Review

Olive pomace bioactives for functional foods and cosmetics

  • Received: 04 March 2024 Revised: 03 June 2024 Accepted: 04 June 2024 Published: 21 June 2024
  • The reuse and valorization of olive mill by-products, among others, is getting attention in the food and drugs-cosmetics sectors, due the recovery of their essential bioactive compounds in order to incorporate them as ingredients in functional foods, cosmetics, and pharmaceuticals. Olive pomace represents olive mill's main residue (by-product), and it is a sustainable and of low-cost renewable source of several bioactive compounds, while its valorization can reduce its environmental impact and make it an additional economic resource for food industries in a circular economy design. In this article, the natural bio-functional compounds of olive pomace with antioxidant and anti-inflammatory bioactivities are thoroughly reviewed. The incorporation of such bioactives as ingredients in functional foods and cosmetics is also discussed in detail. The limitations of such applications are also presented. Thus, promising techniques, such as encapsulation, and their applications for stabilizing and masking undesirable characteristics of such compounds, are also exhibited. The so far promising in vitro outcomes seem to support further in vivo assessment in trials-based setting.

    Citation: Alexandros Tsoupras, Eirini Panagopoulou, George Z. Kyzas. Olive pomace bioactives for functional foods and cosmetics[J]. AIMS Agriculture and Food, 2024, 9(3): 743-766. doi: 10.3934/agrfood.2024040

    Related Papers:

  • The reuse and valorization of olive mill by-products, among others, is getting attention in the food and drugs-cosmetics sectors, due the recovery of their essential bioactive compounds in order to incorporate them as ingredients in functional foods, cosmetics, and pharmaceuticals. Olive pomace represents olive mill's main residue (by-product), and it is a sustainable and of low-cost renewable source of several bioactive compounds, while its valorization can reduce its environmental impact and make it an additional economic resource for food industries in a circular economy design. In this article, the natural bio-functional compounds of olive pomace with antioxidant and anti-inflammatory bioactivities are thoroughly reviewed. The incorporation of such bioactives as ingredients in functional foods and cosmetics is also discussed in detail. The limitations of such applications are also presented. Thus, promising techniques, such as encapsulation, and their applications for stabilizing and masking undesirable characteristics of such compounds, are also exhibited. The so far promising in vitro outcomes seem to support further in vivo assessment in trials-based setting.


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    [1] Goldsmith CD, Vuong QV, Stathopoulos CE, et al. (2018) Ultrasound increases the aqueous extraction of phenolic compounds with high antioxidant activity from olive pomace. LWT 89: 284–290. https://doi.org/10.1016/j.lwt.2017.10.065 doi: 10.1016/j.lwt.2017.10.065
    [2] Dermeche S, Nadour M, Larroche C, et al. (2013) Olive mill wastes: Biochemical characterizations and valorization strategies. Process Biochem 48: 1532–1552. https://doi.org/10.1016/j.procbio.2013.07.010 doi: 10.1016/j.procbio.2013.07.010
    [3] Aliakbarian B, Casazza AA, Perego P (2011) Valorization of olive oil solid waste using high pressure–high temperature reactor. Food Chem 128: 704–710. https://doi.org/10.1016/j.foodchem.2011.03.092 doi: 10.1016/j.foodchem.2011.03.092
    [4] Difonzo G, Vollmer K, Caponio F, et al. (2019) Characterisation and classification of pineapple (Ananas comosus[L.] Merr.) juice from pulp and peel. Food Control 96: 260–270. https://doi.org/10.1016/j.foodcont.2018.09.015 doi: 10.1016/j.foodcont.2018.09.015
    [5] Galanakis CM (2022) Sustainable applications for the valorization of cereal processing by-products. Foods 11: 241. https://doi.org/10.3390/foods11020241 doi: 10.3390/foods11020241
    [6] Jimenez-Lopez C, Carpena M, Lourenço-Lopes C, et al. (2020) Bioactive compounds and quality of extra virgin olive oil. Foods 9: 1014. https://doi.org/10.3390/foods9081014 doi: 10.3390/foods9081014
    [7] Roig A, Cayuela ML, Sánchez-Monedero M (2006) An overview on olive mill wastes and their valorisation methods. Waste Manage 26: 960–969. https://doi.org/10.1016/j.wasman.2005.07.024 doi: 10.1016/j.wasman.2005.07.024
    [8] Banias G, Achillas C, Vlachokostas C, et al. (2017) Environmental impacts in the life cycle of olive oil: A literature review. J Sci Food Agric 97: 1686–1697. https://doi.org/10.1002/jsfa.8143 doi: 10.1002/jsfa.8143
    [9] Romani A, Pinelli P, Ieri F, et al. (2016) Sustainability, innovation, and green chemistry in the production and valorization of phenolic extracts from Olea europaea L. Sustainability 8: 1002. https://doi.org/10.3390/su8101002 doi: 10.3390/su8101002
