Review

Mycotoxins: Factors influencing production and control strategies

  • Received: 17 December 2020 Accepted: 05 February 2021 Published: 22 February 2021
  • Mycotoxins are secondary metabolites produced by filamentous fungi in food and feed due to several conditions that affect fungal growth and mycotoxin production in different ways. This review aims to explore the different factors that affect mycotoxin production and their control methods. Environmental conditions such as high temperature and humidity increase the risk of fungal growth and mycotoxin production. Other factors that affect contamination include pH, fungal strain, and substrate. To control mycotoxin contamination an integrated approach that starts in the field prior to planting and continues throughout the whole food chain is required, so good practices help minimize contamination at every step to deliver safe products. Good practices include proper practices on the field before and after planting, good harvest practices, appropriate drying measures, and good storage practices. Mycotoxin contamination is inevitable in food and once present they tend to remain as they are very stable compounds, although several physical, chemical and biological techniques could be applied to help minimize contamination. Food processing may also play a minimal role in controlling mycotoxins. Finally, regulations serve to keep food markets free from highly contaminated products, while proper sampling procedures and analytical methods ensure regulations endorsement.

    Citation: Rouaa Daou, Karine Joubrane, Richard G. Maroun, Lydia Rabbaa Khabbaz, Ali Ismail, André El Khoury. Mycotoxins: Factors influencing production and control strategies[J]. AIMS Agriculture and Food, 2021, 6(1): 416-447. doi: 10.3934/agrfood.2021025

    Related Papers:

  • Mycotoxins are secondary metabolites produced by filamentous fungi in food and feed due to several conditions that affect fungal growth and mycotoxin production in different ways. This review aims to explore the different factors that affect mycotoxin production and their control methods. Environmental conditions such as high temperature and humidity increase the risk of fungal growth and mycotoxin production. Other factors that affect contamination include pH, fungal strain, and substrate. To control mycotoxin contamination an integrated approach that starts in the field prior to planting and continues throughout the whole food chain is required, so good practices help minimize contamination at every step to deliver safe products. Good practices include proper practices on the field before and after planting, good harvest practices, appropriate drying measures, and good storage practices. Mycotoxin contamination is inevitable in food and once present they tend to remain as they are very stable compounds, although several physical, chemical and biological techniques could be applied to help minimize contamination. Food processing may also play a minimal role in controlling mycotoxins. Finally, regulations serve to keep food markets free from highly contaminated products, while proper sampling procedures and analytical methods ensure regulations endorsement.



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    [1] Zain ME (2011) Impact of mycotoxins on humans and animals. J Saudi Chem Soc 15: 129–144. doi: 10.1016/j.jscs.2010.06.006
    [2] Freire FDCO, da Rocha MEB (2016) Impact of mycotoxins on human health. In: Mérillon JM, Ramawat K. (Eds), Fungal metabolites. Reference Series in Phytochemistry. Springer, Cham, 239–261.
    [3] Kabak B (2009) The fate of mycotoxins during thermal food processing. J Sci Food Agric 89: 549–554. doi: 10.1002/jsfa.3491
    [4] Bennett JW, Klich M (2003) Mycotoxins. Clin Microbiol Rev 16: 497–516. doi: 10.1128/CMR.16.3.497-516.2003
    [5] Alshannaq A, Yu JH (2017) Occurrence, toxicity, and analysis of major mycotoxins in food. Int J Environ Res Public Health 14: 632. doi: 10.3390/ijerph14060632
    [6] Umesha S, Manukumar HMG, Chandrasekhar B, et al. (2017) Aflatoxins and food pathogens: impact of biologically active aflatoxins and their control strategies. J Sci Food Agric 97: 1698–1707. doi: 10.1002/jsfa.8144
    [7] Reverberi M, Ricelli A, Zjalic S, et al. (2010) Natural functions of mycotoxins and control of their biosynthesis in fungi. Appl Microbiol Biotechnol 87: 899–911. doi: 10.1007/s00253-010-2657-5
    [8] Benkerroum N (2016) Mycotoxins in dairy products: A review. Int Dairy J 62:63–75. doi: 10.1016/j.idairyj.2016.07.002
    [9] Magan N, Olsen M (2004) Mycotoxins in food detection and control. Cambridge: CRC.
