Review

Regulation of zebrafish gonadal sex differentiation

  • While the master regulator gene Sry on the mammalian Y chromosome controls the switch for initiating male sex differentiation, many other species rely on environmental factors for gonadal sex differentiation. Yet other species, like zebrafish, appears to rely on a multitude of genetic cues for gonadal sex differentiation. Zebrafish gonadal differentiation initiates with the onset of a juvenile ovary stage and depending on the influence of unknown genetic factors either maintains oocyte development or initiate apoptotic processes to override the female differentiation pathway. In this review, we explore the role of different factors and genes that have been reported to influence zebrafish gonadal sex differentiation. We also give a brief insight of primordial germ cell (PGC) involvement in shaping male and female signaling pathway in gonadal development.

    Citation: Ajay Pradhan, Per-Erik Olsson. Regulation of zebrafish gonadal sex differentiation[J]. AIMS Molecular Science, 2016, 3(4): 567-584. doi: 10.3934/molsci.2016.4.567

    Related Papers:

    [1] Xinyan Chen, Zhaohui Jiang, Qile Tai, Chunshan Shen, Yuan Rao, Wu Zhang . Construction of a photosynthetic rate prediction model for greenhouse strawberries with distributed regulation of light environment. Mathematical Biosciences and Engineering, 2022, 19(12): 12774-12791. doi: 10.3934/mbe.2022596
    [2] Xiaoyue Xie, Jian Shi . A distributed quantile estimation algorithm of heavy-tailed distribution with massive datasets. Mathematical Biosciences and Engineering, 2021, 18(1): 214-230. doi: 10.3934/mbe.2021011
    [3] Peihua Jiang, Longmei Shi . Statistical inference for a competing failure model based on the Wiener process and Weibull distribution. Mathematical Biosciences and Engineering, 2024, 21(2): 3146-3164. doi: 10.3934/mbe.2024140
    [4] M. Nagy, Adel Fahad Alrasheedi . The lifetime analysis of the Weibull model based on Generalized Type-I progressive hybrid censoring schemes. Mathematical Biosciences and Engineering, 2022, 19(3): 2330-2354. doi: 10.3934/mbe.2022108
    [5] Jing Cai, Jianfeng Yang, Yongjin Zhang . Reliability analysis of s-out-of-k multicomponent stress-strength system with dependent strength elements based on copula function. Mathematical Biosciences and Engineering, 2023, 20(5): 9470-9488. doi: 10.3934/mbe.2023416
    [6] Alessia Civallero, Cristina Zucca . The Inverse First Passage time method for a two dimensional Ornstein Uhlenbeck process with neuronal application. Mathematical Biosciences and Engineering, 2019, 16(6): 8162-8178. doi: 10.3934/mbe.2019412
    [7] Bo Dong, Alexey Luzin, Dmitry Gura . The hybrid method based on ant colony optimization algorithm in multiple factor analysis of the environmental impact of solar cell technologies. Mathematical Biosciences and Engineering, 2020, 17(6): 6342-6354. doi: 10.3934/mbe.2020334
    [8] Mehrdad Ahmadi Kamarposhti, Ilhami Colak, Kei Eguchi . Optimal energy management of distributed generation in micro-grids using artificial bee colony algorithm. Mathematical Biosciences and Engineering, 2021, 18(6): 7402-7418. doi: 10.3934/mbe.2021366
    [9] Luyao Yang, Zhikang Wang, Haochen Yu, Baoping Jiang, Zhengtian Wu . Aircraft route recovery based on distributed integer programming method. Mathematical Biosciences and Engineering, 2023, 20(7): 12802-12819. doi: 10.3934/mbe.2023571
    [10] Zheng-Ming Gao, Juan Zhao, Yu-Jun Zhang . Review of chaotic mapping enabled nature-inspired algorithms. Mathematical Biosciences and Engineering, 2022, 19(8): 8215-8258. doi: 10.3934/mbe.2022383
  • While the master regulator gene Sry on the mammalian Y chromosome controls the switch for initiating male sex differentiation, many other species rely on environmental factors for gonadal sex differentiation. Yet other species, like zebrafish, appears to rely on a multitude of genetic cues for gonadal sex differentiation. Zebrafish gonadal differentiation initiates with the onset of a juvenile ovary stage and depending on the influence of unknown genetic factors either maintains oocyte development or initiate apoptotic processes to override the female differentiation pathway. In this review, we explore the role of different factors and genes that have been reported to influence zebrafish gonadal sex differentiation. We also give a brief insight of primordial germ cell (PGC) involvement in shaping male and female signaling pathway in gonadal development.


    Abbreviations: ASAI: electric power distribution service reliability; GC: generalized Cauchy; ACF: autocorrelation function; LRD: long-range dependence; GRA: grey relational analysis; MLE: maximum likelihood estimation; ME: maximum error; PDF: probability density function; fBM: fractional Brownian motion; LSTM: long-short-term memory; MAE: mean absolute error; RMSE: root mean square error; SBTU: the sum of blackout time of users; MAPE: mean absolute percentage error; MAXE: max absolute percentage error

    The power system is one of the pillars of modern society and economy. Power outages cause considerable inconvenience to residents and extensive economic and non-economic losses. The causes of power outages are divided into failure interruption and scheduled interruption. Most of the significant power system accidents are caused by failure interruption. For example, the "8.14" power outage in the eastern United States-Canada was caused by a foreign-body short circuit; the aging equipment caused the "5.25" power outage in Moscow. These accidents have caused significant economic losses and endangered people's lives. However, the power enterprises inform consumers when the scheduled interruptions occur, and the outage losses become negligible. Failure interruptions are challenging to predict because of the randomness and abruptness. The main factors of failure interruption include product quality, climate reasons, equipment aging, foreign-body short circuit, other external factors, and construction influence. Predicting the main factors affecting power-supply reliability in the future through historical data is of great significance for power enterprises to take measures to improve reliability.

    Due to the burstiness of failure interruptions, there are hardly any papers exploring how to analyze and predict power-supply reliability and factors. Milad Doostan et al. [1] proposed Holt-Winters exponential smoothing method to predict vegetation-induced outage time in the distribution systems. This method combined weather and geographic data with past vegetation-related blackout information and predicted future blackout times. Using the random forest classifier, Roope et al. [2] studied the impact of convective storms on power outage loss. The historical data obtained from weather radar, ground weather observations, lightning detectors, and corresponding outage loss data are used as inputs for classification. The obtained model can predict the outage losses under extreme weather. B Chowdhury et al. [3] predicted whether there would be zero, one or two, or more outages when thunderstorms occur by using the weighted logistic regression random forest model and taking advantage of interruption data and weather forecast data. It can be seen that the purpose of the above study is only to analyze a specific factor without a comprehensive analysis of the main factors affecting power-supply reliability, so its significance for improving reliability is not as great as this paper. In addition, the study of power-supply reliability is divided into two aspects. One is to analyze reliability by establishing a mathematical model [4,5] of the distribution systems, including the least path method, fault tree analysis, minimum path set method, failure mode, effects analysis, etc. These methods need to draw the distribution systems structure diagram, so they are very complex. The other is to explore spatial-temporal features based on historical data to predict, including the gray prediction model [6], regression prediction method [7], auto-regressive integrated moving average (ARIMA) model [8], etc. Rajeevan et al. [8] established the reliability model of Wind Farm by using the load curve of the utility grid and the capacity outage probability table developed by the ARIMA wind speed model. Chen et al. [9] proposed to use the improved logistic regression method to predict the reliability of power equipment operation. Li et al. [10] used the least absolute deviation prediction method based on the particle swarm optimization algorithm to carry out the regression model on the power-supply reliability. However, the prediction principles of these methods do not take into account the LRD and self-similarity of the time series. Compared with the GC prediction model introduced in this paper, they have lower prediction accuracy.

