Review

Electrospun biodegradable polymers loaded with bactericide agents

  • Development of materials with an antimicrobial activity is fundamental for different sectors, including medicine and health care, water and air treatment, and food packaging. Electrospinning is a versatile and economic technique that allows the incorporation of different natural, industrial, and clinical agents into a wide variety of polymers and blends in the form of micro/nanofibers. Furthermore, the technique is versatile since different constructs (e.g. those derived from single electrospinning, co-electrospinning, coaxial electrospinning, and miniemulsion electrospinning) can be obtained to influence the ability to load agents with different characteristics and stability and to modify the release behaviour. Furthermore, antimicrobial agents can be loaded during the electrospinning process or by a subsequent coating process. In order to the mitigate burst release effect, it is possible to encapsulate the selected drug into inorganic nanotubes and nanoparticles, as well as in organic cyclodextrine polysaccharides. In the same way, processes that involve covalent linkage of bactericide agents during surface treatment of electrospun samples may also be considered.
    The present review is focused on more recent works concerning the electrospinning of antimicrobial polymers. These include chitosan and common biodegradable polymers with activity caused by the specific load of agents such as metal and metal oxide particles, quaternary ammonium compounds, hydantoin compounds, antibiotics, common organic bactericides, and bacteriophages.

    Citation: Luís J. del Valle, Lourdes Franco, Ramaz Katsarava, Jordi Puiggalí. Electrospun biodegradable polymers loaded with bactericide agents[J]. AIMS Molecular Science, 2016, 3(1): 52-87. doi: 10.3934/molsci.2016.1.52

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  • Development of materials with an antimicrobial activity is fundamental for different sectors, including medicine and health care, water and air treatment, and food packaging. Electrospinning is a versatile and economic technique that allows the incorporation of different natural, industrial, and clinical agents into a wide variety of polymers and blends in the form of micro/nanofibers. Furthermore, the technique is versatile since different constructs (e.g. those derived from single electrospinning, co-electrospinning, coaxial electrospinning, and miniemulsion electrospinning) can be obtained to influence the ability to load agents with different characteristics and stability and to modify the release behaviour. Furthermore, antimicrobial agents can be loaded during the electrospinning process or by a subsequent coating process. In order to the mitigate burst release effect, it is possible to encapsulate the selected drug into inorganic nanotubes and nanoparticles, as well as in organic cyclodextrine polysaccharides. In the same way, processes that involve covalent linkage of bactericide agents during surface treatment of electrospun samples may also be considered.
    The present review is focused on more recent works concerning the electrospinning of antimicrobial polymers. These include chitosan and common biodegradable polymers with activity caused by the specific load of agents such as metal and metal oxide particles, quaternary ammonium compounds, hydantoin compounds, antibiotics, common organic bactericides, and bacteriophages.


    1. Introduction

    Central Asia comprises the five independent republics Kazakhstan, Kyrgyzstan, Tajikistan, Turkmenistan and Uzbekistan. Six of the agro-climatic zones in this vast region occupy about 90% of the entire region. Two of the agro-climatic zones (Semi-arid-cold winter-warm summer, and Arid-cold winter-warm summer) alone occupy up to 60% (Table 1). The climate in Central Asia is mostly arid and semi-arid, and strongly continental, with long, hot summers and short, cold winters. Average annual precipitation, which is concentrated in winter and spring, is about 270 mm, but varies from 80-150 mm in the arid regions to 600 to 800 mm in the semi-arid mountainous zones. The land area of the five countries covers about 393 M ha (Table 2).

    Table 1. Main agro-climatic zones and extent of land area under CA. (Adapted from [4])
    Agro-climatic zones§Total area, haArea planted with elements of CA, haDescription of the elementsSource
    Semi-arid, cold winter, warm summer151,387,76013,700,000§Including 2,100,000 ha of no-tillage, i.e. direct seeding of spring wheat and barleyMinistry of Agriculture of Kazakhstan
    Semi-arid, cold winter26,419,800
    Sub-humid, cold winter23,617,700
    Arid, cold winter, warm summer123,027,520< 700,000§Conservation tillage, sowing of winter wheat into standing cotton Ministry of Agriculture and Water Resources of Uzbekistan, Ministry of Agriculture of Tajikistan and Ministry of Agriculture and Melioration of the Kyrgyz Republic
    Arid, cool winter, warm summer19,572,560
    Semi-arid, cool winter, warm summer5,991,600
    §for detailed description of the agro-climatic zones, see [4] and [5].
     | Show Table
    DownLoad: CSV
    Table 2. Land resources, population and various agricultural indicators of five Central Asian countries.
    CountryTotal territory (M ha)Land area (M ha)Cropland (M ha)Irrigated land (M ha) Rainfed land (M ha) Population (M)% rural populationPer capita cropland (ha)% Agric. GDP
    Kazakhstan272.5269.7241.622.117.0142.81.415.3
    Kyrgyzstan20.019.21.41.10.35.9363.40.2325.8
    Tajikistan14.214.00.90.70.28.6171.40.1019.8
    Turkmenistan48.847.01.81.80.05.4172.00.3322.1
    Uzbekistan44.742.54.94.30.531.0063.50.1519.4
    Total 400.3392.7339.523.168.05
    Mean62.60.489.9
    Source: [6,7,8,9,10]
     | Show Table
    DownLoad: CSV

    Mikhalev and Reimov postulated that Central Asia’s drylands are to be regarded as dry steppe, semi-desert, desert, and salt marshes, which are known to be vulnerable to different kinds of degradation including soil degradation (here defined as a loss of fertility, or increase in salinization or waterlogging), degradation of pastures (due to overgrazing and excessive agricultural and firewood harvest), degradation of forests (due to illegal logging, fires, grazing, erosion), and erosion, landslides, and mudflows [1]. Extensive and intensive land use during the Soviet Union period (1924-1990) and disorganized land management systems introduced after the collapse of the Soviet Union (1991) worsened land degradation in Central Asia. Mono-cropping and a production strategy aimed at increasing the production of agricultural commodities without considering environmental consequences have been listed as major causes of past and on-going land degradation [2,3].

    Gupta et al. argued that during the post-Soviet period, the three primary causes of land degradation included the (i) mismanagement and over-use of natural resources, (ii) insufficiency of economic infrastructures and market mechanisms, and (iii) insufficient development of capacity and weak inter-sector coordination [11]. Despite the control of areas by governmental agencies during Soviet reign, the on-going land degradation could not be stopped and therefore remained high on the political agendas of the countries in Central Asia after independence.

    Areas under land degradation are wide spread in the arid and semi-arid zones of the Central Asian countries, and comprising over 80% of the agricultural area [12]. Some 68% of the agricultural land in the region is degraded due to erosion and increased salinity [3] (Table 3). The degradation of agricultural land in Kazakhstan and Uzbekistan has amounted to 73% and 44%, respectively, mainly caused by increased soil salinity, erosion and loss of vegetation cover. Most of the land resources in Kyrgyzstan and Tajikistan are prone to erosion due to the high proportion (above 90%) of mountainous areas in these two countries (Table 3). The types of degradation within a country vary according to land use type. However, the largest portion of the degraded land is in response to improper farming practices [3]. In particular, the numerous soil tillage practices, which invert the soil using heavy machinery with high ground pressures, agricultural practices that neglect to protect the soil surface, and the insufficient supply of organic material to the soil has resulted in increased soil erosion, decrease of topsoil depth and increase in salinity, with consequent losses in soil fertility and land value. In addition, poor irrigation management have resulted in soil degradation due to waterlogging (Table 3).