    [10] Milani J (2013) Ecological conditions affecting mycotoxin production in cereals: A review. Vet Med-CZECH 58: 405–411. doi: 10.17221/6979-VETMED
    [11] Pitt JI (2000) Toxigenic fungi and mycotoxins. Br Med Bull 56: 184–192. doi: 10.1258/0007142001902888
    [12] Marin S, Ramos AJ, Cano-Sancho G (2013) Mycotoxins : Occurrence, toxicology, and exposure assessment. Food Chem Toxicol 60: 218–237. doi: 10.1016/j.fct.2013.07.047
    [13] Richard JL, Payne GA, Desjardins AE, et al. (2003) Mycotoxins: Risks in plant, animal and human systems. CAST Task Force Rep 139: 101–103.
    [14] Kochiieru Y, Mankevičienė A, Cesevičienė J, et al. (2020) The influence of harvesting time and meteorological conditions on the occurrence of Fusarium species and mycotoxin contamination of spring cereals. J Sci Food Agric 100: 2999–3006. doi: 10.1002/jsfa.10330
    [15] Perdoncini M, Sereia M, Scopel F, et al. (2019) Growth of fungal cells and the production of mycotoxins. Cell growth. DOI: 10.5772/intechopen.86533.
    [16] Smith MC, Madec S, Coton E, et al. (2016) Natural co-occurrence of mycotoxins in foods and feeds and their in vitro combined toxicological effects. Toxins (Basel) 8: 94. doi: 10.3390/toxins8040094
    [17] Doohan FM, Brennan J, Cooke BM (2003) Influence of climatic factors on Fusarium species pathogenic to cereals. Eur J Plant Pathol 109: 755–768. doi: 10.1023/A:1026090626994
    [18] Leslie JF, Bandyopadhyay R, Visconti A (2008) Mycotoxins: Detection methods, management, public health and agricultural trade. Wallingford: CAB International.
    [19] Mannaa M, Kim KD (2017) Influence of temperature and water activity on deleterious fungi and mycotoxin production during grain storage. Mycobiology 45: 240–254. doi: 10.5941/MYCO.2017.45.4.240
    [20] Joubrane K, Mnayer D, El Khoury A, et al. (2020) Co-occurrence of Aflatoxin B1 (AFB1) and Ochratoxin A (OTA) in Lebanese stored wheat. J Food Prot 83: 1547–1552. doi: 10.4315/JFP-20-110
    [21] Dix NJ, Webster J (1995) Fungi of extreme environments. Fungal Ecology. Dordrecht: Springer Netherlands, 322–340.
    [22] Kamil OH, Lupuliasa D, Draganescu D, et al. (2011) Interrelations of drying heat and survival of different fungal spores within the tablets formulation. Stud Univ Vasile Goldiş 21: 339–342.
    [23] Thanushree MP, Sailendri D, Yoha KS, et al. (2019) Mycotoxin contamination in food: An exposition on spices. Trends Food Sci Technol 93: 69–80. doi: 10.1016/j.tifs.2019.08.010
    [24] Palacios-cabrera H, Taniwaki MH, Hashimoto JM, et al. (2005) Growth of Aspergillus ochraceus, a. carbonarius and a. niger on culture media at different water activities and temperatures. Braz J Microbiol 36: 24–28.
    [25] Pardo E, Matin S, Ramos AJ, et al. (2005) Effect of water activity and temperature on mycelial growth and Ochratoxin A production by isolates of Aspergillus ochraceus on irradiated green coffee beans. J Food Prot 68: 133–138. doi: 10.4315/0362-028X-68.1.133
    [26] Grigoryan KM, Hakobyan LL (2015) Effect of water activity, ph and temperature on contamination level of dried vine fruite by filamentous fungi during storage. Proc of the Yerevan State Univ Chemistry and Biology 23–28.
    [27] Lahouar A, Marin S, Crespo-sempere A, et al. (2016) Effects of temperature, water activity and incubation time on fungal growth and aflatoxin B1 production by toxinogenic Aspergillus flavus isolates on sorghum seeds. Rev Argent Microbiol 48: 78–85.