    The GC prediction model is a statistical prediction method, based on historical data consistent with LRD. The LRD means that the changes in the subsequent data are influenced by the current and past data and can be represented by the H and D indicators. The GC process is quite different from the fractional Brownian motion (fBM) model [11], an LRD prediction model with the H and D indicators. There is a linear relationship between H and D. Nevertheless, these indicators of the GC process are two independent parameters, so they can more flexibly describe the long correlation process. The basic principle of the GC prediction model is as follows. First, calculate the time series indicators to determine whether the GC prediction model can predict the series. If it is satisfied, make use of the theory of the Ortigueira fractal linear system to generate the steady GC sequence. The increment of the GC sequence obeys Gaussian distribution, and the variance of increment in the same interval can be achieved through numerical simulation when distribution parameters are determined. Based on the Itˆo process and the application of Scholes and F.Black [12], along with Wang et al. [13] to fBM, the obtained Gaussian distribution can be substituted into the discrete expression for prediction. The drift coefficient and diffusion coefficient in stochastic differential equations (SDE) of the GC process can be obtained by maximum likelihood estimation (MLE) [14] because the GC process is the non-Markov process. It is not easy to get the Probability Distribution Function (PDF) directly, so the approximate PDF can be acquired using the Monte Carlo simulation method.

    GRA focuses on a dynamic system variable to judge the influence degree of its influencing factors on the system. It provides a reference for the development and changing trend of the system and has been applied in distribution systems. It is generally divided into two aspects, one is to sort the factors that affect the systems, and the other is to evaluate different schemes and select the best one. Niu et al. [15] proposed a new short-term empirical mode decomposition-grey relationship analysis-modified particle swarm optimization-least square vector machine load prediction model. The function of GRA is to find out the main influencing factors from many influencing factors and carry out load prediction. Akay et al. [16] proposed a new power quality understanding and evaluation method for low-voltage DC distribution systems through the analytic hierarchy process and entropy weighting coefficient method. GRA is used to calculate the correlation coefficient between the power quality level of the scheme to be evaluated and the ideal power quality to evaluate its power quality. Therefore, it is reasonable to use GRA in this paper to find the main factors affecting power-supply reliability.

    The case study data is the power outage events of the power grid in Shanghai in 2019. By calculating the H and D indicators of outage time series, they all meet the requirements of the GC prediction model, which shows that this model has important application prospects in the power-supply reliability prediction of distribution networks. The result proves that the GC prediction model has better performance than the fBM, LSTM, and DANN (deterministic annealing neural network) [17,18]. The correlation coefficient between the reliability index ASAI of distribution systems and the influencing factors is calculated by GRA to predict the main factors affecting power-supply reliability. According to the conclusion, corresponding technical measures and management methods can be taken in advance to reduce the occurrence of fault interruptions and power outage losses. This method can improve the operation and maintenance level of the power grid and the reliability of the power supply of the distribution system.

    The organization of this paper is as follows. Section 2 mainly describes the analysis of the GC process. Section 3 combines the actual situation, using the GC prediction model and GRA to predict the power-supply reliability and analyze the factors of power failure in Shanghai. The prediction results prove the effectiveness of the prediction model. The last section summarizes and analyzes the whole article.

    If Y(t) is the stationary Gaussian process and its autocorrelation function (ACF) satisfies Eq (1), it is said to be the generalized Cauchy (GC) process [19].

    FYY(τ)=(1+|τ|42D)1H2D (1)

    Here D is the fractal dimension parameter, H is the Hurst parameter and the time interval is denoted as τ. The fractal characteristics [20] show that D and H reveal the local irregularity and global LRD the characteristics of the GC process when 1.5D<2 and 0.5<H<1, respectively.

    Figure 1 shows the ACF curves of the GC process under different parameter values, which show the influence of different H and D indicators on the correlation. It can be seen ACF curve approaches 0 within a short time interval for H<0.5. This indicates that in this case, the time series does not have LRD characteristics. And when H>0.5, the larger the value of H, the higher the ACF curve, which indicates that the larger the value of H, the stronger the LRD characteristics of the time series. In addition, the larger the value of D, the more the curve of ACF approaches 0, which indicates that the larger the value of D, the more complex the time series, and the weaker the LRD characteristics.

    Figure 1.  ACF curve of GC process under different parameters.

    According to probability theory, a heavy-tailed distribution represents a probability distribution whose tails are not exponentially bounded. That is, the tails are "heavier" or "thicker" than the exponential distribution.

    Supposing a random variable Y, its cumulative distribution function can be written in the following form:

    F(y)=P(Y>y) (2)

    If this random variable Y satisfies the following equation:

    limyeρy(1F(y))= (3)

    The distribution of Y is said to be a heavy-tailed distribution, where ρ is a constant arbitrarily greater than 0. According to the properties of the cumulative distribution function,

    0F(y)1 (4)
    01F(y)1 (5)

    eρy is a monotonically increasing exponential function greater than 0. The following form can be obtained by transforming Eq (3).

    limy1F(y)eρy= (6)

    when y, both the numerator and denominator of Eq (6) tend to 0. According to the rule of infinitesimal operation, the limit of Eq (6) is infinity, then the denominator eρy is a higher order infinitesimal of the numerator 1F(y), which means that the random variable Y obeys a distribution that decays more slowly than the exponential distribution when y. This also means that the tails of the heavy-tailed distribution decay more slowly than the tails of the exponential distribution.

    From the Taqqu's law [21], we can obtain that the stochastic process exhibits a heavy-tail on the PDF, which is equivalent to the LRD characteristics on the ACF. The ACF of random process {Y(t),0<t<} at time t1,t2 can be represented by PDF f(x:t1,t2) .

    ry(t1,t2)=E[y(t1)y(t2)]=y(t1)y(t2)fGC(y;t1,t2)dy(t1)dy(t2) (7)

    It follows from Eq (7), that slow decay of PDF leads to the slow decay of ACF. This enables us to state the existence of the strong internal relationship between the heavy tail of PDF analysis and the LRD characteristics of ACF analysis.

    The Cauchy distribution is also a heavy-tailed distribution, and its PDF expression is:

    p(y;ξ,ϖ)=1πϖ[1+(yξϖ)2] (8)

    where the ξ is position parameter, the range parameter ϖ indicates the discrete degree. When ξ=1 , ϖ=0, the above formula can be simplified as:

    p(y)=1π(1+y2) (9)

    In the description of time series, mean and variance are two important statistical characteristics. The former is used to describe the global nature of the time series, that is, the overall development trend of the sequence, similar to the H indicator in the previous section. The latter is used to describe the local nature, that is, the local concentration of the sequence, similar to the D indicator in the previous section. Let ψ and ϱ be the mean and variance of the Cauchy distribution. Their equations are:

    Ψ=yp(y)dy=yπ(1+y2)dy= (10)
    ϱ=y2p(y)dy=y2π(1+y2)dy= (11)

    Since the mean and variance of the Cauchy distribution are infinite, its mean and variance do not exist. This is also the reason why the H and D exponents are used to represent the LRD characteristics. Another PDF equation for the GC process is given by Carrillo et al.

    fGC(y)=ρΓ(2/ρ)ϖ2(Γ(1/ρ))2(ϖρ+|yξ|ρ)2/ρ (12)

    the heavy-tailed parameter ρ indicates the heavy-tailed degree of the PDF. When 0<ρ2, the GC process is a heavy-tailed distribution. Γ() represents the gamma function. In Figure 2, the influence of the parameters of the GC process on the PDF is shown. The parameters μ, γ, and ρ in Figure 2 are position parameters, range parameters, and heavy-tailed parameters, respectively. The range parameter is the symmetry axis of the GC PDF. The range parameter indicates the discrete degree of PDF. The smaller the range parameter, the more concentrated the value of the points in the PDF. The heavy-tailed parameter indicates the heavy-tailed degree of the PDF. The smaller the heavy-tailed parameter, the heavier the tail of the PDF. The GC process is a heavy-tailed distribution when 0<ρ2.

    Figure 2.  PDF of GC process.

    The theory of Ortigueira fractal linear system [22,23] shows that steady-state time series can be obtained through white noise and filters, and the specific process is:

    h(t)=s(t)g(t)=t0g(tτ)s(τ)dτ (13)

    where s(t) is Gaussian white noise obtained by random function, g(t) is the impulse function, τ is the time interval, and h(t) is the generated stationary time series. Similarly, non-stationary white noise can be passed through the linear filter to obtain non-stationary time series, so GC sequence can be obtained by combining Gaussian white noise and impulse function. The concrete form is as follows.

