Qualitative theoretical modeling to study the possibility of detecting multi-virus in blood flow using Nano-quartz crystal microbalance

Mohamed Abbas; Ali Algahtani; Amir Kessentini; Hassen Loukil; Muneer Parayangat; Thafasal Ijyas; Abdul Wase Mohammed; Mohamed Abbas; Ali Algahtani; Amir Kessentini; Hassen Loukil; Muneer Parayangat; Thafasal Ijyas; Abdul Wase Mohammed

doi:10.3934/mbe.2020252

Mathematical Biosciences and Engineering

2020, Volume 17, Issue 5: 4563-4577. doi: 10.3934/mbe.2020252

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Research article

Qualitative theoretical modeling to study the possibility of detecting multi-virus in blood flow using Nano-quartz crystal microbalance

1.
Electrical Engineering Department, College of Engineering, King Khalid University, Asir 61421, Saudi Arabia
2.
Department of Mechanical Engineering, College of Engineering, King Khalid University, Asir 61421, Saudi Arabia
3.
Department of Computers and Communications, College of Engineering, Delta University for Science and Technology, Egypt
4.
Laboratory of Electromechanical Systems (LASEM), National Engineering School of Sfax, University of Sfax, Sfax 43038, Tunisia
5.
Electronics and Information Technology Laboratory, University of Sfax, National Engineering School of Sfax, Sfax 43038, Tunisia
6.
Research Center for Advanced Materials Science (RCAMS), King Khalid University, Asir 61413, Saudi Arabia.
7.
Nabeul’s Foundation Institute for Engineering Studies, University of Carthage, IPEIN, Nabeul 8000, Tunisia

Received: 13 January 2020 Accepted: 23 June 2020 Published: 29 June 2020

Methods for testing the presence of a virus in the blood are of interest to researchers and doctors because they determine how rapidly a virus is detected. In general, virus detection is a major scientific problem due to the serious effects of viruses on the human body. At present, only one virus can be detected in a single test. This potentially costs the medical establishment more time and money that could be saved if blood testing was more efficient. This study presents a qualitative method to enable doctors and researchers to detect more than one virus simultaneously. This was performed using quartz nanoparticles. Using polymer thin films of polydimethylsiloxane (PDMS), each chip emits a different frequency for each specific type of virus on the chip. The multiplicity of these chips allows for the detection of a number of viruses with the same number of nanoscale chips simultaneously. Blood flow around quartz nanoparticles was modelled. In this model, several conventional Quartz Crystal Microbalance (QCM) with nanostructures (Nano-QCM) particles are inserted into the three main types of blood vessels. The results showed that the best location for the Nano-QCM is the large artery and that it is possible to test for a number of viruses in all types of blood vessels.

Keywords:

Citation: Mohamed Abbas, Ali Algahtani, Amir Kessentini, Hassen Loukil, Muneer Parayangat, Thafasal Ijyas, Abdul Wase Mohammed. Qualitative theoretical modeling to study the possibility of detecting multi-virus in blood flow using Nano-quartz crystal microbalance[J]. Mathematical Biosciences and Engineering, 2020, 17(5): 4563-4577. doi: 10.3934/mbe.2020252

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Abstract

References

[1]	Z. Liu, J. R. Clausen, R. R. Rao, C. K. Aidun, Nanoparticle diffusion in sheared cellular blood flow, arXiv preprint arXiv, 2019 (2019).
[2]	R. Ellahi, A. Zeeshan, F. Hussain, A. Asadollahi, Peristaltic Blood Flow of Couple Stress Fluid Suspended with nanoparticles under the Influence of Chemical Reaction and Activation Energy, Symmetry, 11 (2019), 276.
[3]	S. M. Gheibi Hayat, M. Darroudi, Nanovaccine: A novel approach in immunization, J. Cell Physiol., 234 (2019), 12530-12536.
[4]	T. Elnaqeeb, N. A. Shah, K. S. Mekheimer, Hemodynamic Characteristics of Gold Nanoparticle Blood Flow Through a Tapered Stenosed Vessel with Variable nanofluid Viscosity, BionanoScience, 9 (2019), 245-255.
[5]	D. M. Teleanu, I. Negut, V. Grumezescu, A. M. Grumezescu, R. I. Teleanu, Nanomaterials for Drug Delivery to the Central Nervous System, Nanomaterials, 9 (2019), 371.
[6]	A. Zaman, N. Ali, M. Sajjad, Effects of nanoparticles (Cu, TiO2, Al2O3) on unsteady blood flow through a curved overlapping stenosed channel, Math. Comput. Simul., 156 (2019), 279-293.
[7]	K. M. Prasad, T. Sudha, A Mathematical Approach to Study the Blood Flow Through Stenosed Artery with Suspension of nanoparticles, in Numerical Heat Transfer and Fluid Flow, Springer, (2019), 193-202.
[8]	R. L. Hewlin, A. Ciero, J. P. Kizito, Development of a Two-Way Coupled Eulerian-Lagrangian Computational Magnetic Nanoparticle Targeting Model for Pulsatile Flow in a Patient-Specific Diseased Left Carotid Bifurcation Artery, Cardiovasc. Eng. Technol., 10 (2019), 299-313.
[9]	F. Campbell, F. L. Bos, S. Sieber, G. Arias-Alpizar, B. E. Koch, J. Huwyler, et al., Directing nanoparticle Biodistribution through Evasion and Exploitation of Stab2-Dependent Nanoparticle Uptake, ACS Nano, 12 (2018), 2138-2150. doi: 10.1021/acsnano.7b06995
[10]	V. Hamdipoor, M. R. Afzal, T. A. Le, J. Yoon, Haptic-Based Manipulation Scheme of Magnetic nanoparticles in a Multi-Branch Blood Vessel for Targeted Drug Delivery, Micromachines, 9 (2018), 14.
[11]	K. B. Johnsen, M. Bak, P. J. Kempen, F. Melander, A. Burkhart, M. S. Thomsen, et al., A antibody affinity and valency impact brain uptake of transferrin receptor-targeted gold nanoparticles, Theranostics, 8 (2018), 3416.
[12]	H. Ye, Z. Shen, L. Yu, M. Wei, Y. Li, Manipulating nanoparticle transport within blood flow through external forces: An exemplar of mechanics in nanomedicine, Proc. R. Soc. A, 474 (2018), 20170845.
[13]	W. Wicke, A. Ahmadzadeh, V. Jamali, H. Unterweger, C. Alexiou, R. Schober, Magnetic nanoparticle-Based Molecular Communication in Microfluidic Environments, IEEE Trans. NanoBioscience, 18 (2019), 156-169.
[14]	F. N. Dultsev, E. A. Kolosovsky, Identifying a single biological nano-sized particle using a quartz crystal microbalance. A mathematical model, Sens. Actuators B, 143 (2009), 17-24.
[15]	A. D. Polyanin, W. E. Schiesser, A. I. Zhurov, Partial differential equation, Scholarpedia, 3 (2008), 4605.
[16]	R. Selyanchyn, S. Wakamatsu, K. Hayashi, S. W. Lee, A nano-thin film-based prototype QCM sensor array for monitoring human breath and respiratory patterns, Sensors, 15 (2015), 18834-18850.

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