    Table 3. Soil degradation in Central Asia, %.
    Type of soil degradationPercent of Agricultural land
    KazakhstanKyrgyzstanTajikistanTurkmenistanUzbekistan
    Erosion17.2*85.0*75.0*8.9*11.6*
    Waterlogging8.7**1.0**3.6**3.2**8.7**
    Salinity47.7**0.5**5.0**19.1**24.4**
    Total73.6**86.5**83.6**31.2**44.7**
    *[13] **[3]
     | Show Table
    DownLoad: CSV

    The on-going degradation of soil resources in Central Asia is not only widespread, but represents a direct threat to the productive capacity and sustainability of the agricultural production base in the region. Substantial improvements in soil management are therefore direly needed to counter these threats.

    Conservation Agriculture (CA) has the potential to provide various tools to combat soil degradation as well as raise productivity and resilience, and reduce production costs [5,14,15,16]. Conservation Agriculture rests on three interlinked principles: (i) no or minimal mechanical disturbance of the soil through no-till direct seeding to maintain the quality and productivity of the soil, which is at the base of all CA-based farming practices and systems; (ii) maintenance of a permanent soil mulch cover with for instance plant residues including stubbles or cover crops to improve infiltration, reduce water loss and erosion, protect the soil from harsh climate extremes, and serve as a substrate for soil microorganisms and fauna; and (iii) diversified cropping systems over time (rotations, sequences) and space (associations) to further strengthen the systems’ resilience against biotic and abiotic threats [16,17,18]. In this way, CA practices provide important benefits to the environment and the land user alike [18,19,20].

    2. Combating soil degradation with CA

    Originally, CA practices were promoted to combat soil degradation and erosion resulting from tillage that caused the destruction of soil structure and aggregate stability, deplete soil organic matter and soil biological health. In later years, CA helped to reduce production costs, and raise productivity (yield and efficiency) [17]. During the past 20 years, CA has spread across all continents and most agro-ecological zones, particularly in North and South America and in Australia, but more recently also in Asia, Africa and Europe. In 2013, CA was used globally on 155 M ha of annual cropland, corresponding to about 11% of global annual cropland [21,22]. About 50% of the CA area is located in developing countries.

    In Central Asia, the research on crop residue management under no-till and its effect on soil erosion is still in its infancy. Yet, a review of a wealth of literature from outside Central Asia, illustrates numerous benefits. Hence, CA has been shown to be an innovative approach that helps in reducing soil erosion, improving water use efficiency as well as soil quality and helps in increasing soil organic matter, decreasing energy use and above all improving crop and land productivity and in turn the income of (resource poor) farmers [22,24]. For instance, soil erosion in Brazil decreased from 3.4-8.0 t ha−1under conventional tillage to 0.4 t ha−1under CA, whilewater loss decreasedfrom approximately 990 to 170 t ha−1 [25,26]. The reduction in soil erosion led to enhanced surface and ground water quality whilst crop residues retention on the surface helps in holding soil particles in place and keeping any applied plant nutrients and pesticides on the field.

    The overarching experimental evidence from the many different production environments worldwide demonstrate that CA-based management can have both immediate (e.g. reduced production costs, reduced erosion, stabilized crop yield, and improved water productivity) and long-term benefits (e.g. higher soil organic matter contents and improved soil structure), although the magnitude of these benefits tends to be site and year specific depending on the nature of the initial status of land degradation and the prevailing yield level [27,28,29,30].

    Increasingly, CA is considered to be climate-smart also, because of its better adaptability to climate change, and as a means to reach a sustainable intensification of agricultural production with minimum negative impacts on the environment [31,32]. As such, CA is a means for the integration of ecological management with modern, scientific, agricultural production practices. This holistic embrace of knowledge, as well as the capacity of farmers to apply this knowledge, innovate and adjust to evolving local conditions, ensures the sustainability of those who practice CA. A major strength of CA is furthermore the option of a step-wise implementation by farmers of complementary, synergetic soil husbandry practices that build to a robust, cheaper, more productive and environmentally friendly farming system. Therefore, CA practices have an important role to fulfill in the production systems of Central Asia.

    3. Effect of CA on soil quality and land degradation problems

    Soil organic matter (SOM) dynamics: Worldwide evidence has also shown the main benefits of no-till or low soil disturbance tillage on soil organic matter and soil carbon (C) interactions. The maintenance of these important parameters for soil quality depends on a permanent soil mulch cover developed through crop residue retention or cover crops, which is one of the three main principles of CA. In CA in Central Asia, the use of cover crops is not fully developed yet, but crop residues including stubble are retained on the soil surface after harvest where they benefit soil properties and crops, as shown by numerous field investigations [33,34]. Keeping crop residues on the soil surface reduces soil losses, protects the soil from water and wind erosion, and adds organic matter to the soil both in the rainfed and irrigated agriculture conditions worldwide [35,36].

    In CA, no-till, direct seed drilling is the only mechanical operation causing disturbance to the soil surface. All other operations that are normally employed under “conventional tillage agriculture” in the rainfed areas of Kazakhstan such as sweep tillage, disking and harrowing, are thus not included in CA [2]. Intensive experiences with CA practices in Central Asia date from the year 2000 onward. The concept of CA within the irrigated areas of CA has taken some time to become accepted, which has delayed the experimentation and the documentation thereof.

    Organic matter is one of the major indicators of soil quality and biological health, which affects, among other factors, crop yield and the ability of soils to resist erosion. A number of researchers have investigated the impact of different tillage systems on soil organic matter (SOM). There is general agreement that no-till can increase SOM as shown in arid and semi-arid regions in and outside the Central Asia region. Hernanz et al. [37], for instance, conducted a long term experiment in a semi-arid area of Spain using different tillage methods and reported that under no-till with mulch cover, the SOM at a depth of 0-10 and 20 cm had higher organic contents compared to conventional tillage [37]. Numerous results from the irrigated areas of Central Asia showed that crop residue retention improves SOM and soil N content [38,39,40]. The CA practices examined in Central Asia increased SOM significantly with corresponding improvements in soil structure and greater soil moisture holding capacities [38,39].

    Most beneficial effects on soil physical properties reported due to plant residue retention were the positive influences on soil quality, decreasing soil bulk density, increasing soil moisture retention, and increasing biological activity of the soil. That is why a general preservation of crop residues, irrespective of its make-up, improved physiological and biological properties of the soil, which in turn significantly increased soil fertility [41]. More recently, the positive impact of no tillage and crop residue management on properties of a silty loam soil under irrigation in Uzbekistan was reported for a rotation of winter wheat and maize for two years followed by cotton for another two years [42].

    Soil salinization: The on-going soil salinization in the irrigated areas of Central Asia is predominantly caused by the capillary rise of the ground water. This is the major cause of the on-going cropland degradation, especially in the Aral Sea basin [43,44]. A mulching experiment with crop residues decreased soil salinity under the irrigated conditions of Uzbekistan [45]. Pulatov et al. [39] reported that after four years, a no-till CA system had the lowest soil salinity level of all practices tested, i.e., no tillage and residue retention, which influenced also the location and accumulation of salts by reducing evaporation and the upward salt transport in the soil [39].

    Soil erosion:Increasing the SOM content and maintaining crop residues on the soil surface also reduced wind erosion [47]. Depending on the amount of crop residues retained on the soil surface, soil erosion could be reduced to insignificant levels compared to the unprotected, intensively tilled exposed fields [48] and this benefit can be harnessed in Central Asia as well. Water erosion too enhances soil degradation in Central Asia, especially on hilly areas and under irrigated conditions. The effective CA practices showed for many years to constitute a promising set of improved and financially feasible methods of crop production, which concurrently reduced wind and water erosion [49]. The regularly occurring wet springs in much of northern Kazakhstan resulted in severe soil erosion of exposed soil surface in fallowed fields [50]. Although information about the effect of slopes is lacking, in general where they are considered to be long, they resulted in water accumulation in the lower parts and in increasing the velocities of runoff water. However, with crop residue retention, soil erosion could be reduced drastically on the cropped areas [50]. Nevertheless, water and wind erosion studies remain rare in Central Asia despite having been acknowledged as being a core reason for on-going soil degradation (Table 3). Based on the research findings and lessons learned from different agro-climatic regions, several remedies could be examined for adoption in the region.

