Citation: Yu Sato, Hiroyuki Jinnouchi, Atsushi Sakamoto, Anne Cornelissen, Masayuki Mori, Rika Kawakami, Kenji Kawai, Renu Virmani, Aloke V. Finn. Calcification in human vessels and valves: from pathological point of view[J]. AIMS Molecular Science, 2020, 7(3): 183-210. doi: 10.3934/molsci.2020009
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Antimonide based quantum wells and nanostructures continue to attract considerable interest due to their potential for accessing technologically important applications in the spectral range beyond 1.5 µm. In particular GaInSb/GaSb offers a route towards the development of sources and detectors for use in remote gas sensing instrumentation, medical diagnostics and night vision technologies [1,2]. GaSb-based diode lasers, LEDs and photodetectors have been developed with excellent performance characteristics operating at many of the key wavelengths including methane [3], CO2 [4] and CO. However, the lack of semi-insulating GaSb substrates precludes the development of monolithic focal plane arrays and more complex devices, while the relatively high cost of GaSb wafers makes large volume applications cost-sensitive. Consequently, it is worthwhile investigating alternative growth methods for GaInSb based device structures on inexpensive GaAs substrates, which are readily available as semi-insulating wafers and for which there exists a mature processing technology. Recently, the growth of GaSb on GaAs has been successfully demonstrated using the interface misfit (IMF) [5,6,7] technique, which accommodates the lattice mismatch by forming lateral misfit dislocations along the GaSb-GaAs interface rather than threading dislocations in the GaSb bulk. However, samples grown using this molecular beam epitaxy (MBE) technique have shown reduced optical quality compared with homoepitaxial material since not all the dislocations are accommodated at the heterointerface and the remaining threading dislocations can still be problematic. In the present work we report on the MBE growth of AlGaSb as a ternary IMF metamorphic buffer layer on GaAs and study the properties of GaInSb quantum wells grown on this novel relaxed quasi substrate. AlGaSb conveniently provides substantial offsets in both the conduction and valence bands and results in improved photoluminescence efficiency from AlGaSb/InGaSb MQWs.
The Ga1-xInxSb MQW structures were grown on a (100) orientated n-GaSb substrate, or in the case of the IMF samples a (100) n-GaAs substrate, by solid source MBE using a VG-V80H reactor fitted with a Sb valved cracker cell. The GaSb MQW sample (QA216) in Figure1(a) was grown at a substrate temperature of 510 ℃ using growth rates of 0.65 ML/s for the GaSb and 1 ML/s for the Ga1-xInxSb QW respectively. Once a buffer layer of GaSb was grown, GaInSb QWs with 50 nm GaSb barriers were repeated 5 times. The GaSb IMF (QA276) in Figure 1(b) was grown using these conditions with the GaSb IMF growth based on the method used previously for GaSb IMF on GaAs [8]. The ternary AlGaSb IMF sample (QJ410), in Figure1(c) was grown in a similar manner with a 1μm AlGaSb buffer layer. For the AlGaSb MQW sample a growth rate of 0.46 ML/s with a substrate temperature of 515 ℃ was used. After the IMF growth a 1 μm buffer had been grown, 5x InGaSb QWs with 50 nm Al0.53Ga0.47Sb barriers were grown before finally capping with 100 nm of AlGaSb. Details of the resulting structures are given in Table 1.
Figure 1. A schematic diagram showing the different structures studied. (a) QA216: InGaSb/GaSb MQW grown homoepitaxially on GaSb substrate; (b) QA276: the same MQW structure as in (a) but grown on GaAs using the GaSb IMF buffer layer; (c) QJ410: a ternary Al0.53Ga0.47Sb layer is used instead of GaSb for the IMF and also in the MQW barriers for additional confinement. (The IMF is represented with a red dashed line).
| QA216 | QA276 | QJ410 | ||||
| Buffer layer | GaSb | GaSb IMF | AlGaSb IMF | |||
| QW thickness (Lz)/ nm | 4±1 | 4±1 | 7±4 | |||
| QW In content (%) | 34 | 32 | 28 | |||
| Strain (%) | 2.1 | 2.0 | 1.4 | |||
| PL peak | Wavelength (μm) | 1.77 | 1.77 | 1.70 | ||
| Energy (eV) | 0.699 | 0.703 | 0.728 | |||
| Relative PL intensity (10 K) | 1 | 0.025 | 0.66 | |||
| FWHM (meV)at 4 K | 15.4 | 16.7 | 20.5 | |||
| Confinement energy (meV) | e- | 49 | 48 | 506 | ||
| h+ | 98 | 98 | 345 | |||
| Z parameter | 4K | 1.9 | 1.2 | 1.8 | ||
| 225K | 2.2 | - | 2.3 | |||
DownLoad: CSVThe structural properties of the resulting samples were studied using high resolution x-ray diffraction (XRD) and transmission electron microscopy (TEM), to obtain information about dislocations, In content, thickness and perfection of the MQWs. In order to probe the optical properties of the samples, PL spectroscopy (4-300 K) was carried out using a continuous flow helium cryostat (Oxford Instruments Optistat). Excitation at 514 nm was provided by an Ar+ ion laser giving an adjustable power density of 0.4 to 10 Wcm−2 at the sample surface. The PL emission was detected and analysed using a Bentham M300 monochromator having a grating blazed at 3.5 µm, with a 77 K InSb photodiode detector and lock-in amplifier.
