Mathematical Biosciences and Engineering, 2015, 12(6): 1219-1235. doi: 10.3934/mbe.2015.12.1219

Primary: 92C37, 92C50; Secondary: 92C45.

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An integrated cellular and sub-cellular model of cancer chemotherapy and therapies that target cell survival

1. Department of Applied Mathematics, Brown University, 182 George Street, Providence, RI 02906
2. Department of Internal Medicine, University of Michigan, Ann Arbor, MI 48109
3. Department of Mathematics, University of Michigan, 530 Church Street, Ann Arbor, MI 48109-1043

Apoptosis resistance is a hallmark of human cancer, and tumor cells often become resistant due to defects in the programmed cell death machinery.Targeting key apoptosis regulators to overcome apoptotic resistance and promote rapid death of tumor cells is an exciting new strategy for cancer treatment, either alone or in combination with traditionally used anti-cancer drugs that target cell division. Here we present a multiscale modeling framework for investigating the synergism between traditional chemotherapy and targeted therapies aimed at critical regulators of apoptosis.
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