Gracile axonal dystrophy (gad) mouse shows tremor, ataxia and muscular atrophy of hind limbs from about 80-days of age. These clinical features become progressively severe to death. Pathological examination reveals that main and early axonal degeneration exists in a long ascending nervous tract in dorsal column of the spinal cord: gracile nucleus and fascicules. Similar lesions are seen in axonal terminals of peripheral sensory (muscle spindles) and motor endplates. Most striking features of axonal dystrophy are “dying-back” axonal degeneration with partial swellings (“spheroids” in matured type) which come to be most frequently in gracile nucleus, followed by in order of gracile fasciculus of cervical, thoracic and lumber cord levels. Immunocytochemical increase of glial fibrillary acidic protein (GFAP) and substance P (SP) is seen in reactive astrocytes and degenerating axons. Likewise, amyloid precursor protein (APP) and amyloid β-protein (AβP) activity become positive in axons and astrocytes along ascending tract. Moreover, ubiquitin-positive dot-like structures accumulate in gracile nucleus, spinocerebellar tract, and cerebellum in gad mice after 9th-week old. Ubiquitinated structures are localized in spheroids with a larger diameter than normal. The gad mutation is caused by an in-frame deletion including exon 7 and 8 of UCH-L1 gene, encoding the ubiquitin c-terminal hydrolase (UCH) isozyme (UCH-L1) selectively expressed in nervous system and testis/ovary. The gad allele encodes a truncated UCH-L1 lacking a segment of 42 amino acids containing catalytic site. The evaluation as mouse models for Parkinson's and Alzheimer's diseases and the collapse of synapse-axon circulation around central nervous system from peripheral nervous system are discussed.
Citation: Tateki Kikuchi. Circular breakdown of neural networks due to loss of deubiquitinating enzyme (UCH-L1) in gracile axonal dystrophy (gad) mouse[J]. AIMS Molecular Science, 2021, 8(4): 311-324. doi: 10.3934/molsci.2021024
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Gracile axonal dystrophy (gad) mouse shows tremor, ataxia and muscular atrophy of hind limbs from about 80-days of age. These clinical features become progressively severe to death. Pathological examination reveals that main and early axonal degeneration exists in a long ascending nervous tract in dorsal column of the spinal cord: gracile nucleus and fascicules. Similar lesions are seen in axonal terminals of peripheral sensory (muscle spindles) and motor endplates. Most striking features of axonal dystrophy are “dying-back” axonal degeneration with partial swellings (“spheroids” in matured type) which come to be most frequently in gracile nucleus, followed by in order of gracile fasciculus of cervical, thoracic and lumber cord levels. Immunocytochemical increase of glial fibrillary acidic protein (GFAP) and substance P (SP) is seen in reactive astrocytes and degenerating axons. Likewise, amyloid precursor protein (APP) and amyloid β-protein (AβP) activity become positive in axons and astrocytes along ascending tract. Moreover, ubiquitin-positive dot-like structures accumulate in gracile nucleus, spinocerebellar tract, and cerebellum in gad mice after 9th-week old. Ubiquitinated structures are localized in spheroids with a larger diameter than normal. The gad mutation is caused by an in-frame deletion including exon 7 and 8 of UCH-L1 gene, encoding the ubiquitin c-terminal hydrolase (UCH) isozyme (UCH-L1) selectively expressed in nervous system and testis/ovary. The gad allele encodes a truncated UCH-L1 lacking a segment of 42 amino acids containing catalytic site. The evaluation as mouse models for Parkinson's and Alzheimer's diseases and the collapse of synapse-axon circulation around central nervous system from peripheral nervous system are discussed.
Alzheimer's disease;
amyloid precursor protein;
APP-immunoreactivity;
adenosine triphosphate;
amyloid β protein;
AβP-immunoreactivity;
cornu ammonis 1;
cholecystokinin;
central nervous system;
dorsal root ganglia;
gracile axonal dystrophy, mouse name by pathological features;
gracile axonal dystrophy, mouse name after responsible gene was identified;
glial fibrillary acidic protein;
long-term potentiation;
national center for neurology and psychiatry;
Parkinson's disease;
peripheral nervous system;
substance P;
ubiquitin;
ubiquitin c-terminal hydrolase, isozyme L1
Allergic rhinitis (AR) is defined by an inflammatory response triggered by allergens, presenting with characteristic nasal symptoms such as itching, rhinorrhea, nasal obstruction, and sneezing. This condition affects approximately 25% of children and 40% of adults worldwide, causing significant impairment to patients' quality of life and posing a considerable societal burden [1].