    The power spectrum g(w) of Y(t) is the Fourier transform of the ACF of it, as shown in Eq (14). g(w) is related to the impulse function g(t) as follow.

    g(w)=F[(1+|τ|42D)1H2D] (14)
    g(t)=F1[F((1+|τ|42D)1H2D)0.5] (15)

    And the power spectrum of unit white noise is S(w), where θ(w) is the random function. The Fourier inverse transform is carried out to obtain the Gaussian white noise function s(t) as shown in Eq (16).

    s(t)=F1[S(w)]=12πejθejwtdw (16)

    By substituting Eqs (15) and (16) into (13), the expression of GC sequence can be obtained as shown in Eq (17).

    h(t)=12πejθejwtdwF1[F((1+|τ|42D)1H2D)0.5] (17)

    where F() and F1() are respectively Fourier transform and the inverse transform. The process of the procedure for generating the increment of GC sequence is shown in Figure 3. When H = 0.55, D = 1.2, the GC difference time sequence is obtained by difference and the result is shown in Figure 4.

    Figure 3.  Flowchart of the procedure for generating the increment of GC sequence.
    Figure 4.  GC difference time sequence.

    Based on the definition of the Itˆo process, the GC process can be regarded as the stochastic interference term with LRD property. Therefore, the stochastic differential equation (SDE) of the Ito process driven by the GC process is:

    dY(t)=(t)dt+(t)dh(t) (18)

    (t) is the drift coefficient, h(t) is the GC time series generated by Gaussian white noise and impulse function, and (t) is the diffusion coefficient. The drift coefficient represents the overall degradation trend of the degradation process, while the diffusion coefficient represents the uncertainty of the degradation quantity in the degradation process.

    According to the improvement of the fBm model by Scholes, F. Black and Wang et al, they established the Black-Scholes model to describe the trend of the financial option Bt :

    dBt=μBtdt+δBtdFH(t) (19)

    where F(t) is the fBm. The stochastic sequence forecasting model based on the GC process is obtained by combining Eqs (18) and (19), and the form is as follow:

    dY(t)=(t)Y(t)dt+(t)Y(t)dh(t) (20)

    The distribution of increment Δh(t) in the GC process can be obtained by statistical reasoning. The specific solution process is as follows:

    Step 1: Generate a sequence of GC process values according to Eq (17).

    Step 2: Determine the time interval τ, and the difference of the two-state quantities with the interval τ in the sequence, namely,

    Δh(t)=h(t+τ)h(t) (21)

    Step 3: Step 2 is repeated for the time series generated by Step 1, and multiple differences are made to construct an incremental set.

    Step 4: Find the variance of the set distribution. When the increment interval τ is specified, the increment follows the Gaussian distribution, that is, Δh(t) N(0,τ).Thus,

    Δh(t)=h(t+τ)h(t) N(0,τ) (22)

    And because

    ΔY(t)=Y(t+τ)Y(τ) (23)

    Substituting Eqs (22) and (23) into (20), when τ=1, the GC prediction model is obtained:

    Y(t+1)=Y(t)+(t)Y(t)Δt+(t)Y(t)Δh(t) (24)

    Now there are some methods used to compute D and H roughly. For instance, box dimension, root mean square method, and spectroscopy is used to get the value of D. But some methods of these have a slight error, such as spectroscopy. It is better to use the method of box dimension to obtain the fractal dimension. The periodic graph method, the variance method, rescaled range method, and the absolute value method is used to get the value of H. The rescaled range method is commonly used to estimate the parameter value of H. The specific solving processes are as [24].

    There are still two parameter values, including drift coefficient and diffusion coefficient in the above formula, that have not been determined, so some parameter solving method is needed to obtain the parameter values. Given the time series Y(t), the maximum likelihood estimation (MLE) method can be used to calculate the above two parameters. The specific steps are shown in [25].

    Therefore, the flowchart of the procedure of GC prediction model is shown in Figure 5.

    Figure 5.  Flowchart of the procedure for generating the increment of GC sequence.

    To evaluate the predictive performance of the GC prediction model, we used the outage data of the Shanghai power grid in 2019 to predict and analyze the power-supply reliability indicator (ASAI) of the power grid. The formulas of ASAI are as Eqs (25) and (26). The total number of users in Shanghai in 2019 is 166, 554, and the total number of hours in one year is 8760. It is easy to see that the ASAI for the same period is almost uniform because of the large base numbers. The calculation results have shown that the ASAI is about 99.9999% every day, and the values are very close to each other. If the ASAI is predicted directly, the prediction model must have a very high degree of accuracy, leading to significant error. However, according to the formula, if we get the sum of blackout time of users (SBTU), we can also calculate ASAI straightforwardly. Therefore, predicting ASAI by forecasting SBTU will make the results more accurate. According to statistics, the SBTU of every day in Shanghai in 2019 is shown in Figure 6.

    AIHC=SBTU/8760 (25)
    ASAI=(1AIHC/166554)100% (26)
    Figure 6.  Daily blackout time of users in Shanghai in 2019.

    where the total number of customers is 166, 554, the average customer outage time is named AIHC and the total number of hours in one year is 8760.

    As shown in Figure 6, the curve fluctuates wildly after the 220th day, which is an abnormal phenomenon. Suppose the GC prediction model can be used to make predictions for extreme situations. In that case, this shows the accuracy of the GC prediction model, which will also enlighten the power sector to improve the power supply reliability in the distribution systems. Therefore, this article uses the data of the first 220 days as the training set to predict the data of 10, 20, and 30 days. By calculating the H and D indicators of SBTU data in the first 220 days, the result is that H is 0.5341 and D is 1.4709. It satisfies the application requirements of the GC prediction model. The historical data were brought into this model. MAE (mean absolute error), MAPE (mean absolute percentage error), MAXE (max absolute percentage error), RMSE (mean square root error), and ME (maximum error) generated by different forecasting days have been calculated. The results are shown in Table 1.

    Table 1.  The errors of different forecast days.
    Prediction days MAE MAPE RMSE ME MAXE
    10 15.06 5.75 20.59 42.3 8.28
    20 19.72 7.84 26.45 67.24 10.87
    30 22.41 8.94 29.75 78.46 12.92

     | Show Table
    DownLoad: CSV

    From the data in Table 1, it can be seen that when the number of prediction days is 10 days, the prediction effect of the GC prediction model is better. The prediction result is shown in Figure 7.

    Figure 7.  The prediction effects of GC.

    We compared this method with LSTM, DANN, and fBM. The principle of these models is shown below. LSTM is a special RNN (recurrent neural network), which is different from adding three structures to RNN: forget gate, input gate, and output gate. It is proposed to solve the problem of gradient disappearance and gradient explosion in the long sequence training process. The basic principle of DANN is as follow. The barrier and Lagrange functions with neural network are integrated to obtain this method. The annealing technique is used to control the barrier parameter and the Lagrange function and neural network are applied to control the solution parameters. However, given the common feature of annealing algorithms, the performance of DANN partly depends on the selected parameters. Thus, its prediction effect is not stable. fBM contains the Hurst exponent, which is a parameter that describes the LRD, so fBM has LRD characteristics. The principle of this model is to use the drift term to describe the trend term of the degradation process and use the fBM-driven diffusion term to describe the randomness and LRD of the degradation process.

    The prediction results of the SBTU are shown in Figure 8. MAE, MAPE, RMSE, and ME generated by different forecasting methods have been calculated. The results are shown in Table 2. It can be seen that the prediction accuracy of the GC prediction model is significantly higher than that of LSTM, fBM and DANN. These models have some drawbacks compared to GC prediction model.

    Figure 8.  The prediction effects of different models.
    Table 2.  The errors of different forecast models.
    Prediction model MAE MAPE RMSE ME MAXE
    GC 15.06 5.75 20.59 42.3 8.28
    fBM 21.54 8.15 25.72 59.46 11.57
    LSTM 41.96 15.81 32.76 108.72 85.47
    DANN 35.51 22.61 37.69 52.29 40.10

     | Show Table
    DownLoad: CSV

    LSTM does not fully take advantage of the LRD of random sequences. And the GC prediction model fully considers this property, so its prediction accuracy is higher than LSTM. Besides, because there are four fully connected layers in each LSTM cell tuple, if the network is profound or the time is considerable, it requires a lot of training data and training time. The optimal values of DBNN model parameters cannot be calculated theoretically, but can only be obtained from experience and experiments. Therefore, the calculation of this method is very cumbersome, and its prediction accuracy is lower than that of GC prediction model. fBM has a linear relationship between Hurst exponent and fractal dimension, so only one parameter is used to describe the LRD characteristics of random sequences. Compared with the fBM model, the advantage of the GC model is that the Hurst exponent and fractal dimension are independent parameters, so the model has higher flexibility and accuracy.

