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Deep convolutional neural network (CNN) model optimization techniques—Review for medical imaging

  • Received: 22 February 2024 Revised: 02 May 2024 Accepted: 20 May 2024 Published: 25 June 2024
  • MSC : 62M45, 68T45

  • The field of artificial intelligence (AI) and machine learning (ML) has been expanding and is explored by researchers in various fields. In medical diagnosis, for instance, the field of AI/ML is being explored because if medical diagnostic devices are built and designed with a backend of AI/ML, then the benefits would be unprecedented. Automated diagnostic tools would result in reduced health care costs, diagnosis without human intervention, overcoming human errors, and providing adequate and affordable medical care to a wider portion of the population with portions of the actual cost. One domain where AI/ML can make an immediate impact is medical imaging diagnosis (MID), namely the classification of medical images, where researchers have applied optimization techniques aiming to improve image classification accuracy. In this paper, we provide the research community with a comprehensive review of the most relevant studies to date on the use of deep CNN architecture optimization techniques for MID. As a case study, the application of these techniques to COVID-19 medical images were made. The impacts of the related variables, including datasets and AI/ML techniques, were investigated in detail. Additionally, the significant shortcomings and challenges of the techniques were touched upon. We concluded our work by affirming that the application of AI/ML techniques for MID will continue for many years to come, and the performance of the AI/ML classification techniques will continue to increase.

    Citation: Ghazanfar Latif, Jaafar Alghazo, Majid Ali Khan, Ghassen Ben Brahim, Khaled Fawagreh, Nazeeruddin Mohammad. Deep convolutional neural network (CNN) model optimization techniques—Review for medical imaging[J]. AIMS Mathematics, 2024, 9(8): 20539-20571. doi: 10.3934/math.2024998

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  • The field of artificial intelligence (AI) and machine learning (ML) has been expanding and is explored by researchers in various fields. In medical diagnosis, for instance, the field of AI/ML is being explored because if medical diagnostic devices are built and designed with a backend of AI/ML, then the benefits would be unprecedented. Automated diagnostic tools would result in reduced health care costs, diagnosis without human intervention, overcoming human errors, and providing adequate and affordable medical care to a wider portion of the population with portions of the actual cost. One domain where AI/ML can make an immediate impact is medical imaging diagnosis (MID), namely the classification of medical images, where researchers have applied optimization techniques aiming to improve image classification accuracy. In this paper, we provide the research community with a comprehensive review of the most relevant studies to date on the use of deep CNN architecture optimization techniques for MID. As a case study, the application of these techniques to COVID-19 medical images were made. The impacts of the related variables, including datasets and AI/ML techniques, were investigated in detail. Additionally, the significant shortcomings and challenges of the techniques were touched upon. We concluded our work by affirming that the application of AI/ML techniques for MID will continue for many years to come, and the performance of the AI/ML classification techniques will continue to increase.


    The field of interval analysis is a subfield of set-valued analysis, which focuses on sets in mathematics and topology. Historically, Archimede's method included calculating the circumference of a circle, which is an example of interval enclosure. By focusing on interval variables instead of point variables, and expressing computation results as intervals, this method eliminates errors that cause misleading conclusions. An initial objective of the interval-valued analysis was to estimate error estimates for numerical solutions to finite state machines. In 1966, Moore [2], published the first book on interval analysis, which is credited with being the first to use intervals in computer mathematics in order to improve calculation results. There are many situations where the interval analysis can be used to solve uncertain problems because it can be expressed in terms of uncertain variables. In spite of this, interval analysis remains one of the best approaches to solving interval uncertain structural systems and has been used for over fifty years in mathematical modeling such as computer graphics [3], decision-making analysis [4], multi-objective optimization, [5], error analysis [40]. In summary, interval analysis research has yielded numerous excellent results, and readers can consult Refs. [7,8,9], for additional information.