    4. Crop yield under Conservation Agriculture practices

    Early research from similar semi-arid environments showed the yield enhancing effects on barley of reduced and zero tillage systems compared to conventional practices [51]. Crop yields after four years of permanent bed planting in North-western Uzbekistan was 20% higher with zero tillage system compared to the conventional tillage methods [52]. Although results from numerous findings of CA practices on crop yields have been mixed, in the end crop yield is a critical assessment criterion for farmers. Hence, more research needs to be directed towards yield and its parameters under irrigated agriculture. Similarly, for the rainfed areas, results have been promising, but still are sparse. For example, from 1992 to 1995, minimum soil disturbance tillage techniques were introduced and tested particularly in the northern, rainfed parts of Kazakhstan. Excellent results were obtained throughout the areas cultivated with minimized soil disturbance, resulting in both economic savings and increased crop yields [53].

    Many research results from the irrigated areas in Central Asia indicated that bed planting practices improved wheat yields, increased fertilizer efficiency, reduced herbicide use, saved seeds, reduced water demands (on average 30%), and reduced production costs by 25-35% [54,55,56]. According to the Ministry of Agriculture of Kazakhstan, CA and conservation tillage practices were applied on some 11.7 M ha (Table 3), which is 70% of the total area sown to wheat in Kazakhstan [57] (Figure 1). Consequently, the country harvested a record gross output of grain of 20 M t, corresponding to a yield of 1.7 t ha−1 [57]. Hence, CA practices may have contributed to these increased yields and output, although the area under full CA in Kazakhstan is only 2.1 M ha. Results from Tajikistan and Kyrgyzstan showed 25-38% higher wheat yields under raised bed and no-till planting conditions compared to the traditional, tillage-driven planting [54,56].

    Figure 1. Rainfed, no-till winter wheat in Kazakhstan (2008). Photo by Aziz Nurbekov.

    In addition to yield increases, seeding rates under CA in Kyrgyzstan could be reduced by 50% while irrigation water requirement could be lowered by 27% [54]. Similar results were reported in the irrigated conditions of Tajikistan [56]. On the other hand, Nurbekov et al. reported that the application rate of N had no significant effect on winter wheat yields in no-till and conventional systems in Uzbekistan [40]. The yields with 120 kg N ha−1 rates turned out to be as good as with 140 kg N ha−1 under conventional practices using mouldboard ploughs, while with no-till practices a slight increase in grain yields was observed with the higher N rates. Nurbekov et al. reported that winter wheat yields increased with no-till compared to conventional tillage system [40]. Sanginov and Khalikov, carriying out research on the planting of winter wheat before the harvest of cotton in Yavan and Gozimalik districts of Tajikistan, reported that wheat growth and development under no-tillage system resulted in savings of seed quantity and in increased yield [58]. The adoption of CA methods could thus bring about significant productivity and environmental benefits [41].

    So far, only Kazakhstan has issued supportive policies to introduce and spread CA practices and this has increased the area under CA-based practices from virtually none in 2001 to 2.1 M ha in 2013. The other four countries in Central Asia are only gradually moving towards the adoption of supportive policies on CA and in general, a wide-spread adoption of CA is still pending and would need more extension and research support [60].

    Permanent raised bed planting in Uzbekistan consists of raised beds that have been prepared and used during a previous season and subsequently used for growing the next crop (Figure 2). Over the last 20 years, Uzbekistan has been researching different ways of introducing grain crops into the existing crop rotations, which included cotton and alfalfa mainly, albeit predominantly during the Soviet Union epoch. However, since 1990s, winter wheat, previously grown under rainfed conditions only in Central Asia, is being cultivated also under irrigation. Research findings showed that a timely, no-till planting of winter wheat in standing cotton is a promising relay cropping practice. As a consequence, the area under this cotton-winter wheat relay cropping has now reached some 600,000 ha annually [59]. Several development projects in Central Asia, supported by the international donor community, currently include the promotion of CA with permanent raised beds system as part of their priority activities, but according to many these efforts need to be intensified [60].

    Figure 2. Permanent bed planted winter wheat in Uzbekistan (2012). Photo by Aziz Nurbekov.

    Hence, despite the numerous positive research results, CA is still not widely practices among the farming population in the irrigated areas of Central Asia. This is partly due to a predetermined mindset but also due to the relative complexity of CA practices compared to conventional tillage agricultural practices.

    5. Conclusions

    Current research evidence from the rainfed areas of Central Asia, shows that CA practices are promising to combat a series of flaws in the existing cropping systems. However, much less research evidence exists for the irrigated areas even though such research has introduced in all five Central Asian countries and while covering the heterogeneous local conditions. These preliminary research results, albeit limited to a few locations, show the potential for achieving similar, or even higher crop yields over time. The CA practices favoured, such as permanent no-till beds, showed their effectiveness in lowering the rate of land degradation caused by soil salinization. Research on CA practices and its role in combating the on-going water and wind erosion have not been placed high on the research agendas yet. However, the maintenance of a soil coverage by residues reduces wind and water erosion, increases water infiltration and storage capacity, which helps reducing crop water stress, improves soil quality and increases organic matter. These benefits are promising to the scientists in the first place, but not yet to farmers! The findings underscored furthermore that CA is not a single, uniformly applicable technology that can be immediately applied anywhere and in a standard manner. Rather, it represents a set of principles that encourage the formulation of locally adapted practices, approaches and methods, which need to be tested, evaluated and then adopted or implemented not only under various climatic setting but also while considering the socio-economic conditions. Hence, also socio-economic research has to be promoted for instance when addressing the residue management component since this needs to be packaged into an easily adoptable technology, acceptable to farmers. Finally, as is evidenced in Kazakhstan, encouraging policies are needed as well as an effective and functioning agricultural extension system, which only is in its infancy in most Central Asia countries.

    Further research is needed across the agro-climatic zones that should address in detail the effects of various types of CA crop rotations and mulch covers on weed management, on nutrients, pests and water management, on residue levels, sowing depths, dates and density, and on fertilizer and irrigation rates. Needless to repeat the importance of an impact assessment on livelihoods and environmental conditions including the potential of integrating trees and timber production, pastures and livestock into CA farming systems particularly with small-scale farmers.

    Conflict of interest

    All authors declare no conflict of interest.

