
Artificial intelligence (AI) has played a major role in recent developments in healthcare, particularly in cancer diagnosis. This review investigated the dynamic role of AI in the detection of cancer and provides insights into the fundamental contributions of AI in the revolutionization of cancer detection methodologies, focusing on the role of AI in radiology and medical imaging and highlighting AI's advancements in enhancing accuracy and efficiency in identifying cancerous lesions. Furthermore, it explained the indispensable role of pathology and histopathology in cancer diagnosis, emphasizing AI's potential to augment traditional methods and improve diagnostic precision. Genomics and personalized medicine were explored as integral components of cancer detection, illustrating how AI facilitates tailored treatment strategies by analyzing vast genomic datasets. Additionally, the discussion encompassed clinical decision support systems, explaining their utility in aiding healthcare professionals with evidence-based insights for more informed decision-making in cancer detection and management. Finally, the review addressed the challenges and future directions in the integration of AI into cancer detection practices, highlighting the need for continued research and development to overcome existing limitations and realize the full potential of AI-driven solutions in combating cancer.
Citation: Praveen Kumar, Sakshi V. Izankar, Induni N. Weerarathna, David Raymond, Prateek Verma. The evolving landscape: Role of artificial intelligence in cancer detection[J]. AIMS Bioengineering, 2024, 11(2): 147-172. doi: 10.3934/bioeng.2024009
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Artificial intelligence (AI) has played a major role in recent developments in healthcare, particularly in cancer diagnosis. This review investigated the dynamic role of AI in the detection of cancer and provides insights into the fundamental contributions of AI in the revolutionization of cancer detection methodologies, focusing on the role of AI in radiology and medical imaging and highlighting AI's advancements in enhancing accuracy and efficiency in identifying cancerous lesions. Furthermore, it explained the indispensable role of pathology and histopathology in cancer diagnosis, emphasizing AI's potential to augment traditional methods and improve diagnostic precision. Genomics and personalized medicine were explored as integral components of cancer detection, illustrating how AI facilitates tailored treatment strategies by analyzing vast genomic datasets. Additionally, the discussion encompassed clinical decision support systems, explaining their utility in aiding healthcare professionals with evidence-based insights for more informed decision-making in cancer detection and management. Finally, the review addressed the challenges and future directions in the integration of AI into cancer detection practices, highlighting the need for continued research and development to overcome existing limitations and realize the full potential of AI-driven solutions in combating cancer.
Artificial intelligence;
World Health Organization;
Deep learning;
Machine learning;
Magnetic Resonance Imaging;
Computed Tomography;
K-nearest neighbors;
Support Vector Machine;
Convolutional neural network;
Neural network;
Generative adversarial network;
Position Emission Tomography;
Food and Drug Administration;
Computer-assisted diagnosis;
Full Field Digital Mammography;
Advanced intelligent Clear IQ Engine;
Filtered back projection;
Single-photon emission computed tomography;
Diffusion-weighted imaging
Since pioneering works of Pecora and Carroll's [1], chaos synchronization and control have turned a hot topic and received much attention in various research areas. A number of literatures shows that chaos synchronization can be widely used in physics, medicine, biology, quantum neuron and engineering science, particularly in secure communication and telecommunications [1,2,3]. In order to realize synchronization, experts have proposed lots of methods, including complete synchronization and Q-S synchronization [4,5], adaptive synchronization [6], lag synchronization[7,8], phase synchronization [9], observer-based synchronization [10], impulsive synchronization [11], generalized synchronization [12,13], lag projective synchronization [14,15], cascade synchronization et al [16,17,18,19,20]. Among them, the cascade synchronization method is a very effective algorithm, which is characterized by reproduction of signals in the original chaotic system to monitor the synchronized motions.
It is know that, because of the complexity of fractional differential equations, synchronization of fractional-order chaotic systems is more difficult but interesting than that of integer-order systems. Experts find that the key space can be enlarged by the regulating parameters in fractional-order chaotic systems, which enables the fractional-order chaotic system to be more suitable for the use of the encryption and control processing. Therefore, synchronization of fractional-order chaotic systems has gained increasing interests in recent decades [21,22,23,24,25,26,27,28,29,30,31]. It is noticed that most synchronization methods mentioned in [4,5,6,7,8,9,10,11,12,13,14,15,16,17,18,19,20] work for integer-order chaotic systems. Here, we shall extend to cascade synchronization for integer-order chaotic systems to a kind of general form, namely function cascade synchronization (FCS), which means that one chaotic system may be synchronized with another by sending a signal from one to the other wherein a scaling function is involved. The FCS is effective both for the fractional order and integer order chaotic systems. It constitutes a general method, which can be considered as a continuation and extension of earlier works of [13,16,19]. The nice feature of our method is that we introduce a scaling function for achieving synchronization of fractional-order chaotic systems, which can be chosen as a constant, trigonometric function, power function, logarithmic and exponential function, hyperbolic function and even combinations of them. Hence, our method is more general than some existing methods, such as the complete synchronization approach and anti-phase synchronization approach et al.