    Convexity has been recognized for many years as a significant factor in such fields as probability theory, economics, optimal control theory, and fuzzy analysis. On the other hand, generalized convexity of mappings is a powerful tool for solving numerous nonlinear analysis and applied analysis problems, including a wide range of mathematical physics problems. A number of rigorous generalizations of convex functions have recently been investigated, see Refs. [10,11,12,13]. An interesting topic in mathematical analysis is integral inequalities. Convexity plays a significant role in inequality theory. During the last few decades, generalized convexity has played a prominent role in many disciplines and applications of IVFS, see Refs. [14,15,16,17,18,19]. Several recent applications have addressed these inequalities, see Refs. [20,21,22]. First, Breckner describes the idea of continuity for IVFS, see Ref. [23]. Using the generalized Hukuhara derivative, Chalco-Cano et al. [24], and Costa et al. [25], derived some Ostrowski and Opial type inequality for IVFS, respectively. Bai et al. [26], formulated an interval-based Jensen inequality. First, Zhao [27], and co-authors established (H.H) and Jensen inequality using h-convexity for IVFS. In general, the traditional (H.H) inequality has the following definition:

    Θ(g)+Θ(h)21hghgΘ(γ)dγΘ(g+h2). (1.1)

    Because of the nature of its definition, it is the first geometrical interpretation of convex mappings in elementary mathematics, and has attracted a large amount of attention. Several generalizations of this inequality are presented here, see Refs. [28,29,30,31]. Initially, Awan et al. explored (h1,h2)-convex functions and proved the following inequality [32]. Several authors have developed H.H and Jensen-type inequalities utilizing (h1,h2)-convexity. Ruonan Liu [33] developed H.H inequalities for harmonically (h1,h2)-convex functions. Wengui Yang [34] developed H.H inequalities on the coordinates for (p1,h1)-(p2,h2)-convex functions. Shi et al. [35] developed H.H inequalities for (m,h1,h2)-convex functions via Riemann Liouville fractional integrals. Sahoo et al. [36] established H.H and Jensen-type inequalities for harmonically (h1,h2)-Godunova-Levin functions. Afzal et al. [37] developed these inequalities for a generalized class of Godunova-Levin functions using inclusion relation. An et al. [38] developed H.H type inequalities for interval-valued (h1,h2)-convex functions. Results are now influenced by less accurate inclusion relation and interval LU-order relation. For some recent developments using the inclusion relation for the generalized class of Godunova-Levin functions, see Refs. [39,40,44]. It is clear from comparing the examples presented in this literature that the inequalities obtained using these old partial order relations are not as precise as those obtained by using CR-order relation. As a result, it is critically important that we are able to study inequalities and convexity by using a total order relation. Therefore, we use Bhunia's [41], CR-order, which is total interval order relation. The notions of CR-convexity and CR-order relation were used by several authors in 2022, in an attempt to prove a number of recent developments in these inequalities, see Refs. [42,43]. Afzal et al. using the notion of the h-GL function, proves the following result [45].

    Theorem 1.1. (See [45]) Consider Θ:[g,h]RI+. Define h:(0,1)R+ and h(12)0. If ΘSX(CR-h,[g,h],RI+) and Θ IR[g,h], then

    h(12)2Θ(g+h2)CR1hghgΘ(γ)dγCR[Θ(g)+Θ(h)]10dxh(x). (1.2)

    Also, by using the notion of the h-GL function Jensen-type inequality was also developed.

    Theorem 1.2. (See [45]) Let uiR+, ji[g,h]. If h is non-negative super multiplicative function and ΘSX(CR-h,[g,h],RI+), then this holds :

    Θ(1Ukki=1uiji)CRki=1Θ(ji)h(uiUk). (1.3)

    In addition, it introduces a new concept of interval-valued GL-functions pertaining to a total order relation, the Center-Radius order, which is unique as far as the literature goes. With the example presented in this article, we are able to show how CR-IVFS can be used to analyze various integral inequalities. In contrast to classical interval-valued analysis, CR-order interval-valued analysis differs from it. Using the concept of Centre and Radius, we calculate intervals as follows: MC=M_+¯M2 and MR=¯MM_2, respectively, where M=[M_,ˉM]. Inspired by the concepts of interval valued analysis and the strong literature that has been discussed above with particular articles, see e.g., Zhang et al. [39], Bhunia and Samanta [41], Shi et al. [42], Liu et al. [43] and Afzal et al. [44,45], we introduced the idea of CR-(h1,h2)-GL function. By using this new concept we developed H.H and Jensen-type inequalities. The study also includes useful examples to back up its findings.

