜ(δ2)>0. |
The Gauss hypergeometric, confluent hypergeometric and Appell's functions which are respectively defined by(see [27])
2F1(δ1,δ2;δ3;z)=∞∑n=0(δ1)n(δ2)n(δ3)nznn!,(|z|<1), (δ1,δ2,δ3∈C and δ3≠0,−1,−2,−3,⋯), | (1.2) |
and
1Φ1(δ2;δ3;z)=∞∑n=0(δ2)n(δ3)nznn!,(|z|<1), (δ2,δ3∈C and δ3≠0,−1,−2,−3,⋯). | (1.3) |
The Appell's series or bivariate hypergeometric series is defined by
F1(δ1,δ2,δ3;δ4;x,y)=∞∑m,n=0(δ1)m+n(δ2)m(δ3)nxmyn(δ4)m+nm!n!; | (1.4) |
for all δ1,δ2,δ3,δ4∈C,δ4≠0,−1,−2,−3,⋯,|x|,|y|<1<1.
The integral representation of hypergeometric, confluent hypergeometric and Appell's functions are respectively defined by
2F1(δ1,δ2;δ3;z)=Γ(δ3)Γ(δ2)Γ(δ3−δ2)∫10tδ2−1(1−t)δ3−δ2−1(1−zt)−δ1dt, | (1.5) |
(ℜ(δ3)>ℜ(δ2)>0,|arg(1−z)|<π), |
and
1Φ1(δ2;δ3;z)=Γ(δ3)Γ(δ2)Γ(δ3−δ2)∫10tδ2−1(1−t)δ3−δ2−1eztdt, | (1.6) |
(ℜ(δ3)>ℜ(δ2)>0). |
F1(δ1,δ2,δ3;δ4;x,y)=Γ(δ4)Γ(δ1)Γ(δ4−δ1)1∫0tδ1−1(1−t)δ4−δ1−1(1−xt)−δ2(1−yt)−δ3dt. | (1.7) |
The k-gamma function, k-beta function and the k-Pochhammer symbol introduced and studied by Diaz and Pariguan [5]. The integral representation of k-gamma function and k-beta function respectively given by
Γk(z)=kzk−1Γ(zk)=∞∫0tz−1e−zkkdt,ℜ(z)>0,k>0 | (1.8) |
Bk(x,y)=1k1∫0txk−1(1−t)yk−1dt,ℜ(x)>0,ℜ(y)>0. | (1.9) |
Here, we recall the following relations (see [5]).
Bk(x,y)=Γk(x)Γk(y)Γk(x+y), | (1.10) |
(z)n,k=Γk(z+nk)Γk(z), | (1.11) |
where (z)n,k=(z)(z+k)(z+2k)⋯(z+(n−1)k);(z)0,k=1 and k>0
and
∞∑n=0(α)n,kznn!=(1−kz)−αk. | (1.12) |
These studies were followed by Mansour [16], Kokologiannaki [13], Krasniqi [14] and Merovci [17]. In 2012, Mubeen and Habibullah [18] defined the k-hypergeometric function as
2F1,k(δ1,δ2;δ3;z)=∞∑n=0(δ1)n,k(δ2)n,k(δ3)n,kznn!, | (1.13) |
where δ1,δ2,δ3∈C and δ3≠0,−1,−2,⋯ and its integral representation is given by
2F1,k(δ1,δ2;δ3;z)=1kBk(δ2,δ3−δ2)×∫10tδ2k−1(1−t)δ3−δ2k−1(1−ktz)−δ1kdt. | (1.14) |
The k-Riemann-Liouville (R-L) fractional integral using k-gamma function introduced in [19]:
(Iαkf(t))(x)=1kΓk(α)∫x0f(t)(x−t)αk−1dt,k,α∈R+. | (1.15) |
Later on Mubeen and Iqbal [11] established the improved version of Gruss type inequalities by utilizing k-fractional integrals. In [1], Agarwal et al. presented certain Hermite-Hadamard type inequalities for generalized k-fractional integrals. Set et al. [29] presented an integral identity and generalized Hermite–Hadamard type inequalities for Riemann–Liouville fractional integral. Mubeen et al. [24] established integral inequalities of Ostrowski type for k-fractional Riemann–Liouville integrals. Recently, many researchers have introduced generalized version of k-fractional integrals and investigated a large bulk of various inequalities via the said fractional integrals. The interesting readers are referred to see the work of [9,10,26,30]. Farid et al. [7] introduced Hadamard k-fractional integrals. In [8] introduced Hadamard-type inequalities for k-fractional Riemann-Liouville integrals. In [12,31], the authors established certain inequalities by utilizing Hadamard-type inequalities for k-fractional Riemann-Liouville integrals. In [25], Nisar et al. established certain Gronwall type inequalities associated with Riemann-Liouville k- and Hadamard k-fractional derivatives and their applications. In [25], they presented dependence solutions of certain k-fractional differential equations of arbitrary real order with initial conditions. Recently, Samraiz et al. [28] defined an extension of Hadamard k-fractional derivative and proved its various properties.