To sum up, in this paper, we would like to use the FCS approach proposed to study the synchronization of fractional-order chaotic systems. We begin our theoretical work with the Caputo fractional derivative. Then, we give the FCS of the fractional-order chaotic systems in theory. Subsequently, we take the fractional-order unified chaotic system as a concrete example to test the effectiveness of our method. Finally, we make a short conclusion.
As for the fractional derivative, there exists a lot of mathematical definitions [32,33]. Here, we shall only adopt the Caputo fractional calculus, which allows the traditional initial and boundary condition assumptions. The Caputo fractional calculus is described by
dqf(t)dtq=1Γ(q−n)∫t0f(n)(ξ)(t−ξ)q−n+1dξ,n−1<q<n. | (2.1) |
Here, we give the function cascade synchronization method to fractional-order chaotic systems. Take a fractional-order dynamical system:
dqxdtq=f(x)=Lx+N(x) | (2.2) |
as a drive system. In the above x=(x1,x2,x3)T is the state vector, f:R3→R3 is a continuous function, Lx and N(x) represent the linear and nonlinear part of f(x), respectively.
Firstly, on copying any two equations of (2.2), such as the first two, one will obtain a sub-response system:
dqydtq=L1y+N1(y,x3)+˜U | (2.3) |
with y=(X1,Z)T. In the above, x3 is a signal provided by (2.2), while ˜U=(u1,u2)T is a controller to be devised.
For the purpose of realizing the synchronization, we now define the error vector function via
˜e=y−˜Q(˜x)˜x | (2.4) |
where ˜e=(e1,e2)T, ˜x=(x1,x2)T and ˜Q(˜x)=diag(Q1(x1),Q2(x2)).
Definition 1. For the drive system (2.2) and response system (2.3), one can say that the synchronization is achieved with a scaling function matrix ˜Q(˜x) if there exists a suitable controller ˜U such that
limt→∞||˜e||=limt→∞||y−˜Q(˜x)˜x||=0. | (2.5) |
Remark 1. We would like to point out that one can have various different choices on the scaling function ˜Q(˜x), such as constant, power function, trigonometric function, hyperbola function, logarithmic and exponential function, as well as limited quantities of combinations and composite of the above functions. Particularly, when ˜Q(˜x)=I and −I (I being a unit matrix), the problem is reducible to the complete synchronization and anti-phase synchronization of fractional-order chaotic systems, respectively. When ˜Q(˜x)=αI, it becomes to the project synchronization. And when ˜Q(˜x) = diag(α1,α2), it turns to the modified projective synchronization. Hence, our method is more general than the existing methods in [4,13].
It is noticed from (2.5) that the system (2.3) will synchronize with (2.2) if and only if the error dynamical system (2.5) is stable at zero. For this purpose, an appropriate controller ˜U such that (2.5) is asymptotical convergent to zero is designed, which is described in the following theorem.
Theorem 1. For a scaling function matrix ˜Q(˜x), the FCS will happen between (2.2) and (2.3) if the conditions:
(i) the controller ˜U is devised by
˜U=˜K˜e−N1(y,x3)+˜Q(˜x)N1(˜x)+˜P(˜x)˜x | (2.6) |
(ii) the matrix ˜K is a 2×2 matrix such that
L1+˜K=−˜C, | (2.7) |
are satisfied simultaneously. In the above, ˜P(˜x)=diag(˙Q1(x1)dqx1dtq,˙Q2(x2)dqx2dtq), ˜K is a 2×2 function matrix to be designed. While ˜C=(˜Cij) is a 2×2 function matrix wherein
˜Cii>0and˜Cij=−˜Cji,i≠j. | (2.8) |
Remark 2. It needs to point out that the construction of the suitable controller ˜U plays an important role in realizing the synchronization between (2.2) and (2.3). Theorem 2 provides an effective way to design the controller. It is seen from the theorem that the controller ˜U is closely related to the matrix ˜C. Once the condition (2.8) is satisfied, one will has many choices on the controller ˜U.
Remark 3. Based on the fact that the fractional orders themselves are varying parameters and can be applied as secret keys when the synchronization algorithm is adopted in secure communications, it is believed that our method will be more suitable for some engineering applications, such as chaos-based encryption and secure communication.
Proof: Let's turn back to the error function given in (2.4). Differentiating this equation with respect to t and on use of the first two equations of (2.2) and (2.3), one will obtain the following dynamical system
dq˜edtq=dqydtq−˜Q(˜x)dqxdtq−˜P(˜x)˜x=L1y+N1(y,x3)+˜U−˜Q(˜x)[L1˜x+N1(˜x)]−˜P(˜x)˜x=L1˜e+N1(y,x3)−˜Q(˜x)N1(˜x)−˜P(˜x)˜x+˜K˜e−N1(y,x3)+˜Q(˜x)N1(˜x)+˜P(˜x)˜x=(L1+˜K)˜e. | (2.9) |
Assuming that λ is an arbitrary eigenvalue of matrix L1+˜K and its eigenvector is recorded as η, i.e.