The high resolution XRD spectra obtained from each of the samples is shown in Figure 2. Sample (QA216) which was grown homoepitaxially on GaSb, has clearly defined satellite peaks with a full width half maximum (FWHM) of 78 arcsecs and a GaSb peak with FWHM of 27 arcsecs, indicating high crystalline quality. For sample (QA276) the satellite peaks are less distinct, being reduced in intensity with a FWHM of ~200 arcsecs, while the peak from the GaSb grown IMF layer is broadened with a FWHM of ~220 arcsecs; although this behaviour is consistent with the broadening of quasi substrate peaks seen in other IMF samples [9].
Figure 2. High resolution x-ray diffraction (XRD) spectra obtained from each of the samples. (a) QA216 MQW on GaAs; (b) QA276 MQW on GaSb IMF grown on GaAs and (c) QJ410 MQW with AlGaSb barriers grown on ternary AlGaSb IMF on GaAs.
The XRD spectrum of QJ410 with the ternary AlGaSb IMF metamorphic buffer structure shown in Figure 1(c) has no observable satellite peaks and a rather broad AlGaSb “quasi-substrate” broad band with a FWHM of 473 arcsecs. The lack of satellite peaks is normally indicative of a mixed composition layer, or a structure which contains several different lattice parameters. To help elucidate this, TEM images of this sample are shown at different magnifications in Figure 3. The ternary IMF dislocation array is clearly evident at the AlGaSb-GaAs interface in Figure 3(a) and the MQW are shown in the higher magnification image of Figure3(b). Figure 3(c) shows that the overall quality of the metamorphic buffer using the AlGaSb is high with relatively few threading dislocations. Abrupt thickness fluctuations in the QWs are clearly observable under high magnification in Figure 3(b). The target QW thickness was 6 nm but the actual QWs vary in a step-like fashion with thickness from 7 nm to 12 nm across the sample, which is sufficient to prevent the observation of the satellite peaks in the XRD spectrum. The appearance of these abrupt thickness variations is reminiscent of the early stages of quantum dot formation as the strain limit is approached but may also be related to the growth temperature, since 515 ℃ was used throughout to avoid the growth interrupt normally employed to grow InGaSb and AlGaSb layers at their respective optimum temperatures, (480 ℃ and 515 ℃ respectively).
Figure 3. Cross-sectional TEM images of the Al0.53Ga0.47Sb IMF MQW sample; (a) an image of the IMF AlGaSb-GaAs interface showing the misfit dislocation array; (b) a high resolution image of the MQW region, showing the non-uniform thickness of the InGaSb QWs; (c) a low magnification image showing the buffer layer which contains only a few threading dislocations.
A comparison of the 4 K PL spectra from each of the MQW samples is shown in Figure 4. The relative intensities, peak energy and FWHM are given in Table 1. The peak energies are in reasonable agreement with the calculated values obtained using a Schrödinger solver for a finite quantum well within the effective mass approximation. The corresponding confinement energies for electrons and holes are given in Table 1. The calculations are based on the indium compositions and QW thickness values obtained from the growth parameters, XRD measurements and TEM images. Although the MQW in samples QA216 and QA276 have nominally the same structure, the QA276 GaSb IMF sample has a slightly higher peak energy of 0.703 eV compared with 0.699 eV due to a decrease in Indium content of 1.7% which originates from a change in growth rate when growing on the IMF buffer. Meanwhile, in sample QJ410 the higher band offset provided by the Al0.53Ga0.47Sb produces higher confinement and consequently the peak energy is further increased to 0.729eV.
Figure 4. (a) The normalised photoluminescence at 10 K from each of the MQW samples. The FWHM were measured as 15.4, 16.7 and 20.5 meV for GaSb, GaSb IMF and AlGaSb respectively; (b) The 10 K and 300 K PL obtained from sample QJ410.The FWHM of the samples at 4 K (Table 1) compare favourably with samples grown previously both on native GaSb substrates and on Si [10]. The temperature dependent PL of QJ410 exhibits emission up to room temperature due to the stronger carrier confinement provided by the AlGaSb barriers. The FWHM increases to 39.5 meV as shown in Figure4(b), and an exponential tail is observed which extends up to higher energy which is associated with band filling and thermal broadening in the QWs.