    [28] Vylkova S (2017) Environmental pH modulation by pathogenic fungi as a strategy to conquer the host. PLoS Pathog 13: e1006149. doi: 10.1371/journal.ppat.1006149
    [29] Wang YB, Zhang WG, Fu LL (2017) Food Spoilage Microorganisms: Ecology and Control. CRC Press.
    [30] Brzonkalik K, Hümmer D, Syldatk C, et al. (2012) Influence of pH and carbon to nitrogen ratio on mycotoxin production by Alternaria alternata in submerged cultivation. AMB Express 2: 28. doi: 10.1186/2191-0855-2-28
    [31] Nicholson P (2004) Rapid detection of mycotoxigenic fungi in plants, Mycotoxins in Food 111–136.
    [32] Greeff-laubscher MR, Beukes I, Marais GJ (2019) Mycotoxin production by three different toxigenic fungi genera on formulated abalone feed and the effect of an aquatic environment on fumonisins. Mycology 11: 105–117. doi: 10.1080/21501203.2019.1604575
    [33] Kokkonen M, Jestoi M, Rizzo A (2005) The effect of substrate on mycotoxin production of selected Penicillium strains. Int J Food Microbiol 99: 207–214. doi: 10.1016/j.ijfoodmicro.2004.08.014
    [34] Özcelik S, Özcelik N (2004) Interacting effects of time, temperature, pH and simple sugars on biomass and toxic metabolite production by three Alternaria spp. Mycopathologia 109: 171–175. doi: 10.1007/BF00436806
    [35] Duran R, Cary JW, Calvo AM (2010) Role of the osmotic stress regulatory pathway in morphogenesis and secondary metabolism in filamentous fungi. Toxins (Basel) 2: 367–381. doi: 10.3390/toxins2040367
    [36] Hamad H, Mehmet A, Ismael H, et al. (2015) The effect of some sugars on the growth of Aspergillus niger. Kahramanmaraş Sütçü İmam Üniversitesi Doğa Bilim Derg 17: 7. doi: 10.18016/ksujns.28479
    [37] Liu J, Sun LH, Zhang NY, et al. (2016) Effects of nutrients in substrates of different grains on Aflatoxin B 1 production by Aspergillus flavus. Biomed Res Int 2016: 7232858.
    [38] Uppala SS, Bowen KL, Woods FM (2013) Pre-harvest aflatoxin contamination and soluble sugars of peanut. Peanut Sci 40: 40–51. doi: 10.3146/PS12-9.1
    [39] Van der Fels-Klerx HJ (Ine), Liu C, Battilani P (2016) Modelling climate change impacts on mycotoxin contamination. World Mycotoxin J 9: 1–10.
    [40] Medina A, Rodríguez A, Magan N (2015) Climate change and mycotoxigenic fungi: Impacts on mycotoxin production. Curr Opin Food Sci 5: 99–140. doi: 10.1016/j.cofs.2015.11.002
    [41] Miraglia M, De Santis B, Brera C (2008) Climate change: Implications for mycotoxin contamination of foods. J Biotechnol 136: S715. doi: 10.1016/j.jbiotec.2008.07.1702
    [42] Battilani P, Rossi V, Giorni P, et al. (2012) Modelling, predicting and mapping the emergence of aflatoxins in cereals in the EU due to climate change. Scientific report submitted to EFSA.
    [43] Medina A, Akbar A, Baazeem A, et al. (2017) Climate change, food security and mycotoxins: Do we know enough? Fungal Biol Rev 31: 143–154.
    [44] Giorni P, Battilani P, Magan N (2008) Effect of solute and matric potential on in vitro growth and sporulation of strains from a new population of Aspergillus flavus isolated in Italy. Fungal Ecol 1: 102–106. doi: 10.1016/j.funeco.2008.07.001
    [45] Valencia-Quintana R, Milić M, Jakšić D, et al. (2020) Environmental research and public health review environment changes, Aflatoxins, and health issues, a Review. Int J Environ Res Public Health 17: 7850. doi: 10.3390/ijerph17217850
    [46] Paterson RRM (2011) Further mycotoxin effects from climate change. Food Res Int 44: 2555–2566. doi: 10.1016/j.foodres.2011.05.038
    [47] Moses JA, Jayas DS, Alagusundaram K (2015) Climate change and its implications on stored food grains. Agric Res 4: 21–30. doi: 10.1007/s40003-015-0152-z
    [48] Lopez-Garcia R, Park DL, Phillips TD (1999) Integrated mycotoxin management systems, 1999. Available from: http://www.fao.org/3/x2100t/x2100t07.htm.
