Phospholipid synthetic and turnover pathways elicited upon exposure to different xenobiotics

Teresa M. Fonovich; Teresa M. Fonovich

doi:10.3934/molsci.2020010

AIMS Molecular Science

2020, Volume 7, Issue 3: 211-228. doi: 10.3934/molsci.2020010

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Review

Phospholipid synthetic and turnover pathways elicited upon exposure to different xenobiotics

Teresa M. Fonovich ^{1,2
,
,}

1.
School of Science and Technology, National University of San Martín, San Martín, Buenos Aires Province, Argentina
2.
Laboratory of Ecotoxicology, Institute of Research and Environmental Engineering, National University of San Martín, San Martín, Buenos Aires Province, Argentina

Received: 25 March 2020 Accepted: 15 June 2020 Published: 18 June 2020

Phospholipids, neutral lipids and glycolipids metabolism take the place during cell responses to different stimuli. Phospholipase and acyl glycerol lipase activities have been demonstrated to release second messengers that trigger cascade responses. Studies on lipid droplets structure, formation and interaction with other organelles have recently been described in prokaryotes and eukaryotes. Remodeling of membrane phospholipids has also been reported. NMR studies performed on synthetic membranes allowed to postulate membrane lipids polymorphism and to explain how processes like cell division, endocytosis and exocytosis can take place, due to special arrangements of the membranes. Studies from our research group on the pesticide dieldrin and Cu²⁺ effects through exposure of amphibian oocytes and embryos to sub-lethal and acclimation concentrations followed by toxic concentration challenges respectively, are discussed. Membrane phospholipids structure alterations allowing stabilization of bilayer arrangements were found for both stressors in cell and tissues. Metallothionein induction response that prevents oxidative stress was also found in acclimated embryo tissues. Probable connections between enzyme activities taking place on lysophospholipid and triacylglycerol substrates present in lipid droplets as well as phospholipid trafficking leading to modifications on membrane phospholipid ratios are discussed. Current new evidences in agreement with our findings allow us to suggest that our previously published results of dieldrin effects on amphibian cells correspond to joint coordinated activities, which probably had involved various metabolic pathways, in line with the acclimation experiment results and discussion. Independently of the cascade responses each toxicant is able to elicit, lipids play an important role in cell responses, both through rapid turnover and final stabilization of membrane bilayers.

Keywords:

Citation: Teresa M. Fonovich. Phospholipid synthetic and turnover pathways elicited upon exposure to different xenobiotics[J]. AIMS Molecular Science, 2020, 7(3): 211-228. doi: 10.3934/molsci.2020010

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Abstract

1. Introduction

Let $p$ be a prime, $f$ be a polynomial with k variable and $\mathbf{F}_p = \mathbf{Z}/(p)$ be the finite field, where $\mathbf{Z}$ is the integer ring, and let

$N(f;p) = \#\{(x_1, x_2, \cdots, x_k)\in\mathbf{F}_p^k|f(x_1, x_2, \cdots, x_k) = 0\}.$

Many scholars studied the exact formula (including upper bound and lower bound) for $N(f; p)$ for many years, it is one of the main topics in the finite field theory, the most elementary upper bounds was given as follows (see ^[14])

$N(f;p)\leq p^{k-1}deg f.$

Let $ord_p$ denote the p-adic additive valuation normalized such that $ord_pp = 1$ . The famous Chevalley-Warning theorem shows that $ord_pN(f; p) > 0$ if $n > deg f$ . Let [x] denote the least integer $\geq x$ and $e$ denote the extension degree of $\mathbf{F}_q /\mathbf{F}_p$ . Ax (see ^[2]) showed that

$ord_pN(f;q)\geq e\left[\frac{n-deg f}{deg f}\right].$

In 1977, S. Chowla et al. (see ^[7]) investigated a problem about the number of solutions of a equation in finite field $\mathbf{F}_p$ as follow,

$x_1^3+x_2^3+\cdot\cdot\cdot+x_k^3\equiv0,$

where $p$ is a prime with $p\equiv1\bmod\ 3$ and $x_i\in \mathbf{F}_p$ , $1\leq i\leq k$ .

Let $M_k$ denotes the number of solutions of the above equation. They proved that

$\begin{eqnarray} M_3 = p^2+d(p-1), M_4 = p^2+6(p^2-p), \\ \sum\limits_{s = 1}^{\infty}M_sx^s = \frac{x}{1-px}+\frac{x^2(p-1)(2+dx)}{1-3px^2-pdx^3}, \\ \end{eqnarray}$

where $d$ is uniquely determined by $4p = d^2+27y^2$ and $d\equiv1\ mod\ 3$ .