The power dependence of the PL emission from each of the samples was also measured to determine the dominant recombination process based on the PL intensity (L) vs pump power (I) expression; where the exponent Z= 1 corresponds to Shockley-Read-Hall (SRH), Z = 2 corresponds to radiative recombination and Z = 3 corresponds to non-radiative Auger recombination respectively [11]. The corresponding Z parameter are given in Table 1 from which we observe that recombination is predominantly radiative in these samples except for QA276 where SRH recombination is more significant at 10 K. These values are also plotted in Figure 5 showing the much lower value for QA276 which is attributed to defects in the lattice structure whilst showing a nominally constant radiative-dominated process in both QA216 and QJ410. Due to the limitations of this method, differences in Z paramter of ~0.1 can be considered negligible due to the assumptions in the model including the need for a constant number of carriers.
Figure 5. The temperature dependence of the Z value for each of the MQW samples; QA216—black solid diamonds, QJ410—solid blue points, QA276—solid red squares.
The temperature dependence of the integrated PL emission intensity is shown in Figure 6. The high initial intensity of QA216 at 10 K is attributed to better crystalline perfection. The recombination is predominantly radiative and the thermal quenching is determined by limited carrier (electron) confinement in the MQWs. Sample QA276 quenches at about the same rate as QJ410 but has the lowest 4 K PL intensity which is as expected from the increased threading dislocation density originating from the heteroepitaxial growth mediated by the IMF buffer layer. By comparison the 4 K PL intensity of the AlGaSb ternary IMF sample (QJ410) is about one order higher over the entire temperature range. The increased confinement arising from the AlGaSb barriers helps to maintain PL emission up to room temperature compared to the other two samples which are quenched above ~250 K. This is also supported by the nominally equal recombination processes in QA216 and QJ410 but weaker emission from the smaller barriers of QA216. Both IMF based samples (QA276 and QJ410) are also more susceptible to carrier recombination in the barriers due to the higher levels of threading dislocations and structure defects compared with the homoepitaxial sample QA216.
Figure 6. The temperature dependence of the integrated PL emission intensity for each of the MQW samples; QA216—black solid points, QJ410—solid blue diamonds, QA276—solid red squares.
In summary, we have reported the MBE growth of strained InGaSb/(Al)GaSb MQW structures containing ~30% In on GaSb and GaAs substrates using IMF buffers of both GaSb and ternary AlGaSb. The structural properties of the different samples and the effect on the PL emission efficiency and thermal quenching were compared. The structural perfection and crystallinity of the homoepitaxial MQW was found to be superior and the thermal quenching in this case is determined mainly by the electron-hole confinement in the QW. Transferring this structure directly onto GaAs using a GaSb IMF approach resulted in inferior PL emission intensity at 4 K and thermal quenching of the emission above 250 K, which we attributed to non-radiative SRH recombination within the GaSb barriers. By comparison, it has been shown that when a ternary AlGaSb IMF is used instead, the 4 K PL intensity is considerably recovered and the PL emission persists up to room temperature, due to the improved crystallinity of the ternary IMF and the additional carrier confinement for both electrons and holes arising from the AlGaSb barriers. In each case the PL emission peaks were reconciled with the calculated values. Although further optimisation is required to improve the thickness uniformity of the InGaSb MQW, we have shown that Al0.53Ga0.47Sb/Ga0.7In0.3Sb MQWs grown on GaAs using a ternary Al0.53Ga0.47Sb IMF buffer layer can provide a viable alternative to growth on GaSb substrates to access longer wavelength applications since it facilitates the use of both inexpensive and semi-insulating substrates.
This work was supported by The Centre for Global Eco-Innovation, Oxley Developments Ltd & European Regional Development Fund 2007-13. Thanks are also given to Dr Richard Beanland of Warwick University for the TEM images.