    By comparing the prediction results of the GC model with that of LSTM, DANN, and fBM in Figure 8, it can be seen that the prediction effect of the GC prediction model is much better than them. By bringing the prediction results of SBTU into Eqs (25) and (26), the prediction data of ASAI can be obtained. The results are shown in Figure 9.

    Figure 9.  The prediction results of ASAI.

    As mentioned above, we have predicted the changing trend of ASAI. Suppose we can get the significant factors affecting ASAI in the future. In that case, it will be of great significance for regulating the distribution network and improving power-supply reliability. According to the classification of responsibility causes in power industry standard DLT836.2-2016, the fault causes can be divided into these categories: product quality, equipment aging, operation maintenance, vehicle damage, animal reason, foreign-body short circuit, construction influence, other external factors, failure of power transmission and transformation facilities, climate reasons and user impact. According to statistics, SBTU is caused by different causes, as shown in Figure 10.

    Figure 10.  SBTU for different factors.

    According to the data in this figure, the factors that have a significant impact on power-supply reliability can be selected from many influencing factors, which are distributed as follows: product quality, equipment aging, foreign-body short circuit, construction influence, other external factors, and climate reasons. This paper uses the GC prediction model to predict SBTU for these reasons. GRA is used to analyze SBTU and ASAI data obtained above to determine the main influencing factors of future power-supply reliability. By calculating the H and D values of SBTU data for different reasons in the first 220 days, the results are shown in Table 3.

    Table 3.  H value and D value under different factors.
    H D
    Product quality 0.5231 1.4303
    Other external factors 0.5743 1.3983
    Climate reasons 0.5378 1.3814
    Equipment aging 0.5168 1.4253
    Foreign-body 0.638 1.3854
    Construction influence 0.5013 1.3861

     | Show Table
    DownLoad: CSV

    It can be seen from Table 3 that both H and D under different factors meet the requirements of the GC prediction model. Bring the historical data of SBTU under different factors into the model, and the prediction results are shown in Figure 11. We analyze the relationship between the prediction results of ASAI and SBTU under different outage factors by GRA, so as to obtain the correlation coefficient between different outage factors and ASAI. The prediction results and correlation coefficients of different factors are shown in Table 4. The essence of GRA is to consider the correlation degree of changes between curves of different numbers. The prediction results in Figure 11 are mean normalized, and the results are shown in Figure 12.

    Figure 11.  SBTU prediction results under different factors in a state of great fluctuation.
    Table 4.  The correlation coefficient between predicted values of ASAI and different factors.
    ASAI (%) Product quality Other external factors Climate reasons Equipment aging Foreign-body
    short circuit
    Construction
    influence
    1 99.99994203 0.1 4.79 20.16 240.01 53.73 0.3
    2 99.99994005 0.4 2.09 40.65 69.25 2.62 49.05
    3 99.99998228 0.24 0.81 6.73 35.93 1.67 2.86
    4 99.99998457 0.68 10.57 53.65 28.21 0.8 2.24
    5 99.99999124 1.3 5.89 451.84 53.17 0.16 0.24
    6 99.99999442 0.75 2.11 483.57 25.71 2.69 0.75
    7 99.99999505 0.25 9.04 426.85 67.15 2.31 2.07
    8 99.99999026 1.55 50.82 118.21 160.51 0.51 1.36
    9 99.99999758 1.48 3.56 2.85 85.32 2.62 0.85
    10 99.9999909 0.38 24.56 12.82 12.2 2.18 0.32
    correlation coefficients 0.7597 0.9165 0.7808 0.9607 0.9498 0.7813

     | Show Table
    DownLoad: CSV
    Figure 12.  Normalized results of data.

    According to the calculation results of correlation the coefficient in Table 4, the correlation coefficient of predicted main factors affecting ASAI is sorted from large to small: equipment aging, foreign-body short circuit, other external factors, construction influence, climate reasons, and product quality. Furthermore, the correlation coefficient between actual data ASAI and SBTU with different outage causes is calculated in Table 5. It can be seen that the actual main factors affecting ASAI are sorted from large to small: equipment aging, other external factors, foreign-body short circuits, construction influence, product quality, and climate reasons.

    Table 5.  Correlation coefficient between predicted values of ASAI and different factors.
    Failure factors Correlation coefficients
    Product quality 0.918
    Other external factors 0.9254
    Climate reasons 0.7652
    Equipment aging 0.9534
    Foreign-body short circuit 0.9234
    Construction influence 0.9231

     | Show Table
    DownLoad: CSV

    It can be seen from the results that the top three factors affecting reliability obtained by using forecast data are the same as the conclusion calculated from the actual data. Therefore, it can be considered that it is feasible to find the main influencing factors of ASAI in the future through the GRA of the predicted values.

    This paper describes the GC prediction model with LRD features and GRA and applies it to the reliability prediction field of distribution networks. Based on the case study results, this model is used to predict ASAI with good accuracy of the prediction results. In addition, it is used to predict the outage time for different reasons and combined with the power supply reliability index for GRA, which can effectively predict the main factors affecting power supply reliability in the future. This method is vital for power companies to improve the reliability of power supply in distribution networks.

    It is worth to note that the primary purpose of this paper is to analyze the factors affecting the reliability of the power supply network by correlation analysis between the predicted data. However, the GC prediction model can be used as long as it is a random sequence that satisfies the LRD characteristics. For example, in industrial equipment, bearing failure is a common factor leading to a generator failure, so the model can simulate the degradation trend of bearings and thus predict the time of generator failure. In the field of energy and power, wind power generation is related to real-time wind speed. The time series of wind speed is stochastic, so a GC prediction model can predict the wind speed and thus obtain the power generation. From the above cases, we can find that the GC prediction model is also widely used in other fields.

    The work was supported by major project in Ministry of Science and Technology of the People's Republic of China, Grand number: 2020AAA0109301. The name of this major project is Science and technology innovation 2030 "new generation of AI".

    The authors declare there is no conflict of interest.

