Export file:


  • RIS(for EndNote,Reference Manager,ProCite)
  • BibTex
  • Text


  • Citation Only
  • Citation and Abstract

Association of GST gene polymorphism and noise-induced hearing loss
Running title: GST gene polymorphism and NIHL

1 Associate professor, Industrial Diseases Research Center, Center of Excellence for Occupational Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
2 Assistant professor, Department of Occupational Medicine, Faculty of Medicine, Hormozgan University of Medical Sciences, Bandar Abbas, Iran
3 Professor of Medical Genetics, Stem Cell Biology Research Center, Yazd Reproductive Sciences Institute, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
4 Department of Biology, Faculty of Science, Yazd University, Yazd, Iran

Special Issues: Recent advances in Public Health (Basic and Clinical Studies)

Background: It has been proposed that Noise-induced hearing loss is a complex disease that is combination of environmental and genetic factors. There are inconsistent results concerning the association between variation in glutathione S-transferase (GST) genetic polymorphisms (GSTT1 rs1049055 and GSTM1 rs10712361) and susceptibility to Noise-induced hearing loss. Objective: This study was designed to assess the association between GST gene polymorphism and Noise-induced hearing loss among noise-exposed workers. Methods: In a case-control study, male workers from tile and ceramic factories were selected randomly. Subjects were classified into two groups according to the result of audiometry: 73 subjects showed Noise-induced hearing loss which was considered in the case group and 87 subjects without hearing loss was enrolled in the control group. The GSTT1 and GSTM1 polymorphism of both groups were assessed by multiplex polymerase chain reaction. Results: Null GSTT1 and GSTM1 genotypes were more frequent in case group but no significant statistical difference was seen in case and control groups. No significant link between GSTT1 and GSTM1 genotypes was found. Conclusion: This study suggests that the genetic variability of GSTT1 and GSTM1 has no effect on susceptibility to noise induced hearing loss.
  Article Metrics


1. Gopal KV (2008) Audiological findings in individuals exposed to organic solvents: case studies. Noise Health 10: 74–82.    

2. Rabinowitz PRT (2005) Occupational hearing loss, In: Rosenstock L CM, Brodkin C, Redlich C, Textbook of clinical occupational and environmental medicine, 2Eds., Philadelphia, USA: Elsevier Saunders, 426–436.

3. Alberti P (1998) Noise-induced hearing loss–a global problem. Adv Noise Res 1: 7–15.

4. Konings A, Van Laer L, Van Camp G (2009) Genetic studies on noise-induced hearing loss: a review. Ear Hear 30: 151–159.    

5. Abreu-Silva RS, Rincon D, Horimoto AR, et al. (2011) The search of a genetic basis for noise-induced hearing loss (NIHL). Ann Hum Biol 38: 210–218.    

6. Krasitskaya VV, Bashmakova EE, Dobretsov KG, et al. (2017) The genetic aspects of occupational hearing impairment. Vestn Otorinolaringol 82: 71–76.    

7. Derekoy FS, Koken T, Yilmaz D, et al. (2004) Effects of ascorbic acid on oxidative system and transient evoked otoacoustic emissions in rabbits exposed to noise. Laryngoscope 114: 1775–1779.    

8. Lorito G, Giordano P, Prosser S, et al. (2006) Noise-induced hearing loss: a study on the pharmacological protection in the Sprague Dawley rat with N-acetyl-cysteine. Acta Otorhinolaryngo 26: 133–139.

9. Haase GM, Prasad KN, Cole WC, et al. (2011) Antioxidant micronutrient impact on hearing disorders: concept, rationale, and evidence. Am J Otolaryngo 32: 55–61.    

10. Lin CY, Wu JL, Shih TS, et al. (2009) Glutathione S-transferase M1, T1, and P1 polymorphisms as susceptibility factors for noise-induced temporary threshold shift. Hear Res 257: 8–15.    

11. Carlsson PI, Van Laer L, Borg E, et al. (2005) The influence of genetic variation in oxidative stress genes on human noise susceptibility. Hear Res 202: 87–96.    

12. Board PG (1981) Biochemical genetics of glutathione-S-transferase in man. Am J Hum Genet 33: 36–43.

13. Pemble S, Schroeder KR, Spencer SR, et al. (1994) Human glutathione S-transferase theta (GSTT1): cDNA cloning and the characterization of a genetic polymorphism. Biochem J 300: 271–276.    

14. Rabinowitz PM, Wise Sr JP, Mobo BH, et al. (2002) Antioxidant status and hearing function in noise-exposed workers. Hear Res 173: 164–171.    

15. Yang M, Tan H, Zheng JR, et al. (2005) Relationship between GSTM1 and GSTT1 gene polymorphisms and noise induced hearing loss in Chinese workers. J Hyg Res 34: 647–649.

16. Palodetto BPM, Grignoli CRE, Sartorato EL, et al. (2010) Influence of glutathione s-transferase on the ototoxicity caused by aminoglycosides. Braz J Otorhinolaryngol 76: 306–309.    

17. Neale BM, Sham PC (2004) The future of association studies: gene-based analysis and replication. Am J Hum Genet 75: 353–362.    

18. National Institute for Occupational Safety and Health (1998) Criteria for a recommended standard occupational noise exposure. Revis Criter.

19. Kirchner DB, Evenson E, Dobie RA, et al. (2012) Occupational noise-induced hearing loss: ACOEM Task Force on Occupational Hearing Loss. J Occup Environ Med 54: 106–108.    

20. American National Standards Institute (2004) Specifications for Audiometers. ANSI S3. 6–2004.

21. Sliwinska-Kowalska M, Pawelczyk M (2013) Contribution of genetic factors to noise-induced hearing loss: a human studies review. Mutat Res 752: 61–65.    

22. Shen H, Huo X, Liu K, et al. (2012) Genetic Variation in GSTM1 Is Associated With Susceptibility to Noise-Induced Hearing Loss in a Chinese Population. J Occup Environ Med 54: 1157–1162.    

23. Manche SK, Jangala M, Putta P, et al. (2016) Association of oxidative stress gene polymorphisms with presbycusis. Gene 593: 277–283.    

24. Sliwinska-Kowalska M, Dudarewicz A, Kotylo P, et al. (2006) Individual susceptibility to noise-induced hearing loss: Choosing an optimal method of retrospective classification of workers into noise-susceptible and noise-resistant groups. Noise Health 8: 59–60.

© 2019 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution Licese (http://creativecommons.org/licenses/by/4.0)

Download full text in PDF

Export Citation

Article outline

Show full outline
Copyright © AIMS Press All Rights Reserved