Myerson ^[12] extended the result in ^[2] to the field $\mathbf{F}_q$ and first studied the following equation over $\mathbf{F}_q$ ,

$x_1^3+x_2^3+\cdot\cdot\cdot+x_k^3\equiv0.$

Recently J. Zhao et al. (see ^[17]) investigated the following equations over field $\mathbf{F}_p$ ,

$\begin{eqnarray} &&\ \ \ f_1 = x_1^4+x_2^4+x_3^4, \\ &&f_2 = x_1^4+x_2^4+x_3^4+x_4^4. \end{eqnarray}$

And they give exact value of $N(f_1;p)$ and $N(f_2;p)$ . For more general problem about this issue interested reader can see ^[6,9,10,11].

In this paper, let $A(k, p)$ denotes the number of solutions of the following equation in $\mathbf{F}_p$ ,

$x_1^6+x_2^6+\cdot\cdot\cdot+x_k^6\equiv0,$

where $p$ is a prime with $p\equiv1\bmod\ 3$ and $x_i\in \mathbf{F}_p$ , $1\leq i\leq k$ , and for simplicity, in the rest of this paper, we assume there exists an integer $z$ such that $z^3\equiv2\bmod\ p$ , we use analytic methods to give a recurrence formula for the number of solutions of the above equation. And our method is based on the properties of Gauss sum. It is worth noting that we used a novel method to simplify the steps and avoid a lot of complicated calculations. We proved the following:

Theorem 1. For any positive integer $k\geq1$ , we have the recurrence formula

$\begin{eqnarray} A(k+6, p)& = &5pA(k+4, p)+10dpA(k+3, p)\\&&+(46p^2+5d^2p+dp)A(k+2, p)\\ &&+(2p^2+120dp^2+3d^3p+d^2p+dp)A(k+1, p)\\ &&+(-4p^5+2d^2p^4+64p^{7/2}+381p^3+2d^2p^{5/2}\\ &&+(129d^2+11d+6)p^2+d^4p)A(k, p)\\ &&+p^{k+5}-p^{k+4}-(10dp+2d^2)p^{k+3}-64p^{k+5/2}\\&&-(429+121d+5d^2)p^{k+2}\\ &&-2d^2p^{k+3/2}-(3d^3+130d^2+12d+6)p^{k+1}-d^4p^k, \end{eqnarray}$

with the initial condition

$\begin{eqnarray} &&A(1, p) = 1, A(2, p) = 4(p-1)+p, A(3, p) = 10d(p-1)+p^2, \\ &&A(4, p) = 56p(p-1)+10d^2(p-1)+p^3, \\ &&A(5, p) = 188dp(p-1)+5d^3(p-1)+16dC(p)(p-1)+p^4, \\ &&A(6, p) = p^5+1400p^2(p-1)+(388d^2+8d-576)p(p-1)+d^2p-d^2, \end{eqnarray}$

where $d$ is uniquely determined by $4p = d^2+27y^2$ and $d\equiv1\ mod\ 3$ , and $C(p) = \sum\limits_{a = 1}^{p}e_p(a^3)$ .

Remark. Our method is suitable to calculus the number of solutions of the following equation in $\mathbf{F}_p$ ,

$x_1^t+x_2^t+\cdot\cdot\cdot+x_k^t\equiv0,$

where $p$ satisfied a certain congruence conditions, and $t$ is any nature number.

Our Theorem 2 can be deduced from Theorem 1 and the theory of the Difference equations.

Theorem 2. Let $t_i$ ( $1\leq i\leq k$ ) be the real root of the below equation with multiplicity $s_i$ ( $1\leq i\leq k$ ) respectively, and $\rho_je^{\pm iw_j}$ ( $1\leq j\leq h$ ) be the complex root of the below equation with multiplicity $r_j$ ( $1\leq j\leq h$ ) respectively,

$\begin{eqnarray} x^6& = &5px^4+10dpx^3+(46p^2+5d^2p+dp)x^2\\ &&+(2p^2+120dp^2+3d^3p+d^2p+dp)x\\ &&+(-4p^5+2d^2p^4+64p^{7/2}+381p^3+2d^2p^{5/2}\\ &&+(129d^2+11d+6)p^2+d^4p). \end{eqnarray}$