All Authors declare no conflicts of interest in this paper
| [1] |
Torii S, Jinnouchi H, Sakamoto A, et al. (2020) Vascular responses to coronary calcification following implantation of newer-generation drug-eluting stents in humans: impact on healing. Eur Heart J 41: 786-796. doi: 10.1093/eurheartj/ehz850
|
| [2] |
Watanabe Y, Lefèvre T, Bouvier E, et al. (2015) Prognostic value of aortic root calcification volume on clinical outcomes after transcatheter balloon-expandable aortic valve implantation. Catheter Cardiovasc Interv 86: 1105-1113. doi: 10.1002/ccd.25986
|
| [3] |
Iung B, Vahanian A (2011) Epidemiology of valvular heart disease in the adult. Nat Rev Cardiol 8: 162-172. doi: 10.1038/nrcardio.2010.202
|
| [4] |
Bonow RO, Leon MB, Doshi D, et al. (2016) Management strategies and future challenges for aortic valve disease. Lancet 387: 1312-1323. doi: 10.1016/S0140-6736(16)00586-9
|
| [5] |
Nakahara T, Dweck MR, Narula N, et al. (2017) Coronary Artery Calcification: From Mechanism to Molecular Imaging. JACC Cardiovasc Imaging 10: 582-593. doi: 10.1016/j.jcmg.2017.03.005
|
| [6] |
Otsuka F, Sakakura K, Yahagi K, et al. (2014) Has our understanding of calcification in human coronary atherosclerosis progressed? Arterioscler Thromb Vasc Biol 34: 724-736. doi: 10.1161/ATVBAHA.113.302642
|
| [7] |
Stary HC, Blankenhorn DH, Chandler AB, et al. (1992) A definition of the intima of human arteries and of its atherosclerosis-prone regions. A report from the Committee on Vascular Lesions of the Council on Arteriosclerosis, American Heart Association. Circulation 85: 391-405. doi: 10.1161/01.CIR.85.1.391
|
| [8] |
Orlandi A (2015) The contribution of resident vascular stem cells to arterial pathology. Int J Stem Cells 8: 9-17. doi: 10.15283/ijsc.2015.8.1.9
|
| [9] |
Harper E, Forde H, Davenport C, et al. (2016) Vascular calcification in type-2 diabetes and cardiovascular disease: Integrative roles for OPG, RANKL and TRAIL. Vascul Pharmacol 82: 30-40. doi: 10.1016/j.vph.2016.02.003
|
| [10] |
Fadini GP, Rattazzi M, Matsumoto T, et al. (2012) Emerging role of circulating calcifying cells in the bone-vascular axis. Circulation 125: 2772-2781. doi: 10.1161/CIRCULATIONAHA.112.090860
|
| [11] |
Burke AP, Weber DK, Kolodgie FD, et al. (2001) Pathophysiology of calcium deposition in coronary arteries. Herz 26: 239-244. doi: 10.1007/PL00002026
|
| [12] |
Mori H, Torii S, Kutyna M, et al. (2018) Coronary Artery Calcification and its Progression: What Does it Really Mean? JACC Cardiovasc Imaging 11: 127-142. doi: 10.1016/j.jcmg.2017.10.012
|
| [13] |
Sangiorgi G, Rumberger JA, Severson A, et al. (1998) Arterial calcification and not lumen stenosis is highly correlated with atherosclerotic plaque burden in humans: a histologic study of 723 coronary artery segments using nondecalcifying methodology. J Am Coll Cardiol 31: 126-133. doi: 10.1016/S0735-1097(97)00443-9
|
| [14] |
Glagov S, Weisenberg E, Zarins CK, et al. (1987) Compensatory enlargement of human atherosclerotic coronary arteries. N Engl J Med 316: 1371-1375. doi: 10.1056/NEJM198705283162204
|
| [15] |
Burke AP, Virmani R, Galis Z, et al. (2003) 34th Bethesda Conference: Task force #2--What is the pathologic basis for new atherosclerosis imaging techniques? J Am Coll Cardiol 41: 1874-1886. doi: 10.1016/S0735-1097(03)00359-0
|
| [16] |
Williams JK, Adams MR, Klopfenstein HS (1990) Estrogen modulates responses of atherosclerotic coronary arteries. Circulation 81: 1680-1687. doi: 10.1161/01.CIR.81.5.1680
|
| [17] |
Burke AP, Taylor A, Farb A, et al. (2000) Coronary calcification: insights from sudden coronary death victims. Z Kardiol 2: 49-53. doi: 10.1007/s003920070099
|
| [18] |
Burke AP, Farb A, Malcom G, et al. (2001) Effect of menopause on plaque morphologic characteristics in coronary atherosclerosis. Am Heart J 141: S58-62. doi: 10.1067/mhj.2001.109946