(L1+˜K)η=λη,η≠0. | (2.10) |
On multiplying (2.10) by ηH on the left, we obtain that
ηH(L1+˜K)η=ληHη | (2.11) |
where H denotes conjugate transpose. Since ˉλ is also an eigenvalue of L1+˜K, we have that
ηH(L1+˜K)H=ˉληH. | (2.12) |
On multiplying (2.12) by η on the right, we derive that
ηH(L1+˜K)Hη=ˉληHη | (2.13) |
From (2.11) and (2.13), one can easily get that
λ+ˉλ=ηH[(L1+˜K)H+(L1+˜K)]η/ηHη=−ηH(˜C+˜CH)η/ηHη=−ηHΛη/ηHη | (2.14) |
with Λ=˜C+˜CH. Since ˜C satisfy the condition (2.8), one can know that Λ denotes a real positive diagonal matrix. Thus we have ηHΛη>0. Accordingly, we can get
λ+ˉλ=2Re(λ)=−ηHΛη/ηHη<0, | (2.15) |
which shows
|argλ|>π2>qπ2. | (2.16) |
According to the stability theorem in Ref. [34], the error dynamical system (2.9) is asymptotically stable, i.e.
limt→∞||˜e||=limt→∞||y−˜Q(˜x)˜x||=0, | (2.17) |
which implies that synchronization can be achieved between (2.2) and (2.3). The proof is completed.
Next, on copying the last two equations of (2.2), one will get another sub-response system:
dqzdtq=L2z+N2(z,X1)+ˉU | (2.18) |
where X1 is a synchronized variable in (2.3), z=(X2,X3)T and ˉU=(u3,u4)T is the controller being designed.
Here, we make analysis analogous to the above. Now we define the error ˉe via
˜e=z−ˉQ(ˉx)ˉx | (2.19) |
where ˉe=(e3,e4)T, ˉx=(x2,x3)T and ˉQ(ˉx)=diag(Q3(x2),Q4(x3)). If devising the the controller ˉU as
ˉU=ˉKˉe−N2(z,X1)+ˉQ(ˉx)N2(ˉx)+ˉP(ˉx)ˉx | (2.20) |
and L2+ˉK satisfying
L2+ˉK=−ˉC | (2.21) |
where ˉP(ˉx)=diag(˙Q3(x2)dqx2dtq,˙Q4(x3)dqx3dtq), ˉC=(ˉCij) denotes a 2×2 function matrix satisfying
ˉCii>0andˉCij=−ˉCji,i≠j, | (2.22) |
then the error dynamical system (2.19) satisfies
limt→∞||ˉe||=limt→∞||z−ˉQ(ˉx)ˉx||=0. | (2.23) |
Therefore, one achieve the synchronization between the system (2.2) and (2.18). Accordingly, from (2.5) and (2.23), one can obtain that
{limt→∞||X1−Q1(x1)x1||=0,limt→∞||X2−Q3(x2)x2||=0,limt→∞||X3−Q4(x3)x3||=0. | (2.24) |
which indicates the FCS is achieved for the fractional order chaotic systems.
In the sequel, we shall extend the applications of FCS approach to the fractional-order unified chaotic system to test the effectiveness.
The fractional-order unified chaotic system is described by:
{dqx1dtq=(25a+10)(x2−x1),dqx2dtq=(28−35a)x1−x1x3+(29a−1)x2,dqx3dtq=x1x2−a+83x3, | (3.1) |
where xi,(i=1,2,3) are the state parameters and a∈[0,1] is the control parameter. It is know that when 0≤a<0.8, the system (3.1) corresponds to the fractional-order Lorenz system [35]; when a=0.8, it is the Lü system [36]; while when 0.8<a<1, it turns to the Chen system [37].
According to the FCS method in section 2, we take (3.1) as the drive system. On copying the first two equation, we get a sub-response system of (3.1):
{dqX1dtq=(25a+10)(Z−X1)+u1,dqZdtq=(28−35a)X1−Zx3+(29a−1)Z+u2, | (3.2) |
where ˜U=(u1,u2)T is a controller to be determined. In the following, we need to devise the desired controller ˜U such that (3.1) can be synchronized with (3.2). For this purpose, we set the error function ˜e=(e1,e2) via :
˜e=(e1,e2)=(X1−x1(x21+α1),Z−x2tanhx2). | (3.3) |
On devising the controller ˜U as (2.6), one can get that the error dynamical system is
dq˜edtq=(L1+˜K)˜e, | (3.4) |
where
L1=(−10−25a−10−25a28−35a29a−1),N1(y,x3)=(0−X1x3). | (3.5) |
If choosing, for example, the matrix ˜K as
˜K=(−λ1+25a+10x1+x1x2−25a−x1−x1x2+35a−38−λ2−29a+1), | (3.6) |
where λ1>0 and λ2>0, then one can obtain that
˜C=(−λ1x1+x1x2+10−x1−x1x2−10−λ2). | (3.7) |
Therefore the dynamical system (3.4) becomes
dq˜edtq=(−λ1x1+x1x2−x1−x1x2−λ2)˜e. | (3.8) |
According to Theorem 2, the synchronization is realized in the system (3.1) and (3.2).