We have

$\begin{eqnarray*} A(n, p)& = &\sum\limits_{i = 1}^k\sum\limits_{a = 1}^{s_i}C_{ia}n^{s_i-a}t_i^n+\sum\limits_{j = 1}^{h}\sum\limits_{b = 1}^{r_j}D_{jb}n^{r_j-b}\rho_j^n\cos nw_j+\sum\limits_{j = 1}^{h}\sum\limits_{b = 1}^{r_j}E_{jb}n^{r_j-b}\rho_j^n\sin nw_j, \end{eqnarray*}$

where $C_{ia}, D_{jb}, E_{jb}$ , are determined by

$\begin{eqnarray} A(6, p)& = &\sum\limits_{i = 1}^k\sum\limits_{a = 1}^{s_i}C_{ia}6^{s_i-a}t_i^6+\sum\limits_{j = 1}^{h}\sum\limits_{b = 1}^{r_j}D_{jb}6^{r_j-b}\rho_j^6\cos 6w_j+\sum\limits_{j = 1}^{h}\sum\limits_{b = 1}^{r_j}E_{jb}6^{r_j-b}\rho_j^6\sin 6w_j, \\ A(5, p)& = &\sum\limits_{i = 1}^k\sum\limits_{a = 1}^{s_i}C_{ia}5^{s_i-a}t_i^5+\sum\limits_{j = 1}^{h}\sum\limits_{b = 1}^{r_j}D_{jb}5^{r_j-b}\rho_j^5\cos 5w_j+\sum\limits_{j = 1}^{h}\sum\limits_{b = 1}^{r_j}E_{jb}5^{r_j-b}\rho_j^5\sin 5w_j, \\ A(4, p)& = &\sum\limits_{i = 1}^k\sum\limits_{a = 1}^{s_i}C_{ia}4^{s_i-a}t_i^4+\sum\limits_{j = 1}^{h}\sum\limits_{b = 1}^{r_j}D_{jb}4^{r_j-b}\rho_j^4\cos 4w_j+\sum\limits_{j = 1}^{h}\sum\limits_{b = 1}^{r_j}E_{jb}4^{r_j-b}\rho_j^4\sin 4w_j, \\ A(3, p)& = &\sum\limits_{i = 1}^k\sum\limits_{a = 1}^{s_i}C_{ia}3^{s_i-a}t_i^3+\sum\limits_{j = 1}^{h}\sum\limits_{b = 1}^{r_j}D_{jb}3^{r_j-b}\rho_j^3\cos 3w_j+\sum\limits_{j = 1}^{h}\sum\limits_{b = 1}^{r_j}E_{jb}3^{r_j-b}\rho_j^3\sin 3w_j, \\ A(2, p)& = &\sum\limits_{i = 1}^k\sum\limits_{a = 1}^{s_i}C_{ia}2^{s_i-a}t_i^2+\sum\limits_{j = 1}^{h}\sum\limits_{b = 1}^{r_j}D_{jb}2^{r_j-b}\rho_j^2\cos 2w_j+\sum\limits_{j = 1}^{h}\sum\limits_{b = 1}^{r_j}E_{jb}2^{r_j-b}\rho_j^2\sin 2w_j, \\ A(1, p)& = &\sum\limits_{i = 1}^k\sum\limits_{a = 1}^{s_i}C_{ia}t_i+\sum\limits_{j = 1}^{h}\sum\limits_{b = 1}^{r_j}D_{jb}\rho_j\cos w_j+\sum\limits_{j = 1}^{h}\sum\limits_{b = 1}^{r_j}E_{jb}\rho_j\sin w_j.\\ \end{eqnarray}$

(1.1)

2. Some Lemmas

Before we prove these lemmas, we give some notations, $\chi_2$ denotes the second-order character of $\mathbf{F}_p$ , $\chi$ denotes the third-order character of $\mathbf{F}_p$ , $\psi$ denotes the sixth order character of $\mathbf{F}_p$ .

$\begin{eqnarray} e_p(x) = e^{\frac{2\pi ix}{p}}, \tau(\chi) = \sum\limits_{m = 1}^{p}\chi(m)e_p(m), G(\chi, m) = \sum\limits_{a = 1}^{p}\chi(a)e_p(am). \end{eqnarray}$

We call $G(\chi, m)$ the Gauss sum, and we have the following:

$\begin{eqnarray} G(\chi, m) = \tau(\chi)\overline{\chi}(m), (m, p) = 1. \end{eqnarray}$

(2.1)

And also we have

$\begin{eqnarray} |\tau(\chi)| = \sqrt{p}, \end{eqnarray}$

(2.2)

where $\chi$ is a primitive character of $\mathbf{F}_p$ . And let $G(m, 6;p) = \sum\limits_{a = 0}^{p-1}e_p(ma^6)$ . For the property of the exponential sum and the general Gauss sum, interested readers can see ^{[1,4,5,8,13,15]}.

