
To evaluate the automatic segmentation approach for organ at risk (OARs) and compare the parameters of dose volume histogram (DVH) in radiotherapy. Methodology: Thirty-three patients were selected to contour OARs using automatic segmentation approach which based on U-Net, applying them to a number of the nasopharyngeal carcinoma (NPC), breast, and rectal cancer respectively. The automatic contours were transferred to the Pinnacle System to evaluate contour accuracy and compare the DVH parameters.
The time for manual contour was 56.5 ± 9, 23.12 ± 4.23 and 45.23 ± 2.39min for the OARs of NPC, breast and rectal cancer, and for automatic contour was 1.5 ± 0.23, 1.45 ± 0.78 and 1.8 ± 0.56 min. Automatic contours of Eye with the best Dice-similarity coefficients (DSC) of 0.907 ± 0.02 while with the poorest DSC of 0.459 ± 0.112 of Spinal Cord for NPC; And Lung with the best DSC of 0.944 ± 0.03 while with the poorest DSC of 0.709 ± 0.1 of Spinal Cord for breast; And Bladder with the best DSC of 0.91 ± 0.04 while with the poorest DSC of 0.43 ± 0.1 of Femoral heads for rectal cancer. The contours of Spinal Cord in H & N had poor results due to the division of the medulla oblongata. The contours of Femoral head, which different from what we expect, also due to manual contour result in poor DSC.
The automatic contour approach based deep learning method with sufficient accuracy for research purposes. However, the value of DSC does not fully reflect the accuracy of dose distribution, but can cause dose changes due to the changes in the OARs volume and DSC from the data. Considering the significantly time-saving and good performance in partial OARs, the automatic contouring also plays a supervisory role.
Citation: Han Zhou, Yikun Li, Ying Gu, Zetian Shen, Xixu Zhu, Yun Ge. A deep learning based automatic segmentation approach for anatomical structures in intensity modulation radiotherapy[J]. Mathematical Biosciences and Engineering, 2021, 18(6): 7506-7524. doi: 10.3934/mbe.2021371
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To evaluate the automatic segmentation approach for organ at risk (OARs) and compare the parameters of dose volume histogram (DVH) in radiotherapy. Methodology: Thirty-three patients were selected to contour OARs using automatic segmentation approach which based on U-Net, applying them to a number of the nasopharyngeal carcinoma (NPC), breast, and rectal cancer respectively. The automatic contours were transferred to the Pinnacle System to evaluate contour accuracy and compare the DVH parameters.
The time for manual contour was 56.5 ± 9, 23.12 ± 4.23 and 45.23 ± 2.39min for the OARs of NPC, breast and rectal cancer, and for automatic contour was 1.5 ± 0.23, 1.45 ± 0.78 and 1.8 ± 0.56 min. Automatic contours of Eye with the best Dice-similarity coefficients (DSC) of 0.907 ± 0.02 while with the poorest DSC of 0.459 ± 0.112 of Spinal Cord for NPC; And Lung with the best DSC of 0.944 ± 0.03 while with the poorest DSC of 0.709 ± 0.1 of Spinal Cord for breast; And Bladder with the best DSC of 0.91 ± 0.04 while with the poorest DSC of 0.43 ± 0.1 of Femoral heads for rectal cancer. The contours of Spinal Cord in H & N had poor results due to the division of the medulla oblongata. The contours of Femoral head, which different from what we expect, also due to manual contour result in poor DSC.
The automatic contour approach based deep learning method with sufficient accuracy for research purposes. However, the value of DSC does not fully reflect the accuracy of dose distribution, but can cause dose changes due to the changes in the OARs volume and DSC from the data. Considering the significantly time-saving and good performance in partial OARs, the automatic contouring also plays a supervisory role.
Moving bottleneck models have been introduced in the engineering literature starting from the end of the last century to describe the interaction of slow moving vehicles, such as buses or trucks, with bulk traffic, see [9,28,30]. Further approaches have then be proposed in the applied mathematics community [1,15,27,39,41], always following the underlying idea of using multi-scale models consisting of Partial Differential Equations (PDEs) to model the overall traffic flow evolution, coupled with Ordinary Differential Equations (ODEs) accounting for the moving bottlenecks trajectories. Despite the intrinsic difficulties arising as a result of the flux constraint induced by the presence of the slow vehicles, corresponding existence and stability results have been provided, see also [17,20,31,32], together with numerical schemes to compute approximate solutions capturing the emerging non-classical phenomena [2,3,11,14,16].