    [1] Costerton JW, Stewart PS, Greenberg EP (1999) Bacterial Biofilms: A Common Cause of Persistent Infections. Science 27: 1318-1322.
    [2] Davies D (2003) Understanding biofilm resistance to antibacterial agents. Natur Rev Drug Discov 2: 114-122. doi: 10.1038/nrd1008
    [3] Sun G (2014) Prevention of hospital and community acquired infections by using antibacterial textiles and clothing. In: Polymeric materials with antimicrobial activity, Muñoz-Bonilla A, Cerrada ML, Fernández-García M., Eds., RSC Polymer Chemistry Series, Ch 6, 139-154.
    [4] Chen L, Bromberg L, Hatton TA, et al. (2008) Electrospun cellulose acetate fibers containing chlorhexidine as a bactericide. Polymer 49: 1266-1275. doi: 10.1016/j.polymer.2008.01.003
    [5] DeLeo FR, Chambers HF (2009) Reemergence of antibiotic-resistant Staphylococcus aureus in the genomics era. J Clin Invest 119: 2464-2474. doi: 10.1172/JCI38226
    [6] Melaiye A, Sun Z, Hindi K, et al. (2005) Silver(I)−Imidazole Cyclophane gem-Diol Complexes Encapsulated by Electrospun Tecophilic Nanofibers:  Formation of Nanosilver Particles and Antimicrobial Activity. J Am Chem Soc 8: 2285-2291.
    [7] Baley GJ, Peck GE, Banker GS (1977) Bactericidal properties of quaternary ammonium compounds in dispersed systems. J Pharm Sci 66: 696-699. doi: 10.1002/jps.2600660522
    [8] Ortenzio LF, Stuart LS (1959) The behavior of chlorine-bearing organic compounds in the AOAC available chlorine gemicidal equivalent concentration test. J Assoc Off Ana Chem 42: 630-633.
    [9] Chopra I, Roberts M (2001) Tetracycline Antibiotics: Mode of Action, Applications, Molecular Biology, and Epidemiology of Bacterial Resistance. Microbiol Mol Biol Rev 65: 232-260. doi: 10.1128/MMBR.65.2.232-260.2001
    [10] Danese PN (2002) Antibiofilm Approaches: Prevention of Catheter Colonization. Chem Biol 9: 873-880. doi: 10.1016/S1074-5521(02)00192-8
    [11] Jarvis WR (1996) Selected aspects of the socioeconomic impact of nosocomial infections: morbidity, mortality, cost, and prevention. Infect Cont Hosp Ep 17: 552-557. doi: 10.2307/30141291
    [12] McGowan JE (2001) Economic impact of antimicrobial resistance. Emerg Infect Dis 7: 286-292. doi: 10.3201/eid0702.010228
    [13] Reneker DH, Chun I (1996) Nanometre diameter fibres of polymer, produced by electrospinning, Nanotechnology 7: 216-223.
    [14] Li D, Xia Y (2004) Electrospinning of nanofibers: Reinventing the wheel? Adv Mater 16: 1151-1170. doi: 10.1002/adma.200400719
    [15] Deitzel, JM, Kleinmeyer J, Harris D et al. (2001) The effect of processing variables on the morphology of electrospun nanofibers and textiles. Polymer 42: 261-272. doi: 10.1016/S0032-3861(00)00250-0
    [16] Daels N, De Vrieze S, Sampers I, et al (2011) Potential of a functionalised nanofibre microfiltration membrane as an antibacterial water filter. Desalination 275: 285-290. doi: 10.1016/j.desal.2011.03.012
    [17] Zodrow K, Brunet L, Mahendra S (2009) Polysulfone ultrafiltration membranes impregnated with silver nanoparticles show imporved biofouling resistance and virus removal. Water Res 43: 715-723. doi: 10.1016/j.watres.2008.11.014
    [18] Payne RJH, Jansen VAA (2003) Pharmacokinetic principles of bacteriobacteriophage therapy. Clin Pharmacokinet 42: 315-325. doi: 10.2165/00003088-200342040-00002
    [19] Gao Y, Truong YB, Zhu Y, et al. (2014) Electrospun antibacterial nanofibers: production, activity, and in vivo applications. J Appl Polym Sci 131: 40797.
    [20] Wang S, Zheng F, Huang Y, et al. (2012) Encapsulation of amoxicillin within laponite-doped poly(lactic-co-glycolic acid) nanofibers: preparation, characterization, and antibacterial activity. Acs Appl Mater Interfaces 4: 6396-6401.
    [21] Özdemir I, Özcan EO, Günal S (2010) Synthesis and Antimicrobial Activity of Novel Ag-N-Heterocyclic Carbene Complexes. Molecules 15: 2499-2508. doi: 10.3390/molecules15042499
    [22] Clement JL, Jarret PS (1994) Antibacterial Silver. Met Based Drugs 1: 467-482. doi: 10.1155/MBD.1994.467
    [23] Tambe SM, Sampath L, Modak SM (2001) In-vitro evaluation of the risk of developing bacterial resistance to antiseptics and antibiotics used in medical devices. J Antimicrob Chemoth 47: 589-598. doi: 10.1093/jac/47.5.589
    [24] Liu JJ, Galettis P, Farr A, et al. (2008) In vitro antitumour and hepatotoxicity profiles of Au(I) and Ag(I) bidentate pyridyl phosphine complexes and relationships to cellular uptake. J Inorg Biochem 102: 303-310. doi: 10.1016/j.jinorgbio.2007.09.003
    [25] Jeong L, Kim MH, Jung JY, et al. (2014) Effect of silk fibroin nanofibers containing silver sulfadiazine on wound healing. Int J Nanomed 9: 5277-5287.
    [26] Burd A, Kwok CH, Hung SC, et al. (2007) A comparative study of the cyto¬toxicity of silver-based dressings in monolayer cell, tissue explant, and animal model. Wound Repair Regen 15: 94-104. doi: 10.1111/j.1524-475X.2006.00190.x
    [27] Lok CN, Ho CM, Chen R, et al. (2006) Proteomic analysis of the mode of antibacterial action of silver nanoparticles. J Proteome Res 5: 916-924. doi: 10.1021/pr0504079
    [28] Lansdown AB (2005) A guide to the properties and uses of silver dressings in wound care. Prof Nurse 20: 41-43.
    [29] Vepari C, Kaplan DL (2007) Silk as a biomaterial. Prog Polym Sci 32: 991-1007. doi: 10.1016/j.progpolymsci.2007.05.013
    [30] Kasoju N, Bora U (2012) Silk fibroin in tissue engineering. Adv Healthc Mater 1: 393-412. doi: 10.1002/adhm.201200097
    [31] Dong G, Xiao X, Liu X, et al. (2009) Functional Ag porous films prepared by electrospinning. J Appl Surf Sci 255: 7623-7626. doi: 10.1016/j.apsusc.2009.04.039
    [32] Xu X, Yang Q, Wang Y, el al. (2006) Biodegradable electrospun poly(l-lactide) fibers containing antibacterial silver nanoparticles. Eur Polym J 42: 2081-2087. doi: 10.1016/j.eurpolymj.2006.03.032
    [33] Son WK, Youk JH, Park WH (2006) Antimicrobial cellulose acetate nanofibers containing silver nanoparticles. Carbohyd Polym 65: 430-434. doi: 10.1016/j.carbpol.2006.01.037
    [34] Lala NL, Ramaseshan R, Bojun L, et al. (2007) Fabrication of nanofibers with antimicrobial functionality used as filters: protection against bacterial contaminants. Biotechnol Bioeng 97: 1357-1365. doi: 10.1002/bit.21351
    [35] Yang QB, Li DM, Hong YL, el al. (2003) Preparation and characterization of a PAN nanofibre containing Ag nanoparticles via electrospinning Proceedings of the 2002 International Conference on Science and Technology of Synthetic Metals, Elsevier SA, Lausanne, Switzerland, 973-974.
    [36] Sheikh FA, Barakat NAM, Kanjwal MA, el al. (2009) Electrospun antimicrobial polyurethane nanofibers containing silver nanoparticles for biotechnological applications. Macromol Res 17: 688-696. doi: 10.1007/BF03218929