|
| [19] |
Manson JE, Allison MA, Rossouw JE, et al. (2007) Estrogen therapy and coronary-artery calcification. N Engl J Med 356: 2591-2602. doi: 10.1056/NEJMoa071513
|
| [20] |
Bild DE, Detrano R, Peterson D, et al. (2005) Ethnic differences in coronary calcification: the Multi-Ethnic Study of Atherosclerosis (MESA). Circulation 111: 1313-1320. doi: 10.1161/01.CIR.0000157730.94423.4B
|
| [21] | Burke A, Farb A, Kutys R, et al. (2002) Atherosclerotic coronary plaques in African Americans are less likely to calcify than coronary plaques in Caucasian Americans. Circulation 106: 481-481. |
| [22] | Lee TC, O'Malley PG, Feuerstein I, et al. (2003) The prevalence and severity of coronary artery calcification on coronary artery computed tomography in black and white subjects. J Am Coll Cardiol 41: 39-44. |
| [23] |
Loria CM, Liu K, Lewis CE, et al. (2007) Early adult risk factor levels and subsequent coronary artery calcification: the CARDIA Study. J Am Coll Cardiol 49: 2013-2020. doi: 10.1016/j.jacc.2007.03.009
|
| [24] |
Kiel DP, Kauppila LI, Cupples LA, et al. (2001) Bone loss and the progression of abdominal aortic calcification over a 25 year period: the Framingham Heart Study. Calcif Tissue Int 68: 271-276. doi: 10.1007/BF02390833
|
| [25] |
Mauriello A, Servadei F, Zoccai GB, et al. (2013) Coronary calcification identifies the vulnerable patient rather than the vulnerable Plaque. Atherosclerosis 229: 124-129. doi: 10.1016/j.atherosclerosis.2013.03.010
|
| [26] |
Huang CC, Lloyd-Jones DM, Guo X, et al. (2011) Gene expression variation between African Americans and whites is associated with coronary artery calcification: the multiethnic study of atherosclerosis. Physiol Genomics 43: 836-843. doi: 10.1152/physiolgenomics.00243.2010
|
| [27] |
Fornage M, Boerwinkle E, Doris PA, et al. (2004) Polymorphism of the soluble epoxide hydrolase is associated with coronary artery calcification in African-American subjects: The Coronary Artery Risk Development in Young Adults (CARDIA) study. Circulation 109: 335-339. doi: 10.1161/01.CIR.0000109487.46725.02
|
| [28] |
Rumberger JA, Simons DB, Fitzpatrick LA, et al. (1995) Coronary artery calcium area by electron-beam computed tomography and coronary atherosclerotic plaque area. A histopathologic correlative study. Circulation 92: 2157-2162. doi: 10.1161/01.CIR.92.8.2157
|
| [29] |
Raggi P, Shaw LJ, Berman DS, et al. (2004) Prognostic value of coronary artery calcium screening in subjects with and without diabetes. J Am Coll Cardiol 43: 1663-1669. doi: 10.1016/j.jacc.2003.09.068
|
| [30] |
Carson AP, Steffes MW, Carr JJ, et al. (2015) Hemoglobin a1c and the progression of coronary artery calcification among adults without diabetes. Diabetes care 38: 66-71. doi: 10.2337/dc14-0360
|
| [31] |
Burke AP, Kolodgie FD, Farb A, et al. (2001) Healed plaque ruptures and sudden coronary death: evidence that subclinical rupture has a role in plaque progression. Circulation 103: 934-940. doi: 10.1161/01.CIR.103.7.934
|
| [32] |
Burke AP, Kolodgie FD, Zieske A, et al. (2004) Morphologic findings of coronary atherosclerotic plaques in diabetics: a postmortem study. Arterioscler Thromb Vasc Biol 24: 1266-1271. doi: 10.1161/01.ATV.0000131783.74034.97
|
| [33] |
Goodman WG, Goldin J, Kuizon BD, et al. (2000) Coronary-artery calcification in young adults with end-stage renal disease who are undergoing dialysis. N Engl J Med 342: 1478-1483. doi: 10.1056/NEJM200005183422003
|
| [34] |
Sigrist M, Bungay P, Taal MW, et al. (2006) Vascular calcification and cardiovascular function in chronic kidney disease. Nephrol Dial Transplant 21: 707-714. doi: 10.1093/ndt/gfi236
|
| [35] |
Baber U, de Lemos JA, Khera A, et al. (2008) Non-traditional risk factors predict coronary calcification in chronic kidney disease in a population-based cohort. Kidney Int 73: 615-621. doi: 10.1038/sj.ki.5002716