    [10] Schieber A, Stintzing FC, Carle R (2001) By-products of plant food processing as a source of functional compounds—Recent developments. Trends Food Sci Technol 12: 401–413. https://doi.org/10.1016/S0924-2244(02)00012-2 doi: 10.1016/S0924-2244(02)00012-2
    [11] Nunes MA, Costa AS, Bessada S, et al. (2018) Olive pomace as a valuable source of bioactive compounds: A study regarding its lipid-and water-soluble components. Sci Total Environ 644: 229–236. https://doi.org/10.1016/j.scitotenv.2018.06.350 doi: 10.1016/j.scitotenv.2018.06.350
    [12] Nunes MA, Pimentel FB, Costa AS, et al. (2016) Olive by-products for functional and food applications: Challenging opportunities to face environmental constraints. Innovative Food Sci Emerging Technol 35: 139–148. https://doi.org/10.1016/j.ifset.2016.04.016 doi: 10.1016/j.ifset.2016.04.016
    [13] Rodrigues F, Pimentel FB, Oliveira MBP (2015) Olive by-products: Challenge application in cosmetic industry. Ind Crops Prod 70: 116–124. https://doi.org/10.1016/j.indcrop.2015.03.027 doi: 10.1016/j.indcrop.2015.03.027
    [14] Miralles P, Chisvert A, Salvador A (2015) Determination of hydroxytyrosol and tyrosol by liquid chromatography for the quality control of cosmetic products based on olive extracts. J Pharm Biomed Anal 102: 157–161. https://doi.org/10.1016/j.jpba.2014.09.016 doi: 10.1016/j.jpba.2014.09.016
    [15] Kong X, Mao M, Jiang H, et al. (2019) How does collaboration affect researchers' positions in co-authorship networks? J Informetrics 13: 887–900. https://doi.org/10.1016/j.joi.2019.07.005 doi: 10.1016/j.joi.2019.07.005
    [16] Gusenbauer M, Haddaway NR (2020) Which academic search systems are suitable for systematic reviews or meta‐analyses? Evaluating retrieval qualities of Google Scholar, PubMed, and 26 other resources. Res Synth Methods 11: 181–217. https://doi.org/10.1002/jrsm.1378 doi: 10.1002/jrsm.1378
    [17] Rahmanian N, Jafari SM, Galanakis CM (2014) Recovery and removal of phenolic compounds from olive mill wastewater. J Am Oil Chem Soc 91: 1–18. https://doi.org/10.1007/s11746-013-2350-9 doi: 10.1007/s11746-013-2350-9
    [18] Karantonis HC, Tsoupras A, Moran D, et al. (2023) Chapter 5—Olive, apple, and grape pomaces with antioxidant and anti-inflammatory bioactivities for functional foods. In: Zabetakis I, Tsoupras A, Lordan R, et al. (Eds.), Functional Foods and Their Implications for Health Promotion, Academic Press, 131–159. https://doi.org/10.1016/B978-0-12-823811-0.00007-9
    [19] Moral PS, Méndez MVR (2006) Production of pomace olive oil. Grasas y aceites 57: 47–55. https://doi.org/10.3989/gya.2006.v57.i1.21 doi: 10.3989/gya.2006.v57.i1.21
    [20] Tabera J, Guinda Á, Ruiz-Rodríguez A, et al. (2004) Countercurrent supercritical fluid extraction and fractionation of high-added-value compounds from a hexane extract of olive leaves. J Agric Food Chem 52: 4774–4779. https://doi.org/10.1021/jf049881+ doi: 10.1021/jf049881+
    [21] González E, Gómez-Caravaca AM, Giménez B, et al. (2019) Evolution of the phenolic compounds profile of olive leaf extract encapsulated by spray-drying during in vitro gastrointestinal digestion. Food Chem 279: 40–48. https://doi.org/10.1016/j.foodchem.2018.11.127 doi: 10.1016/j.foodchem.2018.11.127
    [22] Fki I, Sayadi S, Mahmoudi A, et al. (2020) Comparative study on beneficial effects of hydroxytyrosol-and oleuropein-rich olive leaf extracts on high-fat diet-induced lipid metabolism disturbance and liver injury in rats. BioMed Res Int 2020: 1315202. https://doi.org/10.1155/2020/1315202 doi: 10.1155/2020/1315202
    [23] Şahin S, Bilgin M (2018) Olive tree (Olea europaea L.) leaf as a waste by‐product of table olive and olive oil industry: a review. Journal of the Science of Food and Agriculture 98: 1271–1279. https://doi.org/10.1002/jsfa.8619 doi: 10.1002/jsfa.8619
    [24] Caponio F, Difonzo G, Calasso M, et al. (2019) Effects of olive leaf extract addition on fermentative and oxidative processes of table olives and their nutritional properties. Food Res Int 116: 1306–1317. https://doi.org/10.1016/j.foodres.2018.10.020 doi: 10.1016/j.foodres.2018.10.020
    [25] Flamminii F, Di Mattia CD, Difonzo G, et al. (2019) From by‐product to food ingredient: evaluation of compositional and technological properties of olive‐leaf phenolic extracts. J Sci Food Agric 99: 6620–6627. https://doi.org/10.1002/jsfa.9949 doi: 10.1002/jsfa.9949
    [26] Difonzo G, Squeo G, Calasso M, et al. (2019) Physico-chemical, microbiological and sensory evaluation of ready-to-use vegetable pâté added with olive leaf extract. Foods 8: 138. https://doi.org/10.3390/foods8040138 doi: 10.3390/foods8040138
    [27] Farag RS, Mahmoud EA, Basuny AM (2007) Use crude olive leaf juice as a natural antioxidant for the stability of sunflower oil during heating. Int J Food Sci Technol 42: 107–115. https://doi.org/10.1111/j.1365-2621.2006.01374.x doi: 10.1111/j.1365-2621.2006.01374.x
    [28] Difonzo G, Pasqualone A, Silletti R, et al. (2018) Use of olive leaf extract to reduce lipid oxidation of baked snacks. Food Res Int 108: 48–56. https://doi.org/10.1016/j.foodres.2018.03.034 doi: 10.1016/j.foodres.2018.03.034
