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Oscillations and NMDA Receptors: Their Interplay Create Memories

1 Biomedical Engineering Program, Faculties of Medicine, Engineering, and Science, University of Manitoba;
2 Department of Pharmacology & Therapeutics, Faculty of Medicine, University of Manitoba;
3 Division of Neurodegenerative Disorders, St. Boniface Hospital Research Winnipeg, Manitoba Canada R2H2A6

Oscillatory activity is inherent in many types of normal cellular function. Importantly, oscillations contribute to cellular network activity and cellular decision making, which are driving forces for cognition. Theta oscillations have been correlated with learning and memory encoding and gamma oscillations have been associated with attention and working memory. NMDA receptors are also implicated in oscillatory activity and contribute to normal function and in disease-related pathology. The interplay between oscillatory activity and NMDA receptors are intellectually curious and a fascinating dimension of inquiry. In this review we introduce some of the essential mathematical characteristics of oscillatory activity in order to provide a platform for additional discussion on recent studies concerning oscillations involving neuronal firing and NMDA receptor activity, and the effect of these dynamic mechanisms on cognitive processing in health and disease.
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Keywords harmonic oscillator; NMDA Receptor; oscillations; memory; NMDA Receptors in Memory

Citation: Chris Cadonic, Benedict C. Albensi. Oscillations and NMDA Receptors: Their Interplay Create Memories. AIMS Neuroscience, 2014, 1(1): 52-64. doi: 10.3934/Neuroscience.2014.1.52