    Finally, the article is designed as follows: In Section 2, preliminary is provided. The main problems and applications are provided in Section 3 and 4. Finally, Section 5 provides the conclusion.

    As for the notions used in this paper but not defined, see Refs. [42,43,45]. It is a good idea to familiarize yourself with some basic arithmetic related to interval analysis in this section since it will prove very helpful throughout the paper.

    [M]=[M_,¯M](xR, M_x¯M;xR)
    [N]=[N_,¯N](xR, N_x¯N;xR)
    [M]+[N]=[M_,¯M]+[N_,¯N]=[M_+N_,¯M+¯N]
    ηM=η[M_,¯M]={[ηM_,η¯M](η>0){0}(η=0)[η¯M,ηM_](η<0),

    where ηR.

    Let RI and R+I be the set of all closed and all positive compact intervals of R, respectively. Several algebraic properties of interval arithmetic will now be discussed.

    Consider M=[M_,ˉM]RI, then Mc=¯M+M_2 and Mr=¯MM_2 are the center and radius of interval M respectively. The CR form of interval M can be defined as:

    M=Mc,Mr=¯M+M_2,¯MM_2.

    Following are the order relations for the center and radius of intervals:

    Definition 2.1. The CR-order relation for M=[M_,¯M]=Mc,Mr, N=[N_,¯N]=Nc,NrRI represented as:

    McrN{Mc<Nc,ifMcNc;MrNr,ifMc=Nc.

    Note: For arbitrary two intervals M,NRI, we have either McrN or NcrM.

    Riemann integral operators for IVFS are presented here.

    Definition 2.2 (See [45]) Let D:[g,h] be an IVF such that D=[D_,¯D]. Then D is Riemann integrable (IR) on [g,h] if D_ and ¯D are IR on [g,h], that is,

    (IR)hgD(s)ds=[(R)hgD_(s)ds,(R)hg¯D(s)ds].

    The collection of all (IR) IVFS on [g,h] is represented by IR([g,h]).

    Shi et al. [42] proved that the based on CR-order relations, the integral preserves order.

    Theorem 2.1. Let D,F:[g,h] be IVFS given by D=[D_,¯D] and F=[F_,¯F]. If D(s)CRF(s), i[g,h], then

    hgD(s)dsCRhgF(s)ds.

    We'll now provide an illustration to support the aforementioned Theorem.

    Example 2.1. Let D=[s,2s] and F=[s2,s2+2], then for s[0,1].

    DC=3s2,DR=s2,FC=s2+1 and FR=1.

    From Definition 2.1, we have D(s)CRF(s), s[0,1].

    Since,

    10[s,2s]ds=[12,1]

    and

    10[s2,s2+2]ds=[13,73].

    Also, from above Theorem 2.1, we have

    10D(s)dsCR10F(s)ds.
    Figure 1.  A clear indication of the validity of the CR-order relationship can be seen in the graph.
    Figure 2.  As can be seen from the graph, the Theorem 2.1 is valid.

    Definition 2.3. (See [42]) Define h1,h2:[0,1]R+. We say that Θ:[g,h]R+ is called (h1,h2)-convex function, or that ΘSX((h1,h2),[g,h],R+), if g1,h1[g,h] and γ[0,1], we have

    Θ(γg1+(1γ)h1) h1(γ)h2(1γ)Θ(g1)+h1(1γ)h2(γ)Θ(h1). (2.1)

    If in (2.1) "" replaced with "" it is called (h1,h2)-concave function or ΘSV((h1,h2),[g,h],R+).

    Definition 2.4. (See [42]) Define h1,h2:(0,1)R+. We say that Θ:[g,h]R+ is called (h1,h2)-GL convex function, or that ΘSGX((h1,h2),[g,h],R+), if g1,h1[g,h] and γ[0,1], we have

    Θ(γg1+(1γ)h1)Θ(g1)h1(γ)h2(1γ)+Θ(h1)h1(1γ)h2(γ). (2.2)

    If in (2.2) "" replaced with "" it is called (h1,h2)-GL concave function or ΘSGV((h1,h2),[g,h],R+).