    [49] Joubrane K, El Khoury A, Lteif R, et al. (2011) Occurrence of aflatoxin B1 and ochratoxin A in Lebanese cultivated wheat. Mycotoxin Res 27: 249–257. doi: 10.1007/s12550-011-0101-z
    [50] Mannaa M, Kim KD (2017) Control strategies for deleterious grain fungi and mycotoxin production from preharvest to postharvest stages of cereal crops: A Review. Life Sci Nat Resour Res 25: 13–27.
    [51] Mahuku G, Nzioki HS, Mutegi C, et al. (2019) Pre-harvest management is a critical practice for minimizing a fl atoxin contamination of maize. Food Control 96: 219–226. doi: 10.1016/j.foodcont.2018.08.032
    [52] Food and Agriculture Organization (2007) On-farm mycotoxin control in food and feed grain. Avaliable from: http://www.fao.org/3/a1416e/a1416e.pdf.
    [53] Munkvold G (2014) Crop management practices to minimize the risk of mycotoxins contamination in temperate‐zone maize. In: Leslie JF, Logrieco AF. (Eds), Mycotoxin Reduction in Grain Chain. 59–77.
    [54] Rose LJ, Okoth S, Flett BC, et al. (2019) Preharvest management strategies and their impact on mycotoxigenic fungi and associated mycotoxins. Fungi and Mycotoxins. Rijeka: IntechOpen.
    [55] Nganchamung T, Robson M (2017) Chemical fertilizer use and acute health effects among chili farmers in Ubon Ratchathani province, Thailand. J Heal Res 31.
    [56] Reboud X, Eychenne N, Délos M, et al. (2016) Withdrawal of maize protection by herbicides and insecticides increases mycotoxins contamination near maximum thresholds. Agron Sustain Dev 36: 43. doi: 10.1007/s13593-016-0376-8
    [57] Rodríguez A, Rodríguez M, Andrade MJ, et al. (2015) Detection of filamentous fungi in foods. Curr Opin Food Sci 5: 36–42. doi: 10.1016/j.cofs.2015.07.007
    [58] El Khoury A, Atoui A, Rizk T, et al. (2011) Differentiation between Aspergillus flavus and Aspergillus parasiticus from Pure Culture and Aflatoxin-Contaminated Grapes Using PCR-RFLP Analysis of aflR-aflJ Intergenic Spacer. J Food Sci 76: 247–253. doi: 10.1111/j.1750-3841.2011.02153.x
    [59] Atoui A, El Khoury A, Kallassy M, et al. (2012) Quantification of Fusarium graminearum and Fusarium culmorum by real-time PCR system and zearalenone assessment in maize. Int J Food Microbiol 154: 59–65. doi: 10.1016/j.ijfoodmicro.2011.12.022
    [60] Simpson DR, Weston GE, Turner JA, et al. (2001) Differential control of head blight pathogens of wheat by fungicides and consequences for mycotoxin contamination of grain. Eur J Plant Pathol 107: 421–431. doi: 10.1023/A:1011225817707
    [61] Nicolopoulou-Stamati P, Maipas S, Kotampasi C, et al. (2016) Chemical pesticides and human health: The urgent need for a new concept in agriculture. Front public Heal 4: 148.
    [62] Blair A, Ritz B, Wesseling C, et al. (2014) Pesticides and human health. Occup Environ Med DOI: 10.1136/oemed-2014-102454.