Lemma 1. Let $p$ be a prime with $p\equiv1\bmod\ 3$ . Then for any third-order character $\chi$ of $\mathbf{F}_p$ , we have the identity

$\tau^3(\chi)+\tau^3(\overline{\chi}) = dp,$

where $d$ is uniquely determined by $4p = d^2+27y^2$ and $d\equiv1\bmod\ 3$ .

Proof. For the proof of this lemma see ^[3].

Lemma 2. Let $\chi$ be a third-order character of $\mathbf{F}_p$ with $p\equiv1\bmod\ 3$ , and $C(p) = \tau(\chi)+\tau(\overline{\chi})$ , then $C(p) = \sum\limits_{a = 1}^{p}e_p(a^3)$ .

Proof.

$A = \tau(\chi)+\tau(\overline{\chi}) = \sum\limits_{a = 1}^p(1+\chi(a)+\overline{\chi}(a))e(\frac{a}{p}) = \sum\limits_{a = 1}^pe(\frac{a^3}{p}).$

Lemma 3. Let $p\equiv1\bmod\ 6$ , $2\equiv z^3\bmod\ p$ for some $z$ , and let $\chi$ be a third-order character of $\mathbf{F}_p$ , $\psi$ be a sixth-order character of $\mathbf{F}_p$ , then we have the identity

$\tau(\psi) = \frac{\tau^2(\chi)}{\sqrt{p}}.\\$

Proof. This is Lemma 3 in ^[16].

Lemma 4. As the definition above, we have the identity

$G(m, 6;p) = \sqrt{p}\chi_2(m)+\frac{\overline{x^2}}{\sqrt{p}}\psi(m)+\frac{x^2}{\sqrt{p}}\overline{\psi}(m)+\overline{x}\chi(m)+x\overline{\chi}(m),$

where $(m, p) = 1$ and $x = \tau(\chi)$ .

Proof. Firstly we have the identity

$\begin{eqnarray} 1+\chi_2\left(m\right)+\chi\left(m\right)+\overline{\chi}\left(m\right)+\psi\left(m\right)+\overline{\psi}\left(m\right) = \left\{ \begin{array}{ll} 6, & \text{ if }\ m\equiv a^6\ \text{mod}\ p; \\ 0, & \text{otherwise.}\end{array}\right. \end{eqnarray}$

So we have

$\begin{eqnarray} G(m, 6;p)& = &\sum\limits_{a = 0}^{p-1}(1+\chi_2\left(a\right)+\chi\left(a\right)+\overline{\chi}\left(a\right)+\psi\left(a\right)+\overline{\psi}\left(a\right))e_p(ma)\\ & = &G(\chi_2, m)+G(\psi, m)+G(\overline{\psi}, m)+G(\chi, m)+G(\overline{\chi}, m) \end{eqnarray}$

By (2.1) and Lemma 3, we have

$\begin{eqnarray} G(m, 6;p)& = &\tau(\chi_2)\chi_2(m)+\tau(\overline{\psi})\psi(m)+\tau(\psi)\overline{\psi}(m)+\tau(\overline{\chi})\chi(m)+\tau(\chi)\overline{\chi}(m)\\ & = &\sqrt{p}\chi_2(m)+\frac{\overline{x^2}}{\sqrt{p}}\psi(m)+\frac{x^2}{\sqrt{p}}\overline{\psi}(m)+\overline{x}\chi(m)+x\overline{\chi}(m).\\ \end{eqnarray}$

(2.3)

By (2.3), we complete the proof of our lemma.

Next we let,

$\begin{eqnarray} G^n(m, 6;p) = a_n+b_n\chi_2(m)+c_n\psi(m)+d_n\overline{\psi}(m)+e_n\chi(m)+f_n\overline{\chi}(m). \end{eqnarray}$

(2.4)

Then we have following Lemma 5.

Lemma 5. Let $a_n, b_n, c_n, d_n, e_n, f_n$ are defined as above, then we have that $a_n, b_n, c_n, d_n, e_n, f_n$ are uniquely determined by $n$ , where $n\geq1$ .