    [29] Magrone T, Spagnoletta A, Salvatore R, et al. (2018) Olive leaf extracts act as modulators of the human immune response. Endocr, Metab Immune Disord-Drug Targets (Formerly Curr Drug Targets-Immune, Endocr Metab Disord) 18: 85–93. https://doi.org/10.2174/1871530317666171116110537 doi: 10.2174/1871530317666171116110537
    [30] DellaGreca M, Monaco P, Pinto G, et al. (2001) Phytotoxicity of low-molecular-weight phenols from olive mill waste waters. Bull Environ Contam Toxicol 67: 0352–0359. https://doi.org/10.1007/s001280132 doi: 10.1007/s001280132
    [31] Filidei S, Masciandaro G, Ceccanti B (2003) Anaerobic digestion of olive oil mill effluents: evaluation of wastewater organic load and phytotoxicity reduction. Water, Air, Soil Pollut 145: 79–94. https://doi.org/10.1023/A:1023619927495 doi: 10.1023/A:1023619927495
    [32] Kavdir Y, Killi D (2008) Influence of olive oil solid waste applications on soil pH, electrical conductivity, soil nitrogen transformations, carbon content and aggregate stability. Bioresour Technol 99: 2326–2332. https://doi.org/10.1016/j.biortech.2007.05.034 doi: 10.1016/j.biortech.2007.05.034
    [33] Demirer GN, Duran M, Güven E, et al. (2000) Anaerobic treatability and biogas production potential studies of different agro-industrial wastewaters in Turkey. Biodegradation 11: 401–405. https://doi.org/10.1023/A:1011659705369 doi: 10.1023/A:1011659705369
    [34] Morillo J, Antizar-Ladislao B, Monteoliva-Sánchez M, et al. (2009) Bioremediation and biovalorisation of olive-mill wastes. Appl Microbiol Biotechnol 82: 25–39. https://doi.org/10.1007/s00253-008-1801-y doi: 10.1007/s00253-008-1801-y
    [35] Peri C (2014) The extra virgin olive oil handbook, Wiley Online Library. https://doi.org/10.1002/9781118460412
    [36] Kapellakis IE, Tsagarakis KP, Crowther JC (2008) Olive oil history, production and by-product management. Rev Environ Sci Bio/Technol 7: 1–26. https://doi.org/10.1007/s11157-007-9120-9 doi: 10.1007/s11157-007-9120-9
    [37] Moubarik A, Barba FJ, Grimi N (2015) Understanding the physicochemical properties of olive kernel to be used as a potential tool in the development of phenol-formaldehyde wood adhesive. Int J Adhes Adhes 61: 122–126. https://doi.org/10.1016/j.ijadhadh.2015.06.003 doi: 10.1016/j.ijadhadh.2015.06.003
    [38] El-Sheikh AH, Newman AP, Al-Daffaee HK, et al. (2004) Characterization of activated carbon prepared from a single cultivar of Jordanian Olive stones by chemical and physicochemical techniques. J Anal Appl Pyrolysis 71: 151–164. https://doi.org/10.1016/S0165-2370(03)00061-5 doi: 10.1016/S0165-2370(03)00061-5
    [39] Aviani I, Raviv M, Hadar Y, et al. (2012) Effects of harvest date, irrigation level, cultivar type and fruit water content on olive mill wastewater generated by a laboratory scale 'Abencor'milling system. Bioresour Technol 107: 87–96. https://doi.org/10.1016/j.biortech.2011.12.041 doi: 10.1016/j.biortech.2011.12.041
    [40] Lesage-Meessen L, Navarro D, Maunier S, et al. (2001) Simple phenolic content in olive oil residues as a function of extraction systems. Food Chem 75: 501–507. https://doi.org/10.1016/S0308-8146(01)00227-8 doi: 10.1016/S0308-8146(01)00227-8
    [41] Mulinacci N, Romani A, Galardi C, et al. (2001) Polyphenolic content in olive oil waste waters and related olive samples. J Agric Food Chem 49: 3509–3514. https://doi.org/10.1021/jf000972q doi: 10.1021/jf000972q
    [42] Obied HK, Bedgood D, Mailer R, et al. (2008) Impact of cultivar, harvesting time, and seasonal variation on the content of biophenols in olive mill waste. J Agric Food Chem 56: 8851–8858. https://doi.org/10.1021/jf801802k doi: 10.1021/jf801802k
    [43] Uribe E, Lemus-Mondaca R, Vega-Gálvez A, et al. (2013) Quality characterization of waste olive cake during hot air drying: nutritional aspects and antioxidant activity. Food Bioprocess Technol 6: 1207–1217. https://doi.org/10.1007/s11947-012-0802-0 doi: 10.1007/s11947-012-0802-0
    [44] Lafka T-I, Lazou AE, Sinanoglou VJ, et al. (2011) Phenolic and antioxidant potential of olive oil mill wastes. Food Chem 125: 92–98. https://doi.org/10.1016/j.foodchem.2010.08.041 doi: 10.1016/j.foodchem.2010.08.041
    [45] Araújo M, Pimentel FB, Alves RC, et al. (2015) Phenolic compounds from olive mill wastes: Health effects, analytical approach and application as food antioxidants. Trends Food Sci Technol 45: 200–211. https://doi.org/10.1016/j.tifs.2015.06.010 doi: 10.1016/j.tifs.2015.06.010
    [46] Obied HK, Allen MS, Bedgood DR, et al. (2005) Investigation of Australian olive mill waste for recovery of biophenols. J Agric Food Chem 53: 9911–9920. https://doi.org/10.1021/jf0518352 doi: 10.1021/jf0518352
    [47] Visioli F, Romani A, Mulinacci N, et al. (1999) Antioxidant and other biological activities of olive mill waste waters. J Agric Food Chem 47: 3397–3401. https://doi.org/10.1021/jf9900534 doi: 10.1021/jf9900534
    [48] D'Alessandro F, Marucchini C, Minuti L, et al. (2005) GC/MS-SIM analysis of phenolic compounds in olive oil waste waters. Ital J Food Sci 17: 83–88.