    [63] Kagot V, Okoth S, Boevre MD, et al. (2019) Biocontrol of aspergillus and fusarium mycotoxins in Africa: benefits and limitations. Toxins (Basel) 11: 109. doi: 10.3390/toxins11020109
    [64] Dorner JW (2004) Biological control of Aflatoxin crop contamination. J Toxicol - Toxin Rev 23: 425–450. doi: 10.1081/TXR-200027877
    [65] Cotty PJ (1994) Influence of field application of an atoxigenic strain of aspergillus flavus on the population of a flavus infecting cotton bolls and on the aflatoxin content of cottonseed. Phytopathology 84: 1270–1277. doi: 10.1094/Phyto-84-1270
    [66] Chiewchan N, Mujumdar AS, Devahastin S (2015) Application of drying technology to control Aflatoxins in foods and feeds: A review. Dry Technol 33: 1700–1707. doi: 10.1080/07373937.2015.1068795
    [67] Wambacq E, Vanhoutte I, Audenaert K, et al. (2016) Occurrence, prevention and remediation of toxigenic fungi and mycotoxins in silage: a review. J Sci Food Agric 96: 2284–2302. doi: 10.1002/jsfa.7565
    [68] Scudamore KA, Livesey CT (1998) Occurrence and significance of mycotoxins in forage crops and silage: a review. J Sci Food Agric 77: 1–17. doi: 10.1002/(SICI)1097-0010(199805)77:1<1::AID-JSFA9>3.0.CO;2-4
    [69] Magan N, Aldred D, Sanchis V (2004) The role of spoilage fungi in seed deterioration. Mycology series. 21: 311–323.
    [70] Pankaj SK, Shi H, Keener KM (2018) A review of novel physical and chemical decontamination technologies for a flatoxin in food. Trends Food Sci Technol 71: 73–83. doi: 10.1016/j.tifs.2017.11.007
    [71] Hojnik N, Cvelbar U, Tavčar-Kalcher G, et al. (2017) Mycotoxin decontamination of food : Cold " classic " decontamination. Toxins (Basel) 9: 151. doi: 10.3390/toxins9050151
    [72] Pleadin J, Frece J, Markov K (2019) Mycotoxins in food and feed. Adv Food Nutr Res 89: 297–345. doi: 10.1016/bs.afnr.2019.02.007
    [73] Karlovsky P, Suman M, Berthiller F, et al. (2016) Impact of food processing and detoxification treatments on mycotoxin contamination. Mycotoxin Res 32: 179–205. doi: 10.1007/s12550-016-0257-7
    [74] Deng LZ, Sutar PP, Mujumdar AS, et al. (2021) Thermal decontamination technologies for microorganisms and mycotoxins in low-moisture foods. Annu Rev Food Sci Technol 12.
    [75] Misra NN, Yadav B, Roopesh MS, et al. (2019) Cold plasma for effective fungal and Mycotoxin control in foods: Mechanisms, inactivation effects, and applications. Compr Rev food Sci Food Saf 18: 106–120. doi: 10.1111/1541-4337.12398
    [76] Suhem K, Matan N, Nisoa M, et al. (2012) Inhibition of Aspergillus flavus on agar media and brown rice cereal bars using cold atmospheric plasma treatment. Int J Food Microbiol 161: 107–111. doi: 10.1016/j.ijfoodmicro.2012.12.002
    [77] Dasan BG, Boyaci IH, Mutlu M (2017) Nonthermal plasma treatment of Aspergillus spp. spores on hazelnuts in an atmospheric pressure fluidized bed plasma system: Impact of process parameters and surveillance of the residual viability of spores. J Food Eng 196: 139–149.
    [78] Lee GJ, Sim GB, Choi EH, et al. (2015) Optical and structural properties of plasma-treated Cordyceps bassiana spores as studied by circular dichroism, absorption, and fluorescence spectroscopy. J Appl Phys 117: 023303. doi: 10.1063/1.4905194
    [79] Deng LZ, Mujumdar A, Pan ZL, et al. (2019) Emerging chemical and physical disinfection technologies of fruits and vegetables: a comprehensive review. Crit Rev Food Sci Nutr 60: 1–28.