    Now let's introduce the concept for CR-order form of convexity.

    Definition 2.5. (See [42]) Define h1,h2:[0,1]R+. We say that Θ:[g,h]R+ is called CR(h1,h2)-convex function, or that ΘSX(CR-(h1,h2),[g,h],R+), if g1,h1[g,h] and γ[0,1], we have

    Θ(γg1+(1γ)h1)CR h1(γ)h2(1γ)Θ(g1)+h1(1γ)h2(γ)Θ(h1). (2.3)

    If in (2.3) "CR" replaced with "CR" it is called CR-(h1,h2)-concave function or ΘSV(CR-(h1,h2),[g,h],R+).

    Definition 2.6. (See [42]) Define h1,h2:(0,1)R+. We say that Θ:[g,h]R+ is called CR-(h1,h2)-GL convex function, or that ΘSGX(CR-(h1,h2),[g,h],R+), if g1,h1[g,h] and γ[0,1], we have

    Θ(γg1+(1γ)h1)CRΘ(g1)h1(γ)h2(1γ)+Θ(h1)h1(1γ)h2(γ). (2.4)

    If in (2.4) "CR" replaced with "CR" it is called CR-(h1,h2)-GL concave function or ΘSGV(CR-(h1,h2),[g,h],R+).

    Remark 2.1.If h1=h2=1, Definition 2.6 becomes a CR-P-function [45].

    If h1(γ)=1h1(γ), h2=1 Definition 2.6 becomes a CR-h-convex function [45].

    If h1(γ)=h1(γ), h2=1 Definition 2.6 becomes a CR-h-GL function [45].

    If h1(γ)=1γs, h2=1 Definition 2.6 becomes a CR-s-convex function [45].

    If h(γ)=γs, Definition 2.6 becomes a CR-s-GL function [45].

    Proposition 3.1. Consider Θ:[g,h]RI given by [Θ_,¯Θ]=(ΘC,ΘR). If ΘC and ΘR are (h1,h2)-GL over [g,h], then Θ is called CR-(h1,h2)-GL function over [g,h].

    Proof. Since ΘC and ΘR are (h1,h2)-GL over [g,h], then for each γ(0,1) and for all g1,h1[g,h], we have

    ΘC(γg1+(1γ)h1)CRΘC(g1)h1(γ)h2(1γ)+ΘC(h1)h1(1γ)h2(γ),

    and

    ΘR(γg1+(1γ)h1)CRΘR(g1)h1(γ)h2(1γ)+ΘR(h1)h1(1γ)h2(γ).

    Now, if

    ΘC(γg1+(1γ)h1)ΘC(g1)h1(γ)h2(1γ)+ΘC(h1)h1(1γ)h2(γ),

    then for each γ(0,1) and for all g1,h1[g,h],

    ΘC(γg1+(1γ)h1)<ΘC(g1)h1(γ)h2(1γ)+ΘC(h1)h1(1γ)h2(γ).

    Accordingly,

    ΘC(γg1+(1γ)h1)CRΘC(g1)h1(γ)h2(1γ)+ΘC(h1)h1(1γ)h2(γ).

    Otherwise, for each γ(0,1) and for all g1,h1[g,h],

    ΘR(νg1+(1γ)h1)ΘR(g1)h1(γ)h2(1γ)+ΘR(h1)h1(1γ)h2(γ)
    Θ(γg1+(1γ)h1)CRΘ(g1)h1(γ)h2(1γ)+Θ(h1)h1(1γ)h2(γ).

    Taking all of the above into account, and Definition 2.6 this can be written as

    Θ(γg1+(1γ)h1)CRΘ(g1)h1(γ)h2(1γ)+Θ(h1)h1(1γ)h2(γ)

    for each γ(0,1) and for all g1,h1[g,h].

    This completes the proof.

    The next step is to establish the H.H inequality for the CR-(h1,h2)-GL function.