Proof. By the orthogonality of characters of $\mathbf{F}_p$ , we have

$\begin{eqnarray} \sum\limits_{a = 1}^{p-1}\chi\left(a\right) = \left\{ \begin{array}{ll} p-1, & \text{ if}\ χ = χ_0; \\ 0, & \text{otherwise.}\end{array}\right. \end{eqnarray}$

(2.5)

By (2.4) and (2.5) we have

$\begin{eqnarray} \sum\limits_{m = 1}^{p-1}G^n(m, 6;p)& = &(p-1)a_n+b_n\sum\limits_{m = 1}^{p-1}\chi_2\left(m\right)+c_n\sum\limits_{m = 1}^{p-1}\psi\left(m\right)+d_n\sum\limits_{m = 1}^{p-1}\overline{\psi}\left(m\right)\\ &&+e_n\sum\limits_{m = 1}^{p-1}\chi\left(m\right)+f_n\sum\limits_{m = 1}^{p-1}\overline{\chi}\left(m\right)\\ & = &(p-1)a_n. \end{eqnarray}$

So we have

$\begin{eqnarray} &&a_n = \frac{1}{p-1}\sum\limits_{m = 1}^{p-1}G^n(m, 6;p). \end{eqnarray}$

(2.6)

By the same method, we have

$\begin{eqnarray} &&b_n = \frac{1}{p-1}\sum\limits_{m = 1}^{p-1}\chi_2(m)G^n(m, 6;p), \\ &&c_n = \frac{1}{p-1}\sum\limits_{m = 1}^{p-1}\overline{\psi}(m)G^n(m, 6;p), \\ &&d_n = \frac{1}{p-1}\sum\limits_{m = 1}^{p-1}\psi(m)G^n(m, 6;p), \\ &&e_n = \frac{1}{p-1}\sum\limits_{m = 1}^{p-1}\overline{\chi}(m)G^n(m, 6;p), \\ &&f_n = \frac{1}{p-1}\sum\limits_{m = 1}^{p-1}\chi(m)G^n(m, 6;p). \end{eqnarray}$

So now it is easy to see the conclusion of the lemma.

Lemma 6. The sequences $\{a_n\}$ , $\{b_n\}$ , $\{c_n\}$ , $\{d_n\}$ , $\{e_n\}$ , $\{f_n\}$ are defined above, then they satisfied the following recurrence formulae ( $n\geq0$ ):

$\begin{eqnarray} &&a_{n+1} = \sqrt{p}b_n+\frac{\overline{x^2}}{\sqrt{p}}d_n+\frac{x^2}{\sqrt{p}}c_n+xe_n+\overline{x}f_n, \end{eqnarray}$

(2.7)

$\begin{eqnarray} &&b_{n+1} = \sqrt{p}a_n+\frac{\overline{x^2}}{\sqrt{p}}e_n+\frac{x^2}{\sqrt{p}}f_n+xd_n+\overline{x}c_n, \end{eqnarray}$

(2.8)

$\begin{eqnarray} &&c_{n+1} = \sqrt{p}f_n+\frac{\overline{x^2}}{\sqrt{p}}a_n+\frac{x^2}{\sqrt{p}}e_n+xb_n+\overline{x}d_n, \end{eqnarray}$

(2.9)

$\begin{eqnarray} &&d_{n+1} = \sqrt{p}e_n+\frac{\overline{x^2}}{\sqrt{p}}f_n+\frac{x^2}{\sqrt{p}}a_n+xc_n+\overline{x}b_n, \end{eqnarray}$

(2.10)

$\begin{eqnarray} &&e_{n+1} = \sqrt{p}d_n+\frac{\overline{x^2}}{\sqrt{p}}c_n+\frac{x^2}{\sqrt{p}}b_n+xf_n+\overline{x}a_n, \end{eqnarray}$

(2.11)

$\begin{eqnarray} &&f_{n+1} = \sqrt{p}c_n+\frac{\overline{x^2}}{\sqrt{p}}b_n+\frac{x^2}{\sqrt{p}}d_n+xa_n+\overline{x}e_n, \end{eqnarray}$

(2.12)

with the initial condition

$a_0 = 1, b_0 = c_0 = d_0 = e_0 = f_0 = 0.$

Proof. We only prove (2.7), the rest can be proved in the same way. By Lemma 5, we know $a_n$ is unique determined by $n$ . We can compare the coefficient of the equation

$G^{n+1}(m, 6;p) = G^{n}(m, 6;p)G(m, 6;p).$

We have

$a_{n+1} = \sqrt{p}b_n+\frac{\overline{x^2}}{\sqrt{p}}d_n+\frac{x^2}{\sqrt{p}}c_n+xe_n+\overline{x}f_n.$

So we complete the proof of the lemma.