    [80] Basaran P, Basaran-Akgul N, Oksuz L (2008) Elimination of Aspergillus parasiticus from nut surface with low pressure cold plasma (LPCP) treatment. Food Microbiol 25: 626–632. doi: 10.1016/j.fm.2007.12.005
    [81] Park BJ, Takatori K, Sugita-Konishi Y, et al. (2007) Degradation of mycotoxins using microwave-induced argon plasma at atmospheric pressure. Surf Coatings Technol 201: 5733–5737. doi: 10.1016/j.surfcoat.2006.07.092
    [82] Ouf SA, Basher AH, Mohamed AH (2014) Inhibitory effect of double atmospheric pressure argon cold plasma on spores and mycotoxin production of Aspergillus niger contaminating date palm fruits. J Sci Food Agric 95: 204–210.
    [83] Gavahian M, Cullen PJ (2020) Cold plasma as an emerging technique for mycotoxin-free food: Efficacy, mechanisms, and trends. Food Rev Int 36: 193–214. doi: 10.1080/87559129.2019.1630638
    [84] Murugesan P, Brunda DK, Moses JA, et al. (2020) Photolytic and photocatalytic detoxification of mycotoxins in foods. Food Control 123: 107748. doi: 10.1016/j.foodcont.2020.107748
    [85] Liu R, Jin Q, Huang J, et al. (2011) Photodegradation of Aflatoxin B1 in peanut oil. Eur Food Res Technol 232: 843–849. doi: 10.1007/s00217-011-1452-6
    [86] Mao J, He B, Zhang L, et al. (2016) A structure identification and toxicity assessment of the degradation products of aflatoxin B1 in peanut Oil under UV irradiation. Toxins (Basel) 8: 332. doi: 10.3390/toxins8110332
    [87] Tripathi S, Mishra HN (2010) Enzymatic coupled with UV degradation of aflatoxin B1 in red chili powder. J Food Quality 33: 186–203. doi: 10.1111/j.1745-4557.2010.00334.x
    [88] Ibarz R, Garvín A, Azuara E, et al. (2015) Modelling of ochratoxin A photo-degradation by a UV multi-wavelength emitting lamp. LWT - Food Sci Technol 61: 385–392. doi: 10.1016/j.lwt.2014.12.017
    [89] Magzoub RAM, Yassin AAA, Abdel-Rahim AM, et al. (2018) Photocatalytic detoxification of aflatoxins in Sudanese peanut oil using immobilized titanium dioxide. Food Control 95: 206–214. doi: 10.1016/j.foodcont.2018.08.009
    [90] Patriarca A, Fernandez Pinto V (2017) Prevalence of mycotoxins in foods and decontamination. Curr Opin Food Sci 14: 50–60. doi: 10.1016/j.cofs.2017.01.011
    [91] Deng LZ, Tao Y, Mujumdar AS, et al. (2020) Recent advances in non-thermal decontamination technologies for microorganisms and mycotoxins in low-moisture foods. Trends Food Sci Technol 106: 104–112. doi: 10.1016/j.tifs.2020.10.012
    [92] European Norm (2006) Commission Regulation (EC) No 1881/2006 of 19 December 2006 setting maximum levels for certain contaminants in foodstuffs. Official Journal of the European Union 49: 5–25.
    [93] Colovic R, Puvača N, Cheli F, et al. (2019) Decontamination of mycotoxin-contaminated feedstuffs and compound feed. Toxins (Basel) 11: 617. doi: 10.3390/toxins11110617
    [94] Milani J, Maleki G (2014) Effects of processing on mycotoxin stability in cereals. J Sci Food Agric 94: 2372–2375. doi: 10.1002/jsfa.6600
    [95] Bullerman LB, Bianchini A (2007) Stability of mycotoxins during food processing. Int J Food Microbiol 119: 140–146. doi: 10.1016/j.ijfoodmicro.2007.07.035
    [96] Scudamore KA, Banks J, MacDonald SJ (2003) Fate of ochratoxin A in the processing of whole wheat grains during milling and bread production. Food Addit Contam 20: 1153–1163. doi: 10.1080/02652030310001605979
    [97] Park DL (2002) Effect of processing on Aflatoxin. Adv Exp Med Biol 504: 173–179. doi: 10.1007/978-1-4615-0629-4_17
    [98] Cheli F, Rossi L, Pinotti L, et al. (2013) Effect of milling procedures on mycotoxin distribution in wheat fractions: A review. LWT - Food Sci Technol 54: 307–314. doi: 10.1016/j.lwt.2013.05.040
    [99] Vidal A, Marín S, Morales H, et al. (2014) The fate of deoxynivalenol and ochratoxin A during the breadmaking process, effects of sourdough use and bran content. Food Chem Toxicol 68: 53–60. doi: 10.1016/j.fct.2014.03.006
    [100] Stoloff L, Trucksess MW (1981) Effect of boiling, frying, and baking on recovery of aflatoxin from naturally contaminated corn grits or cornmeal. J Assoc Off Anal Chem 64: 678–680.
