### Mathematical Biosciences and Engineering

2018, Issue 6: 1345-1385. doi: 10.3934/mbe.2018062

# EARLY AND LATE STAGE PROFILES FOR A CHEMOTAXIS MODEL WITH DENSITY-DEPENDENT JUMP PROBABILITY

• Received: 19 October 2017 Accepted: 24 July 2018 Published: 01 December 2018
• MSC : Primary: 35K51, 35K65; Secondary: 92C17

• In this paper, we derive a chemotaxis model with degenerate diffusion and density-dependent chemotactic sensitivity, and we provide a more realistic description of cell migration process for its early and late stages. Different from the existing studies focusing on the case of non-degenerate diffusion, this model with degenerate diffusion causes us some essential difficulty on the boundedness estimates and the propagation behavior of its compact support. In the presence of logistic damping, for the early stage before tumour cells spread to the whole domain, we first estimate the expanding speed of tumour region as $O(t^{β})$ for $0 \lt β \lt \frac{1}{2}$ . Then, for the late stage of cell migration, we further prove that the asymptotic profile of the original system is just its corresponding steady state. The global convergence of the original weak solution to the steady state with exponential rate $O(e^{-ct})$ for some $c \gt 0$ is also obtained.

Citation: Tianyuan Xu, Shanming Ji, Chunhua Jin, Ming Mei, Jingxue Yin. EARLY AND LATE STAGE PROFILES FOR A CHEMOTAXIS MODEL WITH DENSITY-DEPENDENT JUMP PROBABILITY[J]. Mathematical Biosciences and Engineering, 2018, 15(6): 1345-1385. doi: 10.3934/mbe.2018062

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• In this paper, we derive a chemotaxis model with degenerate diffusion and density-dependent chemotactic sensitivity, and we provide a more realistic description of cell migration process for its early and late stages. Different from the existing studies focusing on the case of non-degenerate diffusion, this model with degenerate diffusion causes us some essential difficulty on the boundedness estimates and the propagation behavior of its compact support. In the presence of logistic damping, for the early stage before tumour cells spread to the whole domain, we first estimate the expanding speed of tumour region as $O(t^{β})$ for $0 \lt β \lt \frac{1}{2}$ . Then, for the late stage of cell migration, we further prove that the asymptotic profile of the original system is just its corresponding steady state. The global convergence of the original weak solution to the steady state with exponential rate $O(e^{-ct})$ for some $c \gt 0$ is also obtained.

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沈阳化工大学材料科学与工程学院 沈阳 110142

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