Lemma 7. Let $a_n$ is defined as above, then we have

$\begin{eqnarray} &&a_0 = 1, a_1 = 0, a_2 = 5p, a_3 = 10dp, a_4 = 56p^2+10d^2p, \\&&a_5 = 188dp^2+5d^3p+16dpC(p). \end{eqnarray}$

Proof. By Lemma 4 and after some elementary calculations we have

$\begin{eqnarray} G^2(m, 6;p)& = &5p+2dp^{1/2}\chi_2(m)+4p^{1/2}x\psi(m)+4p^{1/2}\overline{x}\overline{\psi}(m)\\ &&+(p^{-1}\overline{x^4}+3x^2)\chi(m)+(p^{-1}x^4+3\overline{x^2})\overline{\chi}(m), \\ G^3(m, 6;p)& = &10dp+(16p^{3/2}+dp^{1/2})\chi_2(m)+(15p\overline{x}+2dx^2+p^{-1}x^5)\chi(m)\\ &&+(15px+2d\overline{x^2}+p^{-1}\overline{x^5})\overline{\chi}(m)\\ &&+(4p^{-1/2}x^4+12p^{1/2}\overline{x^2}+2dp^{1/2}x)\psi(m)\\ &&+(4p^{-1/2}\overline{x^4}+12p^{1/2}x^2+2dp^{1/2}\overline{x})\overline{\psi}(m), \\ G^4(m, 6;p)& = &60p^2+9d^2p+dp+48dp^{3/2}\chi_2(m)\\ &&+(p^{-2}x^8+17\overline{x^4}+46px^2+16dp)\chi(m)\\ &&+(p^{-2}\overline{x^8}+17x^4+46p\overline{x^2}+16dp)\overline{\chi}(m)\\ &&+(56p^{3/2}x+4dp^{-1/2}x^4+12dp^{1/2}\overline{x^2}+8p^{-1/2}\overline{x^5})\psi(m)\\ &&+(56p^{3/2}\overline{x}+4dp^{-1/2}\overline{x^4}+12dp^{1/2}x^2+8p^{-1/2}x^5)\overline{\psi}(m), \\ G^5(m, 6;p)& = &188dp^2+5d^3p+16dpC(p)\\ &&+(52d^2p^{3/2}+208p^{5/2}+16dp^{1/2}(x^2+\overline{x^2}))\chi_2(m)\\ &&+(p^{-2/5}x^{10}+p^{-3/2}\overline{x^8}+4dp^{-1/2}\overline{x^5}+71p^{1/2}x^4\\&&+(46p^{3/2}+16p^{1/2})x^2\\ &&+(129p^{3/2}+10d^2p^{1/2})\overline{x^2}+60dp^{3/2}x+16dp^{3/2})\psi(m)\\ &&+(p^{-2/5}\overline{x^{10}}+p^{-3/2}x^8+4dp^{-1/2}x^5+71p^{1/2}\overline{x^4}\\&&+(46p^{3/2}+16p^{1/2})\overline{x^2}\\ &&+(129p^{3/2}+10d^2p^{1/2})x^2+60dp^{3/2}\overline{x}+16dp^{3/2})\overline{\psi}(m)\\ &&+(8p^{-1}\overline{x^7}+p^{-1}x^7+25x^5+52dpx^2\\&&+(28dp+46p^2)x+16d\overline{x^4}+112p^2\overline{x})\chi(m)\\ &&+(8p^{-1}x^7+p^{-1}\overline{x^7}+25\overline{x^5}+52dp\overline{x^2}\\&&+(28dp+46p^2)\overline{x}+16dx^4+112p^2x)\overline{\chi}(m), \end{eqnarray}$

and comparing the above formulae with (2.6), we have

$a_0 = 1, a_1 = 0, a_2 = 5p, a_3 = 10dp, a_4 = 60p^2+9d^2p+dp, a_5 = 188dp^2+5d^3p+16dpC(p).\\$

Lemma 8. Let $a_n$ , $b_n$ , $c_n$ , $d_n$ , $e_n$ , $f_n$ are defined as above, then we have

$\begin{eqnarray} a_6& = &5pa_4+10dpa_3+(46p^2+5d^2p+dp)a_2+(2p^2+120dp^2+3d^3p+d^2p+dp)a_1\\ &&+(-4p^5+2d^2p^4+64p^{7/2}+381p^3+2d^2p^{5/2}+(129d^2+11d+6)p^2+d^4p)a_0\\ b_6& = &5pb_4+10dpb_3+(46p^2+5d^2p+dp)b_2+(2p^2+120dp^2+3d^3p+d^2p+dp)b_1\\ &&+(-4p^5+2d^2p^4+64p^{7/2}+381p^3+2d^2p^{5/2}+(129d^2+11d+6)p^2+d^4p)b_0\\ c_6& = &5pc_4+10dpc_3+(46p^2+5d^2p+dp)c_2+(2p^2+120dp^2+3d^3p+d^2p+dp)c_1\\ &&+(-4p^5+2d^2p^4+64p^{7/2}+381p^3+2d^2p^{5/2}+(129d^2+11d+6)p^2+d^4p)c_0\\ d_6& = &5pd_4+10dpd_3+(46p^2+5d^2p+dp)d_2+(2p^2+120dp^2+3d^3p+d^2p+dp)d_1\\ &&+(-4p^5+2d^2p^4+64p^{7/2}+381p^3+2d^2p^{5/2}+(129d^2+11d+6)p^2+d^4p)d_0\\ e_6& = &5pe_4+10dpe_3+(46p^2+5d^2p+dp)e_2+(2p^2+120dp^2+3d^3p+d^2p+dp)e_1\\ &&+(-4p^5+2d^2p^4+64p^{7/2}+381p^3+2d^2p^{5/2}+(129d^2+11d+6)p^2+d^4p)e_0\\ f_6& = &5pf_4+10dpf_3+(46p^2+5d^2p+dp)f_2+(2p^2+120dp^2+3d^3p+d^2p+dp)f_1\\ &&+(-4p^5+2d^2p^4+64p^{7/2}+381p^3+2d^2p^{5/2}+(129d^2+11d+6)p^2+d^4p)f_0 \end{eqnarray}$