    Theorem 3.1. Define h1,h2:(0,1)R+ and h1(12)h2(12)0. Let Θ:[g,h]RI+, if ΘSGX(CR-(h1,h2),[t,u],RI+) and Θ IR[t,u], we have

    [H(12,12)]2Θ(g+h2)CR1hghgΘ(γ)dγCR[Θ(g)+Θ(h)]10dxH(x,1x).

    Proof. Since ΘSGX(CR-(h1.h2),[g,h],RI+), we have

    [H(12,12)]Θ(g+h2)CRΘ(xg+(1x)h)+Θ((1x)g+xh).

    Integration over (0, 1), we have

    [H(12,12)]Θ(g+h2)CR[10Θ(xg+(1x)h)dx+10Θ((1x)g+xh)dx]=[10Θ_(xg+(1x)h)dx+10Θ_((1x)g+xh)dx,10¯Θ(xg+(1x)h)dx+10¯Θ((1x)g+xh)dx]=[2hghgΘ_(γ)dγ,2hghg¯Θ(γ)dγ]=2hghgΘ(γ)dγ. (3.1)

    By Definition 2.6, we have

    Θ(xg+(1x)h)CRΘ(g)h1(x)h2(1x)+Θ(h)h1(1x)h2(x).

    Integration over (0, 1), we have

    10Θ(xg+(1x)h)dxCRΘ(g)10dxh1(x)h2(1x)+Θ(h)10dxh1(1x)h2(x).

    Accordingly,

    1hghgΘ(γ)dγCR[Θ(g)+Θ(h)]10dxH(x,1x). (3.2)

    Now combining (3.1) and (3.2), we get required result

    [H(12,12)]2Θ(t+u2)CR1hghgΘ(γ)dγCR[Θ(g)+Θ(h)]10dxH(x,1x).

    Remark 3.1.If h1(x)=h2(x)=1, Theorem 3.1 becomes result for CR- P-function:

    12Θ(g+h2)CR1hghgΘ(γ)dγCR [Θ(g)+Θ(h)].

    If h1(x)=h(x), h2(x)=1 Theorem 3.1 becomes result for CR-h-GL-function:

    h(12)2Θ(g+h2)CR1hghgΘ(γ)dγCR 10dxh(x).

    If h1(x)=1h(x), h2(x)=1 Theorem 3.1 becomes result for CR-h-convex function:

    12h(12)Θ(g+h2)CR1hghgΘ(γ)dγCR 10h(x)dx.

    If h1(x)=1h1(x), h2(x)=1h2(x) Theorem 3.1 becomes result for CR-(h1,h2)-convex function:

    12[H(12,12)]Θ(g+h2)CR1hghgΘ(γ)dγCR 10dxH(x,1x).

    Example 3.1. Consider [t,u]=[0,1], h1(x)=1x, h2(x)=1, x (0,1). Θ:[g,h]RI+ is defined as

    Θ(γ)=[γ2,2γ2+1].

    where

    [H(12,12)]2Θ(g+h2)=Θ(12)=[14,32],
    1hghgΘ(γ)dγ=[10(γ2)dγ,10(2γ2+1)dγ]=[13,53],
    [Θ(g)+Θ(h)]10dxH(x,1x)=[12,2].

    As a result,

    [14,32]CR[13,53]CR[12,2].

    This proves the above theorem.

    Theorem 3.2. Define h1,h2:(0,1)R+ and h1(12)h2(12)0. Let Θ:[g,h]RI+, if ΘSGX(CR-(h1,h2),[t,u],RI+) and Θ IR[g,h], we have

    [H(12,12)]24Θ(g+h2)CR1CR1hghgΘ(γ)dγCR2
    CR{[Θ(g)+Θ(h)][12+1H(12,12)]}10dxH(x,1x),

    where

    1=H(12,12)4[Θ(3g+h4)+Θ(3h+g4)],
    2=[Θ(g+h2)+Θ(g)+Θ(h)2]10dxH(x,1x).

    Proof. Take [g,g+h2], we have

    Θ(g+g+h22)=Θ(3g+h2)CRΘ(xg+(1x)g+h2)H(12,12)+Θ((1x)g+xg+h2)H(12,12).

