Research article

Female breast cancer mortality in relation to puberty on Staten Island, New York

  • Received: 19 May 2020 Accepted: 04 June 2020 Published: 08 June 2020
  • Pursuant to a Congressional act in 2008, the Department of Health and Human Services established the Interagency Breast Cancer and Environmental Research Coordinating Committee to address the burden of breast cancer in the United States. Subsequently, the Committee recommended researchers study the timing of exposure to breast cancer risk factors. Given the high breast cancer mortality rate on Staten Island, this paper presents a case-control study investigating breast cancer risk associated with puberty while living on Staten Island. The dataset combined New York City Department of Health and Mental Hygiene female death certificate information between 1985 and 2006, with life history information from newspaper obituaries. Data analyzed included: age, length of residence on Staten Island, birth on Staten Island, and residence on Staten Island during puberty. Cases were individuals who died of breast cancer and controls were individuals who died of non-malignant causes. Analysis included multivariate logistic regression on the full dataset and multiple replicates of randomized one case to two controls simulations. Results indicated that living on Staten Island during puberty (ages 9–19) was associated with an elevated risk of dying from breast cancer (odds ratio 1.35, p < 0.001, 95% CI = 1.18, 1.55). This paper suggests the importance of studying puberty as a window of susceptibility for breast cancer risk.

    Citation: Alfred M Levine, Donna B Gerstle. Female breast cancer mortality in relation to puberty on Staten Island, New York[J]. AIMS Public Health, 2020, 7(2): 344-353. doi: 10.3934/publichealth.2020029

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  • Pursuant to a Congressional act in 2008, the Department of Health and Human Services established the Interagency Breast Cancer and Environmental Research Coordinating Committee to address the burden of breast cancer in the United States. Subsequently, the Committee recommended researchers study the timing of exposure to breast cancer risk factors. Given the high breast cancer mortality rate on Staten Island, this paper presents a case-control study investigating breast cancer risk associated with puberty while living on Staten Island. The dataset combined New York City Department of Health and Mental Hygiene female death certificate information between 1985 and 2006, with life history information from newspaper obituaries. Data analyzed included: age, length of residence on Staten Island, birth on Staten Island, and residence on Staten Island during puberty. Cases were individuals who died of breast cancer and controls were individuals who died of non-malignant causes. Analysis included multivariate logistic regression on the full dataset and multiple replicates of randomized one case to two controls simulations. Results indicated that living on Staten Island during puberty (ages 9–19) was associated with an elevated risk of dying from breast cancer (odds ratio 1.35, p < 0.001, 95% CI = 1.18, 1.55). This paper suggests the importance of studying puberty as a window of susceptibility for breast cancer risk.