Subsequently, on copying the last two equations of (3.1), we get another sub-response system:
{∂qX2∂tq=(28−35a)X1−X1X3+(29a−1)X2+u3,∂qX3∂tq=X1X2−a+83X3+u4, | (3.9) |
where ˉU=(u3, u4)T is the controller needed. When choosing the error function ˉe=(e3,e4) as:
ˉe=(e3,e4)=(X2−α2x2,X3−x3(α3+e−x3)), | (3.10) |
and the controller ˉU as (2.20), where
L2=(29a−100−a+83),N2(z,X1)=(−X1X3X1X2), | (3.11) |
and the matrix ˉK is chosen by
ˉK=(−λ3−29a+11+x2x3+e−x3−1−x2x3−e−x3−λ4−a+83), | (3.12) |
where λ3>0 and λ4>0. Calculations show that the error dynamical system (2.19) becomes
dqˉedtq=(−λ31+x2x3+e−x3−1−x2x3−e−x3−λ4)ˉe. | (3.13) |
which, according to the stability theorem, indicates that ˉe will approach to zero with time evolutions. Therefore, the FCS is realized for the fractional-order unified chaotic system.
In the above, we have revealed that the FCS is achieved for the fractional-order unified chaotic system in theory. In the sequel, we shall show that the FCS is also effective in the numerical algorithm.
For illustration, we set the fractional order q=0.98 and the parameters λi(i=1,⋯,4) as (λ1,λ2,λ3,λ4)=(2,3,0.5,0.3). It is noticed that when the value of a∈[0,1] is given, the system (3.1) will be reduced to a concrete system. For example, when a=0.2, it corresponds to the fractional-order Lorenz system. The chaotic attractors are depicted in Figure 1. Time responses of states variables and synchronization errors of the Lorenz system are showed in Figures 2 and 3, respectively. When a=0.8, it is the fractional-order Lü system. The chaotic attractors, time responses of state variables and synchronization errors are exhibited in Figures 4–6, respectively. When a=0.95, it turns to the fractional-order Chen system. Numerical simulation results are depicted in Figures 7–9. From the chaotic attractors pictures marked by Figures 1, 4 and 5, one can easily see that the trajectories of the response system (colored red) display certain consistency to that of the drive system (colored black) because of the special scaling functions chosen. Meanwhile, one can also see the synchronization is realized from Figures 3, 6 and 9. Therefore, we conclude that the FCS is a very effective algorithm for achieving the synchronization of the fractional-order unified chaotic system.
Chaos synchronization, because of the potential applications in telecommunications, control theory, secure communication et al, has attracted great attentions from various research fields. In the present work, via the stability theorem, we successfully extend the cascade synchronization of integer-order chaotic systems to a kind of general function cascade synchronization algorithm for fractional-order chaotic systems. Meanwhile, we apply the method to the fractional-order unified chaotic system for an illustrative test. Corresponding numerical simulations fully reveal that our method is not only accuracy, but also effective.
It is worthy of pointing out that the scaling function introduced makes the method more general than the complete synchronization, anti-phase synchronization, modified projective synchronization et al. Therefore, in this sense, our method is applicable and representative. However, the present work just study the fractional-order chaotic system without time-delay. It is known that in many cases the time delay is inevitably in the real engineering applications. Lag synchronization seems to be more practical and reasonable. Hence, it will be of importance and interest to study whether the FCS method can be used to realize the synchronization of fractional-order chaotic systems with time-delay. We shall considered it in our future work.
The authors would like to express their sincere thanks to the referees for their kind comments and valuable suggestions. This work is supported by the National Natural Science Foundation of China under grant No.11775116 and No.11301269.
We declare that we have no conflict of interests.