    Integration over (0, 1), we have

    Θ(3g+h2)CR1H(12,12)[10Θ(xg+(1x)g+h2)dx+10Θ(xg+h2+(1x)h)dx]
    =1H(12,12)[2hgg+h2gη(γ)dγ+2hgg+h2gΘ(γ)dγ]
    =4H(12,12)[1hgg+h2gΘ(γ)dγ].

    Accordingly,

    H(12,12)4Θ(3g+h2)CR1hgg+h2gΘ(γ)dγ. (3.3)

    Similarly for interval [g+h2,h], we have

    H(12,12)4Θ(3h+g2)CR1hgg+h2gΘ(γ)dγ. (3.4)

    Adding inequalities (3.3) and (3.4), we get

    1=H(12,12)4[Θ(3g+h4)+Θ(3h+g4)]CR[1hghgΘ(γ)dγ].

    Now

    [H(12,12)]24Θ(g+h2)
    =[H(12,12)]24Θ(12(3g+h4)+12(3h+g4))
    CR[H(12,12)]24[Θ(3g+h4)h(12)+Θ(3h+g4)h(12)]
    =H(12,12)4[Θ(3g+h4)+Θ(3h+g4)]
    =1
    CRH(12,12)4{1H(12,12)[Θ(g)+Θ(g+h2)]+1H(12,12)[Θ(h)+Θ(g+h2)]}
    =12[Θ(g)+Θ(h)2+Θ(g+h2)]
    CR[Θ(g)+Θ(h)2+Θ(g+h2)]10dxH(x,1x)
    =2
    CR[Θ(g)+Θ(h)2+Θ(g)H(12,12)+Θ(h)H(12,12)]10dxH(x,1x)
    CR[Θ(g)+Θ(h)2+1H(12,12)[Θ(g)+Θ(h)]]10dxH(x,1x)
    CR{[Θ(g)+Θ(h)][12+1H(12,12)]}10dxH(x,1x).

    Example 3.2. Thanks to Example 3.1, we have

    [H(12,12)]24Θ(g+h2)=Θ(12)=[14,32],
    1=12[Θ(14)+Θ(34)]=[516,138],
    2=[Θ(0)+Θ(1)2+Θ(12)]10dxH(x,1x),
    2=12([14,32]+[12,2]),
    2=[38,74],
    {[Θ(g)+Θ(h)][12+1H(12,12)]}10dxH(x,1x)=[12,2].

    Thus we obtain

    [14,32]CR[516,138]CR[13,53]CR[38,74]cr[12,2].

    This proves the above theorem.

    Theorem 3.3. Let Θ,θ:[g,h]RI+,h1,h2:(0,1)R+ such that h1,h20. If ΘSGX(CR-h1,[g,h],RI+), θSGX(CR-h2,[g,h],RI+) and Θ,θ IR[g,h] then, we have

    1hghgΘ(γ)θ(γ)dγCRM(g,h)10dxH2(x,1x)+N(g,h)10dxH(x,x)H(1x,1x),

    where

    M(g,h)=Θ(g)θ(g)+Θ(h)θ(h),N(g,h)=Θ(g)θ(h)+Θ(h)θ(g).

    Proof. Conider ΘSGX(CR-h1,[g,h],RI+), θSGX(CR-h2,[g,h],RI+) then, we have

    Θ(gx+(1x)h)CRΘ(g)h1(x)h2(1x)+Θ(h)h1(1x)h2(x),
    θ(gx+(1x)h)CRθ(g)h1(x)h2(1x)+θ(h)h1(1x)h2(x).

    Then,

    Θ(gx+(1x)h)θ(tx+(1x)u)
    CRΘ(g)θ(g)H2(x,1x)+Θ(g)θ(h)+Θ(g)θ(g)H2(1x,x)+Θ(h)θ(h)H(x,x)H(1x,1x).

    Integration over (0, 1), we have

    10Θ(gx+(1x)h)θ(gx+(1x)h)dx
    =[10Θ_(gx+(1x)h)θ_(gx+(1x)h)dx,10¯Θ(gx+(1x)h)¯θ(gx+(1x)h)dx]
    =[1hghgΘ_(γ)θ_(γ)dγ,1hghg¯Θ(γ)¯θ(γdγ]=1hghgΘ(γ)θ(γ)dγ
    CR10[Θ(g)θ(g)+Θ(h)θ(h)]H2(x,1x)dx+10[Θ(g)θ(h)+Θ(h)θ(g)]H(x,x)H(1x,1x)dx.