    [49] Damak N, Allouche N, Hamdi B, et al. (2012) New secoiridoid from olive mill wastewater. Natural Product Research 26: 125–131. https://doi.org/10.1080/14786419.2010.535147 doi: 10.1080/14786419.2010.535147
    [50] Japón-Luján R, Luque de Castro MD (2007) Static- dynamic superheated liquid extraction of hydroxytyrosol and other biophenols from alperujo (a semisolid residue of the olive oil industry). J Agric Food Chem 55: 3629–3634. https://doi.org/10.1021/jf0636770 doi: 10.1021/jf0636770
    [51] Lo Scalzo R, Scarpati ML (1993) A new secoiridoid from olive wastewaters. J Nat Prod 56: 621–623. https://doi.org/10.1021/np50094a026 doi: 10.1021/np50094a026
    [52] Servili M, Baldioli M, Selvaggini R, et al. (1999) Phenolic compounds of olive fruit: one-and two-dimensional nuclear magnetic resonance characterization of nüzhenide and its distribution in the constitutive parts of fruit. J Agric Food Chem 47: 12–18. https://doi.org/10.1021/jf9806210 doi: 10.1021/jf9806210
    [53] Rubio-Senent F, Rodríguez-Gutíerrez G, Lama-Muñoz A, et al. (2012) New phenolic compounds hydrothermally extracted from the olive oil byproduct alperujo and their antioxidative activities. J Agric Food Chem 60: 1175–1186. https://doi.org/10.1021/jf204223w doi: 10.1021/jf204223w
    [54] Pérez-Serradilla J, Japón-Luján R, Luque de Castro M (2008) Static–dynamic sequential superheated liquid extraction of phenols and fatty acids from alperujo. Anal Bioanal Chem 392: 1241–1248. https://doi.org/10.1007/s00216-008-2376-2 doi: 10.1007/s00216-008-2376-2
    [55] Boskou D (2008) Phenolic compounds in olives and olive oil. In: Olive oil: Minor constituents and health 1. https://doi.org/10.1201/9781420059946.ch1
    [56] Suárez M, Romero M-P, Ramo T, et al. (2009) Methods for preparing phenolic extracts from olive cake for potential application as food antioxidants. J Agric Food Chem 57: 1463–1472. https://doi.org/10.1021/jf8032254 doi: 10.1021/jf8032254
    [57] Cioffi G, Pesca MS, De Caprariis P, et al. (2010) Phenolic compounds in olive oil and olive pomace from Cilento (Campania, Italy) and their antioxidant activity. Food Chem 121: 105–111. https://doi.org/10.1016/j.foodchem.2009.12.013 doi: 10.1016/j.foodchem.2009.12.013
    [58] Peralbo-Molina A, Priego-Capote F, Luque de Castro MD (2012) Tentative identification of phenolic compounds in olive pomace extracts using liquid chromatography–tandem mass spectrometry with a quadrupole–quadrupole-time-of-flight mass detector. J Agric Food Chem 60: 11542–11550. https://doi.org/10.1021/jf302896m doi: 10.1021/jf302896m
    [59] Alu'datt MH, Alli I, Ereifej K, et al. (2010) Optimisation, characterisation and quantification of phenolic compounds in olive cake. Food Chem 123: 117–122. https://doi.org/10.1016/j.foodchem.2010.04.011 doi: 10.1016/j.foodchem.2010.04.011
    [60] Rigane G, Bouaziz M, Baccar N, et al. (2012) Recovery of Hydroxytyrosol rich extract from two‐phase Chemlali olive pomace by chemical treatment. J Food Sci 77: C1077–C1083. https://doi.org/10.1111/j.1750-3841.2012.02898.x doi: 10.1111/j.1750-3841.2012.02898.x
    [61] Ibanez E, Palacios J, Senorans F, et al. (2000) Isolation and separation of tocopherols from olive by‐products with supercritical fluids. J Am Oil Chem Soc 77: 187–190. https://doi.org/10.1007/s11746-000-0030-8 doi: 10.1007/s11746-000-0030-8
    [62] Seçmeler Ö, Üstündağ ÖG, Fernández-Bolaños J, et al. (2018) Effect of subcritical water and steam explosion pretreatments on the recovery of sterols, phenols and oil from olive pomace. Food Chem 265: 298–307. https://doi.org/10.1016/j.foodchem.2018.05.088 doi: 10.1016/j.foodchem.2018.05.088
    [63] Gallardo‐Guerrero L, Roca M, Isabel Mínguez‐Mosquera M (2002) Distribution of chlorophylls and carotenoids in ripening olives and between oil and alperujo when processed using a two‐phase extraction system. J Am Oil Chem Soc 79: 105–109. https://doi.org/10.1007/s11746-002-0442-5 doi: 10.1007/s11746-002-0442-5
    [64] Zarrouk A, Martine L, Grégoire S, et al. (2019) Profile of fatty acids, tocopherols, phytosterols and polyphenols in mediterranean oils (argan oils, olive oils, milk thistle seed oils and nigella seed oil) and evaluation of their antioxidant and cytoprotective activities. Curr Pharm Des 25: 1791–1805. https://doi.org/10.2174/1381612825666190705192902 doi: 10.2174/1381612825666190705192902
    [65] Galanakis CM, Tsatalas P, Galanakis IM (2018) Implementation of phenols recovered from olive mill wastewater as UV booster in cosmetics. Ind Crops Prod 111: 30–37. https://doi.org/10.1016/j.indcrop.2017.09.058 doi: 10.1016/j.indcrop.2017.09.058
    [66] Otero P, Garcia-Oliveira P, Carpena M, et al. (2021) Applications of by-products from the olive oil processing: Revalorization strategies based on target molecules and green extraction technologies. Trends Food Sci Technol 116: 1084–1104. https://doi.org/10.1016/j.tifs.2021.09.007 doi: 10.1016/j.tifs.2021.09.007
    [67] Obied HK, Bedgood Jr D, Prenzler PD, et al. (2007) Bioscreening of Australian olive mill waste extracts: biophenol content, antioxidant, antimicrobial and molluscicidal activities. Food Chem Toxicol 45: 1238–1248. https://doi.org/10.1016/j.fct.2007.01.004 doi: 10.1016/j.fct.2007.01.004
    [68] Fernández-Bolaños J, Rodríguez G, Rodríguez R, et al. (2006) Extraction of interesting organic compounds from olive oil waste. Grasas y aceites 57: 95–106. https://doi.org/10.3989/gya.2006.v57.i1.25 doi: 10.3989/gya.2006.v57.i1.25
    [69] Covas M-I, de la Torre K, Farré-Albaladejo M, et al. (2006) Postprandial LDL phenolic content and LDL oxidation are modulated by olive oil phenolic compounds in humans. Free Radical Biol Med 40: 608–616. https://doi.org/10.1016/j.freeradbiomed.2005.09.027 doi: 10.1016/j.freeradbiomed.2005.09.027
    [70] EFSA Scientific Committee (2012) Guidance on selected default values to be used by the EFSA Scientific Committee, Scientific Panels and Units in the absence of actual measured data. EFSA J 10: 2579. https://doi.org/10.2903/j.efsa.2012.2579 doi: 10.2903/j.efsa.2012.2579
    [71] Karantonis HC, Tsantila N, Stamatakis G, et al. (2008) Bioactive polar lipids in olive oil, pomace and waste byproducts. J Food Biochem 32: 443–459. https://doi.org/10.1111/j.1745-4514.2008.00160.x doi: 10.1111/j.1745-4514.2008.00160.x
    [72] Tsoupras AB, Fragopoulou E, Nomikos T, et al. (2007) Characterization of the de novo biosynthetic enzyme of platelet activating factor, DDT-insensitive cholinephosphotransferase, of human mesangial cells. Mediators Inflammation 2007: 027683. https://doi.org/10.1155/2007/27683 doi: 10.1155/2007/27683
    [73] Tsoupras A, Fragopoulou E, Iatrou C, et al. (2011) In vitro protective effects of Olive Pomace Polar Lipids towards Platelet Activating Factor metabolism in human renal cells. Curr Top Nutraceutical Res 9: 105–110.