    [1] Dooley K, Zon LI (2000) Zebrafish: a model system for the study of human disease. Curr Opin Genet Dev 10: 252-256. doi: 10.1016/S0959-437X(00)00074-5
    [2] Goldsmith JR, Jobin C (2012) Think Small: Zebrafish as a Model System of Human Pathology. J Biomed Biotechnol 2012: 817341.
    [3] Lieschke GJ, Currie PD (2007) Animal models of human disease: zebrafish swim into view. Nat Rev Genet 8: 353-367. doi: 10.1038/nrg2091
    [4] Mandrekar N, Thakur NL (2009) Significance of the zebrafish model in the discovery of bioactive molecules from nature. Biotechnol Lett 31: 171-179. doi: 10.1007/s10529-008-9868-1
    [5] Zon LI, Peterson RT (2005) In vivo drug discovery in the zebrafish. Nat Rev Drug Discov 4: 35-44. doi: 10.1038/nrd1606
    [6] Skakkebaek NE, Jorgensen N, Main KM, et al. (2006) Is human fecundity declining? Int J Androl 29: 2-11. doi: 10.1111/j.1365-2605.2005.00573.x
    [7] Dumesic DA, Abbott DH, Padmanabhan V (2007) Polycystic ovary syndrome and its developmental origins. Rev Endocr Metab Disord 8: 127-141. doi: 10.1007/s11154-007-9046-0
    [8] van der Zwan YG, Biermann K, Wolffenbuttel KP, et al. (2014) Gonadal Maldevelopment as Risk Factor for Germ Cell Cancer: Towards a Clinical Decision Model. Eur Urol 67: 692-701.
    [9] Wilhelm D, Palmer S, Koopman P (2007) Sex determination and gonadal development in mammals. Physiol Rev 87: 1-28. doi: 10.1152/physrev.00009.2006
    [10] Angelopoulou R, Lavranos G, Manolakou P (2012) Sex determination strategies in 2012: towards a common regulatory model? Reprod Biol Endocrinol 10: 13. doi: 10.1186/1477-7827-10-13
    [11] Devlin RH, Nagahama Y (2002) Sex determination and sex differentiation in fish: an overview of genetic, physiological, and environmental influences. Aquaculture 208: 191-364.
    [12] Liew WC, Bartfai R, Lim Z, et al. (2012) Polygenic sex determination system in zebrafish. PLoS One 7: e34397. doi: 10.1371/journal.pone.0034397
    [13] Liew WC, Orban L (2013) Zebrafish sex: a complicated affair. Brief Funct Genom 13: 172-187.
    [14] Ser JR, Roberts RB, Kocher TD (2010) Multiple interacting loci control sex determination in lake Malawi cichlid fish. Evolution 64: 486-501. doi: 10.1111/j.1558-5646.2009.00871.x
    [15] Vandeputte M, Dupont-Nivet M, Chavanne H, et al. (2007) A polygenic hypothesis for sex determination in the European sea bass Dicentrarchus labrax. Genetics 176: 1049-1057.
    [16] Matsuda M, Nagahama Y, Shinomiya A, et al. (2002) DMY is a Y-specific DM-domain gene required for male development in the medaka fish. Nature 417: 559-563. doi: 10.1038/nature751
    [17] Barske LA, Capel B (2008) Blurring the edges in vertebrate sex determination. Curr Opin Genet Dev 18: 499-505. doi: 10.1016/j.gde.2008.11.004
    [18] Sato E, Endo T, Yamahira K, et al. (2005) Induction of female-to-male sex reversal by high temperature treatment in Medaka, Oryzias latipes. Zoolog Sci 22: 985-988. doi: 10.2108/zsj.22.985
    [19] Ospina-Alvarez N, Piferrer F (2008) Temperature-dependent sex determination in fish revisited: prevalence, a single sex ratio response pattern, and possible effects of climate change. PLoS One 3: e2837. doi: 10.1371/journal.pone.0002837
    [20] Takahashi H (1977) Juvenile Hermaphroditism in the Zebrafish, Brachydanio rerio. Bull Fac Fish Hokkaido Univ 28: 57-65.
    [21] Wang XG, Bartfai R, Sleptsova-Freidrich I, et al. (2007) The timing and extent of 'juvenile ovary' phase are highly variable during zebrafish testis differentiation. J Fish Biol 70: 33-44. doi: 10.1111/j.1095-8649.2007.01363.x
    [22] Siegfried KR, Nusslein-Volhard C (2008) Germ line control of female sex determination in zebrafish. Dev Biol 324: 277-287. doi: 10.1016/j.ydbio.2008.09.025
    [23] Luzio A, Monteiro SM, Garcia-Santos S, et al. (2015) Zebrafish sex differentiation and gonad development after exposure to 17alpha-ethinylestradiol, fadrozole and their binary mixture: A stereological study. Aquat Toxicol 166: 83-95. doi: 10.1016/j.aquatox.2015.07.015
    [24] Uchida D, Yamashita M, Kitano T, et al. (2002) Oocyte apoptosis during the transition from ovary-like tissue to testes during sex differentiation of juvenile zebrafish. J Exp Biol 205: 711-718.
    [25] Pradhan A, Khalaf H, Ochsner SA, et al. (2012) Activation of NF-kappaB protein prevents the transition from juvenile ovary to testis and promotes ovarian development in zebrafish. J Biol Chem 287: 37926-37938. doi: 10.1074/jbc.M112.386284
    [26] Sola L, Gornung E (2001) Classical and molecular cytogenetics of the zebrafish, Danio rerio (Cyprinidae, Cypriniformes): an overview. Genetica 111: 397-412. doi: 10.1023/A:1013776323077
    [27] Wallace B-M, Wallace H (2003) Synaptonemal complex karyotype of zebrafish. Heredity 90: 136-140. doi: 10.1038/sj.hdy.6800184
    [28] Traut W, Winking H (2001) Meiotic chromosomes and stages of sex chromosome evolution in fish: zebrafish, platypus and guppy. Chromosome Res 9: 659-672. doi: 10.1023/A:1012956324417
    [29] Phillips RB, Reed KM (2000) Localization of repetitive DNAs to zebrafish (Danio rerio) chromosomes by fluorescence in situ hybridization (FISH). Chromosome Res 8: 27-35. doi: 10.1023/A:1009271017998
    [30] Singer A, Perlman H, Yan Y, et al. (2002) Sex-specific recombination rates in zebrafish (Danio rerio). Genetics 160: 649-657.
    [31] Tong SK, Hsu HJ, Chung BC (2010) Zebrafish monosex population reveals female dominance in sex determination and earliest events of gonad differentiation. Dev Biol 344: 849-856. doi: 10.1016/j.ydbio.2010.05.515
    [32] Sharma KK, Sharma OP, Tripathi NK (1998) Female heterogamety in Danio rerio (Cypriniformes: Cyprinidae). Proc Natl Acad Sci India Sect B 68: 123-126.
    [33] Wilson CA, High SK, McCluskey BM, et al. (2014) Wild sex in zebrafish: loss of the natural sex determinant in domesticated strains. Genetics 198: 1291-1308. doi: 10.1534/genetics.114.169284
    [34] Shang EH, Yu RM, Wu RS (2006) Hypoxia affects sex differentiation and development, leading to a male-dominated population in zebrafish (Danio rerio). Environ Sci Technol 40: 3118-3122. doi: 10.1021/es0522579
    [35] Villamizar N, Ribas L, Piferrer F, et al. (2012) Impact of daily thermocycles on hatching rhythms, larval performance and sex differentiation of zebrafish. PLoS One 7: e52153. doi: 10.1371/journal.pone.0052153
    [36] Luzio A, Santos D, Fontainhas-Fernandes AA, et al. (2016) Effects of 17alpha-ethinylestradiol at different water temperatures on zebrafish sex differentiation and gonad development. Aquat Toxicol 174: 22-35. doi: 10.1016/j.aquatox.2016.02.003
    [37] Bradley KM, Breyer JP, Melville DB, et al. (2011) An SNP-based linkage map for zebrafish reveals sex determination loci. G3 (Bethesda) 1: 3-9. doi: 10.1534/g3.111.000190
    [38] Anderson JL, Rodriguez Mari A, Braasch I, et al. (2012) Multiple sex-associated regions and a putative sex chromosome in zebrafish revealed by RAD mapping and population genomics. PLoS One 7: e40701. doi: 10.1371/journal.pone.0040701
    [39] Mishima Y, Giraldez AJ, Takeda Y, et al. (2006) Differential regulation of germline mRNAs in soma and germ cells by zebrafish miR-430. Curr Biol 16: 2135-2142. doi: 10.1016/j.cub.2006.08.086
    [40] Staton AA, Knaut H, Giraldez AJ (2011) miRNA regulation of Sdf1 chemokine signaling provides genetic robustness to germ cell migration. Nat Genet 43: 204-211. doi: 10.1038/ng.758