Proof. We only proof the first formula, the rest can be proof in the same way. By Lemma 6, we have

$\begin{eqnarray} a_6& = &\sqrt{p}b_5+\frac{\overline{x^2}}{\sqrt{p}}d_5+\frac{x^2}{\sqrt{p}}c_5+xe_5+\overline{x}f_5\\ & = &5pa_4+2dp^{1/2}b_4+4p^{1/2}\overline{x}c_4+4p^{1/2}xd_4\\&&+(3\overline{x^2}+p^{-1}x^4)e_4+(3x^2+p^{-1}\overline{x^4})f_4\\ & = &5pa_4+10dpa_3+(d^2p^{1/2}+12p^{3/2})b_3+(2dp^{1/2}\overline{x}\\&&+8p^{1/2}x^2+p^{-1/2}\overline{x^4})c_3\\ &&+(2dp^{1/2}x+8p^{1/2}\overline{x^2}+p^{-1/2}x^4)d_3+(11px+\overline{x^2}+p^{-1}\overline{x^5})e_3\\ &&+(11p\overline{x}+x^2+p^{-1}x^5)f_3\\ & = &5pa_4+10dpa_3+(46p^2+5d^2p+dp)a_2+(25dp^{3/2}+2p^{3/2})b_2\\ &&+(p^{-3/2}\overline{x^7}+2p^{-1/2}x^5+p^{-1/2}\overline{x^4}+42p^{3/2}\overline{x}+2dp^{1/2}x^2\\&&+(d^2+1)p^{1/2}\overline{x})c_2\\ &&+(p^{-3/2}x^7+2p^{-1/2}\overline{x^5}+p^{-1/2}x^4+42p^{3/2}x+2dp^{1/2}\overline{x^2}\\&&+(d^2+1)p^{1/2}x)d_2\\ &&+(10x^4+(32p+d^2)\overline{x^2}+(4dp+p)x)e_2\\&&+(10\overline{x^4}+(32p+d^2)x^2+(4dp+p)\overline{x})f_2\\ & = &5pa_4+10dpa_3+(46p^2+5d^2p+dp)a_2\\&&+(2p^2+120dp^2+3d^3p+d^2p+dp)a_1\\ &&+(-4p^5+2d^2p^4+64p^{7/2}+381p^3+2d^2p^{5/2}\\&&+(129d^2+11d+6)p^2+d^4p)a_0. \end{eqnarray}$

So we complete the proof of this lemma.

Lemma 9. Let $a_n$ is defined as above, then for any integer $n\geq0$ , we have

$\begin{eqnarray} a_{n+6}& = &5pa_{n+4}+10dpa_{n+3}+(46p^2+5d^2p+dp)a_{n+2}\\&&+(2p^2+120dp^2+3d^3p+d^2p+dp)a_{n+1}\\ &&+(-4p^5+2d^2p^4+64p^{7/2}+381p^3+2d^2p^{5/2}\\&&+(129d^2+11d+6)p^2+d^4p)a_n. \end{eqnarray}$

Proof. By (2.4) and Lemma 8, we have

$\begin{eqnarray} G^{6}(m, 6;p)& = &5pG^{4}(m, 6;p)+10dpG^{3}(m, 6;p)+(46p^2+5d^2p+dp)G^{2}(m, 6;p)\\ &&+(2p^2+120dp^2+3d^3p+d^2p+dp)G(m, 6;p)\\ &&+(-4p^5+2d^2p^4+64p^{7/2}+381p^3+2d^2p^{5/2}\\&&+(129d^2+11d+6)p^2+d^4p). \end{eqnarray}$