    [74] Tsantila N, Karantonis HC, Perrea DN, et al. (2007) Antithrombotic and antiatherosclerotic properties of olive oil and olive pomace polar extracts in rabbits. Mediators Inflammation 2007: 036204. https://doi.org/10.1155/2007/36204 doi: 10.1155/2007/36204
    [75] Tsantila N, Karantonis HC, Perrea DN, et al. (2010) Atherosclerosis regression study in rabbits upon olive pomace polar lipid extract administration. Nutr, Metab Cardiovasc Dis 20: 740–747. https://doi.org/10.1016/j.numecd.2009.06.008 doi: 10.1016/j.numecd.2009.06.008
    [76] Ntzouvani A, Antonopoulou S, Fragopoulou E, et al. (2021) Effect of differently fed farmed gilthead sea bream consumption on platelet aggregation and circulating haemostatic markers among apparently healthy adults: a double-blind randomized crossover trial. Nutrients 13: 286. https://doi.org/10.3390/nu13020286 doi: 10.3390/nu13020286
    [77] Ribeiro AS, Estanqueiro M, Oliveira MB, et al. (2015) Main benefits and applicability of plant extracts in skin care products. Cosmetics 2: 48–65. https://doi.org/10.3390/cosmetics2020048 doi: 10.3390/cosmetics2020048
    [78] Carito V, Ciafrh S, Tarani L, et al. (2015) TNF-α and IL-10 modulation induced by polyphenols extracted by olive pomace in a mouse model of paw inflammation. Annali dell'Istituto superiore di sanità 51: 382–386.
    [79] Herrero-Encinas J, Blanch M, Pastor J, et al. (2020) Effects of a bioactive olive pomace extract from Olea europaea on growth performance, gut function, and intestinal microbiota in broiler chickens. Poult Sci 99: 2–10. https://doi.org/10.3382/ps/pez467 doi: 10.3382/ps/pez467
    [80] Demopoulos CA, Karantonis HC, Antonopoulou S (2003) Platelet activating factor—A molecular link between atherosclerosis theories. Eur J Lipid Sci Technol 105: 705–716. https://doi.org/10.1002/ejlt.200300845 doi: 10.1002/ejlt.200300845
    [81] Nasopoulou C, Karantonis HC, Detopoulou M, et al. (2014) Exploiting the anti-inflammatory properties of olive (Olea europaea) in the sustainable production of functional food and neutraceuticals. Phytochem Rev 13: 445–458. https://doi.org/10.1007/s11101-014-9350-8 doi: 10.1007/s11101-014-9350-8
    [82] Cedola A, Cardinali A, Del Nobile MA, et al. (2019) Enrichment of bread with olive oil industrial by-product. J Agric Sci Technol B 9: 119–127. https://doi.org/10.17265/2161-6264/2019.02.005 doi: 10.17265/2161-6264/2019.02.005
    [83] Conterno L, Martinelli F, Tamburini M, et al. (2019) Measuring the impact of olive pomace enriched biscuits on the gut microbiota and its metabolic activity in mildly hypercholesterolaemic subjects. Eur J Nutr 58: 63–81. https://doi.org/10.1007/s00394-017-1572-2 doi: 10.1007/s00394-017-1572-2
    [84] Lin S, Chi W, Hu J, et al. (2017) Sensory and nutritional properties of chinese olive pomace based high fibre biscuit. Emirates J Food Agric 2017: 495–501. https://doi.org/10.9755/ejfa.2016-12-1908 doi: 10.9755/ejfa.2016-12-1908
    [85] Durante M, Bleve G, Selvaggini R, et al. (2019) Bioactive compounds and stability of a typical Italian bakery products "taralli" enriched with fermented olive paste. Molecules 24: 3258. https://doi.org/10.3390/molecules24183258 doi: 10.3390/molecules24183258
    [86] Simonato B, Trevisan S, Tolve R, et al. (2019) Pasta fortification with olive pomace: Effects on the technological characteristics and nutritional properties. LWT 114: 108368. https://doi.org/10.1016/j.lwt.2019.108368 doi: 10.1016/j.lwt.2019.108368
    [87] Lomuscio E, Bianchi F, Cervini M, et al. (2022) Durum wheat fresh pasta fortification with trub, a beer industry by-product. Foods 11: 2496. https://doi.org/10.3390/foods11162496 doi: 10.3390/foods11162496
    [88] Cecchi L, Schuster N, Flynn D, et al. (2019) Sensory profiling and consumer acceptance of pasta, bread, and granola bar fortified with dried olive pomace (pâté): A byproduct from virgin olive oil production. J Food Sci 84: 2995–3008. https://doi.org/10.1111/1750-3841.14800 doi: 10.1111/1750-3841.14800
    [89] Padalino L, D'Antuono I, Durante M, et al. (2018) Use of olive oil industrial by-product for pasta enrichment. Antioxidants 7: 59. https://doi.org/10.3390/antiox7040059 doi: 10.3390/antiox7040059
    [90] Nasopoulou C, Lytoudi K, Zabetakis I (2018) Evaluation of olive pomace in the production of novel broilers with enhanced in vitro antithrombotic properties. Eur J Lipid Sci Technol 120: 1700290. https://doi.org/10.1002/ejlt.201700290 doi: 10.1002/ejlt.201700290
    [91] Sioriki E, Smith TK, Demopoulos CA, et al. (2016) Structure and cardioprotective activities of polar lipids of olive pomace, olive pomace-enriched fish feed and olive pomace fed gilthead sea bream (Sparus aurata). Food Res Int 83: 143–151. https://doi.org/10.1016/j.foodres.2016.03.015 doi: 10.1016/j.foodres.2016.03.015
    [92] Nasopoulou C, Smith T, Detopoulou M, et al. (2014) Structural elucidation of olive pomace fed sea bass (Dicentrarchus labrax) polar lipids with cardioprotective activities. Food Chem 145: 1097–1105. https://doi.org/10.1016/j.foodchem.2013.08.091 doi: 10.1016/j.foodchem.2013.08.091
    [93] Khoshkholgh M, Mosapour Shajani M, Mohammadi M (2020) Partial replacement of wheat flour and corn meal with olive pomace in diet of rainbow trout (Oncorhynchus mykiss): effects on growth performance, body composition, hematological parameters and sensory evaluation. Sustainable Aquacult Health Manage J 6: 63–77. https://doi.org/10.29252/ijaah.6.1.63 doi: 10.29252/ijaah.6.1.63