    [41] von Hofsten J, Olsson PE (2005) Zebrafish sex determination and differentiation: involvement of FTZ-F1 genes. Reprod Biol Endocrinol 3: 63. doi: 10.1186/1477-7827-3-63
    [42] Orban L, Sreenivasan R, Olsson PE (2009) Long and winding roads: testis differentiation in zebrafish. Mol Cell Endocrinol 312: 35-41. doi: 10.1016/j.mce.2009.04.014
    [43] Rodriguez-Mari A, Yan YL, Bremiller RA, et al. (2005) Characterization and expression pattern of zebrafish Anti-Mullerian hormone (Amh) relative to sox9a, sox9b, and cyp19a1a, during gonad development. Gene Expr Patterns 5: 655-667.
    [44] Luzio A, Coimbra AM, Benito C, et al. (2015) Screening and identification of potential sex-associated sequences in Danio rerio. Mol Reprod Dev 82: 756-764. doi: 10.1002/mrd.22508
    [45] Sim H, Argentaro A, Harley VR (2008) Boys, girls and shuttling of SRY and SOX9. Trends Endocrinol Metab 19: 213-222. doi: 10.1016/j.tem.2008.04.002
    [46] Biason-Lauber A (2010) Control of sex development. Best Pract Res Clin Endocrinol Metab 24: 163-186. doi: 10.1016/j.beem.2009.12.002
    [47] Koopman P (2005) Sex determination: a tale of two Sox genes. Trends Genet 21: 367-370. doi: 10.1016/j.tig.2005.05.006
    [48] Sekido R, Lovell-Badge R (2009) Sex determination and SRY: down to a wink and a nudge? Trends Genet 25: 19-29. doi: 10.1016/j.tig.2008.10.008
    [49] Ross AJ, Capel B (2005) Signaling at the crossroads of gonad development. Trends Endocrinol Metab 16: 19-25. doi: 10.1016/j.tem.2004.11.004
    [50] Jakob S, Lovell-Badge R (2011) Sex determination and the control of Sox9 expression in mammals. FEBS J 278: 1002-1009. doi: 10.1111/j.1742-4658.2011.08029.x
    [51] Kocer A, Reichmann J, Best D, et al. (2009) Germ cell sex determination in mammals. Mol Hum Reprod 15: 205-213. doi: 10.1093/molehr/gap008
    [52] Sreenivasan R, Cai M, Bartfai R, et al. (2008) Transcriptomic analyses reveal novel genes with sexually dimorphic expression in the zebrafish gonad and brain. PLoS One 3: e1791. doi: 10.1371/journal.pone.0001791
    [53] Jorgensen A, Morthorst JE, Andersen O, et al. (2008) Expression profiles for six zebrafish genes during gonadal sex differentiation. Reprod Biol Endocrinol 6: 25. doi: 10.1186/1477-7827-6-25
    [54] Bowles J, Feng CW, Spiller C, et al. (2010) FGF9 suppresses meiosis and promotes male germ cell fate in mice. Dev Cell 19: 440-449. doi: 10.1016/j.devcel.2010.08.010
    [55] Jameson SA, Lin YT, Capel B (2012) Testis development requires the repression of Wnt4 by Fgf signaling. Dev Biol 370: 24-32. doi: 10.1016/j.ydbio.2012.06.009
    [56] Colvin JS, Green RP, Schmahl J, et al. (2001) Male-to-female sex reversal in mice lacking fibroblast growth factor 9. Cell 104: 875-889. doi: 10.1016/S0092-8674(01)00284-7
    [57] Lasala C, Carre-Eusebe D, Picard JY, et al. (2004) Subcellular and molecular mechanisms regulating anti-Mullerian hormone gene expression in mammalian and nonmammalian species. DNA Cell Biol 23: 572-585. doi: 10.1089/dna.2004.23.572
    [58] Lourenco D, Brauner R, Rybczynska M, et al. (2011) Loss-of-function mutation in GATA4 causes anomalies of human testicular development. Proc Natl Acad Sci U S A 108: 1597-1602. doi: 10.1073/pnas.1010257108
    [59] Miyamoto Y, Taniguchi H, Hamel F, et al. (2008) A GATA4/WT1 cooperation regulates transcription of genes required for mammalian sex determination and differentiation. BMC Mol Biol 9: 44. doi: 10.1186/1471-2199-9-44
    [60] Hattori RS, Murai Y, Oura M, et al. (2012) A Y-linked anti-Mullerian hormone duplication takes over a critical role in sex determination. Proc Natl Acad Sci U S A 109: 2955-2959. doi: 10.1073/pnas.1018392109
    [61] Wang XG, Orban L (2007) Anti-Mullerian hormone and 11 beta-hydroxylase show reciprocal expression to that of aromatase in the transforming gonad of zebrafish males. Dev Dyn 236: 1329-1338. doi: 10.1002/dvdy.21129
    [62] Kluver N, Pfennig F, Pala I, et al. (2007) Differential expression of anti-Mullerian hormone (amh) and anti-Mullerian hormone receptor type II (amhrII) in the teleost medaka. Dev Dyn 236: 271-281. doi: 10.1002/dvdy.20997
    [63] Kamiya T, Kai W, Tasumi S, et al. (2012) A Trans-Species Missense SNP in Amhr2 Is Associated with Sex Determination in the Tiger Pufferfish, Takifugu rubripes (Fugu). PLoS Genet 8: e1002798.
    [64] Pradhan A, Olsson PE (2014) Juvenile Ovary to Testis Transition in Zebrafish Involves Inhibition of Ptges. Biol Reprod 91: 33. doi: 10.1095/biolreprod.114.119016
    [65] Sreenivasan R, Jiang J, Wang X, et al. (2013) Gonad Differentiation in Zebrafish Is Regulated by the Canonical Wnt Signaling Pathway. Biol Reprod 90: 45.
    [66] Kazanskaya O, Glinka A, del Barco Barrantes I, et al. (2004) R-Spondin2 is a secreted activator of Wnt/beta-catenin signaling and is required for Xenopus myogenesis. Dev Cell 7: 525-534. doi: 10.1016/j.devcel.2004.07.019
    [67] Jin YR, Yoon JK (2012) The R-spondin family of proteins: emerging regulators of WNT signaling. Int J Biochem Cell Biol 44: 2278-2287. doi: 10.1016/j.biocel.2012.09.006
    [68] Zhang Y, Li F, Sun D, et al. (2011) Molecular analysis shows differential expression of R-spondin1 in zebrafish (Danio rerio) gonads. Mol Biol Rep 38: 275-282. doi: 10.1007/s11033-010-0105-3
    [69] Smith CA, Shoemaker CM, Roeszler KN, et al. (2008) Cloning and expression of R-Spondin1 in different vertebrates suggests a conserved role in ovarian development. BMC Dev Biol 8: 72. doi: 10.1186/1471-213X-8-72
    [70] Yoon JK, Lee JS (2012) Cellular signaling and biological functions of R-spondins. Cell Signal 24: 369-377. doi: 10.1016/j.cellsig.2011.09.023
    [71] Eisinger AL, Nadauld LD, Shelton DN, et al. (2007) Retinoic acid inhibits beta-catenin through suppression of Cox-2: a role for truncated adenomatous polyposis coli. J Biol Chem 282: 29394-29400. doi: 10.1074/jbc.M609768200
    [72] Goessling W, North TE, Loewer S, et al. (2009) Genetic interaction of PGE2 and Wnt signaling regulates developmental specification of stem cells and regeneration. Cell 136: 1136-1147. doi: 10.1016/j.cell.2009.01.015
    [73] Pannetier M, Fabre S, Batista F, et al. (2006) FOXL2 activates P450 aromatase gene transcription: towards a better characterization of the early steps of mammalian ovarian development. J Mol Endocrinol 36: 399-413. doi: 10.1677/jme.1.01947
    [74] Fleming NI, Knower KC, Lazarus KA, et al. (2010) Aromatase Is a Direct Target of FOXL2: C134W in Granulosa Cell Tumors via a Single Highly Conserved Binding Site in the Ovarian Specific Promoter. PLoS One 5: e14389. doi: 10.1371/journal.pone.0014389
    [75] Nef S, Vassalli JD (2009) Complementary pathways in mammalian female sex determination. J Biol 8: 74. doi: 10.1186/jbiol173
    [76] Guiguen Y, Fostier A, Piferrer F, et al. (2010) Ovarian aromatase and estrogens: a pivotal role for gonadal sex differentiation and sex change in fish. Gen Comp Endocrinol 165: 352-366. doi: 10.1016/j.ygcen.2009.03.002
    [77] Fenske M, Segner H (2004) Aromatase modulation alters gonadal differentiation in developing zebrafish (Danio rerio). Aquat Toxicol 67: 105-126. doi: 10.1016/j.aquatox.2003.10.008
    [78] Takatsu K, Miyaoku K, Roy SR, et al. (2013) Induction of female-to-male sex change in adult zebrafish by aromatase inhibitor treatment. Sci Rep 3: 3400.