    It follows that

    1hghgΘ(γ)θ(γ)dγCRM(g,h)10dxH2(x,1x)+N(g,h)10dxH(x,x)H(1x,1x).

    Theorem is proved.

    Example 3.3. Consider [g,h]=[1,2], h1(x)=1x, h2(x)=1 x (0,1). Θ,θ:[g,h]RI+ be defined as

    Θ(γ)=[γ2,2γ2+1],θ(γ)=[γ,γ].

    Then,

    1hghgΘ(γ)θ(γ)dγ=[154,9],
    M(g,h)101H2(x,1x)dx=M(1,2)10x2dx=[7,7],
    N(g,h)101H(x,x)H(1x,1x)dx=N(1,2)10x(1x)dx=[156,156].

    It follows that

    [154,9]CR[7,7]+[156,156]=[192,192].

    It follows that the theorem above is true.

    Theorem 3.4. Let Θ,θ:[g,h]RI+,h1,h2:(0,1)R+ such that h1,h20. If ΘSGX(CR-h1,[g,h],RI+), θSGX(CR-h2,[g,h],RI+) and Θ,θ IR[g,h] then, we have

    [H(12,12)]22Θ(g+h2)θ(g+h2)CR1hghgΘ(γ)θ(γ)dγ+M(g,h)10dxH(x,x)H(1x,1x)+N(g,h)10dxH2(x,1x).

    Proof. Since ΘSGX(CR-h1,[g,h],RI+), θSGX(CR-h2,[g,h],RI+), we have

    Θ(g+h2)CRΘ(gx+(1x)h)H(12,12)+Θ(g(1x)+xh)H(12,12),
    θ(g+h2)CRθ(gx+(1x)h)H(12,12)+θ(g(1x)+xh)H(12,12).

    Then,

    Θ(g+h2)θ(g+h2)CR1[H(12,12)]2[Θ(gx+(1x)h)θ(gx+(1x)h)+Θ(g(1x)+xh)θ(g(1x)+xh)]+1[H(12,12)]2[Θ(gx+(1x)h)θ(g(1x)+xh)+Θ(g(1x)+xh)θ(gx+(1x)h)]+CR1[H(12,12)]2[Θ(gx+(1x)h)θ(gx+(1x)h)+Θ(g(1x)+(xh)θ(g(1x)+xh)]+1[H(12,12)]2[(Θ(g)H(x,1x)+θ(h)H(1x,x))(θ(h)H(1x,x)+θ(h)H(x,1x))]+[(Θ(g)H(1x,x)+Θ(h)H(x,1x))(θ(g)H(x,1x)+θ(h)H(1x,x))]CR1[H(12,12)]2[Θ(gx+(1x)h)θ(gx+(1x)h)+Θ(g(1x)+xh)θ(g(1x)+xh)]+1[H(12,12)]2[(2H(x,x)H(1x,1x))M(g,h)+(1H2(x,1x)+1H2(1x,x))N(g,h)].

    Integration over (0,1), we have

    10Θ(g+h2)θ(g+h2)dx=[10Θ_(g+h2)θ_(g+h2)dx,10¯Θ(g+h2)¯θ(g+h2)dx]=Θ(g+h2)θ(g+h2)dxCR2[H(12,12)]2[1hghgΘ(γ)θ(γ)dγ]+2[H(12,12)]2[M(g,h)101H(x,x)H(1x,1x)dx+N(g,h)101H2(x,1x)dx].

    Multiply both sides by [H(12,12)]22 above equation, we get the required result

    [H(12,12)]22Θ(g+h2)θ(g+h2)CR1hghgΘ(γ)θ(γ)dγ+M(g,h)10dxH(x,x)H(1x,1x)+N(g,h)10dxH2(x,1x).

    As a result, the proof is complete.