The sensitization patterns of allergens in AR exhibit global variations, influenced by a range of geographical, climatic, cultural, and genetic factors [2]. Worldwide, house dust mites (HDMs) and grass pollen are consistently identified as the most prevalent inhalant allergens [3,4,5]. However, despite numerous studies exploring allergen sensitization in China, most of them have focused primarily on specific geographical regions and the Han ethnic group [6,7,8]. In 2009, a study aimed to assess the frequency of common aeroallergens among allergic asthma and/or rhinitis across China reported an overall positive skin prick response rate of 59.0% for Dermatophagoides farinae and 57.6% for Dermatophagoides pteronyssinus [9].
In this study, we aim to compare the types of allergens in children from two different provinces in China with different ethnic groups, in an attempt to analyze the effects of environmental and genetic factors on allergen types.
From January 2019 to December 2023, children presenting with typical nasal symptoms such as rhinorrhea, nasal obstruction, itching, and sneezing were recruited for the study in accordance with the ARIA guidelines at our hospital [1]. All children recruited from Guangzhou are Han nationality, and all children recruited from Liuzhou are Zhuang nationality. Utilizing the ImmunoCAP 100 system (Thermo Fisher), the specific IgE response to a comprehensive panel of foods and inhalant allergens pertinent to the Chinese diet was evaluated. The inhalant allergens tested included Dermatophagoides farinae, Dermatophagoides pteronyssinus, German cockroach, cat dander, dog dander, common ragweed, and mugwort. A serum-specific IgE (sIgE) level of ≥0.35 kUA/L was considered positive for allergen sensitization. Exclusion criteria for the study were as follows: Children with negative allergen screening results; children had undergone systemic steroid or biological treatment or malignancy therapy; children with nasal polyps or chronic sinusitis; and children diagnosed with severe autoimmune diseases, parasitic infections, or cancer. The protocol was approved by the local Ethics Committee Guangzhou Medical University.
Statistical analysis was conducted using the SPSS 20 software package. The data were summarized using the median, discrete numbers, and ratios to provide a comprehensive overview. For comparisons, the Chi-square test or Fisher's exact test was employed, depending on the nature of the data and the assumptions of each test. A statistically significant result was defined as a P-value lower than 0.05, indicating a meaningful difference between the groups or variables being compared.
A total of 9684 and 1679 AR children from Guangzhou and Liuzhou were recruited. As shown in Table 1, the age, sex ratio, mono-sensitized ratio, poly-sensitized ratio, and disease duration showed no significant differences between the two groups (P > 0.05).
| Guangzhou | Liuzhou | |
| Cases | 9684 | 1679 |
| Age | 6.91 ± 2.81 | 5.23 ± 3.16 |
| Sex ratio (male/female) | 68%/32% | 60%/40% |
| Mono-sensitized ratio | 7.1% | 13.5% |
| Poly-sensitized ratio | 92.9% | 86.5% |
| Disease duration (years) | 2.2 ± 1.5 | 1.8 ± 1.6 |
| Living environment: Rural area | 85.2% | 82.1% |
| Living environment: Urban area | 14.8% | 17.9% |
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The sensitization rates to D. farinae, D. pteronyssinus, cat dander, dog dander, common ragweed, and mugwort in Guangzhou were significantly higher than those in Liuzhou (Table 2). The sensitization rates to cockroaches showed no significant differences between the two cities (Table 2).
| Guangzhou | Liuzhou | P | |
| D. farinae | 96.0% | 89.6% | 0.0001 |
| D. pteronyssinus | 93.7% | 91.4% | 0.0004 |
| German cockroach | 6.5% | 7.6% | 0.0729 |
| Cat dander | 9.3% | 5.7% | 0.0001 |
| Dog dander | 6.4% | 4.1% | 0.0003 |
| Common ragweed | 2.6% | 1.2% | 0.0135 |
| Mugwort | 6.4% | 2.0% | 0.0001 |
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The sensitization rates to D. farina in Guangzhou were significantly higher than those in Liuzhou of all three age groups (Table 3). In preschool children (1–6 years old), the positive rates of sensitization to cockroaches, dog dander, common ragweed, and mugwort were significantly different between Guangzhou and Liuzhou, while the positive rates of sensitization to D. pteronyssinus and cat dander showed no significant differences between the two cities (Table 3).