    [79] Brion F, Tyler CR, Palazzi X, et al. (2004) Impacts of 17beta-estradiol, including environmentally relevant concentrations, on reproduction after exposure during embryo-larval-, juvenile- and adult-life stages in zebrafish (Danio rerio). Aquat Toxicol 68: 193-217. doi: 10.1016/j.aquatox.2004.01.022
    [80] Orn S, Holbech H, Norrgren L (2016) Sexual disruption in zebrafish (Danio rerio) exposed to mixtures of 17alpha-ethinylestradiol and 17beta-trenbolone. Environ Toxicol Pharmacol 41: 225-231. doi: 10.1016/j.etap.2015.12.010
    [81] Schulz RW, Bogerd J, Male R, et al. (2007) Estrogen-induced alterations in amh and dmrt1 expression signal for disruption in male sexual development in the zebrafish. Environ Sci Technol 41: 6305-6310.
    [82] Reyhanian Caspillo N, Volkova K, Hallgren S, et al. (2014) Short-term treatment of adult male zebrafish (Danio Rerio) with 17alpha-ethinyl estradiol affects the transcription of genes involved in development and male sex differentiation. Comp Biochem Physiol C Toxicol Pharmacol 164: 35-42. doi: 10.1016/j.cbpc.2014.04.003
    [83] Lor Y, Revak A, Weigand J, et al. (2015) Juvenile exposure to vinclozolin shifts sex ratios and impairs reproductive capacity of zebrafish. Reprod Toxicol 58: 111-118. doi: 10.1016/j.reprotox.2015.09.003
    [84] Baumann L, Knorr S, Keiter S, et al. (2014) Persistence of endocrine disruption in zebrafish (Danio rerio) after discontinued exposure to the androgen 17beta-trenbolone. Environ Toxicol Chem 33: 2488-2496. doi: 10.1002/etc.2698
    [85] Mukhi S, Torres L, Patino R (2007) Effects of larval-juvenile treatment with perchlorate and co-treatment with thyroxine on zebrafish sex ratios. Gen Comp Endocrinol 150: 486-494. doi: 10.1016/j.ygcen.2006.11.013
    [86] Sharma P, Tang S, Mayer GD, et al. (2016) Effects of thyroid endocrine manipulation on sex-related gene expression and population sex ratios in Zebrafish. Gen Comp Endocrinol 235: 38-47. doi: 10.1016/j.ygcen.2016.05.028
    [87] Sharma P, Patino R (2013) Regulation of gonadal sex ratios and pubertal development by the thyroid endocrine system in zebrafish (Danio rerio). Gen Comp Endocrinol 184: 111-119. doi: 10.1016/j.ygcen.2012.12.018
    [88] Aggarwal BB, Sethi G, Nair A, et al. (2006) Nuclear factor- κB: A holy grail in cancer prevention and therapy. Curr Signal Transduct Ther 1: 25-52. doi: 10.2174/157436206775269235
    [89] Li X, Stark GR (2002) NF-κB-dependent signaling pathways. Exp Hematol 30: 285-296. doi: 10.1016/S0301-472X(02)00777-4
    [90] Ghosh S, May MM, Kopp EB (1998) NF-κB and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol 16: 225-260. doi: 10.1146/annurev.immunol.16.1.225
    [91] Siebenlist U, Franzoso G, Brown K (1994) Structure, regulation and function of NF-κB. Annu Rev Cell Biol 10: 405-455.
    [92] Xiao W (2004) Advances in NF-kappaB signaling transduction and transcription. Cell Mol Immunol 1: 425-435.
    [93] Beg AA, Baldwin AS (1993) The I kappa B proteins: multifunctional regulators of Rel/NF-kappa B transcription factors. Genes Dev 7: 2064-2070. doi: 10.1101/gad.7.11.2064
    [94] Ghosh S, Karin M (2002) Missing pieces in the NFkB puzzle. Cell Metab 109: 81-96.
    [95] Beg AA, Finco TS, Nantermet PV, et al. (1993) Tumor necrosis factor and interleukin-1 lead to phosphorylation and loss of I kappa B alpha: a mechanism for NF-kappa B activation. Mol Cell Biol 13: 3301-3310. doi: 10.1128/MCB.13.6.3301
    [96] Finco TS, Beg AA, Baldwin AS Jr (1994) Inducible phosphorylation of I kappa B alpha is not sufficient for its dissociation from NF-kappa B and is inhibited by protease inhibitors. Proc Natl Acad Sci U S A 91: 11884-11888. doi: 10.1073/pnas.91.25.11884
    [97] Shishodia S, Aggarwal BB (2002) Nuclear factor-κB activation: A question of life or death. J Biochem Mol Biol 35: 28-40. doi: 10.5483/BMBRep.2002.35.1.028
    [98] Rao NA, McCalman MT, Moulos P, et al. (2011) Coactivation of GR and NFKB alters the repertoire of their binding sites and target genes. Genome Res 21: 1404-1416. doi: 10.1101/gr.118042.110
    [99] Palvimo JJ, Reinikainen P, Ikonen T, et al. (1996) Mutual transcriptional interference between RelA and androgen receptor. J Biol Chem 271: 24151–24156.
    [100] McKay LI, Cidlowski JA (1998) Cross-talk between Nuclear factor-kB and the steroid hormone receptors: Mechanisms of mutual antagonism. Mol Endocrinol 12: 45-56. doi: 10.1210/mend.12.1.0044
    [101] Delfino F, Walker WH (1998) Stage-specific nuclear expression of NF-κB in mammalian testis. Mol Endocrinol 12: 1696-1707.
    [102] Hong CY, Park JH, Seo KH, et al. (2003) Expression of MIS in the Testis Is Downregulated by Tumor Necrosis Factor Alpha through the Negative Regulation of SF-1 Transactivation by NF-κB. Mol Cell Biol 23: 6000-6012. doi: 10.1128/MCB.23.17.6000-6012.2003
    [103] Sobolewski C, Cerella C, Dicato M, et al. (2010) The role of cyclooxygenase-2 in cell proliferation and cell death in human malignancies. Int J Cell Biol 2010: 215158.
    [104] Simmons DL, Botting RM, Hla T (2004) Cyclooxygenase isozymes: the biology of prostaglandin synthesis and inhibition. Pharmacol Rev 56: 387-437. doi: 10.1124/pr.56.3.3
    [105] Kang YJ, Mbonye UR, DeLong CJ, et al. (2007) Regulation of intracellular cyclooxygenase levels by gene transcription and protein degradation. Prog Lipid Res 46: 108-125. doi: 10.1016/j.plipres.2007.01.001
    [106] Morita I (2002) Distinct functions of COX-1 and COX-2. Prostaglandins Other Lipid Mediat 68-69: 165-175. doi: 10.1016/S0090-6980(02)00029-1
    [107] Tanabe T, Tohnai N (2002) Cyclooxygenase isozymes and their gene structures and expression. 68-69: 95-114.
    [108] Klein T, Shephard P, Kleinert H, et al. (2007) Regulation of cyclooxygenase-2 expression by cyclic AMP. Biochim Biophys Acta 1773: 1605-1618. doi: 10.1016/j.bbamcr.2007.09.001
    [109] Schmedtje JF, Ji YS, Liu RN, et al. (1997) Hypoxia induces cyclooxygenase-2 via the NF-kB p65 transcription factor in human vascular endothelial cells. J Biol Chem 272: 601-608. doi: 10.1074/jbc.272.1.601
    [110] Tsatsanis C, Androulidaki A, Venihaki M, et al. (2006) Signalling networks regulating cyclooxygenase-2. Int J Biochem Cell Biol 38: 1654-1661. doi: 10.1016/j.biocel.2006.03.021
    [111] Poligone B, Baldwin AS (2001) Positive and negative regulation of NF-kappaB by COX-2: roles of different prostaglandins. J Biol Chem 276: 38658-38664. doi: 10.1074/jbc.M106599200
    [112] Grosser T, Yusuff S, Cheskis E, et al. (2002) Developmental expression of functional cyclooxygenases in zebrafish. Proc Natl Acad Sci U S A 99: 8418-8423. doi: 10.1073/pnas.112217799
    [113] Adams IR, McLaren A (2002) Sexually dimorphic devlopment of mouse primordial germ cells: switch from oogenesis to spermatogenesis. Development 129: 1155-1164.
    [114] Wilhelm D, Hiramatsu R, Mizusaki H, et al. (2007) SOX9 regulates prostaglandin D synthase gene transcription in vivo to ensure testis development. J Biol Chem 282: 10553-10560. doi: 10.1074/jbc.M609578200
    [115] Breyer RM, Bagdassarian CK, Myers SA, et al. (2001) Prostanoid receptors: subtypes and signaling. Annu Rev Pharmacol Toxicol 41: 661-690. doi: 10.1146/annurev.pharmtox.41.1.661
    [116] Cai Z, Kwintkiewicz J, Young ME, et al. (2007) Prostaglandin E2 increases Cyp19 expression in Rat Granulosa Cells: Implication of GATA-4. Mol Cell Endocrinol 263: 181-189. doi: 10.1016/j.mce.2006.09.012
