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Findings on prenatal, lactational and later childhood exposure to dioxins and dioxin-like compounds: a review of the Amsterdam-Zaandam cohort 1987-2005

1 Department of Paediatrics and Neonatology, Westfriesgasthuis, Maelsonstraat 3, 1624 NP Hoorn, The Netherlands;
2 University Hospital Aachen, Department of Dermatology, 52074 Aachen, Germany;
3 Ecobaby Foundation, Hollandstraat 6, 3634 AT Loenersloot, The Netherlands;
4 IBED/ESS, University of Amsterdam, Sciencepark 904, 1098 XH Amsterdam, The Netherlands;
5 Department of Paediatrics, Emma Children's Hospital Academic Medical Center, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands

Special Issues: Systems Biology and Prenatal Exposure

The Amsterdam-Zaandam cohort has been studied intermittently since 1987. The cohort was selected for optimal pregnancy and birth, in whom prenatal, lactational and more recently current dioxin exposures were measured. In the perinatal period and during the years thereafter, effects on various organ systems have been documented: thyroid, metabolism, immunity, haematology, motor development, brain development, lung function and puberty. We present a review of the endpoints studied, from the perinatal period into adolescence.
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Copyright Info: © 2015, Janna G. Koppe, et al., licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution Licese (http://creativecommons.org/licenses/by/4.0)

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