    Many scientific and technological disciplines are engaged in developing and manufacturing high-quality, highly functional, and nutritious food. However, these efforts are being increasingly challenged by a significant need for new tools, data, and information that are essential for winning the war against food fraud. The phenomenon of food fraud or adulteration is not new and has impacted human civilizations since the beginning of food production and trading. In most cases, food fraud is economically driven, however, its direct and indirect actual and potential influence reaches far beyond its economic impact on individuals and societies. In many cases, adulterated food contains harmful or toxic chemical, physical, and/or biological constituents that present significant food-safety-related risks. Food fraud leads to loss of reputation that spans throughout the entire food supply chain and damages consumer confidence. In many cases, intentionally adulterated or fraudulent foods present challenges that are related to food defense and/or food security. Food fraud can have social- dietary- and/or religion-related implications. Food fraud may also present potential homeland security-related implications (bioterrorism). It is thus essential to recognize that food fraud exhibits a very wide sphere of challenges that must be addressed collectively as food crimes. The annual global economic loss that results from food crimes is estimated to be about $70 billion and affects individuals, companies, regions, and national economies. Strategies and means that are aimed at enhancing our capability to identify and fight these crimes have therefore to be developed and implemented in a way that successfully addresses the multifaceted nature of food crimes. There are different ways by which food products, food raw materials, and ingredients, as well as information about them are adulterated. In its most basic form, food crime is based on counterfeiting and marketing illegal replication of a legal product. In other cases, food products are diluted with water or inferior/toxic ingredients. Food crimes may involve substitution of a high-value component of a product with inferior, lower-value, and/or unsafe ingredients. Adulteration of food may also involve concealment of defects or poor quality of a product or its components. In yet other cases, food crimes may involve enhancement of product or its ingredients with banned and/or toxic ingredients or application of an unapproved process to improve the product quality. Gray market theft and diversion as well as marketing of mislabeled products with incorrect or missing information about their nature or their regional origin are also common aspects of food crimes. In recent years, the regional origin of specific food products has gained a significant importance and value among consumers and thus has become a major target of adulteration. Identifying and fighting food crimes is highly dependent on our capability to effectively authenticate food products, their constituent raw materials, and food ingredients. In simple terms, authentication must provide answers to two questions: a) is this what it says it is? And b), in most cases, where does it come from? Answering these questions requires the application of a broad array of effective and credible analytical tools and approaches that can identify the fraudulent nature of a product in questions. Success in fighting food crimes is also determined by our ability to trace every product and/or its ingredient throughout the entire supply chain. Many analytical tools for food authentication exist, however, success also requires having a continuously validated and updated data bank consisting of the "fingerprints" of all such products and ingredients. These data sets should be developed in a way that reflects (for each product and ingredient) the inherent biological-, physical-, chemical-, regional- seasonal-, and agrotechnological-related variabilities. The latter mounts to a major knowledge gap that hinders our ability to effectively identify and fight food crimes. During recent decades, the food supply chain has been globalized and evolved from a relatively simple linear chain of regional transactions into a very complicated and convoluted series of events that span all over the globe. This evolution and the among-regions differences in analytical and traceability capabilities compromise success of food traceability and authentication and thus the deterrence of food fraud. The latter presents a major challenge that must be addressed. If food crime remains a "profitable low-risk criminal activity" it will continue to grow and flourish. This aspect is reflected in the significant involvement of organized crime in food crimes. A very effective legislation and enforcement effort is therefore needed at the local, regional, and international level to successfully fight food crimes. I would like to call upon funding agencies, academia, research institutes, and governments to direct means and efforts at developing and introducing the basic knowledge and applicable information that are needed in order to close the above-described knowledge and data gaps and affectively address the current challenges that are presented by food crimes. I would like to invite all those who will become engaged in such efforts to publish their work in our journal.

    Moshe Rosenberg, D.Sc., Editor in Chief

    Professor Emeritus Food Science and Technology

    Department of Food Science and Technology

    University of California, Davis

    Davis, CA 95616

    U.S.A


    Acknowledgments



    This work was funded in part by New York State grants sponsored by NYS Senator Andrew Lanza RF#'s 50007-00 01, 50009-00 01, 50010-00 01, 50014-00 01, 50019-00 01, 50022-00 01, New York City Council Speaker Christine Quinn and NYC Council Member James Oddo RF#'s 58273-00 01, 58273-00 02, 58273-00 03, 58967-00 02, 58967-00 03, NYC Council Speaker Melissa Mark-Viverito, NYC Council Speaker Corey Johnson, NYC Council Member Steven Matteo RF#'s 58967-00 04, 58967-00 05, 58967-00 06, 58967-00 07, 58967-00 08, 58967-00 09, 58967-00 10 and NYC Council Member Debi Rose 58393-00 02.
    The authors are grateful to the New York City Department of Health and Mental Hygiene for providing the data on death certificates.
    The authors wish to thank Ann Torino for her tireless work in data preparation and manuscript editing. The authors also wish to thank Dr. Elena McCoy, Robin Johnson, Jose Colon, Brianna Marselle, Mary Segarra, Caitlyn Nichols, Kristen White Van Buren and the many staff members at the Center for Environmental Science.

    Conflict of interests



    All authors declare no conflicts of interest in this paper.

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