|
| [36] |
Block GA, Raggi P, Bellasi A, et al. (2007) Mortality effect of coronary calcification and phosphate binder choice in incident hemodialysis patients. Kidney Int 71: 438-441. doi: 10.1038/sj.ki.5002059
|
| [37] |
Raggi P, Boulay A, Chasan-Taber S, et al. (2002) Cardiac calcification in adult hemodialysis patients. A link between end-stage renal disease and cardiovascular disease? J Am Coll Cardiol 39: 695-701. doi: 10.1016/S0735-1097(01)01781-8
|
| [38] |
Oh J, Wunsch R, Turzer M, et al. (2002) Advanced coronary and carotid arteriopathy in young adults with childhood-onset chronic renal failure. Circulation 106: 100-105. doi: 10.1161/01.CIR.0000020222.63035.C0
|
| [39] |
Chertow GM, Raggi P, Chasan-Taber S, et al. (2004) Determinants of progressive vascular calcification in haemodialysis patients. Nephrol Dial Transplant 19: 1489-1496. doi: 10.1093/ndt/gfh125
|
| [40] |
Chertow GM, Burke SK, Raggi P (2002) Sevelamer attenuates the progression of coronary and aortic calcification in hemodialysis patients. Kidney Int 62: 245-252. doi: 10.1046/j.1523-1755.2002.00434.x
|
| [41] |
Guerin AP, London GM, Marchais SJ, et al. (2000) Arterial stiffening and vascular calcifications in end-stage renal disease. Nephrol Dial Transplant 15: 1014-1021. doi: 10.1093/ndt/15.7.1014
|
| [42] |
Adeney KL, Siscovick DS, Ix JH, et al. (2009) Association of serum phosphate with vascular and valvular calcification in moderate CKD. J Am Soc Nephrol 20: 381-387. doi: 10.1681/ASN.2008040349
|
| [43] |
Kestenbaum B, Sampson JN, Rudser KD, et al. (2005) Serum phosphate levels and mortality risk among people with chronic kidney disease. J Am Soc Nephrol 16: 520-528. doi: 10.1681/ASN.2004070602
|
| [44] |
Dhingra R, Sullivan LM, Fox CS, et al. (2007) Relations of serum phosphorus and calcium levels to the incidence of cardiovascular disease in the community. Arch Intern Med 167: 879-885. doi: 10.1001/archinte.167.9.879
|
| [45] |
Palmer SC, Gardner S, Tonelli M, et al. (2016) Phosphate-Binding Agents in Adults With CKD: A Network Meta-analysis of Randomized Trials. Am J Kidney Dis 68: 691-702. doi: 10.1053/j.ajkd.2016.05.015
|
| [46] |
Raggi P, Bellasi A, Bushinsky D, et al. (2020) Slowing Progression of Cardiovascular Calcification With SNF472 in Patients on Hemodialysis: Results of a Randomized Phase 2b Study. Circulation 141: 728-739. doi: 10.1161/CIRCULATIONAHA.119.044195
|
| [47] |
Raggi P, Chertow GM, Torres PU, et al. (2011) The ADVANCE study: a randomized study to evaluate the effects of cinacalcet plus low-dose vitamin D on vascular calcification in patients on hemodialysis. Nephrol Dial Transplant 26: 1327-1339. doi: 10.1093/ndt/gfq725
|
| [48] |
Sadek T, Mazouz H, Bahloul H, et al. (2003) Sevelamer hydrochloride with or without alphacalcidol or higher dialysate calcium vs calcium carbonate in dialysis patients: an open-label, randomized study. Nephrol Dial Transplant 18: 582-588. doi: 10.1093/ndt/18.3.582
|
| [49] |
Sawabe M, Arai T, Kasahara I, et al. (2006) Sustained progression and loss of the gender-related difference in atherosclerosis in the very old: a pathological study of 1074 consecutive autopsy cases. Atherosclerosis 186: 374-379. doi: 10.1016/j.atherosclerosis.2005.07.023
|
| [50] |
Dalager S, Paaske WP, Kristensen IB, et al. (2007) Artery-related differences in atherosclerosis expression: implications for atherogenesis and dynamics in intima-media thickness. Stroke 38: 2698-2705. doi: 10.1161/STROKEAHA.107.486480
|
| [51] |
Yahagi K, Kolodgie FD, Otsuka F, et al. (2016) Pathophysiology of native coronary, vein graft, and in-stent atherosclerosis. Nat Rev Cardiol 13: 79-98. doi: 10.1038/nrcardio.2015.164
|
| [52] |
Herisson F, Heymann MF, Chetiveaux M, et al. (2011) Carotid and femoral atherosclerotic plaques show different morphology. Atherosclerosis 216: 348-354. doi: 10.1016/j.atherosclerosis.2011.02.004
