An analog electronic circuit model for cAMP-dependent pathway—towards creation of Silicon life

Maria Waqas; Urooj Ainuddin; Umar Iftikhar; Maria Waqas; Urooj Ainuddin; Umar Iftikhar

doi:10.3934/bioeng.2022011

AIMS Bioengineering

2022, Volume 9, Issue 2: 145-162. doi: 10.3934/bioeng.2022011

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Research article

An analog electronic circuit model for cAMP-dependent pathway—towards creation of Silicon life

Department of Computer and Information Systems Engineering, NED University of Engineering and Technology, University Road, Karachi - 75270, Pakistan

Received: 31 January 2022 Revised: 19 March 2022 Accepted: 21 April 2022 Published: 25 April 2022

Among the most sought after breakthroughs nowadays to combat computational saturation in the electronic hardware realm, neuromorphic and cytomorphic mimetics of biological structures seem potentially promising. Biological circuits are distinguishable due to their minuscule dimensions and immensely low power consumption; yet they achieve extremely complex and magnificent tasks of life, such as, thinking, memorizing, decision making and self-regulating in response to the surroundings. Low power analog circuit solutions are edged over digital ones as they are inherently noisy and fuzzy like bio-systems. In this paper, an analog circuit equivalent for a well-known biological pathway, cyclic adenosine monophosphate (cAMP), has been proposed, exploiting the fabrication characteristics of an analog transistor. The work demonstrates an application of previously published research of the authors, where it was shown that a single transistor operating in analog mode can mimic some fundamental biological circuit processes like receptor-ligand binding, Michaelis Menten and Hill process reactions. Since biological pathways are chain connections of such reactions, same modular approach can be used to build electronic pathways using those basic transistor circuits. Although the idea of creating silicon life seems far-fetched at this stage, this work supplements the idea of cytomorphic chips which is already gaining interest of bio-engineering community.
- analog circuit mimetics,
- cAMP pathway,
- computational biology,
- cytomorphic hardware design,
- Michaelis Menten kinetics,
- receptor-ligand binding
Citation: Maria Waqas, Urooj Ainuddin, Umar Iftikhar. An analog electronic circuit model for cAMP-dependent pathway—towards creation of Silicon life[J]. AIMS Bioengineering, 2022, 9(2): 145-162. doi: 10.3934/bioeng.2022011

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Abstract

Among the most sought after breakthroughs nowadays to combat computational saturation in the electronic hardware realm, neuromorphic and cytomorphic mimetics of biological structures seem potentially promising. Biological circuits are distinguishable due to their minuscule dimensions and immensely low power consumption; yet they achieve extremely complex and magnificent tasks of life, such as, thinking, memorizing, decision making and self-regulating in response to the surroundings. Low power analog circuit solutions are edged over digital ones as they are inherently noisy and fuzzy like bio-systems. In this paper, an analog circuit equivalent for a well-known biological pathway, cyclic adenosine monophosphate (cAMP), has been proposed, exploiting the fabrication characteristics of an analog transistor. The work demonstrates an application of previously published research of the authors, where it was shown that a single transistor operating in analog mode can mimic some fundamental biological circuit processes like receptor-ligand binding, Michaelis Menten and Hill process reactions. Since biological pathways are chain connections of such reactions, same modular approach can be used to build electronic pathways using those basic transistor circuits. Although the idea of creating silicon life seems far-fetched at this stage, this work supplements the idea of cytomorphic chips which is already gaining interest of bio-engineering community.

Conflict of interest

The authors declare no conflict of interest.

Author Contributions:

The first two authors, Maria Waqas and Urooj Ainuddin, contributed equally in the research work and article write-up. The third author, Umar Iftikhar, assisted in write-up and technical finishing of the article.

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