[1] | Report of National Cancer. ICMR NCDIR 2024 . Available from: https://www.ncdirindia.org/All_Reports/Report_2020/default.aspx |
[2] | Cancer Case. WHO, 2024 . Available from: https://www.who.int/news-room/fact-sheets/detail/cancer |
[3] |
Esteva A, Kuprel B, Novoa RA, et al. (2017) Dermatologist-level classification of skin cancer with deep neural networks. Nature 542: 115-118. https://doi.org/10.1038/nature21056 ![]() |
[4] |
Coudray N, Ocampo PS, Sakellaropoulos T, et al. (2018) Classification and mutation prediction from non-small cell lung cancer histopathology images using deep learning. Nat Med 24: 1559-1567. https://doi.org/10.1038/s41591-018-0177-5 ![]() |
[5] |
Bai B, Yang X, Li Y, et al. (2023) Deep learning-enabled virtual histological staining of biological samples. Light Sci Appl 12: 57. https://doi.org/10.1038/s41377-023-01104-7 ![]() |
[6] | Mathur P, Mummadi SR, Khanna A, et al. (2020) 2019 Year in review: Machine learning in healthcare. Team BrainX BrainX Community . https://doi.org/10.13140/RG.2.2.34310.52800 |
[7] |
Kim G, Bahl M (2021) Assessing risk of breast cancer: A review of risk prediction models. J Breast Imaging 3: 144-155. https://doi.org/10.1093/jbi/wbab001 ![]() |
[8] |
Huang S, Yang J, Fong S, et al. (2020) Artificial intelligence in cancer diagnosis and prognosis: Opportunities and challenges. Cancer Lett 471: 61-71. https://doi.org/10.1016/j.canlet.2019.12.007 ![]() |
[9] | Sadoughi F, Kazemy Z, Hamedan F, et al. (2018) Artificial intelligence methods for the diagnosis of breast cancer by image processing: a review. Breast Cancer 10: 219-230. https://doi.org/10.2147/BCTT.S175311 |
[10] |
Sheth D, Giger ML (2020) Artificial intelligence in the interpretation of breast cancer on MRI. J Magn Reson Imaging 51: 1310-1324. https://doi.org/10.1002/jmri.26878 ![]() |
[11] |
Houssami N, Kirkpatrick-Jones G, Noguchi N, et al. (2019) Artificial intelligence (AI) for the early detection of breast cancer: A scoping review to assess AI's potential in breast screening practice. Expert Rev Med Devices 16: 351-362. https://doi.org/10.1080/17434440.2019.1610387 ![]() |
[12] |
Goldenberg SL, Nir G, Salcudean SE (2019) A new era: Artificial intelligence and machine learning in prostate cancer. Nat Rev Urol 16: 391-403. https://doi.org/10.1038/s41585-019-0193-3 ![]() |
[13] |
Medina MA, Oza G, Sharma A, et al. (2020) Triple-Negative breast cancer: A review of conventional and advanced therapeutic strategies. Int J Environ Res Public Health 17: 2078. https://doi.org/10.3390/ijerph17062078 ![]() |
[14] |
Koh DM, Papanikolaou N, Bick U, et al. (2022) Artificial intelligence and machine learning in cancer imaging. Commun Med 2: 133. https://doi.org/10.1038/s43856-022-00199-0 ![]() |
[15] |
Bhinder B, Gilvary C, Madhukar NS, et al. (2021) Artificial intelligence in cancer research and precision medicine. Cancer Discov 11: 900-915. https://doi.org/10.1158/2159-8290.CD-21-0090 ![]() |
[16] |
Corti C, Cobanaj M, Dee EC, et al. (2023) Artificial intelligence in cancer research and precision medicine: Applications, limitations and priorities to drive transformation in the delivery of equitable and unbiased care. Cancer Treat Rev 112: 102498. https://doi.org/10.1016/j.ctrv.2022.102498 ![]() |
[17] |
Rezaei SR, Ahmadi A (2023) A hierarchical GAN method with ensemble CNN for accurate nodule detection. Int J Comput Assist Radiol Surg 18: 695-705. https://doi.org/10.1007/s11548-022-02807-9 ![]() |
[18] |
Alruily M, Said W, Mostafa AM, et al. (2023) Breast ultrasound images augmentation and segmentation using GAN with identity block and modified U-Net 3. Sensors 23: 8599. https://doi.org/10.3390/s23208599 ![]() |
[19] | Shams S, Platania R, Zhang J, et al. (2018) Deep generative breast cancer screening and diagnosis. Medical Image Computing and Computer Assisted Intervention–MICCAI 2018 : 859-867. https://doi.org/10.1007/978-3-030-00934-2_95 |
[20] |
Luchini C, Pea A, Scarpa A (2022) Artificial intelligence in oncology: Current applications and future perspectives. Br J Cancer 126: 4-9. https://doi.org/10.1038/s41416-021-01633-1 ![]() |
[21] |
Nabulsi Z, Sellergren A, Jamshy S, et al. (2021) Deep learning for distinguishing normal versus abnormal chest radiographs and generalization to two unseen diseases tuberculosis and COVID-19. Sci Rep 11: 15523. https://doi.org/10.1038/s41598-021-93967-2 ![]() |
[22] |