The solution of some integral equations involving confluent k-hypergeometric functions and k-analogue of Kummer's first formula are given in [22,23]. While the k-hypergeometric and confluent k-hypergeometric differential equations are introduced in [20]. In 2015, Mubeen et al. [21] introduced k-Appell hypergeometric function as
F1,k(δ1,δ2,δ3;δ4;z1,z2)=∞∑m,n=0(δ1)m+n,k(δ2)m,k(δ3)m,k(δ4)m+n,kzm1zn2m!n! | (1.16) |
for all δ1,δ2,δ3,δ4∈C,δ4≠0,−1,−2,−3,⋯,max{|z1|,|z2|}<1k and k>0. Also, Mubeen et al. defined its integral representation as
F1,k(δ1,δ2,δ3;δ4;z1,z2)=1kBk(δ1,δ4−δ1)1∫0tδ1k−1(1−t)δ4−δ1k−1(1−kz1t)−δ2k(1−kz2t)−δ3kdt, | (1.17) |
(ℜ(δ4)>ℜ(δ1)>0). |
In this section, we recall the following definition of fractional derivatives from and give a new extension called Riemann-Liouville k-fractional derivative.
Definition 2.1. The well-known R-L fractional derivative of order μ is defined by
Dμx{f(x)}=1Γ(−μ)∫x0f(t)(x−t)−μ−1dt,ℜ(μ)<0. | (2.1) |
For the case m−1<ℜ(μ)<m where m=1,2,⋯, it follows
Dμx{f(x)}=dmdxmDμ−mx{f(x)}=dmdxm{1Γ(−μ+m)∫x0f(t)(x−t)−μ+m−1dt}. | (2.2) |
For further study and applications, we refer the readers to the work of [2,3,4,15,32]. In the following, we define Riemann-Liouville k-fractional derivative of order μ as
Definition 2.2.
kDμx{f(x)}=1kΓk(−μ)∫x0f(t)(x−t)−μk−1dt,ℜ(μ)<0,k∈R+. | (2.3) |
For the case m−1<ℜ(μ)<m where m=1,2,⋯, it follows
kDμx{f(x)}=dmdxmkDμ−mkx{f(x)}=dmdxm{1kΓk(−μ+mk)∫x0f(t)(x−t)−μk+m−1dt}. | (2.4) |
Note that for k=1, definition 2.2 reduces to the classical R-L fractional derivative operator given in definition 2.1.
Now, we are ready to prove some theorems by using the new definition 2.2.
Theorem 1. The following formula holds true,
kDμz{zηk}=zη−μkΓk(−μ)Bk(η+k,−μ),ℜ(μ)<0. | (2.5) |
Proof. From (2.3), we have
kDμz{zηk}=1kΓk(−μ)∫z0tηk(z−t)−μk−1dt. | (2.6) |
Substituting t=uz in (2.6), we get
kDμz{zηk}=1kΓk(−μ)∫10(uz)ηk(z−uz)−μk−1zdu=zη−μkkΓk(−μ)∫10uηk(1−u)−μk−1du. |
Applying definition (1.9) to the above equation, we get the desired result.