    [101] Park JW, Kim YB (2006) Effect of pressure cooking on aflatoxin B1 in rice. J Agric Food Chem 54: 2431–2435. doi: 10.1021/jf053007e
    [102] Ryu D, Hanna MA, Bullerman LB (1999) Stability of zearalenone during extrusion of corn grits. J Food Prot 62: 1482–1484. doi: 10.4315/0362-028X-62.12.1482
    [103] Baxter ED, Slaiding IR, Kelly B (2001) Behavior of Ochratoxin A in brewing. J Am Soc Brew Chem 59: 98–100.
    [104] Méndez-Albores A, Campos-Aguilar AZ, Moreno-Martínez E (2013) Physical and chemical degradation of B-aflatoxins during the roasting and dutching of cocoa liquor. J Agric Sci Technol 15: 557–567.
    [105] Milanez TV, Leitão MFF (1996) The effect of cooking on ochratoxin A content of beans, variety 'Carioca'. Food Addit Contam 13: 89–93. doi: 10.1080/02652039609374383
    [106] Rastegar H, Shoeibi S, Yazdanpanah H, et al. (2016) Removal of aflatoxin B1 by roasting with lemon juice and/or citric acid in contaminated pistachio nuts. Food Control 71: 271–284.
    [107] Jasutiene I, Garmiene G, Kulikauskiene M (2006) Pasteurisation and fermentation effects on Aflatoxin M1 stability. Milchwissenschaft 61: 75–79.
    [108] Govaris A, Roussi V, Koidis PA, et al. (2001) Distribution and stability of aflatoxin M1 during processing, ripening and storage of Telemes cheese. Food Addit Contam 18: 437–443. doi: 10.1080/02652030120550
    [109] Govaris A, Roussi V, Koidis PA, et al. (2002) Distribution and stability of aflatoxin M1 during production and storage of yoghurt. Food Addit Contam 19: 1043–1050. doi: 10.1080/0265203021000007831
    [110] Assatarakul K, Churey JJ, Manns DC, et al. (2012) Patulin reduction in apple juice from concentrate by UV radiation and comparison of kinetic degradation models between apple juice and Apple Cider. J Food Prot 75: 717–724. doi: 10.4315/0362-028X.JFP-11-429
    [111] European Commission (2018) The rapid alert system for food and feed 2018 annual report.
    [112] Barkai-Golan R, Paster N (2008) Mycotoxins in Fruits and Vegetables. Elsevier.
    [113] Whitaker TB (2006) Sampling foods for mycotoxins. Food Addit Contam 23: 50–61. doi: 10.1080/02652030500241587
    [114] Beyene AM, Du XW, Schrunk DE, et al. (2019) High - performance liquid chromatography and Enzyme - Linked Immunosorbent Assay techniques for detection and quantification of aflatoxin -B1 in feed samples : A comparative study. BMC Res Note 12: 492. doi: 10.1186/s13104-019-4538-z
    [115] Sakamoto S, Putalun W, Vimolmangkang S, et al. (2018) Enzyme - linked immunosorbent assay for the quantitative / qualitative analysis of plant secondary metabolites. J Nat Med 72: 32–42. doi: 10.1007/s11418-017-1144-z
    [116] Zhang L, Dou XW, Zhang C, et al. (2018) A review of current methods for analysis of mycotoxins in herbal medicines. Toxins (Basel) 10: 65. doi: 10.3390/toxins10020065
    [117] Rahman HU, Yue XF, Yu QY, et al. (2019) Specific antigen-based and emerging detection technologies of mycotoxins. J Sci Food Agric 99: 4869–4877. doi: 10.1002/jsfa.9686
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