We multiple $G^{n}(m, 6;p)$ to the both side of the above formula, we have

$\begin{eqnarray} G^{n+6}(m, 6;p)& = &5pG^{n+4}(m, 6;p)+10dpG^{n+3}(m, 6;p)\\&&+(46p^2+5d^2p+dp)G^{n+2}(m, 6;p)\\ &&+(2p^2+120dp^2+3d^3p+d^2p+dp)G^{n+1}(m, 6;p)\\ &&+(-4p^5+2d^2p^4+64p^{7/2}+381p^3+2d^2p^{5/2}\\&&+(129d^2+11d+6)p^2+d^4p)G^n(m, 6;p). \end{eqnarray}$

By Lemma 5, we can compare the coefficient of the above equation, we have

3. Proof of the theorem 1

In the formula below, we always let $k\geq1$ . By the following formula,

$\begin{eqnarray} \sum\limits_{a = 0}^{p-1}e_p\left(ma\right) = \left\{ \begin{array}{ll} p, & \text{ if }\ p\mid m; \\ 0, & \text{ otherwise, }\end{array}\right. \end{eqnarray}$

we have

$\begin{eqnarray} A(k, p)& = &\frac{1}{p}\sum\limits_{m = 0}^{p-1}\sum\limits_{x_1 = 0, x_2 = 0, \cdot\cdot\cdot, x_k = 0}^{p-1}e_p(m(x_1^6+x_2^6+\cdot\cdot\cdot+x_k^6))\\& = &\frac{1}{p}\sum\limits_{m = 0}^{p-1}G^k(m, 6;p). \end{eqnarray}$

(3.1)

By (8), we have

$\begin{eqnarray} A(k, p)& = &\frac{1}{p}\sum\limits_{m = 0}^{p-1}G^k(m, 6;p)\\ & = &\frac{1}{p}(\sum\limits_{m = 1}^{p-1}G^k(m, 6;p)+p^k)\\ & = &\frac{1}{p}((p-1)a_k+p^k) = \frac{p-1}{p}a_k+p^{k-1}. \end{eqnarray}$

(3.2)

So by Lemma 9, we have

$\begin{eqnarray} A(k+6, p)-p^{k+5}& = &5p(A(k+4, p)-p^{k+3})+10dp(A(k+3, p)-p^{k+2})\\ &&+(46p^2+5d^2p+dp)(A(k+2, p)-p^{k+1})\\ &&+(2p^2+120dp^2+3d^3p+d^2p+dp)(A(k+1, p)-p^k)\\ &&+(-4p^5+2d^2p^4+64p^{7/2}+381p^3+2d^2p^{5/2}\\ &&+(129d^2+11d+6)p^2+d^4p)(A(k, p)-p^{k-1}). \end{eqnarray}$

So we have

And by Lemma 7 and (3.2), we have the initial conditions

$\begin{eqnarray} &&A(1, p) = 1, A(2, p) = 4(p-1)+p, A(3, p) = 10d(p-1)+p^2, \\ &&A(4, p) = 56p(p-1)+10d^2(p-1)+p^3, \\ &&A(5, p) = 188dp(p-1)+5d^3(p-1)+16dC(p)(p-1)+p^4.\\ &&A(6, p) = p^5+1400p^2(p-1)+(388d^2+8d-576)p(p-1)+d^2p-d^2. \end{eqnarray}$

So we complete the proof of the theorem.

4. Conclusion

The main purpose of this paper is using analytic methods to give a recurrence formula of the number of solutions of an equation over finite field. And we give an expression of the number of solutions of the above equation by the root of sixth degree polynomial. We use analytic methods to give a recurrence formula for the number of solutions of the above equation. And our method is based on the properties of the Gauss sum. It is worth noting that we used a novel method to simplify the steps and avoid complicated calculations.

Acknowledgements

The author thanks to referees for very important recommendations and warnings which improved the paper.

Conflict of interest

The author declares that there is no competing interest.

Acknowledgments

This work was supported in part by the Science, Technology and Innovation Ministry (under grant FONCyT PICT 2017-0706) and by the School of Science and Technology from National University of San Martín. Figures 1 and 2 were illustrated by Silvina Mariel Schroeder. The author appreciates Cristina Pérez Coll kindly provision of embryo photograph shown in Figure 2. Photograph shown in Figure 1 belongs to the author.

Conflict of interest

The author declares no conflict of interest for the contributions in this manuscript.

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Phospholipid synthetic and turnover pathways elicited upon exposure to different xenobiotics

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Phospholipid synthetic and turnover pathways elicited upon exposure to different xenobiotics

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