Role of actin cytoskeleton at multiple levels of T cell activation

Martina Huranova; Ondrej Stepanek; Martina Huranova; Ondrej Stepanek

doi:10.3934/molsci.2016.4.585

AIMS Molecular Science

2016, Volume 3, Issue 4: 585-596. doi: 10.3934/molsci.2016.4.585

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Review Topical Sections

Role of actin cytoskeleton at multiple levels of T cell activation

Martina Huranova ,
Ondrej Stepanek ^,

Laboratory of Adaptive Immunity, Institute of Molecular Genetics, Czech Academy of Sciences, Videnska 1083, Prague, Czech Republic

Received: 10 August 2016 Accepted: 11 October 2016 Published: 18 October 2016

Actin cytoskeleton is an essential cellular structure that is involved in many physiological aspects, including T cell antigenic responses. In has been proposed that actin modulates biophysical parameters of the antigen recognition, forms a barrier inhibiting spontaneous signaling in resting T cells, facilitates TCR signal transduction, stabilizes contacts between T cells and antigen presenting cells, and contributes to the establishment of the antigen affinity threshold. In this review, we discuss the role of actin cytoskeleton at these particular levels of T cell activation.
- T cell,
- actin,
- cytoskeleton,
- TCR,
- signal transduction,
- antigen recognition,
- antigen affinity threshold,
- immunological synapse
Citation: Martina Huranova, Ondrej Stepanek. Role of actin cytoskeleton at multiple levels of T cell activation[J]. AIMS Molecular Science, 2016, 3(4): 585-596. doi: 10.3934/molsci.2016.4.585

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Abstract

Actin cytoskeleton is an essential cellular structure that is involved in many physiological aspects, including T cell antigenic responses. In has been proposed that actin modulates biophysical parameters of the antigen recognition, forms a barrier inhibiting spontaneous signaling in resting T cells, facilitates TCR signal transduction, stabilizes contacts between T cells and antigen presenting cells, and contributes to the establishment of the antigen affinity threshold. In this review, we discuss the role of actin cytoskeleton at these particular levels of T cell activation.

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