|
| [53] |
Derksen WJM, de Vries J-PPM, Vink A, et al. (2010) Histologic atherosclerotic plaque characteristics are associated with restenosis rates after endarterectomy of the common and superficial femoral arteries. J Vasc Surg 52: 592-599. doi: 10.1016/j.jvs.2010.03.063
|
| [54] | Soor GS, Vukin I, Leong SW, et al. (2008) Peripheral vascular disease: who gets it and why? A histomorphological analysis of 261 arterial segments from 58 cases. Pathology (Phila) 40: 385-391. |
| [55] |
Lachman AS, Spray TL, Kerwin DM, et al. (1977) Medial calcinosis of Monckeberg. A review of the problem and a description of a patient with involvement of peripheral, visceral and coronary arteries. Am J Med 63: 615-622. doi: 10.1016/0002-9343(77)90207-8
|
| [56] |
Amos RS, Wright V (1980) Monckeberg's arteriosclerosis and metabolic bone disease. Lancet 2: 248-249. doi: 10.1016/S0140-6736(80)90133-6
|
| [57] | Kolodgie F, Nakazawa G, Santorgi G, et al. (2007) Differences and commons in pathology and reaction on stents between cardiac and peripheral arteries. European Symposium of Vascular Biomaterials 2007 New Technologies in Vascular Biomaterials Strasbourg: EUROPROT 49-70. |
| [58] |
Torii S, Mustapha AJ, Narula J, et al. (2019) Histopathologic Characterization of Peripheral Arteries in Subjects with Abundant Risk Factors. JACC Cardiovasc Imaging 12: 1501-1513. doi: 10.1016/j.jcmg.2018.08.039
|
| [59] |
Mauriello A, Sangiorgi GM, Virmani R, et al. (2010) A pathobiologic link between risk factors profile and morphological markers of carotid instability. Atherosclerosis 208: 572-580. doi: 10.1016/j.atherosclerosis.2009.07.048
|
| [60] | Diehm N, Silvestro A, Baumgartner I, et al. (2009) Chronic critical limb ischemia: European experiences. J Cardiovasc Surg (Torino) 50: 647-653. |
| [61] |
Narula N, Dannenberg AJ, Olin JW, et al. (2018) Pathology of Peripheral Artery Disease in Patients With Critical Limb Ischemia. J Am Coll Cardiol 72: 2152-2163. doi: 10.1016/j.jacc.2018.08.002
|
| [62] |
Kamenskiy A, Poulson W, Sim S, et al. (2018) Prevalence of Calcification in Human Femoropopliteal Arteries and its Association with Demographics, Risk Factors, and Arterial Stiffness. Arterioscler Thromb Vasc Biol 38: e48-e57. doi: 10.1161/ATVBAHA.117.310490
|
| [63] |
Deas DS, Marshall AP, Bian A, et al. (2015) Association of cardiovascular and biochemical risk factors with tibial artery calcification. Vasc Med 20: 326-331. doi: 10.1177/1358863X15581448
|
| [64] |
Shao JS, Cheng SL, Sadhu J, et al. (2010) Inflammation and the osteogenic regulation of vascular calcification: a review and perspective. Hypertension 55: 579-592. doi: 10.1161/HYPERTENSIONAHA.109.134205
|
| [65] |
Moe SM, Chen NX (2004) Pathophysiology of vascular calcification in chronic kidney disease. Circ Res 95: 560-567. doi: 10.1161/01.RES.0000141775.67189.98
|
| [66] |
Kroger K, Stang A, Kondratieva J, et al. (2006) Prevalence of peripheral arterial disease - results of the Heinz Nixdorf recall study. Eur J Epidemiol 21: 279-285. doi: 10.1007/s10654-006-0015-9
|
| [67] |
Vasuri F, Fittipaldi S, Pacilli A, et al. (2016) The incidence and morphology of Monckeberg's medial calcification in banked vascular segments from a monocentric donor population. Cell Tissue Bank 17: 219-223. doi: 10.1007/s10561-016-9543-z
|
| [68] |
Creager MA, Belkin M, Bluth EI, et al. (2012) 2012 ACCF/AHA/ACR/SCAI/SIR/STS/SVM/SVN/SVS key data elements and definitions for peripheral atherosclerotic vascular disease: a report of the American College of Cardiology Foundation/American Heart Association Task Force on Clinical Data Standards (Writing Committee to Develop Clinical Data Standards for Peripheral Atherosclerotic Vascular Disease). Circulation 125: 395-467. doi: 10.1161/CIR.0b013e31823299a1
|
| [69] |