| 1–6 years old | 7–12 years old | 13–18 years old | ||||
| GZ | LZ | GZ | LZ | GZ | LZ | |
| D. farinae | 95.1% | 90.5%* | 97.1% | 86.9%* | 97.5% | 88.9%* |
| D. pteronyssinus | 92.8% | 92.6% | 94.7% | 87.7%* | 95.3% | 88.9% |
| German cockroach | 5.6% | 7.7%* | 7.4%# | 8.8% | 9.5%# | 3.2%*# |
| Cat dander | 7.2% | 5.8% | 11.3%# | 5.4%* | 13.8%# | 6.5%* |
| Dog dander | 5.5% | 3.8%* | 7.5% | 4.5%* | 6.3% | 8.1%# |
| Common ragweed | 2.8% | 1.1%* | 2.4% | 1.1%* | 2.8% | 3.0%# |
| Mugwort | 6.0% | 1.8%* | 6.7% | 2.3%* | 6.3% | 3.0%* |
| GZ, Guangzhou; LZ, Liuzhou. *Comparison between Guangzhou and Liuzhou group, P < 0.05. #Comparison with 1–6-year-old group, P < 0.05. | ||||||
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In the school-age group (7–12 years old), the positive rates of sensitization to D. farina, D. pteronyssinus, cat dander, dog dander, and mugwort were significantly different between Guangzhou and Liuzhou, while the positive rates of sensitization to cockroaches, cat dander, and common ragweed showed no significant differences (Table 3).
In the 13–18 years old group, the positive rates of sensitization to D. farina, cockroaches, and cat dander were significantly different between Guangzhou and Liuzhou, while the positive rates of sensitization to other allergens showed no significant differences between the two cities (Table 3).
As shown in Table 4, the positive rates of sensitization to all allergens except for cockroaches were higher in Guangzhou boys compared with Liuzhou boys (Table 4). The positive rates of sensitization to all allergens except for cockroaches and common ragweed were higher in Guangzhou girls compared with Liuzhou girls (Table 4). The positive rates of sensitization to all allergens showed no significant differences between Guangzhou boys and girls. Similarly, the positive rates of sensitization to all allergens also showed no significant differences between Liuzhou boys and girls (Table 4).
| Male | Female | |||
| GZ | LZ | GZ | LZ | |
| D. farinae | 96.1% | 89.7%* | 96.0% | 89.6%* |
| D. pteronyssinus | 93.9% | 91.8%* | 93.6% | 90.6%* |
| German cockroach | 6.8% | 7.7% | 6.0% | 7.8% |
| Cat dander | 9.4% | 5.6%* | 9.3% | 6.0%* |
| Dog dander | 6.1% | 4.4%* | 7.1% | 3.7%* |
| Common ragweed | 2.8% | 1.1%* | 2.2% | 1.4%* |
| Mugwort | 6.2% | 2.3%* | 6.8% | 1.4%* |
| GZ, Guangzhou, LZ, Liuzhou. *Comparison between Guangzhou and Liuzhou group, P < 0.05. | ||||
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In spring, the positive rates of sensitization to D. farina, D. pteronyssinus, and cockroaches were significantly different between Guangzhou and Liuzhou (Table 5). In summer, the positive rates of sensitization to D. farina, cat dander, dog dander, and mugwort were significantly different between Guangzhou and Liuzhou (Table 5). In autumn, the positive rates of sensitization to D. farina, cat dander, common ragweed, and mugwort were significantly different between Guangzhou and Liuzhou (Table 5). In winter, only the positive rate of sensitization to D. farina was significantly different between Guangzhou and Liuzhou (Table 5).