    [37] Gliscinska E, Gutarowska B, Brycki B, el al. (2012) Electrospun Polyacrylonitrile Nanofibers Modified by Quaternary Ammonium Salts. J Appl Polym Sci 128: 767-775.
    [38] Yarin AL, Zussman E (2004) Upward needleless electrospinning of multiple nanofibers. Polymer 45: 2977-2980. doi: 10.1016/j.polymer.2004.02.066
    [39] Nomiya K, Tsuda K, Sudoh T, el al. (1997) Ag(I)-N bond-containing compound showing wide spectra in effective antimicrobial activities: Polymeric silver(I) imidazolate. J Inorg Biochem 68: 39-44. doi: 10.1016/S0162-0134(97)00006-8
    [40] Nomiya K, Noguchi R, Oda M (2000) Synthesis and crystal structure of coinage metal(I) complexes with tetrazole (Htetz) and triphenylphosphine ligands, and their antimicrobial activities. A helical polymer of silver(I) complex [Ag(tetz)(PPh3)2]n and a monomeric gold(I) complex [Au(tetz)(PPh3)]. Inorg Chim Acta 298: 24-32.
    [41] Atiyeh BS, Ioannovich J, Al-Amm CA, el al. (2002) Management of acute and chronic open wounds: the importance of moist environment in opimal wound healing. Curr Pharm Biotechnol 3: 179-195. doi: 10.2174/1389201023378283
    [42] Akhavan O, Ghaderi E (2009) Enhancement of antibacterial properties of Ag nanorods by electric field. Sci Technol Adv Mat 10: 015003. doi: 10.1088/1468-6996/10/1/015003
    [43] Tijing LD, Amarjargal A, Jiang Z (2013) Antibacterial tourmaline nanoparticles/polyurethane hybrid mat decorated with silver nanoparticles prepared by electrospinning and UV photoreduction. Curr Appl Phys 13: 205-210. doi: 10.1016/j.cap.2012.07.011
    [44] Raffi M, Mehrwan S, Bhatti TM, et al. (2010) Investigations into the antibacterial behavior of copper nanoparticles against Escherichia coli. Ann Microbiol 60: 75-80. doi: 10.1007/s13213-010-0015-6
    [45] Zhong W, Zishena W, Zhenhuana Y, et al. (1994) Synthesis, characterization and antifungal activity of copper (II), zinc (II), cobalt (II) and nickel (II) complexes derived from 2-chlorobenzaldehyde and glycine. Synth React Inorg Met-Org Chem 24: 1453-1460. doi: 10.1080/00945719408002572
    [46] Sheikh FA, Kanjwal MA, Saran S, et al. (2011) Polyurethane nanofibers containing copper nanoparticles as future materials. Appl Surf Sci 257: 3020-3026. doi: 10.1016/j.apsusc.2010.10.110
    [47] Hwang SH, Song J, Jung Y, et al. (2011) Electrospun ZnO/TiO2 composite nanofibers as a bactericidal agent. J Chem Commun 47: 9164-9166. doi: 10.1039/c1cc12872h
    [48] Lee S (2009) Multifunctionality of layered fabric systems based on electrospun polyurethane/zinc oxide nanocomposite fibers. J Appl Polym Sci 114: 3652-3658. doi: 10.1002/app.30778
    [49] Lee K, Lee S (2012) Multifunctionality of poly(vinyl alcohol) nanofiber webs containing titanium dioxide. J Appl Polym Sci 124: 4038-4046. doi: 10.1002/app.34929
    [50] Yu W, Lan CH, Wang SJ, et al. (2010), Influence of Zinc oxide nanoparticles on the crystallization behavior of electrospun poly(3-hydroxybutyrate-co-3-hydroxyvalerate) nanofibers. Polymer 51: 2403.
    [51] Drew C, Liu X, Ziegler D, et al. (2003) Metal oxide-coated polymer nanofibers. Nano Lett 3: 143-147. doi: 10.1021/nl025850m
    [52] Horzum N, Mari M, Wagner M, et al. (2015) Controlled surface mineralization of metal oxides on nanofibers. RSC Adv 5: 37340-37345. doi: 10.1039/C5RA02140E
    [53] Klabunde KJ, Stark J, Koper O, et al. (1996) Nanocrystals as stoichiometric reagents with unique surface chemistry. J Phys Chem 100: 12142-12153. doi: 10.1021/jp960224x
    [54] Stoimenov PK, Klinger RL, Marchin GL (2002) Metal Oxide Nanoparticles as Bactericidal Agents. Langmuir 18: 6679-6686. doi: 10.1021/la0202374
    [55] Koper O, Klabunde J, Marchin G, et al. (2012) Nanoscale Powders and Formulations with Biocidal Activity Toward Spores and Vegetative Cells of Bacillus Species, Viruses, and Toxins. Curr Microbiol 44: 49-55.
    [56] McDonnell G, Russell AD (1999) Antiseptics and disinfectants: activity, action, and resistance. Clin Microbiol Rev 12: 147-179.
    [57] Kügler R, Bouloussa O, Rondelez F (2005) Evidence of a charge-density threshold for optimum Synthesis and antimicrobial activity of modified poly(glycidyl methacrylate-co-2-hydroxy -ethyl methacrylate) derivatives with quaternary ammonium and phosphonium salts. J Polym Sci Pol Chem 40: 2384-2393.
    [58] Kenawy ER, Abdel-Hay FI, El-Shanshoury A, et al. (2002) Biologically active polymers. V. Synthesis and antimicrobial activity of modified poly(glycidyl methacrylate-co-2-hydroxyethyl methacrylate) derivatives with quaternary ammonium and phosphonium salts. J Polym Sci Part A: Polym Chem 40: 2384-2393.
    [59] Kenawy ER, Mahmoud YAG (2003) Biological active polymers. Macromol Biosci 3: 107-116. doi: 10.1002/mabi.200390016
    [60] Lundin JG, Coneski PN, Fulmer PA, et al. (2014) Relationship between surface concentration of amphiphilic quaternary ammonium biocides in electrospun polymer fibers and biocidal activity. React Funct Polym 77: 39-46. doi: 10.1016/j.reactfunctpolym.2014.02.004
    [61] Arumugam GK, Khan S, Heiden PA (2009) Comparison of the Effects of an Ionic Liquid and Other Salts on the Properties of Electrospun Fibers, 2-Poly(vinyl alcohol). Macromol Mater Eng 294: 45-53. doi: 10.1002/mame.200800199
    [62] You Y, Lee SJ, Min BM, et al. (2006) Effect of solution properties on nanofibrous structure of electrospun poly(lactic-co-glycolic acid). J Appl Polym Sci 99: 1214-1221. doi: 10.1002/app.22602
    [63] Tong HW, Wang M (2011) Electrospinning of poly(hydroxybutyrate-co-hydroxyvalerate) fibrous scaffolds for tissue engineering applications: effects of electrospinning parameters and solution properties. J Macromol Sci 50: 1535-1558. doi: 10.1080/00222348.2010.541008
    [64] Park JA, Kim SB (2015) Preparation and characterization of antimicrobial electrospun poly(vinyl alcohol) nanofibers containing benzyl triethylammonium chloride. React Funct Polym 93: 30-37. doi: 10.1016/j.reactfunctpolym.2015.05.008
    [65] Kim SJ, Nam YS, Rhee DM, et al. (2007) Preparation and characterization of antimicrobial polycarbonate nanofibrous membrane. Eur Polym J 43: 3146-3152. doi: 10.1016/j.eurpolymj.2007.04.046
    [66] Nicosia A, Gieparda W, Foksowicz-Flaczyk J, et al. (2015) Air filtration and antimicrobial capabilities of electrospun PLA/PHB containing ionic liquid. Sep Purif Technol 154: 154-160. doi: 10.1016/j.seppur.2015.09.037
    [67] Buruiana EC, Buruiana T (2002) Recent developments in polyurethane cationomers. Photoisomerization reactions in azoaromatic polycations. J Photoch Photobiol A: Chem 151: 237-252. doi: 10.1016/S1010-6030(02)00181-8