Theorem 2. Let ℜ(μ)>0 and suppose that the function f(z) is analytic at the origin with its Maclaurin expansion given by f(z)=∑∞n=0anzn where |z|<ρ for some ρ∈R+. Then
kDμz{f(z)}=∞∑n=0ankDμz{zn}. | (2.7) |
Proof. Using the series expansion of the function f(z) in (2.3) gives
kDμz{f(z)}=1kΓk(−μ)∫z0∞∑n=0antn(z−t)−μk−1dt. |
As the series is uniformly convergent on any closed disk centered at the origin with its radius smaller then ρ, therefore the series so does on the line segment from 0 to a fixed z for |z|<ρ. Thus it guarantee terms by terms integration as follows
kDμz{f(z)}=∞∑n=0an{1kΓk(−μ)∫z0tn(z−t)−μk−1dt=∞∑n=0ankDμz{zn}, |
which is the required proof.
Theorem 3. The following result holds true:
kDη−μz{zηk−1(1−kz)−βk}=Γk(η)Γk(μ)zμk−12F1,k(β,η;μ;z), | (2.8) |
where ℜ(μ)>ℜ(η)>0 and |z|<1.
Proof. By direct calculation, we have
kDη−μz{zηk−1(1−kz)−βk}=1kΓk(μ−η)∫z0tηk−1(1−kt)−βk(z−t)μ−ηk−1dt=zμ−ηk−1kΓk(μ−η)∫z0tηk−1(1−kt)−βk(1−tz)μ−ηk−1dt. |
Substituting t=zu in the above equation, we get
kDη−μz{zηk−1(1−kz)−βk}=zμk−1kΓk(μ−η)∫10uηk−1(1−kuz)−βk(1−u)μ−ηk−1zdu. |
Applying (1.14) and after simplification we get the required proof.
Theorem 4. The following result holds true:
kDη−μz{zηk−1(1−kaz)−αk(1−kbz)−βk}=Γk(η)Γk(μ)zμk−1F1,k(η,α,β;μ;az,bz), | (2.9) |
where ℜ(μ)>ℜ(η)>0, ℜ(α)>0, ℜ(β)>0, max{|az|,|bz|}<1k.
Proof. To prove (2.9), we use the power series expansion
(1−kaz)−αk(1−kbz)−βk=∞∑m=0∞∑n=0(α)m,k(β)n,k(az)mm!(bz)nn!. |
Now, applying Theorem 1, we obtain
kDη−μz{zηk−1(1−kaz)−αk(1−kbz)−βk}=∞∑m=0∞∑n=0(α)m,k(β)n,k(a)mm!(b)nn!kDη−μz{zηk+m+n−1}=∞∑m=0∞∑n=0(α)m,k(β)n,k(a)mm!(b)nn!βk(η+mk+nk,μ−η)Γk(μ−η)zμk+m+n−1=∞∑m=0∞∑n=0(α)m,k(β)n,k(a)mm!(b)nn!Γk(η+mk+nk)Γk(μ+mk+nk)zμk+m+n−1. |
In view of (1.16), we get
kDη−μz{zηk−1(1−kaz)−αk(1−kbz)−βk}=Γk(η)Γk(μ)zμk−1F1,k(η,α,β;μ;az,bz). |
Theorem 5. The following Mellin transform formula holds true:
M{e−xkDμz(zηk);s}=Γ(s)Γk(−μ)Bk(η+k,−μ)zη−μk, | (2.10) |
where ℜ(η)>−1, ℜ(μ)<0, ℜ(s)>0.
Proof. Applying the Mellin transform on definition (2.3), we have
M{e−xkDμz(zηk);s}=∫∞0xs−1e−xkDμz(zη);s}dx=1kΓk(−μ)∫∞0xs−1e−x{∫z0tηk(z−t)−μk−1dt}dx=z−μk−1kΓk(−μ)∫∞0xs−1e−x{∫z0tηk(1−tz)−μk−1dt}dx=zη−μkkΓk(−μ)∫∞0xs−1e−x{∫10uηk(1−u)−μk−1du}dx |
Interchanging the order of integrations in above equation, we get
M{e−xkDμz(zηk);s}=zη−μkkΓk(−μ)∫10uηk(1−u)−μk−1(∫∞0xs−1e−xdx)du.=zη−μkkΓk(−μ)Γ(s)∫10uηk(1−u)−μk−1du=Γ(s)Γk(−μ)Bk(η+k,−μ)zη−μk, |
which completes the proof.