| Spring | Summer | Autumn | Winter | |||||
| GZ | LZ | GZ | LZ | GZ | LZ | GZ | LZ | |
| D. farinae | 95.4% | 87.9%* | 96.8% | 91.6%* | 96.2% | 89.4%* | 95.3% | 87.7%* |
| D. pteronyssinus | 93.7% | 89.4%* | 94.6% | 93.2% | 93.6% | 92.1% | 91.8% | 88.7% |
| German cockroach | 6.1% | 9.4%* | 6.6% | 5.6% | 7.3% | 8.3% | 6.4% | 9.3% |
| Cat dander | 9.5% | 7.6% | 9.2% | 4.3%* | 9.4% | 5.7%* | 9.7% | 6.2% |
| Dog dander | 7.0% | 6.7% | 6.0% | 2.6%* | 5.5% | 3.4%* | 7.9% | 4.1% |
| Common ragweed | 2.6% | 2.8% | 2.1% | 0.7%* | 3.5% | 0.6%* | 3% | 0.1% |
| Mugwort | 6.3% | 5.5% | 6.5% | 0.4%* | 6.9% | 0%* | 5.7% | 2.1% |
| GZ, Guangzhou, LZ, Liuzhou. *Comparison between Guangzhou and Liuzhou group, P < 0.05. | ||||||||
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The positive rates of sensitization to all allergens in Guangzhou were not significantly different between different seasons. Similarly, the positive rates of sensitization to all allergens in Liuzhou showed no significant differences between different seasons.
The positive rates of sensitization to all allergens showed no significant differences when grouped according to disease duration and living environment (Tables 6 and 7).
| < 1 year | > 1 year | |||
| GZ | LZ | GZ | LZ | |
| D. farinae | 92.5% | 84.3% | 97.7% | 91.2% |
| D. pteronyssinus | 94.2% | 90.3% | 92.8% | 93.1% |
| German cockroach | 6.2% | 8.2% | 6.4% | 6.6% |
| Cat dander | 8.5% | 5.6% | 9.9% | 5.7% |
| Dog dander | 6.5% | 3.6% | 6.3% | 4.7% |
| Common ragweed | 2.6% | 1.5% | 2.9% | 1.3% |
| Mugwort | 6.1% | 1.8% | 6.7% | 2.4% |
| GZ, Guangzhou, LZ, Liuzhou. | ||||
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| Rural area | Urban area | |||
| GZ | LZ | GZ | LZ | |
| D. farinae | 94.0% | 89.6% | 97.2% | 89.6% |
| D. pteronyssinus | 92.7% | 90.5% | 94.5% | 91.9% |
| German cockroach | 6.1% | 7.9% | 6.7% | 7.1% |
| Cat dander | 9.3% | 5.7% | 9.3% | 5.7% |
| Dog dander | 6.4% | 4.1% | 6.4% | 4.1% |
| Common ragweed | 2.6% | 1.2% | 2.6% | 1.2% |
| Mugwort | 5.8 % | 1.6% | 6.9% | 2.3% |
| GZ, Guangzhou, LZ, Liuzhou. | ||||
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Atopic sensitization is a significant risk factor for the development of both upper and lower respiratory symptoms [10]. Given its pivotal role in the onset and progression of allergic conditions, allergen avoidance is a crucial aspect of treating allergic rhinitis. By identifying and avoiding allergens as early as possible, individuals can potentially slow down the development and severity of allergic rhinitis, thereby improving their overall quality of life and reducing the need for more aggressive treatment options.
China, a vast country with a rapidly developing economy, diverse geography, climate, and ethnicities, exhibits significant regional variations in the distribution of allergens. Previous reports have revealed the prevalence and patterns of allergen sensitization in different regions of China. For instance, Li et al. conducted a survey in 2009 among 6,304 patients with asthma and/or rhinitis across 17 cities in four regions of China [9]. They found that Dermatophagoides farina and Dermatophagoides pteronyssinus were the most common aeroallergens among patients with perennial/persistent allergic rhinitis. Notably, the highest prevalence of sensitization to house dust mites was observed in the southwestern region of China. Another hospital-based survey in southern China reported that sensitization to house dust mites (D. pteronyssinus, D. farinae, and B. tropicalis) was the most common, followed by sensitization to other allergens such as dog dander, cockroaches, mold mix, and various pollens [11]. More recently, Sun's team reported on the overall prevalence of positive sIgE responses to nine common allergens across China [12]. Their findings indicated that the highest prevalence was for sensitization to house dust mites, followed by cockroaches, tree pollen mix, dog dander, and mold mix.