Rajpurkar P, Irvin J, Ball RL, et al. (2018) Deep learning for chest radiograph diagnosis: A retrospective comparison of the CheXNeXt algorithm to practicing radiologists. PLoS Med 15: e1002686. https://doi.org/10.1371/journal.pmed.1002686 ![]() |
[23] |
Liang CH, Liu YC, Wu MT, et al. (2020) Identifying pulmonary nodules or masses on chest radiography using deep learning: External validation and strategies to improve clinical practice. Clin Radiol 75: 38-45. https://doi.org/10.1016/j.crad.2019.08.005 ![]() |
[24] |
Nayak SR, Nayak DR, Sinha U, et al. (2021) Application of deep learning techniques for detection of COVID-19 cases using chest X-ray images: A comprehensive study. Biomed Signal Proces 64: 102365. https://doi.org/10.1016/j.bspc.2020.102365 ![]() |
[25] |
Topol EJ (2019) High-performance medicine: the convergence of human and artificial intelligence. Nat Med 25: 44-56. https://doi.org/10.1038/s41591-018-0300-7 ![]() |
[26] | Shimron E, Perlman O (2023) AI in MRI: Computational frameworks for a faster, optimized, and automated imaging workflow. Bioeng 10: 492. https://doi.org/10.3390/bioengineering10040492 |
[27] | Zou J, Li C, Jia S, et al. (2022) SelfCoLearn: Self-supervised collaborative learning for accelerating dynamic MR imaging. Bioeng 9: 650. https://doi.org/10.3390/bioengineering9110650 |
[28] |
Artesani A, Bruno A, Gelardi F, et al. (2024) Empowering PET: Harnessing deep learning for improved clinical insight. Eur Radiol Exp 8: 17. https://doi.org/10.1186/s41747-023-00413-1 ![]() |
[29] |
Hammernik K, Klatzer T, Kobler E, et al. (2018) Learning a variational network for reconstruction of accelerated MRI data. Magn Reson Med 79: 3055-3071. https://doi.org/10.1002/mrm.26977 ![]() |
[30] | Ronneberger O, Fischer P, Brox T (2015) U-net: Convolutional networks for biomedical image segmentation. Medical Image Computing and Computer-Assisted Intervention–MICCAI 2015: 18th International Conference : 234-241. https://doi.org/10.48550/arXiv.1505.04597 |
[31] |
Malik H, Anees T, Din M, et al. (2023) CDC_Net: Multi-classification convolutional neural network model for detection of COVID-19, pneumothorax, pneumonia, lung cancer, and tuberculosis using chest X-rays. Multimed Tools Appl 82: 13855-13880. https://doi.org/10.1007/s11042-022-13843-7 ![]() |
[32] |
Miwa S, Otsuka T (2017) Practical use of imaging technique for management of bone and soft tissue tumors. J Orthop Sci 22: 391-400. https://doi.org/10.1016/j.jos.2017.01.006 ![]() |
[33] |
Aisen AM, Martel W, Braunstein EM, et al. (1986) MRI and CT evaluation of primary bone and soft-tissue tumors. Am J Roentgenol 146: 749-756. https://doi.org/10.2214/ajr.146.4.749 ![]() |
[34] |
Siegel MJ (2001) Magnetic resonance imaging of musculoskeletal soft tissue masses. Radiol Clin N Am 39: 701-720. https://doi.org/10.1016/s0033-8389(05)70306-7 ![]() |
[35] |
Fischerova D (2011) Ultrasound scanning of the pelvis and abdomen for staging of gynecological tumors: A review. Ultrasound Obst Gyn 38: 246-266. https://doi.org/10.1002/uog.10054 ![]() |
[36] |
Czernin J, Phelps ME (2002) Positron emission tomography scanning: current and future applications. Annu Rev Med 53: 89-112. https://doi.org/10.1146/annurev.med.53.082901.104028 ![]() |
[37] |
Keown GA, Jayaraman S, Davidson J (2020) Metastatic osseous disease masquerading as infection, diagnosed on bone scintigraphy and SPECT/CT. J Nucl Med Technol 48: 179-180. https://doi.org/10.2967/jnmt.119.232850 ![]() |
[38] |
Manca G, Rubello D, Tardelli E, et al. (2016) Sentinel lymph node biopsy in breast cancer: Indications, contraindications, and controversies. Clin Nucl Med 41: 126-133. https://doi.org/10.1097/RLU.0000000000000985 ![]() |
[39] |
Petousis S, Christidis P, Margioula-Siarkou C, et al. (2022) Axillary lymph node dissection vs. sentinel node biopsy for early-stage clinically node-negative breast cancer: A systematic review and meta-analysis. Arch Gynecol Obstet 306: 1221-1234. https://doi.org/10.1007/s00404-022-06458-8 ![]() |
[40] |
Pisano ED, Gatsonis C, Hendrick E, et al. (2005) Diagnostic performance of digital versus film mammography for breast-cancer screening. N Engl J Med 353: 1773-1783. https://doi.org/10.1056/NEJMoa052911 ![]() |
[41] | Screening P, Board PE, PDQ® Cancer Information Summaries: Screening/Detection (Testing for Cancer). National Cancer Institute (US), 2023 . Available from: https://www.cancer.gov/publications/pdq/information-summaries/screening |
[42] |
Arora N, Martins D, Ruggerio D, et al. (2008) Effectiveness of a noninvasive digital infrared thermal imaging system in the detection of breast cancer. Am J Surg 196: 523-526. https://doi.org/10.1016/j.amjsurg.2008.06.015 ![]() |