    [68] Uykun N, Ergal I, Kurt H, et al. (2014) Electrospun antibacterial nanofibrous polyvinylpyrrolidone/ cetyltrimethylammonium bromide membranes for biomedical applications. J Bioact Compat Pol 29: 382-397. doi: 10.1177/0883911514535153
    [69] Qun XL, Fanf Y, Shan Y, et al. (2010) Antibacterial Nanofibers of Self-quaternized Block Copolymers of 4-Vinyl Pyridine and Pentachlorophenyl Acrylate. High Perform Polym 22: 359-376. doi: 10.1177/0954008309104776
    [70] Cashion MP, Li X, Geng Y, at al. (2010) Gemini Surfactant Electrospun Membranes. Langmuir 26: 678-683. doi: 10.1021/la902287b
    [71] Singh G, Bittner AM, Loscher S, et al. (2008) Electrospinning of diphenylalanine nanotube. Adv Mater 20: 2332-2336. doi: 10.1002/adma.200702802
    [72] Worley SD, Williams DE (1988) Halamine Water Disinfectants. Crit Rev Environ Control 18: 133-175. doi: 10.1080/10643388809388345
    [73] Song J, Jang J (2014) Antimicrobial polymer nanostructures: Synthetic route, mechanism of action and perspective. Adv Colloid Interface Sci 203: 37-50. doi: 10.1016/j.cis.2013.11.007
    [74] Cerkez I, Worley SD, Broughton RM, et al. Huang (2013) Rechargeable antimicrobial coatings for poly(lactic acid) nonwoven fabrics. Polymer 54: 536-541. doi: 10.1016/j.polymer.2012.11.049
    [75] Chen Z, Sun Y (2005) N-Chloro-Hindered Amines as Multifunctional Polymer Additives. Macromolecules 38: 8116-8119. doi: 10.1021/ma050874b
    [76] Chen Z, Sun Y (2005) Antimicrobial Functions of N-Chloro-Hindered Amines. Polym Preprint 46: 835-836.
    [77] Dong A, Zhang Q, Wang T, et al. (2010) Immobilization of cyclic N-halamine on polystyrene-functionalized silica nanoparticles: synthesis, characterization, and biocidal activity. J Phys Chem C 114: 17298-17303. doi: 10.1021/jp104083h
    [78] Kang J, Han J, Gao Y, et al. (2015) Unexpected Enhancement in Antibacterial Activity of N-Halamine Polymers from Spheres to Fibers. ACS Appl Mater Interfaces 7: 17516-17526. doi: 10.1021/acsami.5b05429
    [79] Sun X, Zhang L, Cao Z, et al. (2010) Electrospun Composite Nanofiber Fabrics Containing Uniformly Dispersed Antimicrobial Agents As an Innovative Type of Polymeric Materials with Superior Antimicrobial Efficacy. ACS Appl Mater Interfaces 2: 952-956. doi: 10.1021/am100018k
    [80] Tan K, Obendorf SK (2007) Fabrication and evaluation of electrospun antimicrobial nylon 6 membranes. J Membrane Sci 305: 287-298. doi: 10.1016/j.memsci.2007.08.015
    [81] Dickerson MB, Sierra AA, Bedford NM, et al. (2013) Keratin-based antimicrobial textiles, films, and nanofibers. J Mater Chem B 1: 5505-5514.
    [82] Fan X, Jiang Q, Sun Z, et al. (2015) Preparation and Characterization of Electrospun Antimicrobial Fibrous Membranes Based on Polyhydroxybutyrate (PHB). Fiber Polym 16: 1751-1758. doi: 10.1007/s12221-015-5108-1
    [83] Ignatova M, Rashkov I, Manolova N (2013) Drug-loaded electrospun materials in wound-dressing applications and in local cancer treatment. Expert Opin Drug Del 10: 469-483. doi: 10.1517/17425247.2013.758103
    [84] Kim K, Luu YK, Chang C et al. (2004) Incorporation and controlled release of a hydrophilic antibiotic using poly(lactide-co-glycolide)-based electrospun nanofibrous scaffolds. J Control Release 98: 47-56. doi: 10.1016/j.jconrel.2004.04.009
    [85] Yoo HS, Kim TG, Park TG (2009) Surface-functionalized electrospun nanofibers for tissue engineering and drug delivery. Adv Drug Deliver Rev 61: 1033-1042. doi: 10.1016/j.addr.2009.07.007
    [86] Zong XH, Li S, Chen E, at al. (2004) Prevention of postsurgery-induced abdominal adhesions by electrospun bioabsorbable nanofibrous poly(lactide-co-glycolide)-based membranes. Ann Surg 240: 910-915. doi: 10.1097/01.sla.0000143302.48223.7e
    [87] Hong Y, Fujimoto K, Hashizume R, et al. (2008) Generating elastic, biodegradable polyurethane/poly(lactide-co-glycolide) fibrous sheets with controlled antibiotic release via two-stream electrospinning. Biomacromolecules 9: 1200-1207. doi: 10.1021/bm701201w
    [88] Thakur RA, Florek CA, Kohn J, et al. (2008) Electrospun nanofibrous polymeric scaffold with targeted drug release profiles for potential application as wound dressing. Int J Pharm 364: 87-93. doi: 10.1016/j.ijpharm.2008.07.033
    [89] Gilchrist SE, Lange D, Letchford DK, et al. (2013) Fusidic acid and rifampicin co-loaded PLGA nanofibers for the prevention of orthopedic implant associated infections. J Control Release 170: 64-73. doi: 10.1016/j.jconrel.2013.04.012
    [90] Qi R, Guo R, Shen M, et al. (2010) Electrospun poly(lactic-co-glycolic acid)/halloysite nanotube composite nanofibers for drug encapsulation and sustained release. J Mater Chem 20: 10622-10629. doi: 10.1039/c0jm01328e
    [91] Moghe AK, Gupta BS (2008) Co‐axial Electrospinning for Nanofiber Structures: Preparation and Applications. Polym Rev 48: 353-377. doi: 10.1080/15583720802022257
    [92] Viseras C, Cerezo P, Sanchez R, et al. (2010) Current challenges in clay minerals for drug delivery. Appl Clay Sci 48: 291-295. doi: 10.1016/j.clay.2010.01.007
    [93] McMurry LM, Oethinger M, Levy SB (1998) Triclosan targets lipid synthesis. Nature 394: 531-532. doi: 10.1038/28970
    [94] Green JBD, Fulghum T, Nordhaus MA (2011, Immobilized antimicrobial agents: a critical perspective, In: Science Against Microbial Pathogens: Communicating Current Research and Technological Advances, Formatex Microbiology Books Series, Méndez-Vila E, Ed., Badajoz (Spain).
    [95] Kaehn K (2010) Polihexanide: A Safe and Highly Effective Biocide. Skin Pharmacol Physiol 23: 7-16. doi: 10.1159/000318237
    [96] Gilbert P, Pemberton D, Wilkinson DE (1990) Synergism within polyhexamethylene biguanide biocide formulations. J Appl Bacteriol 69: 593-598. doi: 10.1111/j.1365-2672.1990.tb01553.x
    [97] del Valle LJ, Camps R, Díaz A, et al. (2011) Electrospinning of polylactide and polycaprolactone mixtures for preparation of materials with tunable drug release properties. J Polym Res 18: 1903-1917. doi: 10.1007/s10965-011-9597-3
    [98] del Valle LJ, Díaz A, Royo M, et al. (2012) Biodegradable polyesters reinforced with triclosan loaded polylactide micro/nanofibers: Properties, release and biocompatibility. Express Polym Lett 6: 266-282. doi: 10.3144/expresspolymlett.2012.30
    [99] Llorens E, Bellmunt S, del Valle LJ, et al. (2014) Scaffolds constituted by mixed polylactide and poly(ethylene glycol) electrospun microfibers. J Polym Res 21: 603. doi: 10.1007/s10965-014-0603-4
    [100] Llorens E, Ibañez H, del Valle LJ, et al. (2015) Biocompatibility and drug release behavior of scaffolds prepared by coaxial electrospinning of poly(butylene succinate) and polyethylene glycol. Mater Sci Eng C 49: 472-484. doi: 10.1016/j.msec.2015.01.039