In this study, we compared two cities in southern China, Guangzhou in the Guangdong Province and Liuzhou in the Guangxi Province. Guangzhou and Liuzhou are located at similar latitudes, with similar annual average temperatures (22 ℃ vs. 21 ℃), humidity (78% vs. 79%), and rainfall (1830.2 mm vs. 1841.5 mm). We hope to compare the types of allergens in children from two nationalities with similar climate conditions to preliminarily analyze the impact of racial factors on allergens. Our results show that children with allergic rhinitis in two cities are mainly allergic to mites, but the sensitization rates of two types of mites in Guangzhou are higher than those in Liuzhou. This may be related to the slightly higher average temperature in Guangzhou compared to Liuzhou, which is more suitable for mite growth (22 ℃ vs. 21 ℃). Allergies to cat and dog dander also show a higher trend in Guangzhou than in Liuzhou, which may be related to the higher pet ownership in Guangzhou, which was, however, not collected in this study. Therefore, future studies on the correlation between allergy and pet ownership are needed. The sensitization rates of ragweed and mugwort in Guangzhou are also higher than those in Liuzhou, while there is no significant difference in the sensitization rates of cockroaches between the two. Besides the reasons mentioned above, we believe that the following may also potentially explain the difference in sensitization rates between the two regions: The urbanization level, air pollution (especially particulate matter and ozone levels), lifestyle and habits (such as housing conditions, e.g., apartment versus detached houses and ventilation systems), dietary habits (including the consumption of allergenic foods), hygiene practices that may affect the microbial environment and immune system development, and socioeconomic status.
Boulet proposed that sensitization to all allergens intensifies and peaks during young adulthood [13]. Wu's study found that individuals in the 7–14 year age bracket demonstrated heightened reactivity to tested airborne allergens compared to those aged 0–6 years [14]. A longitudinal study in an urban Italian population center noted an 11.6% increase in the positive rate of skin prick tests over a 6–10 year observation period [15]. We observed age-related allergen sensitization disparities between Guangzhou and Liuzhou. In Guangzhou, sensitization to dust mites, mugwort, dog/cat hair, and ragweed was generally higher across all ages, with increasing trends in Liuzhou for dog/cat hair. Cockroach sensitization varied; it was lower in 1–6-year-olds but higher in 13–18-year-olds in Guangzhou vs. Liuzhou, also rising with age in Guangzhou.
The positive rates of sensitization to all allergens (except for cockroaches) were higher in Guangzhou boys compared with Liuzhou boys. However, we did not find differences in sensitization rate between Guangzhou boys and girls. Arbes et al. documented a similar trend, observing a greater likelihood of positive allergen test responses among men [16]. Additionally, a cross-sectional study conducted in China, encompassing 6,304 asthma and/or rhinitis patients, identified male gender as a contributory risk factor for allergen sensitization [17].
Seasonally, dust mites showed minimal variation, higher in Guangzhou year-round except for house dust mites in spring. Cockroaches sensitized more during spring in Liuzhou. Guangzhou children had a higher sensitization to cat/dog hair, ragweed, and mugwort in summer/autumn. However, we did not find a correlation between sensitization and disease duration or living environment.
In sum, in this study, we compared the allergen types of AR children in two cities in southern China with very similar climatic conditions. Overall, the composition of AR allergens in children is similar between the two cities, with house dust mites and dust mites as the main allergens. However, the sensitization rates of all allergens, except for cockroaches, are higher in Guangzhou than those in Liuzhou. Our results suggest that the causes of allergen sensitization are complex, and genetic and environmental factors cannot be ignored. Identifying specific allergens in the local region can guide families to adopt measures such as regular cleaning, using allergen-proof covers for bedding, minimizing outdoor activities during peak pollen seasons, and using preventive medication before the pollen seasons.
Our study also had limitations. In the future, the collection of longitudinal data could help to determine whether sensitization patterns change over time and how they correlate with disease progression. Moreover, exploring the impact of environmental interventions on sensitization rates or genetic predispositions would be helpful for understanding the mechanism of sensitization.