    [94] Dal Bosco A, Mourvaki E, Cardinali R, et al. (2012) Effect of dietary supplementation with olive pomaces on the performance and meat quality of growing rabbits. Meat Sci 92: 783–788. https://doi.org/10.1016/j.meatsci.2012.07.001 doi: 10.1016/j.meatsci.2012.07.001
    [95] Chiofalo B, Liotta L, Zumbo A, et al. (2004) Administration of olive cake for ewe feeding: Effect on milk yield and composition. Small Ruminant Res 55: 169–176. https://doi.org/10.1016/j.smallrumres.2003.12.011 doi: 10.1016/j.smallrumres.2003.12.011
    [96] Vargas-Bello-Pérez E, Vera R, Aguilar C, et al. (2013) Feeding olive cake to ewes improves fatty acid profile of milk and cheese. Anim Feed Sci Technol 184: 94–99. https://doi.org/10.1016/j.anifeedsci.2013.05.016 doi: 10.1016/j.anifeedsci.2013.05.016
    [97] Terramoccia S, Bartocci S, Taticchi A, et al. (2013) Use of dried stoned olive pomace in the feeding of lactating buffaloes: Effect on the quantity and quality of the milk produced. Asian-Australas J Anim Sci 26: 971. https://doi.org/10.5713/ajas.2012.12627 doi: 10.5713/ajas.2012.12627
    [98] Luciano G, Pauselli M, Servili M, et al. (2013) Dietary olive cake reduces the oxidation of lipids, including cholesterol, in lamb meat enriched in polyunsaturated fatty acids. Meat Sci 93: 703–714. https://doi.org/10.1016/j.meatsci.2012.11.033 doi: 10.1016/j.meatsci.2012.11.033
    [99] Branciari R, Galarini R, Giusepponi D, et al. (2017) Oxidative status and presence of bioactive compounds in meat from chickens fed polyphenols extracted from olive oil industry waste. Sustainability 9: 1566. https://doi.org/10.3390/su9091566 doi: 10.3390/su9091566
    [100] Iannaccone M, Ianni A, Contaldi F, et al. (2019) Whole blood transcriptome analysis in ewes fed with hemp seed supplemented diet. Sci Rep 9: 16192. https://doi.org/10.1038/s41598-019-52712-6 doi: 10.1038/s41598-019-52712-6
    [101] Detopoulou M, Ntzouvani A, Petsini F, et al. (2021) Consumption of enriched yogurt with paf inhibitors from olive pomace affects the major enzymes of PAF metabolism: A randomized, double blind, three arm trial. Biomolecules 11: 801. https://doi.org/10.3390/biom11060801 doi: 10.3390/biom11060801
    [102] Madureira J, Margaça FM, Santos‐Buelga C, et al. (2022) Applications of bioactive compounds extracted from olive industry wastes: A review. Compr Rev Food Sci Food Saf 21: 453–476. https://doi.org/10.1111/1541-4337.12861 doi: 10.1111/1541-4337.12861
    [103] Lo Giudice V, Faraone I, Bruno MR, et al. (2021) Olive trees by-products as sources of bioactive and other industrially useful compounds: A systematic review. Molecules 26: 5081. https://doi.org/10.3390/molecules26165081 doi: 10.3390/molecules26165081
    [104] Cedola A, Cardinali A, D'Antuono I, et al. (2020) Cereal foods fortified with by-products from the olive oil industry. Food Biosci 33: 100490. https://doi.org/10.1016/j.fbio.2019.100490 doi: 10.1016/j.fbio.2019.100490
    [105] Ying D, Hlaing MM, Lerisson J, et al. (2017) Physical properties and FTIR analysis of rice-oat flour and maize-oat flour based extruded food products containing olive pomace. Food Res Int 100: 665–673. https://doi.org/10.1016/j.foodres.2017.07.062 doi: 10.1016/j.foodres.2017.07.062
    [106] Aggoun M, Arhab R, Cornu A, et al. (2016) Olive mill wastewater microconstituents composition according to olive variety and extraction process. Food Chem 209: 72–80. https://doi.org/10.1016/j.foodchem.2016.04.034 doi: 10.1016/j.foodchem.2016.04.034
    [107] He Y, Wang Y, Yang K, et al. (2022) Maslinic acid: A new compound for the treatment of multiple organ diseases. Molecules 27: 8732. https://doi.org/10.3390/molecules27248732 doi: 10.3390/molecules27248732
    [108] Cheng Y, Xia Q, Lu Z, et al. (2023) Maslinic acid attenuates UVB‐induced oxidative damage in HFF‐1 cells. J Cosmet Dermatol 22: 2352–2360. https://doi.org/10.1111/jocd.15730 doi: 10.1111/jocd.15730
    [109] González-Acedo A, Ramos-Torrecillas J, Illescas-Montes R, et al. (2023) The benefits of olive oil for skin health: Study on the effect of Hydroxytyrosol, Tyrosol, and Oleocanthal on human fibroblasts. Nutrients 15: 2077. https://doi.org/10.3390/nu15092077 doi: 10.3390/nu15092077
    [110] Melguizo-Rodríguez L, González-Acedo A, Illescas-Montes R, et al. (2022) Biological effects of the olive tree and its derivatives on the skin. Food Funct 13: 11410–11424. https://doi.org/10.1039/D2FO01945K doi: 10.1039/D2FO01945K
    [111] Ramírez EM, Brenes M, Romero C, et al. (2023) Olive leaf processing for infusion purposes. Foods 12: 591. https://doi.org/10.3390/foods12030591 doi: 10.3390/foods12030591
    [112] Filipović M, Gledović A, Lukić M, et al. (2016) Alp Rose stem cells, olive oil squalene and a natural alkyl polyglucoside emulsifier: Are they appropriate ingredients of skin moisturizers-in vivo efficacy on normal and sodium lauryl sulfate-irritated skin? Vojnosanitetski pregled 73: 991–1002. https://doi.org/10.2298/VSP150116122F doi: 10.2298/VSP150116122F
    [113] Wołosik K, Knaś M, Zalewska A, et al. (2013) The importance and perspective of plant-based squalene in cosmetology. J Cosmet Sci 64: 59–66.