    [117] Guan Y, Zhang Y, Schneider A, et al. (2001) Urogenital distribution of a mouse membrane-associated prostaglandin E2 synthase. Am J Physiol Renal Physiol 281: 1173-1177. doi: 10.1152/ajprenal.0116.2001
    [118] Sun T, Deng WB, Diao HL, et al. (2006) Differential expression and regulation of prostaglandin E synthases in the mouse ovary during sexual maturation and luteal development. J Endocrinol 189: 89-101. doi: 10.1677/joe.1.06147
    [119] Bayne RA, Eddie SL, Collins CS, et al. (2009) Prostaglandin E2 as a regulator of germ cells during ovarian development. J Clin Endocrinol Metab 94: 4053-4060. doi: 10.1210/jc.2009-0755
    [120] Takahashi T, Morrow JD, Wang H, et al. (2006) Cyclooxygenase-2-derived prostaglandin E(2) directs oocyte maturation by differentially influencing multiple signaling pathways. J Biol Chem 281: 37117-37129. doi: 10.1074/jbc.M608202200
    [121] Mank JE, Promislow DEL, Avise JC (2006) Evolution of alternative sex-determining mechanisms in teleost fishes. Biol J Linn Soc 87: 83-93. doi: 10.1111/j.1095-8312.2006.00558.x
    [122] Slanchev K, Stebler J, de la Cueva-Mendez G, et al. (2005) Development without germ cells: the role of the germ line in zebrafish sex differentiation. Proc Natl Acad Sci U S A 102: 4074-4079. doi: 10.1073/pnas.0407475102
    [123] Kurokawa H, Saito D, Nakamura S, et al. (2007) Germ cells are essential for sexual dimorphism in the medaka gonad. Proc Natl Acad Sci U S A 104: 16958-16963. doi: 10.1073/pnas.0609932104
    [124] Tzung KW, Goto R, Saju JM, et al. (2014) Early Depletion of Primordial Germ Cells in Zebrafish Promotes Testis Formation. Stem Cell Rep 4: 61-73.
    [125] McLaren A (2003) Primordial germ cells in the mouse. Dev Biol 262: 1-15. doi: 10.1016/S0012-1606(03)00214-8
    [126] DiNapoli L, Capel B (2007) Germ cell depletion does not alter the morphogenesis of the fetal testis or ovary in the red-eared slider turtle (Trachemys scripta). J Exp Zool B Mol Dev Evol 308: 236-241.
    [127] Goto R, Saito T, Takeda T, et al. (2012) Germ cells are not the primary factor for sexual fate determination in goldfish. Dev Biol 370: 98-109. doi: 10.1016/j.ydbio.2012.07.010
    [128] Fujimoto T, Nishimura T, Goto-Kazeto R, et al. (2010) Sexual dimorphism of gonadal structure and gene expression in germ cell-deficient loach, a teleost fish. Proc Natl Acad Sci U S A 107: 17211-17216. doi: 10.1073/pnas.1007032107
    [129] Petersen AM, Earp NC, Redmond ME, et al. (2016) Perchlorate Exposure Reduces Primordial Germ Cell Number in Female Threespine Stickleback. PLoS One 11: e0157792. doi: 10.1371/journal.pone.0157792
    [130] Dranow DB, Tucker RP, Draper BW (2013) Germ cells are required to maintain a stable sexual phenotype in adult zebrafish. Dev Biol 376: 43-50. doi: 10.1016/j.ydbio.2013.01.016
    [131] Rodriguez-Mari A, Canestro C, Bremiller RA, et al. (2010) Sex reversal in zebrafish fancl mutants is caused by Tp53-mediated germ cell apoptosis. PLoS Genet 6: e1001034. doi: 10.1371/journal.pgen.1001034
    [132] Rios-Rojas C, Bowles J, Koopman P (2015) On the role of germ cells in mammalian gonad development: quiet passengers or back-seat drivers? Reproduction 149: R181-191. doi: 10.1530/REP-14-0663
    [133] Behringer RR, Cate RL, Froelick GJ, et al. (1990) Abnormal sexual development in transgenic mice chronically expressing mullerian inhibiting substance. Nature 345: 167-170. doi: 10.1038/345167a0
    [134] Couse JF, Hewitt SC, Bunch DO, et al. (1999) Postnatal sex reversal of the ovaries in mice lacking estrogen receptors alpha and beta. Science 286: 2328-2331. doi: 10.1126/science.286.5448.2328
    [135] Maatouk DM, Mork L, Hinson A, et al. (2012) Germ cells are not required to establish the female pathway in mouse fetal gonads. PLoS One 7: e47238. doi: 10.1371/journal.pone.0047238
    [136] Molyneaux K, Wylie C (2004) Primordial germ cell migration. Int J Dev Biol 48: 537-544. doi: 10.1387/ijdb.041833km
    [137] Saitou M, Yamaji M (2012) Primordial germ cells in mice. Cold Spring Harb Perspect Biol 4: 59-66.
    [138] Kashimada K, Svingen T, Feng CW, et al. (2011) Antagonistic regulation of Cyp26b1 by transcription factors SOX9/SF1 and FOXL2 during gonadal development in mice. FASEB J 25: 3561-3569. doi: 10.1096/fj.11-184333
    [139] Bowles J, Knight D, Smith C, et al. (2006) Retinoid signaling determines germ cell fate in mice. Science 312: 596-600. doi: 10.1126/science.1125691
    [140] Koubova J, Menke DB, Zhou Q, et al. (2006) Retinoic acid regulates sex-specific timing of meiotic initiation in mice. Proc Natl Acad Sci U S A 103: 2474-2479. doi: 10.1073/pnas.0510813103
    [141] Moniot B, Ujjan S, Champagne J, et al. (2014) Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis. Development 141: 3561-3571. doi: 10.1242/dev.103408
    [142] Kipp JL, Golebiowski A, Rodriguez G, et al. (2011) Gene expression profiling reveals Cyp26b1 to be an activin regulated gene involved in ovarian granulosa cell proliferation. Endocrinology 152: 303-312. doi: 10.1210/en.2010-0749
    [143] Pradhan A, Olsson PE (2015) Inhibition of retinoic acid synthesis disrupts spermatogenesis and fecundity in zebrafish. Gen Comp Endocrinol 217-218: 81-91. doi: 10.1016/j.ygcen.2015.02.002
    [144] Alsop D, Matsumoto J, Brown S, et al. (2008) Retinoid requirements in the reproduction of zebrafish. Gen Comp Endocrinol 156: 51-62. doi: 10.1016/j.ygcen.2007.11.008
    [145] Rodriguez-Mari A, Canestro C, BreMiller RA, et al. (2013) Retinoic acid metabolic genes, meiosis, and gonadal sex differentiation in zebrafish. PLoS One 8: e73951. doi: 10.1371/journal.pone.0073951
    [146] Azziz R, Marin C, Hoq L, et al. (2005) Health care-related economic burden of the polycystic ovary syndrome during the reproductive life span. J Clin Endocrinol Metab 90: 4650-4658. doi: 10.1210/jc.2005-0628
    [147] Agrawal R, Sharma S, Bekir J, et al. (2004) Prevalence of polycystic ovaries and polycystic ovary syndrome in lesbian women compared with heterosexual women. Fertil Steril 82: 1352-1357. doi: 10.1016/j.fertnstert.2004.04.041
    [148] Abbott DH, Barnett DK, Bruns CM, et al. (2005) Androgen excess fetal programming of female reproduction: a developmental aetiology for polycystic ovary syndrome? Hum Reprod Update 11: 357-374. doi: 10.1093/humupd/dmi013
    [149] Skakkebaek NE, Rajpert-De Meyts E, Main KM (2001) Testicular dysgenesis syndrome: an increasingly common developmental disorder with environmental aspects. Hum Reprod 16: 972-978. doi: 10.1093/humrep/16.5.972
    [150] Juul A, Almstrup K, Andersson AM, et al. (2014) Possible fetal determinants of male infertility. Nat Rev Endocrinol 10: 553-562. doi: 10.1038/nrendo.2014.97
  • This article has been cited by:

    1. Zhao Fei, Xue Longjiang, Zhu Jingliang, Chen Ding, Fang Jinghui, Wu Jun, A novel investment strategy for renewable-dominated power distribution networks, 2023, 10, 2296-598X, 10.3389/fenrg.2022.968944
    2. Sergey Frenkel, 2025, Chapter 10, 978-3-031-76933-7, 151, 10.1007/978-3-031-76934-4_10
  • Reader Comments
  • © 2016 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Metrics

Article views(10359) PDF downloads(1482) Cited by(12)

Figures and Tables

Figures(3)

Other Articles By Authors

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return

Catalog