The authors declare they have not used Artificial Intelligence (AI) tools in the creation of this article.
This study was supported by grants from the National Natural Science Grant of China (No.82271142), Guangdong Special Support Plan for Top Young Talents, Guangdong Province Natural Science Grant (No.2024A1515012386), Guangxi Natural Science Foundation (2024GXNSFBA010264).
The authors declare that they have no relevant conflicts of interest.
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Figures(3)
Tateki Kikuchi. Circular breakdown of neural networks due to loss of deubiquitinating enzyme (UCH-L1) in gracile axonal dystrophy (gad) mouse[J]. AIMS Molecular Science, 2021, 8(4): 311-324. doi: 10.3934/molsci.2021024
| Guangzhou | Liuzhou | |
| Cases | 9684 | 1679 |
| Age | 6.91 ± 2.81 | 5.23 ± 3.16 |
| Sex ratio (male/female) | 68%/32% | 60%/40% |
| Mono-sensitized ratio | 7.1% | 13.5% |
| Poly-sensitized ratio | 92.9% | 86.5% |
| Disease duration (years) | 2.2 ± 1.5 | 1.8 ± 1.6 |
| Living environment: Rural area | 85.2% | 82.1% |
| Living environment: Urban area | 14.8% | 17.9% |
DownLoad:
CSV
| Guangzhou | Liuzhou | P | |
| D. farinae | 96.0% | 89.6% | 0.0001 |
| D. pteronyssinus | 93.7% | 91.4% | 0.0004 |
| German cockroach | 6.5% | 7.6% | 0.0729 |
| Cat dander | 9.3% | 5.7% | 0.0001 |
| Dog dander | 6.4% | 4.1% | 0.0003 |
| Common ragweed | 2.6% | 1.2% | 0.0135 |
| Mugwort | 6.4% | 2.0% | 0.0001 |
DownLoad:
CSV
| 1–6 years old | 7–12 years old | 13–18 years old | ||||
| GZ | LZ | GZ | LZ | GZ | LZ | |
| D. farinae | 95.1% | 90.5%* | 97.1% | 86.9%* | 97.5% | 88.9%* |
| D. pteronyssinus | 92.8% | 92.6% | 94.7% | 87.7%* | 95.3% | 88.9% |
| German cockroach | 5.6% | 7.7%* | 7.4%# | 8.8% | 9.5%# | 3.2%*# |
| Cat dander | 7.2% | 5.8% | 11.3%# | 5.4%* | 13.8%# | 6.5%* |
| Dog dander | 5.5% | 3.8%* | 7.5% | 4.5%* | 6.3% | 8.1%# |
| Common ragweed | 2.8% | 1.1%* | 2.4% | 1.1%* | 2.8% | 3.0%# |
| Mugwort | 6.0% | 1.8%* | 6.7% | 2.3%* | 6.3% | 3.0%* |
| GZ, Guangzhou; LZ, Liuzhou. *Comparison between Guangzhou and Liuzhou group, P < 0.05. #Comparison with 1–6-year-old group, P < 0.05. | ||||||
DownLoad:
CSV
| Male | Female | |||
| GZ | LZ | GZ | LZ | |
| D. farinae | 96.1% | 89.7%* | 96.0% | 89.6%* |
| D. pteronyssinus | 93.9% | 91.8%* | 93.6% | 90.6%* |
| German cockroach | 6.8% | 7.7% | 6.0% | 7.8% |
| Cat dander | 9.4% | 5.6%* | 9.3% | 6.0%* |
| Dog dander | 6.1% | 4.4%* | 7.1% | 3.7%* |
| Common ragweed | 2.8% | 1.1%* | 2.2% | 1.4%* |
| Mugwort | 6.2% | 2.3%* | 6.8% | 1.4%* |