    [114] Alves E, Domingues MRM, Domingues P (2018) Polar lipids from olives and olive oil: A review on their identification, significance and potential biotechnological applications. Foods 7: 109. https://doi.org/10.3390/foods7070109 doi: 10.3390/foods7070109
    [115] Alves E, Rey F, Melo T, et al. (2022) Bioprospecting bioactive polar lipids from olive (Olea europaea cv. Galega vulgar) fruit seeds: LC-HR-MS/MS fingerprinting and sub-geographic comparison. Foods 11: 951. https://doi.org/10.3390/foods11070951 doi: 10.3390/foods11070951
    [116] Moussaoui R, Labbaci W, Hemar N, et al. (2008) Physico-chemical characteristics of oils extracted from three compartments of the olive fruit (pulp, endocarp and seed) of variety Chemlal cultivated in Kabylia (Algeria). J Food Agric Environ 6: 52–5.
    [117] Van Hoogevest P, Wendel A (2014) The use of natural and synthetic phospholipids as pharmaceutical excipients. Eur Lipid Sci Technol 116: 1088–1107. https://doi.org/10.1002/ejlt.201400219 doi: 10.1002/ejlt.201400219
    [118] Lodén M (2003) Role of topical emollients and moisturizers in the treatment of dry skin barrier disorders. Am J Clinical Dermatol 4: 771–788. https://doi.org/10.2165/00128071-200304110-00005 doi: 10.2165/00128071-200304110-00005
    [119] Tsoupras A, Lordan R, Zabetakis I (2018) Inflammation, not cholesterol, is a cause of chronic disease. Nutrients 10: 604. https://doi.org/10.3390/nu10050604 doi: 10.3390/nu10050604
    [120] Hans S, Stanton JE, Sauer AK, et al. (2024) Polar lipids modify Alzheimer's Disease pathology by reducing astrocyte pro-inflammatory signaling through platelet-activating factor receptor (PTAFR) modulation. Lipids Health Dis 23: 1–15. https://doi.org/10.1186/s12944-024-02106-z doi: 10.1186/s12944-024-02106-z
    [121] Laveriano‐Santos EP, Vallverdú‐Queralt A, Bhat R, et al. (2024) Unlocking the potential of olive residues for functional purposes: Update on human intervention trials with health and cosmetic products. J Sci Food Agric 104: 3816–3822. https://doi.org/10.1002/jsfa.13451 doi: 10.1002/jsfa.13451
    [122] Liebmann J, Born M, Kolb-Bachofen V (2010) Blue-light irradiation regulates proliferation and differentiation in human skin cells. J Invest Dermatol 130: 259–269. https://doi.org/10.1038/jid.2009.194 doi: 10.1038/jid.2009.194
    [123] Pourzand C, Albieri-Borges A, Raczek NN (2022) Shedding a new light on skin aging, iron-and redox-homeostasis and emerging natural antioxidants. Antioxidants 11: 471. https://doi.org/10.3390/antiox11030471 doi: 10.3390/antiox11030471
    [124] Brüning AK, Schiefer JL, Fuchs PC, et al. (2023) Low-Dose Blue Light (420 nm) Reduces Metabolic Activity and Inhibits Proliferation of Human Dermal Fibroblasts. Life 13: 331. https://doi.org/10.3390/life13020331 doi: 10.3390/life13020331
    [125] Nakashima Y, Ohta S, Wolf AM (2017) Blue light-induced oxidative stress in live skin. Free Radical Biol Med 108: 300–310. https://doi.org/10.1016/j.freeradbiomed.2017.03.010 doi: 10.1016/j.freeradbiomed.2017.03.010
    [126] Draelos ZD (2021) Revisiting the skin health and beauty pyramid: A clinically based guide to selecting topical skincare products. J Drugs Dermatol 20: 695–699. https://doi.org/10.36849/JDD.6037 doi: 10.36849/JDD.6037
    [127] Wilson N (2008) Market evolution of topical anti-aging treatments. Skin Aging Handbook: An Integrated Approach to Biochemistry and Product Development, 16–31. https://doi.org/10.1016/B978-0-8155-1584-5.50006-5 doi: 10.1016/B978-0-8155-1584-5.50006-5
    [128] Wölfle U, Seelinger G, Bauer G, et al. (2014) Reactive molecule species and antioxidative mechanisms in normal skin and skin aging. Skin Pharmacol Physiol 27: 316–332. https://doi.org/10.1159/000360092 doi: 10.1159/000360092
    [129] Burke KE (2009) Prevention and treatment of aging skin with topical antioxidants. Skin Aging Handbook, William Andrew Publishing, 149–176. https://doi.org/10.1016/B978-0-8155-1584-5.50012-0
    [130] Farris PK, Krol Y (2015) Under persistent assault: understanding the factors that deteriorate human skin and clinical efficacy of topical antioxidants in treating aging skin. Cosmetics 2: 355–367. https://doi.org/10.3390/cosmetics2040355 doi: 10.3390/cosmetics2040355
    [131] Fuller RW, Cardellina JH, Cragg GM, et al. (1994) Cucurbitacins: differential cytotoxicity, dereplication and first isolation from Gonystylus keithii. J Nat Prod 57: 1442–1445. https://doi.org/10.1021/np50112a015 doi: 10.1021/np50112a015
    [132] Lecci RM, D'Antuono I, Cardinali A, et al. (2021) Antioxidant and pro-oxidant capacities as mechanisms of photoprotection of olive polyphenols on uva-damaged human keratinocytes. Molecules 26: 2153. https://doi.org/10.3390/molecules26082153 doi: 10.3390/molecules26082153
    [133] Rodrigues F, da Mota Nunes MA, Oliveira MBPP (2017) Applications of recovered bioactive compounds in cosmetics and health care products, Olive Mill Waste, Academic Press, 255–274. https://doi.org/10.1016/B978-0-12-805314-0.00012-1
    [134] Pouillot A, Polla LL, Tacchini P, et al. (2011) Natural antioxidants and their effects on the skin. Formulating, Packaging, and Marketing of Natural Cosmetic Products, 239–257. https://doi.org/10.1002/9781118056806.ch13 doi: 10.1002/9781118056806.ch13