Sahasakul Y, Edwards WD, Naessens JM, et al. (1988) Age-related changes in aortic and mitral valve thickness: implications for two-dimensional echocardiography based on an autopsy study of 200 normal human hearts. Am J Cardiol 62: 424-430. doi: 10.1016/0002-9149(88)90971-X
|
| [70] |
Nkomo VT, Gardin JM, Skelton TN, et al. (2006) Burden of valvular heart diseases: a population-based study. Lancet 368: 1005-1011. doi: 10.1016/S0140-6736(06)69208-8
|
| [71] |
Sakamoto A, Guo L, Virmani R, et al. (2019) Is there a role for activated platelets in progression of aortic valve calcification? Eur Heart J 40: 1374-1377. doi: 10.1093/eurheartj/ehy775
|
| [72] | Butany J, Collins MJ, Demellawy DEI, et al. (2005) Morphological and clinical findings in 247 surgically excised native aortic valves. Can J Cardiol 21: 747-755. |
| [73] |
Roberts WC, Ko JM (2004) Weights of individual cusps in operatively-excised stenotic three-cuspid aortic valves. Am J Cardiol 94: 681-684. doi: 10.1016/j.amjcard.2004.05.045
|
| [74] |
Owens DS, Katz R, Takasu J, et al. (2010) Incidence and progression of aortic valve calcium in the Multi-ethnic Study of Atherosclerosis (MESA). Am J Cardiol 105: 701-708. doi: 10.1016/j.amjcard.2009.10.071
|
| [75] |
Mohler ER, Gannon F, Reynolds C, et al. (2001) Bone formation and inflammation in cardiac valves. Circulation 103: 1522-1528. doi: 10.1161/01.CIR.103.11.1522
|
| [76] |
O'Brien KD, Reichenbach DD, Marcovina SM, et al. (1996) Apolipoproteins B, (a), and E accumulate in the morphologically early lesion of ‘degenerative’ valvular aortic stenosis. Arterioscler Thromb Vasc Biol 16: 523-532. doi: 10.1161/01.ATV.16.4.523
|
| [77] |
Milin AC, Vorobiof G, Aksoy O, et al. (2014) Insights into aortic sclerosis and its relationship with coronary artery disease. J Am Heart Assoc 3: 001111. doi: 10.1161/JAHA.114.001111
|
| [78] |
Chiu JJ, Chien S (2011) Effects of disturbed flow on vascular endothelium: pathophysiological basis and clinical perspectives. Physiol Rev 91: 327-387. doi: 10.1152/physrev.00047.2009
|
| 1. | L. Chenini, A. Aissat, M. Halbwax, J.P. Vilcot, Performance simulation of an InGaSb/GaSb based quantum well structure for laser diode applications, 2023, 03759601, 128711, 10.1016/j.physleta.2023.128711 | |
| 2. | L. S. Lunin, M. L. Lunina, A. S. Pashchenko, A. V. Donskaya, Effect of Concentration Supercooling on the Structure and Properties of GaInAsSbP/GaP Heterostructures, 2025, 19, 1027-4510, 21, 10.1134/S1027451025700041 |
Figures(11)
Yu Sato, Hiroyuki Jinnouchi, Atsushi Sakamoto, Anne Cornelissen, Masayuki Mori, Rika Kawakami, Kenji Kawai, Renu Virmani, Aloke V. Finn. Calcification in human vessels and valves: from pathological point of view[J]. AIMS Molecular Science, 2020, 7(3): 183-210. doi: 10.3934/molsci.2020009
| QA216 | QA276 | QJ410 | ||||
| Buffer layer | GaSb | GaSb IMF | AlGaSb IMF | |||
| QW thickness (Lz)/ nm | 4±1 | 4±1 | 7±4 | |||
| QW In content (%) | 34 | 32 | 28 | |||
| Strain (%) | 2.1 | 2.0 | 1.4 | |||
| PL peak | Wavelength (μm) | 1.77 | 1.77 | 1.70 | ||
| Energy (eV) | 0.699 | 0.703 | 0.728 | |||
| Relative PL intensity (10 K) | 1 | 0.025 | 0.66 | |||
| FWHM (meV)at 4 K | 15.4 | 16.7 | 20.5 | |||
| Confinement energy (meV) | e- | 49 | 48 | 506 | ||
| h+ | 98 | 98 | 345 | |||
| Z parameter | 4K | 1.9 | 1.2 | 1.8 | ||
| 225K | 2.2 | - | 2.3 | |||
DownLoad: CSV| QA216 | QA276 | QJ410 | ||||
| Buffer layer | GaSb | GaSb IMF | AlGaSb IMF | |||
| QW thickness (Lz)/ nm | 4±1 | 4±1 | 7±4 | |||
| QW In content (%) | 34 | 32 | 28 | |||
| Strain (%) | 2.1 | 2.0 | 1.4 | |||
| PL peak | Wavelength (μm) | 1.77 | 1.77 | 1.70 | ||
| Energy (eV) | 0.699 | 0.703 | 0.728 | |||
| Relative PL intensity (10 K) | 1 | 0.025 | 0.66 | |||
| FWHM (meV)at 4 K | 15.4 | 16.7 | 20.5 | |||
| Confinement energy (meV) | e- | 49 | 48 | 506 | ||
| h+ | 98 | 98 | 345 | |||
| Z parameter | 4K | 1.9 | 1.2 | 1.8 | ||
| 225K | 2.2 | - | 2.3 | |||