| GZ, Guangzhou, LZ, Liuzhou. *Comparison between Guangzhou and Liuzhou group, P < 0.05. | ||||
DownLoad:
CSV
| Spring | Summer | Autumn | Winter | |||||
| GZ | LZ | GZ | LZ | GZ | LZ | GZ | LZ | |
| D. farinae | 95.4% | 87.9%* | 96.8% | 91.6%* | 96.2% | 89.4%* | 95.3% | 87.7%* |
| D. pteronyssinus | 93.7% | 89.4%* | 94.6% | 93.2% | 93.6% | 92.1% | 91.8% | 88.7% |
| German cockroach | 6.1% | 9.4%* | 6.6% | 5.6% | 7.3% | 8.3% | 6.4% | 9.3% |
| Cat dander | 9.5% | 7.6% | 9.2% | 4.3%* | 9.4% | 5.7%* | 9.7% | 6.2% |
| Dog dander | 7.0% | 6.7% | 6.0% | 2.6%* | 5.5% | 3.4%* | 7.9% | 4.1% |
| Common ragweed | 2.6% | 2.8% | 2.1% | 0.7%* | 3.5% | 0.6%* | 3% | 0.1% |
| Mugwort | 6.3% | 5.5% | 6.5% | 0.4%* | 6.9% | 0%* | 5.7% | 2.1% |
| GZ, Guangzhou, LZ, Liuzhou. *Comparison between Guangzhou and Liuzhou group, P < 0.05. | ||||||||
DownLoad:
CSV
| < 1 year | > 1 year | |||
| GZ | LZ | GZ | LZ | |
| D. farinae | 92.5% | 84.3% | 97.7% | 91.2% |
| D. pteronyssinus | 94.2% | 90.3% | 92.8% | 93.1% |
| German cockroach | 6.2% | 8.2% | 6.4% | 6.6% |
| Cat dander | 8.5% | 5.6% | 9.9% | 5.7% |
| Dog dander | 6.5% | 3.6% | 6.3% | 4.7% |
| Common ragweed | 2.6% | 1.5% | 2.9% | 1.3% |
| Mugwort | 6.1% | 1.8% | 6.7% | 2.4% |
| GZ, Guangzhou, LZ, Liuzhou. | ||||
DownLoad:
CSV
| Rural area | Urban area | |||
| GZ | LZ | GZ | LZ | |
| D. farinae | 94.0% | 89.6% | 97.2% | 89.6% |
| D. pteronyssinus | 92.7% | 90.5% | 94.5% | 91.9% |
| German cockroach | 6.1% | 7.9% | 6.7% | 7.1% |
| Cat dander | 9.3% | 5.7% | 9.3% | 5.7% |
| Dog dander | 6.4% | 4.1% | 6.4% | 4.1% |
| Common ragweed | 2.6% | 1.2% | 2.6% | 1.2% |
| Mugwort | 5.8 % | 1.6% | 6.9% | 2.3% |
| GZ, Guangzhou, LZ, Liuzhou. | ||||
DownLoad:
CSV
| Guangzhou | Liuzhou | |
| Cases | 9684 | 1679 |
| Age | 6.91 ± 2.81 | 5.23 ± 3.16 |
| Sex ratio (male/female) | 68%/32% | 60%/40% |
| Mono-sensitized ratio | 7.1% | 13.5% |
| Poly-sensitized ratio | 92.9% | 86.5% |
| Disease duration (years) | 2.2 ± 1.5 | 1.8 ± 1.6 |
| Living environment: Rural area | 85.2% | 82.1% |
| Living environment: Urban area | 14.8% | 17.9% |
| Guangzhou | Liuzhou | P | |
| D. farinae | 96.0% | 89.6% | 0.0001 |
| D. pteronyssinus | 93.7% | 91.4% | 0.0004 |
| German cockroach | 6.5% | 7.6% | 0.0729 |
| Cat dander | 9.3% | 5.7% | 0.0001 |
| Dog dander | 6.4% | 4.1% | 0.0003 |
| Common ragweed | 2.6% | 1.2% | 0.0135 |
| Mugwort | 6.4% | 2.0% | 0.0001 |
| 1–6 years old | 7–12 years old | 13–18 years old | ||||
| GZ | LZ | GZ | LZ | GZ | LZ | |
| D. farinae | 95.1% | 90.5%* | 97.1% | 86.9%* | 97.5% | 88.9%* |
