Viscoelastic capillary flow: the case of whole blood

David Gosselin; Maxime Huet; Myriam Cubizolles; David Rabaud; Naceur Belgacem; Didier Chaussy; Jean Berthier; David Gosselin; Maxime Huet; Myriam Cubizolles; David Rabaud; Naceur Belgacem; Didier Chaussy; Jean Berthier

doi:10.3934/biophy.2016.3.340

AIMS Biophysics

2016, Volume 3, Issue 3: 340-357. doi: 10.3934/biophy.2016.3.340

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Research article

Viscoelastic capillary flow: the case of whole blood

1.
Univ. Grenoble Alpes, F-38000 Grenoble, France
2.
CEA LETI MlNATEC Campus, F-38054 Grenoble France.
3.
University Grenoble Alpes, LGP2, F-38000 Grenoble, France
4.
CNRS, LGP2, F-38000 Grenoble, France
5.
Agefpi, LGP2, F-38000 Grenoble, France

Received: 06 June 2016 Accepted: 20 July 2016 Published: 22 July 2016

The dynamics of spontaneous capillary flow of Newtonian fluids is well-known and can be predicted by the Lucas-Washburn-Rideal (LWR) law. However a wide variety of viscoelastic fluids such as alginate, xanthan and blood, does not exhibit the same Newtonian behavior.
In this work we consider the Herschel-Bulkley (HB) rheological model and Navier-Stokes equation to derive a generic expression that predicts the capillary flow of non-Newtonian fluids. The Herschel-Bulkley rheological model encompasses a wide variety of fluids, including the Power-law fluids (also called Ostwald fluids), the Bingham fluids and the Newtonian fluids. It will be shown that the proposed equation reduces to the Lucas-Washburn-Rideal law for Newtonian fluids and to the Weissenberg-Rabinowitsch-Mooney (WRM) law for power-law fluids. Although HB model cannot reduce to Casson’s law, which is often used to model whole blood rheology, HB model can fit the whole blood rheology with the same accuracy.
Our generalized expression for the capillary flow of non-Newtonian fluid was used to accurately fit capillary flow of whole blood. The capillary filling of a cylindrical microchannel by whole blood was monitored. The blood first exhibited a Newtonian behavior, then after 7 cm low shear stress and rouleaux formation made LWR fails to fit the data: the blood could not be considered as Newtonian anymore. This non-Newtonian behavior was successfully fit by the proposed equation.
- spontaneous capillary flow,
- whole blood,
- non-Newtonian fluid,
- RBCs rouleaux,
- Herschel-Bulkley fluids,
- viscoelastic fluids,
- yield stress
Citation: David Gosselin, Maxime Huet, Myriam Cubizolles, David Rabaud, Naceur Belgacem, Didier Chaussy, Jean Berthier. Viscoelastic capillary flow: the case of whole blood[J]. AIMS Biophysics, 2016, 3(3): 340-357. doi: 10.3934/biophy.2016.3.340

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Abstract

The dynamics of spontaneous capillary flow of Newtonian fluids is well-known and can be predicted by the Lucas-Washburn-Rideal (LWR) law. However a wide variety of viscoelastic fluids such as alginate, xanthan and blood, does not exhibit the same Newtonian behavior.
In this work we consider the Herschel-Bulkley (HB) rheological model and Navier-Stokes equation to derive a generic expression that predicts the capillary flow of non-Newtonian fluids. The Herschel-Bulkley rheological model encompasses a wide variety of fluids, including the Power-law fluids (also called Ostwald fluids), the Bingham fluids and the Newtonian fluids. It will be shown that the proposed equation reduces to the Lucas-Washburn-Rideal law for Newtonian fluids and to the Weissenberg-Rabinowitsch-Mooney (WRM) law for power-law fluids. Although HB model cannot reduce to Casson’s law, which is often used to model whole blood rheology, HB model can fit the whole blood rheology with the same accuracy.
Our generalized expression for the capillary flow of non-Newtonian fluid was used to accurately fit capillary flow of whole blood. The capillary filling of a cylindrical microchannel by whole blood was monitored. The blood first exhibited a Newtonian behavior, then after 7 cm low shear stress and rouleaux formation made LWR fails to fit the data: the blood could not be considered as Newtonian anymore. This non-Newtonian behavior was successfully fit by the proposed equation.

References

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