Outcomes of dietary interventions in the prevention and progression of Parkinson's disease: A literature review

Ubaid Ansari; Alexi Omid; Dawnica Nadora; Jimmy Wen; Arman Omid; Forshing Lui; Ubaid Ansari; Alexi Omid; Dawnica Nadora; Jimmy Wen; Arman Omid; Forshing Lui

doi:10.3934/Neuroscience.2024032

AIMS Neuroscience

2024, Volume 11, Issue 4: 520-532. doi: 10.3934/Neuroscience.2024032

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Review

Outcomes of dietary interventions in the prevention and progression of Parkinson's disease: A literature review

California Northstate University College of Medicine, USA

Received: 16 September 2024 Revised: 18 December 2024 Accepted: 23 December 2024 Published: 30 December 2024

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms, primarily due to the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Factors contributing to this neuronal degeneration include mitochondrial dysfunction, oxidative stress, and neuronal excitotoxicity. Despite extensive research, the exact etiology of PD remains unclear, with both genetic and environmental factors playing significant roles. Given the increasing prevalence of PD, particularly in aging populations, effective preventive and therapeutic strategies are urgently needed. Emerging research suggests that dietary interventions might offer promising approaches to managing PD progression. This literature review examines various dietary interventions that differ in their composition and mechanisms of action, including the Mediterranean, vegan, carnivore, paleo, and ketogenic diets, and their potential neuroprotective effects. By evaluating the current evidence, this review aims to identify dietary strategies that may improve the quality of life for individuals with PD. Additionally, it explores the underlying mechanisms through which diet may influence PD pathophysiology, thus providing insights into how nutritional modifications can be integrated into holistic management plans for the disease.
- Parkinson's disease,
- neurodegenerative disease,
- mediterranean diet,
- vegan diet,
- carnivore diet,
- paleolithic diet,
- ketogenic diet
Citation: Ubaid Ansari, Alexi Omid, Dawnica Nadora, Jimmy Wen, Arman Omid, Forshing Lui. Outcomes of dietary interventions in the prevention and progression of Parkinson's disease: A literature review[J]. AIMS Neuroscience, 2024, 11(4): 520-532. doi: 10.3934/Neuroscience.2024032

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Abstract

Parkinson's disease (PD) is a progressive neurodegenerative disorder characterized by motor and non-motor symptoms, primarily due to the degeneration of dopaminergic neurons in the substantia nigra pars compacta (SNpc). Factors contributing to this neuronal degeneration include mitochondrial dysfunction, oxidative stress, and neuronal excitotoxicity. Despite extensive research, the exact etiology of PD remains unclear, with both genetic and environmental factors playing significant roles. Given the increasing prevalence of PD, particularly in aging populations, effective preventive and therapeutic strategies are urgently needed. Emerging research suggests that dietary interventions might offer promising approaches to managing PD progression. This literature review examines various dietary interventions that differ in their composition and mechanisms of action, including the Mediterranean, vegan, carnivore, paleo, and ketogenic diets, and their potential neuroprotective effects. By evaluating the current evidence, this review aims to identify dietary strategies that may improve the quality of life for individuals with PD. Additionally, it explores the underlying mechanisms through which diet may influence PD pathophysiology, thus providing insights into how nutritional modifications can be integrated into holistic management plans for the disease.

Conflict of interest

The authors declare no conflict of interest.

Author Contributions

The authors confirm contribution to the paper as follows: study conception and design: Ubaid Ansari, Alexi Omid, Dawnica Nadora, Jimmy Wen, Arman Omid and Forshing Lui MD; data collection: Ubaid Ansari, Alexi Omid, Dawnica Nadora, Jimmy Wen, Arman Omid and Forshing Lui MD; analysis and interpretation of results: Ubaid Ansari, Alexi Omid, Dawnica Nadora, Jimmy Wen, Arman Omid and Forshing Lui MD; draft manuscript preparation: Ubaid Ansari, Alexi Omid, Dawnica Nadora, Jimmy Wen, Arman Omid and Forshing Lui MD. All authors reviewed the results and approved the final version of the manuscript.

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