| D. pteronyssinus | 92.8% | 92.6% | 94.7% | 87.7%* | 95.3% | 88.9% |
| German cockroach | 5.6% | 7.7%* | 7.4%# | 8.8% | 9.5%# | 3.2%*# |
| Cat dander | 7.2% | 5.8% | 11.3%# | 5.4%* | 13.8%# | 6.5%* |
| Dog dander | 5.5% | 3.8%* | 7.5% | 4.5%* | 6.3% | 8.1%# |
| Common ragweed | 2.8% | 1.1%* | 2.4% | 1.1%* | 2.8% | 3.0%# |
| Mugwort | 6.0% | 1.8%* | 6.7% | 2.3%* | 6.3% | 3.0%* |
| GZ, Guangzhou; LZ, Liuzhou. *Comparison between Guangzhou and Liuzhou group, P < 0.05. #Comparison with 1–6-year-old group, P < 0.05. | ||||||
| Male | Female | |||
| GZ | LZ | GZ | LZ | |
| D. farinae | 96.1% | 89.7%* | 96.0% | 89.6%* |
| D. pteronyssinus | 93.9% | 91.8%* | 93.6% | 90.6%* |
| German cockroach | 6.8% | 7.7% | 6.0% | 7.8% |
| Cat dander | 9.4% | 5.6%* | 9.3% | 6.0%* |
| Dog dander | 6.1% | 4.4%* | 7.1% | 3.7%* |
| Common ragweed | 2.8% | 1.1%* | 2.2% | 1.4%* |
| Mugwort | 6.2% | 2.3%* | 6.8% | 1.4%* |
| GZ, Guangzhou, LZ, Liuzhou. *Comparison between Guangzhou and Liuzhou group, P < 0.05. | ||||
| Spring | Summer | Autumn | Winter | |||||
| GZ | LZ | GZ | LZ | GZ | LZ | GZ | LZ | |
| D. farinae | 95.4% | 87.9%* | 96.8% | 91.6%* | 96.2% | 89.4%* | 95.3% | 87.7%* |
| D. pteronyssinus | 93.7% | 89.4%* | 94.6% | 93.2% | 93.6% | 92.1% | 91.8% | 88.7% |
| German cockroach | 6.1% | 9.4%* | 6.6% | 5.6% | 7.3% | 8.3% | 6.4% | 9.3% |
| Cat dander | 9.5% | 7.6% | 9.2% | 4.3%* | 9.4% | 5.7%* | 9.7% | 6.2% |
| Dog dander | 7.0% | 6.7% | 6.0% | 2.6%* | 5.5% | 3.4%* | 7.9% | 4.1% |
| Common ragweed | 2.6% | 2.8% | 2.1% | 0.7%* | 3.5% | 0.6%* | 3% | 0.1% |
| Mugwort | 6.3% | 5.5% | 6.5% | 0.4%* | 6.9% | 0%* | 5.7% | 2.1% |
| GZ, Guangzhou, LZ, Liuzhou. *Comparison between Guangzhou and Liuzhou group, P < 0.05. | ||||||||
| < 1 year | > 1 year | |||
| GZ | LZ | GZ | LZ | |
| D. farinae | 92.5% | 84.3% | 97.7% | 91.2% |
| D. pteronyssinus | 94.2% | 90.3% | 92.8% | 93.1% |
| German cockroach | 6.2% | 8.2% | 6.4% | 6.6% |
| Cat dander | 8.5% | 5.6% | 9.9% | 5.7% |
| Dog dander | 6.5% | 3.6% | 6.3% | 4.7% |
| Common ragweed | 2.6% | 1.5% | 2.9% | 1.3% |
| Mugwort | 6.1% | 1.8% | 6.7% | 2.4% |
| GZ, Guangzhou, LZ, Liuzhou. | ||||
| Rural area | Urban area | |||
| GZ | LZ | GZ | LZ | |
| D. farinae | 94.0% | 89.6% | 97.2% | 89.6% |
| D. pteronyssinus | 92.7% | 90.5% | 94.5% | 91.9% |
| German cockroach | 6.1% | 7.9% | 6.7% | 7.1% |
| Cat dander | 9.3% | 5.7% | 9.3% | 5.7% |
| Dog dander | 6.4% | 4.1% | 6.4% | 4.1% |
| Common ragweed | 2.6% | 1.2% | 2.6% | 1.2% |
| Mugwort | 5.8 % | 1.6% | 6.9% | 2.3% |
| GZ, Guangzhou, LZ, Liuzhou. | ||||