    [101] Llorens E, del Valle LJ, Puiggalí J (2015) Electrospun scaffolds of polylactide with a different enantiomeric content and loaded with anti-inflammatory and antibacterial drugs. Macromol Res 23: 636-648. doi: 10.1007/s13233-015-3082-5
    [102] Veiga M, Merino M, Cirri M. et al. (2005) Comparative study on triclosan interactions in solution and in the solid state with natural and chemically modified cyclodextrins. J Incl Phenom Macrocycl Chem 53: 77-83. doi: 10.1007/s10847-005-1047-6
    [103] Kayaci F, Umu OCO, Tekinay T, et al. (2013) Antibacterial electrospun Poly(lactic acid) (PLA) nanofibrous webs incorporating triclosan/cyclodextrin inclusion Complexes. J Agric Food Chem 61: 3901-3908. doi: 10.1021/jf400440b
    [104] Celebioglu A, Umu OCO, Tekinay T, et al. (2014) Antibacterial electrospun nanofibers from triclosan/cyclodextrin inclusion complexes. Colloid Surface B 116: 612-619. doi: 10.1016/j.colsurfb.2013.10.029
    [105] Chen L, Bromberg L, Hatton TA (2008) Electrospun cellulose acetate fibers containing chlorhexidine as a bactericide. Polymer 49: 1266-1275. doi: 10.1016/j.polymer.2008.01.003
    [106] Ignatova M, Stoilova O, N Manolova N, et al. (2010) Electrospun mats from styrene/maleic anhydride copolymers: Modification with amines and assessment of antimicrobial activity. Macromol Biosci 10: 944-954. doi: 10.1002/mabi.200900433
    [107] Fernandes JG, Correia DM, Botelho G, et al. (2014) PHB-PEO electrospun fiber membranes containing chlorhexidine for drug delivery applications. Polym Test 34: 64-71. doi: 10.1016/j.polymertesting.2013.12.007
    [108] del Valle LJ, Roa M, Díaz A, et al. (2012) Electrospun nanofibers of a degradable poly(ester amide). Scaffolds loaded with antimicrobial agents. J Polym Res 19: 9792.
    [109] Díaz A, Katsarava R, Puiggalí J (2014) Synthesis, properties and applications of biodegradable polymers derived from diols and dicarboxylic Acids: From Polyesters to poly(ester amide)s. Int J Mol Sci 15: 7064-7123. doi: 10.3390/ijms15057064
    [110] Rodríguez-Galán A, Franco L, Puiggalí J (2011) Degradable poly(ester amide)s for biomedical applications. Polymers 3: 65-99.
    [111] Murase SK, del Valle LJ, Kobauri S, et al. (2015) Electrospun fibrous mats from a L-phenylalanine based poly(ester amide): Drug delivery and accelerated degradation by loading enzymes. Polym Degrad Stab 119: 275-287. doi: 10.1016/j.polymdegradstab.2015.05.018
    [112] Díaz A, del Valle LJ, Tugushi D, et al. (2015) New poly(ester urea) derived from L-leucine: Electrospun scaffolds loaded with antibacterial drugs and enzymes. Mater Sci Eng C 46: 450-462. doi: 10.1016/j.msec.2014.10.055
    [113] Saha K, Butola BS, Joshi M (2014) Drug-loaded polyurethane/clay nanocomposite nanofibers for topical drug-delivery application. J Appl Polym Sci 131: 40230.
    [114] Llorens E, Calderón S, del Valle LJ, et al. (2015) Polybiguanide (PHMB) loaded in PLA scaffolds displaying high hydrophobic, biocompatibility and antibacterial properties. Mater Sci Eng C 50: 74-84. doi: 10.1016/j.msec.2015.01.100
    [115] Dash M, Chiellini F, Ottenbrite RM, et al. (2007) Chitosan-a versatile semi-synthetic polymer in biomedical applications. Prog Polym Sci 36: 981-1014.
    [116] Fischer TH, Bode AP, Demcheva M, et al. (2007) Hemostatic properties of glucosamine-based materials. J Biomed Mater Res A 80: 167-174.
    [117] Muzzarelli RAA, Belcher R, Freisers H, In: Chitosan in natural chelating polymer; alginic acid, chitin and chitosan, Pergamon Press, Oxford, Pergamon Press, Oxford, 1973, 144-176.
    [118] Geng X, Kwon OH, Jang J (2005) Electrospinning of chitosan dissolved in concentrated acetic acid solution. Biomaterials 26: 5427-5432. doi: 10.1016/j.biomaterials.2005.01.066
    [119] Spasova M, Manolova N, Paneva D, et al (2004) Preparation of chitosan-containing nanofibres by electrospinning of chitosan/poly(ethylene oxide) blend solutions. e-Polymers 4: 624-635.
    [120] Bhattaraia B, Edmondson D, Veiseh O, et al. (2005) Electrospun chitosan-based nanofibers and their cellular compatibility. Biomaterials 26: 6176-6184. doi: 10.1016/j.biomaterials.2005.03.027
    [121] Ignatova M, Starbova K, Markova N, et al. (2006) Electrospun nano-fibre mats with antibacterial properties from quaternised chitosan and poly(vinyl alcohol). Carbohyd Res 341: 2098-2107. doi: 10.1016/j.carres.2006.05.006
    [122] Min BM, Lee SW, Lim JN, et al. (2004) Chitin and chitosan nanofibers: Electrospinning of chitin and deacetylation of chitin nanofibers. Polymer 45: 7137-7142. doi: 10.1016/j.polymer.2004.08.048
    [123] Ohkawa K, Cha D, Kim H, et al. (2004) Electrospinning of chitosan. Macromol Rapid Comm 25: 1600-1605. doi: 10.1002/marc.200400253
    [124] Neamnark A, Rujiravaniti R, Supaphol P (2006) Electrospinning of hexanoyl chitosan. Carbohydrate. Polymers 66: 298-305. doi: 10.1016/j.carbpol.2006.03.015
    [125] Homayoni H, Ravandi SH, Valizadeh M (2009) Electrospinning of chitosan nanofibers: Processing optimization. Carbohyd Polym 77: 656-661. doi: 10.1016/j.carbpol.2009.02.008
    [126] Zong X, Kim K, Fang D, et al. (2002) Structure and process relationship on electrospun bioabsorbable nanofiber membranes. Polymer 43: 4403-4412. doi: 10.1016/S0032-3861(02)00275-6
    [127] Au HT, Pham LN, Vu THT, et al. (2012) Fabrication of an antibacterial non-woven mat of a poly(lactic acid)/chitosan blend by electrospinning. Macromol Res 20: 51-58. doi: 10.1007/s13233-012-0010-9
    [128] Shalumon KT, Anulekha KH, Girish CM, et al. (2010) Single step electrospinning of chitosan/poly(caprolactone) nanofibers using formic acid/acetone solvent mixture. Carbohyd Polym 80: 413-417. doi: 10.1016/j.carbpol.2009.11.039
    [129] Cooper A, Oldinski R, Ma H, et al. (2013) Chitosan-based nanofibrous membranes for antibacterial filter applications. Carbohyd Polym 92: 254-259. doi: 10.1016/j.carbpol.2012.08.114
    [130] Zheng H, Du Y, Yu J, et al. (2001) Preparation and characterization of chitosan/poly(vinyl alcohol) blend fibers. J Appl Polym Sci 80: 2558-2565. doi: 10.1002/app.1365
    [131] Chuang WY, Young TH, Yao CH, et al. (1999) Properties of the poly(vinyl alcohol)/chitosan blend and its effect on the culture of fibroblast in vitro. Biomaterials 20: 1479-1487. doi: 10.1016/S0142-9612(99)00054-X
    [132] Jia YT, Gong J, Gu XH, et al. (2007) Fabrication and characterization of poly(vinyl alcohol)/chitosan blend nanofibers produced by electrospinning method. Carbohyd Polym 67: 403-409. doi: 10.1016/j.carbpol.2006.06.010
    [133] Zhang H, Li S, White CJB, et al. (2009) Studies on electrospun nylon-6/chitosan complex nanofiber interactions. Electrochim Acta 54: 5739-5745. doi: 10.1016/j.electacta.2009.05.021