[43] | Kumar V, Abbas AK, Fausto N, et al. (2014) Robbins and Cotran Pathologic Basis of Disease, Professional Edition E-Book. Amsterdam: Elsevier. |
[44] | Mills S (2006) Histology for Pathologists. Philadelphia: Wolters Kluwer. https://doi.org/10.1001/jama.297.14.1602-a |
[45] |
Coleman RE (2001) Metastatic bone disease: Clinical features, pathophysiology and treatment strategies. Cancer Treat Rev 27: 165-176. https://doi.org/10.1053/ctrv.2000.0210 ![]() |
[46] |
Jin Y, Van Nostrand D, Cheng L, et al. (2018) Radioiodine refractory differentiated thyroid cancer. Crit Rev Oncol Hemat 125: 111-120. https://doi.org/10.1016/j.critrevonc.2018.03.012 ![]() |
[47] |
Brose MS, Smit J, Capdevila J, et al. (2012) Regional approaches to the management of patients with advanced, radioactive iodine-refractory differentiated thyroid carcinoma. Expert Rev Anticanc 12: 1137-1147. https://doi.org/10.1586/era.12.96 ![]() |
[48] |
Strosberg J, El-Haddad G, Wolin E, et al. (2017) Phase 3 trial of 177lu-dotatate for midgut neuroendocrine tumors. N Engl J Med 376: 125-135. https://doi.org/10.1056/NEJMoa1607427 ![]() |
[49] |
Kim I, Kang K, Song Y, et al. (2022) Application of artificial intelligence in pathology: Trends and challenges. Diagnostics 12: 2794. https://doi.org/10.3390/diagnostics12112794 ![]() |
[50] | Zhang D, Schroeder A, Yan H, et al. (2024) Inferring super-resolution tissue architecture by integrating spatial transcriptomics with histology. Nat Biotechnol : 1-6. https://doi.org/10.1038/s41587-023-02019-9 |
[51] |
Schubert JM, Bird B, Papamarkakis K, et al. (2010) Spectral cytopathology of cervical samples: Detecting cellular abnormalities in cytologically normal cells. Lab Invest 90: 1068-1077. https://doi.org/10.1038/labinvest.2010.72 ![]() |
[52] |
Das S, Dey MK, Devireddy R, et al. (2023) Biomarkers in cancer detection, diagnosis, and prognosis. Sensors-Basel 24: 37. https://doi.org/10.3390/s24010037 ![]() |
[53] |
Vora LK, Gholap AD, Jetha K, et al. (2023) Artificial intelligence in pharmaceutical technology and drug delivery design. Pharmaceutics 15: 1916. https://doi.org/10.3390/pharmaceutics15071916 ![]() |
[54] |
Xu J, Yang P, Xue S, et al. (2019) Translating cancer genomics into precision medicine with artificial intelligence: Applications, challenges and future perspectives. Hum Genet 138: 109-124. https://doi.org/10.1007/s00439-019-01970-5 ![]() |
[55] |
Williams AM, Liu Y, Regner KR, et al. (2018) Artificial intelligence, physiological genomics, and precision medicine. Physiol Genomics 50: 237-243. https://doi.org/10.1152/physiolgenomics.00119.2017 ![]() |
[56] |
Suwinski P, Ong C, Ling MHT, et al. (2019) Advancing personalized medicine through the application of whole exome sequencing and big data analytics. Front Genet 10: 49. https://doi.org/10.3389/fgene.2019.00049 ![]() |
[57] |
Quazi S (2022) Artificial intelligence and machine learning in precision and genomic medicine. Med Oncol 39: 120. https://doi.org/10.1007/s12032-022-01711-1 ![]() |
[58] |
Johnson KB, Wei WQ, Weeraratne D, et al. (2021) Precision medicine, AI, and the future of personalized health care. Clin Transl Sci 14: 86-93. https://doi.org/10.1111/cts.12884 ![]() |
[59] |
Zheng D, Xia K, Yu L, et al. (2021) A novel six metastasis-related prognostic gene signature for patients with osteosarcoma. Front Cell Dev Biol 9: 699212. https://doi.org/10.3389/fcell.2021.699212 ![]() |
[60] |
Zuo D, Xiao J, An H, et al. (2022) Screening for lipid-metabolism-related genes and identifying the diagnostic potential of ANGPTL6 for HBV-related early-stage hepatocellular carcinoma. Biomolecules 12: 1700. https://doi.org/10.3390/biom12111700 ![]() |
[61] |
Geeleher P, Cox NJ, Huang RS (2014) Clinical drug response can be predicted using baseline gene expression levels and in vitro drug sensitivity in cell lines. Genome Biol 15: R47. https://doi.org/10.1186/gb-2014-15-3-r47 ![]() |
[62] |
Wang D, Wang J, Lu M, et al. (2010) Inferring the human microRNA functional similarity and functional network based on microRNA-associated diseases. Bioinformatics 26: 1644-1650. https://doi.org/10.1093/bioinformatics/btq241 ![]() |
[63] |
Zhan C, Tang T, Wu E, et al. (2023) From multi-omics approaches to personalized medicine in myocardial infarction. Front Cardiovasc Med 10: 1250340. https://doi.org/10.3389/fcvm.2023 ![]() |
[64] |
