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Parametric and the Cox risk model in the analysis of factors affecting the time of diagnosis of retinopathy with patients type 2 diabetes

  • Received: 10 March 2019 Accepted: 26 May 2019 Published: 25 June 2019
  • Background: The aim of this study was to compare the effectiveness of Cox model and Exponential parametric, Weibull, Log Normal and Log Logistic models in evaluating factors affecting retinopathy diagnostic time in patients with type 2 diabetes. Methods: In this prospective historical study, 400 patients with type 2 diabetes without retinopathy referred to the Ophthalmology Clinic of Yazd Diabetes Research Center in 2008 were followed up for diagnosis of retinopathy by January 2013. Significant variables in the univariate model were introduced into the Cox multivariate and parametric models to determine the effective factors on the time of retinopathy diagnosis. The criterion for comparing the performance of the models was the Akaike’s criterion. All calculations were performed using R software and a significant level of 0.05 was considered. Resuls: The mean and median time of retinopathy diagnosis was 52.46 and 58 months, respectively. 3% of patients in less than one year and 16% of patients in less than two years of retinopathy were diagnosed. Conclusion: According to Akaike’s criterion, Cox model has the best fit in determining the factors affecting the time of retinopathy diagnosis.

    Citation: Fatemeh keshavarzi, Mohsen Askarishahi, Maryam Gholamniya Foumani, Hossein Falahzadeh. Parametric and the Cox risk model in the analysis of factors affecting the time of diagnosis of retinopathy with patients type 2 diabetes[J]. AIMS Medical Science, 2019, 6(2): 170-178. doi: 10.3934/medsci.2019.2.170

    Related Papers:

  • Background: The aim of this study was to compare the effectiveness of Cox model and Exponential parametric, Weibull, Log Normal and Log Logistic models in evaluating factors affecting retinopathy diagnostic time in patients with type 2 diabetes. Methods: In this prospective historical study, 400 patients with type 2 diabetes without retinopathy referred to the Ophthalmology Clinic of Yazd Diabetes Research Center in 2008 were followed up for diagnosis of retinopathy by January 2013. Significant variables in the univariate model were introduced into the Cox multivariate and parametric models to determine the effective factors on the time of retinopathy diagnosis. The criterion for comparing the performance of the models was the Akaike’s criterion. All calculations were performed using R software and a significant level of 0.05 was considered. Resuls: The mean and median time of retinopathy diagnosis was 52.46 and 58 months, respectively. 3% of patients in less than one year and 16% of patients in less than two years of retinopathy were diagnosed. Conclusion: According to Akaike’s criterion, Cox model has the best fit in determining the factors affecting the time of retinopathy diagnosis.


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    Acknowledgments



    This manuscript was extracted from an MSc thesis approved by council of Shahid Sadoughi University of Medical Sciences, Yazd, Iran. We appreciated the staff of council of Shahid Sadoughi University of Medical Sciences.

    Conflict of interest



    The authors declare no conflict of interest.

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