More recently, moving bottleneck models have been applied to traffic flow regulation by means of Autonomous Vehicles (AVs), see e.g., [4,5,6,7,8,34]. Indeed, AVs can act as endogenous actuators of moving variable speed limits, improving throughput by hindering upstream traffic. This possibility has already been the object of several theoretical studies (see e.g., [13,24,26,35,40,42] and [19,Chapter 11]), but also artificial [25] and real world [38] experiments. In particular, it has been demonstrated that even low AV penetration rates can have a significant impact on reducing congestion phenomena and the associated energy consumption. In this context, macroscopic approaches are needed to address the curse of dimensionality in control design for microscopic models [18].
Even if some of the above works account for the presence of multiple AVs on the road, very few of them allow for AV interactions, and only in very specific modeling frameworks [21,37]. In this paper, we aim at generalizing the control framework designed in [20,34] for the Lighthill-Whitham-Richards model [33,36] to multiple, possibly interacting, moving bottlenecks, as if they were distributed on several lanes and they were allowed both to merge (if on the same lane) and to overtake (if on different lanes). This can be achieved by a careful study of the corresponding Riemann-type problems, and a natural generalization of the numerical reconstruction technique presented in [3].
The proposed model can be used to develop a general simulation environment accounting for several AVs interacting with the surrounding traffic flow and among themselves, which in turns allows to design optimization-based control strategies having fleets of AVs as actuators.
The paper is organized as follows: Section 2 details the model framework, providing a mathematical description of the fully coupled PDE-ODE model and the interactions among AVs at the level of Riemann problems. Section 3 describes the numerical scheme and Section 4 shows the results of the numerical experiments.
Following [15,20], we consider the following strongly coupled PDE-ODEs system
∂tρ(t,x)+∂xf(ρ(t,x))=0, | (2.1a) |
[5pt]˙yℓ(t)=min{uℓ(t),v(ρ(t,yℓ(t)+))}, | (2.1b) |
[5pt]f(ρ(t,yℓ(t)))−˙yℓ(t)ρ(t,yℓ(t))≤Fα(˙yℓ(t)):=maxρ∈[0,R](αf(ρ/α)−ρ˙yℓ(t)), | (2.1c) |
ρ(0,x)=ρ0(x), | (2.1d) |
[5pt]yℓ(0)=y0ℓ, | (2.1e) |
for ℓ=1,…,N and t>0,x∈R, where ρ=ρ(t,x)∈[0,R] denotes the macroscopic traffic density at time t≥0 and at position x∈R, f=f(ρ)=ρv(ρ) is the (strictly convex) flux and v∈C2([0,R];[0,V]) is a strictly decreasing function such that v(0)=V and v(R)=0, which represents the average speed of cars (R being the maximal vehicle density attainable on the considered road section). Above, ρ0∈[0,R] and y0ℓ∈R, ℓ=1,…,N, are respectively the initial traffic density and AV positions, while the function Fα in Eq (2.1c), α∈ [0,1], represents the road capacity reduction rate due to the presence of the AV at x=yℓ(t), ℓ=1,…,N, acting as a moving bottleneck which imposes a unilateral flux constraint at its position. For simplicity, we assume that this parameter is the same for all AVs, and it is a function of the number of lanes: α=(M−1)/M, where M∈N denotes the number of lanes. (The extension to a more general framework would follow the same lines detailed in this work.) To determine the function Fα, we consider the rescaled flux function
fα:[0,αR]⟶R+ρ⟼ρv(ρ/α)=αf(ρ/α), |
which is strictly concave function and such that fα(0)=fα(αR)=0. For every u∈[0,V], we define the point ˜ρu as the unique solution to the equation f′α(ρ)=u. Moreover, for every u∈[0,V], we define the function
φu:[0,R]⟶R+ρ⟼fα(˜ρu)+u(ρ−˜ρu). |
Hence, if ˙y(t)=u, the function Fα in Eq (2.1c) is defined by
Fα:[0,V]⟶R+u⟼φu(0)=fα(˜ρu)−u˜ρu. |
If ˙y(t)=v(ρ(t,y(t)+)), the inequality (2.1c) is trivially satisfied since the left-hand side is zero. Finally, the points 0≤ˇρu≤˜ρu≤ˆρu≤ρ∗u≤R are uniquely defined by
ˇρu=minIu,ˆρu=maxIu,Iu={ρ∈[0,R]:f(ρ)=φu(ρ)},v(ρ∗u)=u, |
see [15,20] and Figure 1. We remark that ˇρV=˜ρV=ˆρV=ρ∗V=0.