Theorem 6. The following Mellin transform formula holds true:
M{e−xkDμz((1−kz)−αk);s}=z−μkΓ(s)Γk(−μ)Bk(k,−μ)2F1,k(α,k;−μ+k;z), | (2.11) |
where ℜ(α)>0, ℜ(μ)<0, ℜ(s)>0, and |z|<1.
Proof. Using the power series for (1−kz)−αk and applying Theorem 5 with η=nk, we can write
M{e−xkDμz((1−kz)−αk);s}=∞∑n=0(α)n,kn!M{e−xkDμz(zn);s}=Γ(s)kΓk(−μ)∞∑n=0(α)n,kn!Bk(nk+k,−μ)zn−μk=Γ(s)z−μkΓk(−μ)∞∑n=0Bk(nk+k,−μ)(α)n,kznn!=Γ(s)z−μk∞∑n=0Γk(k+nk)Γk(−μ+k+nk)(α)n,kznn!=Γ(s)Γk(−μ+k)z−μk∞∑n=0(k)n,k(−μ+k)n,k(α)n,kznn!=Γ(s)z−μkΓk(−μ)Bk(k,−μ)2F1,k(α,k;−μ+k;z), |
which is the required proof.
Theorem 7. The following result holds true:
kDη−μz[zηk−1Eμk,γ,δ(z)]=zμk−1kΓk(μ−η)∞∑n=0(μ)n,kΓk(γn+δ)Bk(η+nk,μ−η)znn!, | (2.12) |
where γ,δ,μ∈C, ℜ(p)>0, ℜ(q)>0, ℜ(μ)>ℜ(η)>0 and Eμk,γ,δ(z) is k-Mittag-Leffler function (see [6]) defined as:
Eμk,γ,δ(z)=∞∑n=0(μ)n,kΓk(γn+δ)znn!. | (2.13) |
Proof. Using (2.13), the left-hand side of (2.12) can be written as
kDη−μz[zηk−1Eμk,γ,δ(z)]=kDη−μz[zηk−1{∞∑n=0(μ)n,kΓk(γn+δ)znn!}]. |
By Theorem 2, we have
kDη−μz[zηk−1Eμk,γ,δ(z)]=∞∑n=0(μ)n,kΓk(γn+δ){kDμz[zηk+n−1]}. |
In view of Theorem 1, we get the required proof.
Theorem 8. The following result holds true:
kDη−μz{zηk−1mΨn[(αi,Ai)1,m;|z(βj,Bj)1,n;]}=zμk−1kΓk(μ−η)×∞∑n=0∏mi=1Γ(αi+Ain)∏nj=1Γ(βj+BjnBk(η+nk,μ−η)znn!, | (2.14) |
where ℜ(p)>0, ℜ(q)>0, ℜ(μ)>ℜ(η)>0 and mΨn(z) is the Fox-Wright function defined by (see [15], pages 56–58)
mΨn(z)=mΨn[(αi,Ai)1,m;|z(βj,Bj)1,n;]=∞∑n=0∏mi=1Γ(αi+Ain)∏nj=1Γ(βj+Bjnznn!. | (2.15) |
Proof. Applying Theorem 1 and followed the same procedure used in Theorem 7, we get the desired result.
Recently, many researchers have introduced various generalizations of fractional integrals and derivatives. In this line, we have established a k-fractional derivative and its various properties. If we letting k→1 then all the results established in this paper will reduce to the results related to the classical Reimann-Liouville fractional derivative operator.
The author K.S. Nisar thanks to Deanship of Scientific Research (DSR), Prince Sattam bin Abdulaziz University for providing facilities and support.
The authors declare no conflict of interest.
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