    [134] Lin SJ, Hsiao WU, Jee SH, et al. (2006) Study on the effects of nylon–chitosan-blended membranes on the spheroid-forming activity of human melanocytes. Biomaterials 27: 5079-5088. doi: 10.1016/j.biomaterials.2006.05.035
    [135] Ma Z, Kotaki M, Yong T, et al. (2005) Surface engineering of electrospun polyethylene terephthalate (PET) nanofibers towards development of a new material for blood vessel engineering. Biomaterials 26: 2527-2536. doi: 10.1016/j.biomaterials.2004.07.026
    [136] Jung KH, Huh MW, Meng W, et al. (2007) Preparation and antibacterial activity of PET/chitosan nanofibrous mats using an electrospinning technique. J Appl Polym Sci 105: 2816-2823. doi: 10.1002/app.25594
    [137] An J, Zhang H, Zhang JT, et al. (2009) Preparation and antibacterial activity of electrospun chitosan/poly(ethylene oxide) membranes containing silver nanoparticles. Colloid Polym Sci 287: 1425-1434. doi: 10.1007/s00396-009-2108-y
    [138] Zhuang XP, Cheng BW, Kang WM, et al. (2010) Electrospun chitosan/gelatin nanofibers containing silver nanoparticles. Carbohyd Polym 82: 524-527. doi: 10.1016/j.carbpol.2010.04.085
    [139] Cai ZX, Mo XM, Zhang KH, et al. (2010) Fabrication of chitosan/silk fibroin composite nanofibers for wound dressing applications. Int J Mol Sci 11: 3529-3539. doi: 10.3390/ijms11093529
    [140] Alipour SM, Nouri M, Mokhtari J, et al. (2009) Electrospinning of poly(vinyl alcohol)–water-soluble quaternized chitosan derivative blend. Carbohyd Res 344: 2496-2501. doi: 10.1016/j.carres.2009.10.004
    [141] Fu GD, Yao F, Li Z, et al. (2008) Solvent-resistant antibacterial microfibers of self-quaternized block copolymers from atom transfer radical polymerization and electrospinning. J Mater Chem 18: 859-867. doi: 10.1039/b716127a
    [142] Parfitt T (2005) Georgia: an unlikely stronghold for bacteriophage therapy. The Lancet 365: 2166-2167. doi: 10.1016/S0140-6736(05)66759-1
    [143] Sulakvelidze A, Kutter E (2005) Bacteriophage therapy in humans, In: Bacteriophages: Biology and Applications, Kutter E, Sulakvelidze A, Eds., CRC Press, Boca Raton, FL, 381-436.
    [144] Kutter E, De Vos D, Gvasalia G, et al. (2010) Phage therapy in clinical practice: treatment of human infections. Curr Pharm Biotechnol 11: 69-86. doi: 10.2174/138920110790725401
    [145] Abedon S, Kuhl S, Blasdel B, et al. (2011) Phage treatment of human infections. Bacteriophage 1: 66-85. doi: 10.4161/bact.1.2.15845
    [146] FDA (2006) FDA approval of Listeria-specific bacteriophage preparation on ready-to-eat (RTE) meat and poultry products. FDA, Washington, DC.
    [147] Frykberg RG, Armstrong DG, Giurini J, et al. (2000) Diabetic foot disorders: a clinical practice guideline. J Foot Ankle Surg 39: S1-S60. doi: 10.1016/S1067-2516(00)80057-5
    [148] Anany H, Chen W, Pelton R (2011) Biocontrol of Listeria monocytogenes and Escherichia coli O157:H7 in Meat by Using Phages Immobilized on Modified Cellulose Membranes. Appl Environ Microb 77: 6379-6387. doi: 10.1128/AEM.05493-11
    [149] Markoishvili K, Tsitlanadze G, Katsarava R, et al. (2002) A novel sustained-release matrix based on biodegradable poly(ester amide)s and impregnated with bacteriophages and an antibiotic shows promise in management of infected venous stasis ulcers and other poorly healing wounds. Int J Dermatol 41: 453-458. doi: 10.1046/j.1365-4362.2002.01451.x
    [150] Katsarava R, Alavidze Z (2004) Polymer Blends as Biodegradable Matrices for Preparing Biocomposites, US Patent 6,703,040 (Assigned to Intralytix, Inc.).
    [151] Katsarava R, Gomurashvili Z (2011) Biodegradable Polymers Composed of Naturally Occurring α-Amino Acids, In: Handbook of Biodegradable Polymers—Isolation, Synthesis, Characterization and Applications. Lendlein A, Sisson A, Eds., Wiley-VCH, Verlag GmbH & Co KGaA, Ch. 5.
    [152] Jikia D, Chkhaidze N, Imedashvili E, et al. (2005) The use of a novel biodegradable preparation capable of the sustained release of bacteriophages and ciprofloxacin, in the complex treatment of multidrug - resistant Staphylococcus aureus-infected local radiation injuries caused by exposure to Sr90. Clin Exp Dermatol 30: 23-26. doi: 10.1111/j.1365-2230.2004.01600.x
    [153] Puapermpoonsiri U, Spencer J, van der Walle CF (2009) A freeze-dried formulation of bacteriophage encapsulated in biodegradable microspheres. Eur J Pharm Biopharm 72: 26-33. doi: 10.1016/j.ejpb.2008.12.001
    [154] Gervais L, Gel M, Allain B, et al. (2007) Immobilization of biotinylated bacteriophages on biosensor surfaces. Sensor Actuat B-Chem 125: 615-621. doi: 10.1016/j.snb.2007.03.007
    [155] Nanduri V, Balasubramanian S, Sista S, et al. (2007) Highly sensitive phage-based biosensor for the detection of β-galactosidase. Anal Chim Acta 589: 166-172. doi: 10.1016/j.aca.2007.02.071
    [156] Tawil N, Sacher E, Rioux D, et al. (2015) Surface Chemistry of Bacteriophage and Laser Ablated Nanoparticle Complexes for Pathogen Detection. J Phys Chem C 119: 14375-14382.
    [157] Sun W, Brovko L, Griffiths M (2001) Food-borne pathogens. Use of bioluminescent salmonella for assessing the efficiency of Constructed phage-based biosorbent. J Ind Microbiol Biot 27: 126-128.
    [158] Cademartiri R, Anany H, Gross I, et al. (2010). Immobilization of bacteriophages on modified silica particles. Biomaterials 31: 1904-1910. doi: 10.1016/j.biomaterials.2009.11.029
    [159] Bennett AR, Davids FGC, Vlahodimou S, et al. (1997) The use of bacteriophage-based systems for the separation and concentration of Salmonella. J Appl Microbiol 83: 259-265. doi: 10.1046/j.1365-2672.1997.00257.x
    [160] Pearson HA, Sahukhal GS, Elasri MO, et al. (2013) Phage-Bacterium War on Polymeric Surfaces: Can Surface-Anchored Bacteriophages Eliminate Microbial Infections? Biomacromolecules 14: 1257-1261. doi: 10.1021/bm400290u
    [161] Dai M, Senecal A, Nugen SR (2014) Electrospun water-soluble polymer nanofibers for the dehydration and storage of sensitive reagents. Nanotechnology 25: 225101. doi: 10.1088/0957-4484/25/22/225101
    [162] Korehei R, Kadla J (2011) Incorporating pre-encapsulated bacteriophage in electrospun fibres, 16th International Symposium on Wood, Fiber and Pulping Chemistry, Tianjin, People’s Republic of China. Proceedings ISWFPC 2: 1302-1306.
    [163] Lee SW, Belcher AM (2004) Virus-based fabrication of micro- and nanofibers using electrospinning. J Nano Lett 4: 387-390. doi: 10.1021/nl034911t
    [164] Salalha W, Kuhn J, Dror Y, et al. (2006) Encapsulation of bacteria and viruses in electrospun nanofibers. Nanotechnology 17: 4675-4681. doi: 10.1088/0957-4484/17/18/025
    [165] Korehei R, Kadla J (2013) Incorporation of T4 bacteriophage in electrospun fibres. J Appl Microbiol 114: 1425-1434. doi: 10.1111/jam.12158
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