    [135] Lademann J, Vergou T, Darvin ME, et al. (2016) Influence of topical, systemic and combined application of antioxidants on the barrier properties of the human skin. Skin Pharmacol Physiol 29: 41–46. https://doi.org/10.1159/000441953 doi: 10.1159/000441953
    [136] Michalak M (2022) Plant-derived antioxidants: Significance in skin health and the ageing process. Int J Mol Sci 23: 585. https://doi.org/10.3390/ijms23020585 doi: 10.3390/ijms23020585
    [137] de Lima Cherubim DJ, Buzanello Martins CV, Oliveira Fariña L, et al. (2020) Polyphenols as natural antioxidants in cosmetics applications. J Cosmet Dermatol 19: 33–37. https://doi.org/10.1111/jocd.13093 doi: 10.1111/jocd.13093
    [138] Hoang HT, Moon JY, Lee YC (2021) Natural antioxidants from plant extracts in skincare cosmetics: Recent applications, challenges and perspectives. Cosmetics 8: 106. https://doi.org/10.3390/cosmetics8040106 doi: 10.3390/cosmetics8040106
    [139] Siddique MI, Katas H, Jamil A, et al. (2019) Potential treatment of atopic dermatitis: Tolerability and safety of cream containing nanoparticles loaded with hydrocortisone and hydroxytyrosol in human subjects. Drug Delivery Transl Res 9: 469–481. https://doi.org/10.1007/s13346-017-0439-7 doi: 10.1007/s13346-017-0439-7
    [140] Siddique MI, Katas H, Sarfraz M, et al. (2021) Clinical insights into topically applied multipronged nanoparticles in subjects with atopic dermatitis. J Drug Delivery Sci Technol 65: 102744. https://doi.org/10.1016/j.jddst.2021.102744 doi: 10.1016/j.jddst.2021.102744
    [141] Nunes A, Gonçalves L, Marto J, et al. (2021) Investigations of olive oil industry by-products extracts with potential skin benefits in topical formulations. Pharmaceutics 13: 465. https://doi.org/10.3390/pharmaceutics13040465 doi: 10.3390/pharmaceutics13040465
    [142] Wanitphakdeedecha R, Ng JNC, Junsuwan N, et al. (2020) Efficacy of olive leaf extract–containing cream for facial rejuvenation: A pilot study. J Cosmet Dermatol 19: 1662–1666. https://doi.org/10.1111/jocd.13457 doi: 10.1111/jocd.13457
    [143] Jeon S, Choi M (2018) Anti-inflammatory and anti-aging effects of hydroxytyrosol on human dermal fibroblasts (HDFs). Biomed Dermatol 2: 1–8. https://doi.org/10.1186/s41702-018-0031-x doi: 10.1186/s41702-018-0031-x
    [144] Aparicio‐Soto M, Redhu D, Sánchez‐Hidalgo M, et al. (2019) Olive‐Oil‐Derived Polyphenols Effectively Attenuate Inflammatory Responses of Human Keratinocytes by Interfering with the NF‐κB Pathway. Mol Nutr Food Res 63: 1900019. https://doi.org/10.1002/mnfr.201900019 doi: 10.1002/mnfr.201900019
    [145] Avola R, Graziano ACE, Pannuzzo G, et al. (2019) Hydroxytyrosol from olive fruits prevents blue‐light‐induced damage in human keratinocytes and fibroblasts. J Cell Pysiol 234: 9065–9076. https://doi.org/10.1002/jcp.27584 doi: 10.1002/jcp.27584
    [146] Schlupp P, Schmidts TM, Pössl A, et al. (2019) Effects of a phenol-enriched purified extract from olive mill wastewater on skin cells. Cosmetics 6: 30. https://doi.org/10.3390/cosmetics6020030 doi: 10.3390/cosmetics6020030
    [147] da Silva AC, Paiva JP, Diniz RR, et al. (2019) Photoprotection assessment of olive (Olea europaea L.) leaves extract standardized to oleuropein: In vitro and in silico approach for improved sunscreens. J Photochem Photobiol B: Biol 193: 162–171. https://doi.org/10.1016/j.jphotobiol.2019.03.003 doi: 10.1016/j.jphotobiol.2019.03.003
    [148] Cadiz-Gurrea M de la L, Pinto D, Delerue-Matos C, et al. (2021) Olive fruit and leaf wastes as bioactive ingredients for cosmetics—A preliminary study. Antioxidants 10: 245. https://doi.org/10.3390/antiox10020245 doi: 10.3390/antiox10020245
    [149] Musa A, Shady NH, Ahmed SR, et al. (2021) Antiulcer potential of Olea europea L. cv. arbequina leaf extract supported by metabolic profiling and molecular docking. Antioxidants 10: 644. https://doi.org/10.3390/antiox10050644 doi: 10.3390/antiox10050644
    [150] Smeriglio A, Denaro M, Mastracci L, et al. (2019) Safety and efficacy of hydroxytyrosol-based formulation on skin inflammation: in vitro evaluation on reconstructed human epidermis model. DARU J Pharm Sci 27: 283–293. https://doi.org/10.1007/s40199-019-00274-3 doi: 10.1007/s40199-019-00274-3
    [151] Parente E, Miraballes M, Gámbaro A (2023) Use of completion projective technique to understand consumer's perception upon a novelty cosmetic with olive oil. J Sens Stud 38: e12800. https://doi.org/10.1111/joss.12800 doi: 10.1111/joss.12800
    [152] Parente ME, Gámbaro A, Boinbaser L, et al. (2013) Sensory characterization of virgin olive oil-based cosmetic creams. J Cosmet Sci 64: 371–380.
    [153] Chaabane D, Yakdhane A, Vatai G, et al. (2022) Microencapsulation of olive oil: a comprehensive review. Period Polytech Chem Eng 66: 354–366. https://doi.org/10.3311/PPch.19587 doi: 10.3311/PPch.19587
    [154] Aliakbarian B, Paini M, Adami R, et al. (2017) Use of Supercritical Assisted Atomization to produce nanoparticles from olive pomace extract. Innovative Food Sci Emerging Technol 40: 2–9. https://doi.org/10.1016/j.ifset.2016.09.016 doi: 10.1016/j.ifset.2016.09.016
    [155] Panagiotopoulou M, Papadaki S, Bagia H, et al. (2022) Valorisation of olive processing waste for the development of value-added products. Sustainable Chem Pharm 28: 100736. https://doi.org/10.1016/j.scp.2022.100736 doi: 10.1016/j.scp.2022.100736
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