    Example 3.4. Consider [g,h]=[1,2], h1(x)=1x, h2(x)=14, x (0,1). Θ,θ:[g,h]RI+ be defined as

    Θ(γ)=[γ2,2γ2+1],θ(γ)=[γ,γ].

    Then,

    [H(12,12)]22Θ(g+h2)θ(g+h2)=18Θ(32)θ(32)=[3332,3332],
    1hghgΘ(γ)θ(γ)dγ=[154,9],
    M(g,h)10dxH(x,x)H(1x,1x)=(16)M(1,2)10x(1x)dx=[56,56],
    N(g,h)10dxH2(x,1x)=(16)N(1,2)10x2dx=[80,80].

    It follows that

    [3332,3332]CR[154,9]+[56,56]+[80,80]=[5294,145].

    This proves the above theorem. Next, we will develop the Jensen-type inequality for CR-(h1,h2)-GL functions.

    Theorem 4.1. Let uiR+, ji[g,h]. If h1,h2 is super multiplicative non-negative functions and if ΘSGX(CR-(h1,h2),[g,h],RI+). Then the inequality become as :

    Θ(1Ukki=1uiji)CRki=1[Θ(ji)H(uiUk,Uk1Ek)], (4.1)

    where Uk=ki=1ui

    Proof. When k=2, then (4.1) holds. Suppose that (4.1) is also valid for k1, then

    Θ(1Ukki=1uiji)=Θ(ukUkvk+k1i=1uiUkji)
    CRΘ(jk)h1(ukUk)h2(Uk1Uk)+Θ(k1i=1uiUkji)h1(Uk1Uk)h2(ukUk)
    CRΘ(jk)h1(ukUk)h2(Uk1Uk)+k1i=1[Θ(ji)H(uiUk,Uk2Uk1)]1h1(Uk1Uk)h2(ukUk)
    CRΘ(jk)h1(ukUk)h2(Uk1Uk)+k1i=1[Θ(ji)H(uiUk,Uk2Uk1)]
    CRki=1[Θ(ji)H(uiUk,Uk1Uk)].

    It follows from mathematical induction that the conclusion is correct.

    Remark 4.1.If h1(x)=h2(x)=1, Theorem 4.1 becomes result for CR- P-function:

    Θ(1Ukki=1uiji)CRki=1Θ(ji).

    If h1(x)=1h1(x), h2(x)=1h2(x) Theorem 4.1 becomes result for CR-(h1,h2)-convex function:

    Θ(1Ukki=1uiji)CRki=1H(uiUk,Uk1Uk)Θ(ji).

    If h1(x)=1x, h2(x)=1 Theorem 4.1 becomes result for CR-convex function:

    Θ(1Ukki=1uiji)CRki=1uiUkΘ(ji).

    If h1(x)=1h(x), h2(x)=1 Theorem 4.1 becomes result for CR-h-convex function:

    Θ(1Ukki=1uiji)CRki=1h(uiUk)Θ(ji).

    If h1(x)=h(x), h2(x)=1 Theorem 4.1 becomes result for CR-h-GL-function:

    Θ(1Ukki=1uiji)CRki=1[Θ(ji)h(uiUk)].

    If h1(x)=1(x)s, h2(x)=1 Theorem 4.1 becomes result for CR-s-convex function:

    η(1Ukki=1uiji)CRki=1(uiUk)sΘ(ji).

    A useful alternative for incorporating uncertainty into prediction processes is IVFS. The present study introduces the (h1,h2)-GL concept for IVFS using the CR-order relation. As a result of utilizing this new concept, we observe that the inequality terms derived from this class of convexity and pertaining to Cr-order relations give much more precise results than other partial order relations. These findings are generalized from the very recent results described in [37,42,43,45]. There are many new findings in this study that extend those already known. In addition, we provide some numerical examples to demonstrate the validity of our main conclusions. Future research could include determining equivalent inequalities for different types of convexity utilizing various fractional integral operators, including Katugampola, Riemann-Liouville and generalized K-fractional operators. The fact that these are the most active areas of study for integral inequalities will encourage many mathematicians to examine how different types of interval-valued analysis can be applied. We anticipate that other researchers working in a number of scientific fields will find this idea useful.

    The authors declare that there is no conflict of interest in publishing this paper.



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