  • 1. Buzsaki G, Draguhn A. (2004) Neuronal oscillations in cortical networks. Science 304(5679):1926-9.
  • 2. Albensi BC. (2007) The NMDA receptor/ion channel complex: a drug target for modulating synaptic plasticity and excitotoxicity. Curr Pharm Des 13(31): 3185-94.
  • 3. Seeburg PH. (1994) Molecular biology of NMDA receptors. In: Watkins JC, Collingridge GL. Authors, The NMDA receptor, 2 Eds. , New York: Oxford University Press.
  • 4. Gibb AJ. (1994) Activation of NMDA receptors. In: Watkins JC, Collingridge GL. Authors, The NMDA receptor, 2 Eds. , New York: Oxford University Press.
  • 5. Alford S, Brodin L. (1994) The role of NMDA receptors in synaptic integration and the organization of motor patterns. In: Watkins JC, Collingridge GL. Authors, The NMDA receptor, 2 Eds. , New York: Oxford University Press.
  • 6. Morris RGM, Davis M. (1994) The role of NMDA receptors in learning and memory. In: Watkins JC, Collingridge GL. Authors, The NMDA receptor, 2 Eds. , New York: Oxford University Press.
  • 7. Garthwaite J. (1994) NMDA receptors, neuronal development, and neurodegeneration. In: Watkins JC, Collingridge GL. Authors, The NMDA receptor, 2 Eds. , New York: Oxford University Press.
  • 8. Bear MF, Malenka RC. (1994) Synaptic plasticity: LTP and LTD. Curr Opin Neurobiol 4(3):389-99.
  • 9. Möddel G, Jacobson B, Ying Z, et al. (2005) The NMDA receptor NR2B subunit contributes to epileptogenesis in human cortical dysplasia. Brain Res 1046(1-2): 10-23.
  • 10. Mody I, MacDonald JF. (1995) NMDA receptor-dependent excitotoxicity: the role of intracellular Ca2+ release. Trends Pharmacol Sci 16(10): 356-9.
  • 11. Nagle R, Saff B, Snider A. (2012) Fundamentals of differential equations and boundary value problems. 6 Eds. , Boston: Addison-Wesley.
  • 12. Izhikevich EM. (2007) Dynamical systems in neuroscience: the geometry of excitability and bursting. Computational neuroscience, Cambridge: MIT Press, 441.
  • 13. Koch C, Segev I. (1998) Methods in neuronal modeling: From ions to networks, Cambridge, Massachusetts: MIT Press.
  • 14. Kuramoto Y. (1984) Chemical oscillations, waves, and turbulence. In: Springer series in synergetics of Berlin, New York: Springer-Verlag, 156.
  • 15. Niedermeyer E, Schomer DL, Lopes da Silva FH. (2011) Niedermeyer's electroencephalography: basic principles, clinical applications, and related fields. 6 Eds. , Philadelphia: Wolters Kluwer Health/Lippincott Williams & Wilkins, 1275.
  • 16. Tass PA. (2007) Phase resetting in medicine and biology stochastic modelling and data analysis, In: Springer Series in Synergetics, Berlin: Springer-Verlag.
  • 17. Albensi BC, et al. (2004) Why do many NMDA antagonists fail, while others are safe and effective at blocking excitotoxicity associated with dementia and acute injury? Am J Alzheimers Dis Other Demen 19(5): 269-74.
  • 18. Bliss TV, Collingridge GL. (1993) A synaptic model of memory: long-term potentiation in the hippocampus. Nature 361(6407): 31-9.
  • 19. Lynch MA. (2004) Long-term potentiation and memory. Physiol Rev 84(1): 87-136.
  • 20. Lisman J. (2003) Long-term potentiation: outstanding questions and attempted synthesis. Philos Trans R Soc Lond B Biol Sci 358(1432): 829-42.
  • 21. Malenka RC. (1994) Synaptic plasticity in the hippocampus: LTP and LTD. Cell 78(4): 535-8.
  • 22. Yang SN, Tang YG, Zucker RS. (1999) Selective induction of LTP and LTD by postsynaptic [Ca2+]i elevation. J Neurophysiol 81(2): 781-7.
  • 23. Huang YY, Malenka RC. (1993) Examination of TEA-induced synaptic enhancement in area CA1 of the hippocampus: the role of voltage-dependent Ca2+ channels in the induction of LTP. J Neurosci 13(2): 568-76.
  • 24. Abraham WC, Williams JM. (2003) Properties and mechanisms of LTP maintenance. Neuroscientist 9(6): 463-74.
  • 25. Chen HS, Lipton SA. (2006) The chemical biology of clinically tolerated NMDA receptor antagonists. J Neurochem 97(6): 1611-26.
  • 26. McIlhinney RA, et al. (2003) Assembly of N-methyl-D-aspartate (NMDA) receptors. Biochem Soc Trans 31(Pt 4): 865-8.
  • 27. Waxman EA, Lynch DR. (2005) N-methyl-D-aspartate receptor subtypes: multiple roles in excitotoxicity and neurological disease. Neuroscientist 1(1): 37-49.
  • 28. Dingledine R, et al. (1999) The glutamate receptor ion channels. Pharmacol Rev 51(1): 7-61.
  • 29. Lynch DR, Guttmann RP. (2001) NMDA receptor pharmacology: perspectives from molecular biology. Curr Drug Targets 2(3): 215-31.
  • 30. Farber NB, Newcomer JW, Olney JW. (1998) The glutamate synapse in neuropsychiatric disorders, progress in brain research. In: Ottersen OP, Langmoen IA, Gjerstad L. Authors, The gluatmate synapse as a therapeutic target: molecular organization and pathology of the glutamate synapse, New York: Elsevier.
  • 31. Lindsley CW, et al. (2006) Progress towards validating the NMDA receptor hypofunction hypothesis of schizophrenia. Curr Top Med Chem 6(8): 771-85.
  • 32. Ikonomidou C, Turski L. (2002) Why did NMDA receptor antagonists fail clinical trials for stroke and traumatic brain injury? Lancet Neurol 1(6): 383-6.
  • 33. Hardingham GE, Bading H. (2003) The Yin and Yang of NMDA receptor signalling. Trends Neurosci 26(2): 81-9.
  • 34. Whittington MA, Traub RD, Jefferys JG. (1995) Synchronized oscillations in interneuron networks driven by metabotropic glutamate receptor activation. Nature 373(6515): 612-5.
  • 35. Middleton S, et al. (2008) NMDA receptor-dependent switching between different gamma rhythm-generating microcircuits in entorhinal cortex. Proc Natl Acad Sci USA 105(47): 18572-7.
  • 36. Lazarewicz MT, et al. (2010) Ketamine modulates theta and gamma oscillations. J Cogn Neurosci 22(7): 1452-64.
  • 37. Cabral HO, et al. (2014) Oscillatory dynamics and place field maps reflect hippocampal ensemble processing of sequence and place memory under NMDA receptor control. Neuron81(2): 402-15.
  • 38. Jacobsen RB, Ulrich D, Huguenard JR. (2001) GABA(B) and NMDA receptors contribute to spindle-like oscillations in rat thalamus in vitro. J Neurophysiol 86(3): 1365-75.
  • 39. Korotkova T, et al. (2010) NMDA receptor ablation on parvalbumin-positive interneurons impairs hippocampal synchrony, spatial representations, and working memory. Neuron 68(3):557-69.
  • 40. Carlen M, et al. (2012) A critical role for NMDA receptors in parvalbumin interneurons for gamma rhythm induction and behavior. Mol Psychiatry 17(5): 537-48.
  • 41. Anver H, et al. (2010) NMDA receptor hypofunction phase couples independent gamma-oscillations in the rat visual cortex. Neuropsychopharmacology 36(2): 519-28.
  • 42. van Wingerden M, et al. (2012) NMDA receptors control cue-outcome selectivity and plasticity of orbitofrontal firing patterns during associative stimulus-reward learning. Neuron 76(4):813-25.
  • 43. Wallen P, Grillner S. (1987) N-methyl-D-aspartate receptor-induced, inherent oscillatory activity in neurons active during fictive locomotion in the lamprey. J Neurosci 7(9): 2745-55.
  • 44. Wang D, Grillner S, Wallen P. (2013) Calcium dynamics during NMDA-induced membrane potential oscillations in lamprey spinal neurons, contribution of L-type calcium channels (CaV1. 3). J Physiol 591(Pt 10): 2509-21.
  • 45. Lee S, Sen K, Kopell N. (2009), Cortical gamma rhythms modulate NMDAR-mediated spike timing dependent plasticity in a biophysical model. PLoS Comput Biol 5(12): e1000602.
  • 46. McNaughton BL, et al. (2006) Path integration and the neural basis of the "cognitive map". Nat Rev Neurosci 7(8): 663-78.
  • 47. Burgess N. (2006) Spatial memory: how egocentric and allocentric combine. Trends Cogn Sci10(12): 551-7.
  • 48. O'Keefe J, Nadel L. (1978) The Hippocampus as a Cogntive Map. London: University of Oxford Press.


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Copyright Info: 2014, Benedict C. Albensi, et al., licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution Licese (http://creativecommons.org/licenses/by/4.0)

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