Oldoni E, Saunders G, Bietrix F, et al. (2022) Tackling the translational challenges of multi-omics research in the realm of European personalised medicine: A workshop report. Front Mol Biosci 9: 974799. https://doi.org/10.3389/fmolb.2022.974799 ![]() |
[65] |
Liu S, Wright AP, Patterson BL, et al. (2023) Using AI-generated suggestions from ChatGPT to optimize clinical decision support. J Am Med Inform Assoc 30: 1237-1245. https://doi.org/10.1093/jamia/ocad072 ![]() |
[66] |
Magrabi F, Ammenwerth E, McNair JB, et al. (2019) Artificial intelligence in clinical decision support: Challenges for evaluating AI and practical implications. Yearb Med Inform 28: 128-134. https://doi.org/10.1055/s-0039-1677903 ![]() |
[67] |
Amann J, Vetter D, Blomberg SN, et al. (2022) To explain or not to explain?—Artificial intelligence explainability in clinical decision support systems. PLOS Digit Health 1: e0000016. https://doi.org/10.1371/journal.pdig.0000016 ![]() |
[68] |
McKinney SM, Sieniek M, Godbole V, et al. (2020) International evaluation of an AI system for breast cancer screening. Nature 577: 89-94. https://doi.org/10.1038/s41586-019-1799-6 ![]() |
[69] | Rana M, Bhushan M (2022) Machine learning and deep learning approach for medical image analysis: Diagnosis to detection. Multimed Tools Appl 24: 1-39. https://doi.org/10.1007/s11042-022-14305-w |
[70] |
Peng ZW, Zhang YJ, Liang HH, et al. (2012) Recurrent hepatocellular carcinoma treated with sequential transcatheter arterial chemoembolization and RF ablation versus RF ablation alone: A prospective randomized trial. Radiology 262: 689-700. https://doi.org/10.1148/radiol.11110637 ![]() |
[71] |
Dembrower K, Crippa A, Colón E, et al. (2023) Artificial intelligence for breast cancer detection in screening mammography in Sweden: A prospective, population-based, paired-reader, non-inferiority study. Lancet Digit Health 5: e703-e711. https://doi.org/10.1016/S2589-7500(23)00153-X ![]() |
[72] |
Fan BE, Yong BSJ, Li R, et al. (2021) From microscope to micropixels: A rapid review of artificial intelligence for the peripheral blood film. Blood Rev 64: 101144. https://doi.org/10.1016/j.blre.2023.101144 ![]() |
[73] |
Panayides AS, Amini A, Filipovic ND, et al. (2020) AI in medical imaging informatics: Current challenges and future directions. IEEE J Biomed Health 24: 1837-1857. https://doi.org/10.1109/JBHI.2020.2991043 ![]() |
[74] |
Melarkode N, Srinivasan K, Qaisar SM, et al. (2023) AI-Powered diagnosis of skin cancer: A contemporary review, open challenges and future research directions. Cancers 15: 1183. https://doi.org/10.3390/cancers15041183 ![]() |
[75] |
Sharma S, Rawal R, Shah D (2023) Addressing the challenges of AI-based telemedicine: Best practices and lessons learned. J Educ Health Promot 12: 338. https://doi.org/10.4103/jehp.jehp_402_23 ![]() |
[76] |
Uzun Ozsahin D, Ikechukwu Emegano D, Uzun B, et al. (2022) The systematic review of artificial intelligence applications in breast cancer diagnosis. Diagnostics 13: 45. https://doi.org/10.3390/diagnostics13010045 ![]() |
[77] |
Mittermaier M, Raza MM, Kvedar JC (2023) Bias in AI-based models for medical applications: Challenges and mitigation strategies. NPJ Digit Med 6: 113. https://doi.org/10.1038/s41746-023-00858-z ![]() |
[78] |
van de Sande D, Van Genderen ME, Smit JM, et al. (2022) Developing, implementing and governing artificial intelligence in medicine: A step-by-step approach to prevent an artificial intelligence winter. BMJ Health Care Inform 29: e100495. https://doi.org/10.1136/bmjhci-2021-100495 ![]() |
[79] |
Sebastian AM, Peter D (2022) Artificial intelligence in cancer research: Trends, challenges and future directions. Life-Basel 12: 1991. https://doi.org/10.3390/life12121991 ![]() |
[80] |
Du Y, Rafferty AR, McAuliffe FM, et al. (2022) An explainable machine learning-based clinical decision support system for prediction of gestational diabetes mellitus. Sci Rep 12: 1170. https://doi.org/10.1038/s41598-022-05112-2 ![]() |
[81] |
Dixit S, Kumar A, Srinivasan K (2023) A current review of machine learning and deep learning models in oral cancer diagnosis: Recent technologies, open challenges, and future research directions. Diagnostics 13: 1353. https://doi.org/10.3390/diagnostics13071353 ![]() |
[82] | Weerarathna IN, Kamble AR, Luharia A (2023) Artificial intelligence applications for biomedical cancer research: A review. Cureus 15: e48307. https://doi.org/10.7759/cureus.48307 |
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