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Global dynamics of a delay virus model with recruitment and saturation effects of immune responses

. Department of Mathematics, School of Biomedical Engineering, Third Military Medical University, Chongqing 400038, China

In this paper, we formulate a virus dynamics model with the recruitment of immune responses, saturation effects and an intracellular time delay. With the help of uniform persistence theory and Lyapunov method, we show that the global stability of the model is totally determined by the basic reproductive number $R_0$. Furthermore, we analyze the effects of the recruitment of immune responses on virus infection by numerical simulation. The results show ignoring the recruitment of immune responses will result in overestimation of the basic reproductive number and the severity of viral infection.

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Keywords Global stability; Lyapunov functional; viral dynamics; immune response; time delay

Citation: Cuicui Jiang, Kaifa Wang, Lijuan Song. Global dynamics of a delay virus model with recruitment and saturation effects of immune responses. Mathematical Biosciences and Engineering, 2017, 14(5&6): 1233-1246. doi: 10.3934/mbe.2017063


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