Solutions to Eq (2.1) are defined as follows (see [20,Definition 3.1]):
Definition 2.1. The N+1-tuple (ρ,y1,…,yN) provides a solution to (2.1) if the following conditions hold.
1. ρ∈C0(R+;L1loc(R;[0,R])) and TV(ρ(t))<+∞ for all t∈R+;
2. yℓ∈W1,1loc(R+;R) for ℓ=1,…,N;
3. For every κ∈R and for all φ∈C1c(R2;R+) it holds
∫R+∫R(|ρ−κ|∂tφ+sgn(ρ−κ)(f(ρ)−f(κ))∂xφ)dxdt+∫R|ρ0−κ|φ(0,x)dx+2N∑ℓ=1∫R+(f(κ)−˙yℓ(t)κ−min{f(κ)−˙yℓ(t)κ,Fα(˙yℓ(t))})φ(t,y(t))dt≥0; |
4. For a.e. t>0, f(ρ(t,yℓ(t)±))−˙yℓ(t)ρ(t,yℓ(t)±)≤Fα(˙yℓ(t)) for ℓ=1,…,N;
5. For a.e. t>0, ˙yℓ(t)=min{uℓ(t),v(ρ(t,yℓ(t)+))} for ℓ=1,…,N.
As long as AV trajectories do not intersect, one can apply the theory and the numerical schemes developed in [3,14,15,16,20]. In particular, we recall that the Constrained Riemann Solver is defined as follows.
Definition 2.2. The Constrained Riemann Solver Rα for
∂tρ(t,x)+∂xf(ρ(t,x))=0, | (2.2a) |
[5pt]˙y(t)=min{u,v(ρ(t,y(t)+))}, | (2.2b) |
[5pt]f(ρ(t,y(t)))−˙y(t)ρ(t,y(t))≤Fα(˙y(t)), | (2.2c) |
ρ(0,x)={ρLif x<0,ρRif x>0, | (2.2d) |
[5pt]y(0)=0, | (2.2e) |
is the map Rα:[0,R]2×[0,V]→L1loc(R,[0,R]) defined as follows.
1. If f(R(ρL,ρR)(u))>Fα(u)+uR(ρL,ρR)(u), then
Rα(ρL,ρR;u)(x/t)={R(ρL,ˆρu)(x/t)ifx<ut,R(ˇρu,ρR)(x/t)ifx≥ut,andy(t)=ut. |
2. If f(R(ρL,ρR)(u))≤Fα(u)+uR(ρL,ρR)(u), then
Rα(ρL,ρR;u)=R(ρL,ρR)andy(t)=min{u,v(ρR)}t. |
Above, R denotes the standard (i.e., without the constraint (2.2c)) Riemann solver for Eqs (2.2a)–(2.2d), i.e., the (right continuous) map (t,x)↦R(ρL,ρR)(x/t) given by the standard weak entropy solution to Eqs (2.2a)–(2.2d).
In this paper, we are interested in describing what happens when two vehicles AVi and AVj, with i,j∈{1,…,N}, i≠j, interact. Let us assume yi(t)<yj(t) with constant speeds ui(t)=ui>uj(t)=uj for t∈]ˉt−ε,ˉt[, so that yi(ˉt)=yj(ˉt) for some ˉt>0, see Figure 2. Depending on the surrounding traffic density conditions, only three situations may occur in a Riemann-like setting (piece-wise constant density with at most one jump discontinuity):
● The constraint (2.1c) is enforced for ℓ=i (we will say that AVi is active), so that ρ(t,x)=ˆρui for x<yi(t) and ρ(t,x)=ˇρui for x>yi(t). Since, at x=yj(t), it holds f(ˇρui)−ujˇρui≤Fα(uj) (see Figure 2), the constraint is not enforced for ℓ=j (AVj is then inactive).
● If AVj is active, we have ρ(t,x)=ˆρuj for x<yj(t) and ρ(t,x)=ˇρuj for x>yj(t). At x=yi(t), it therefore holds f(ˆρuj)−uiˆρuj≤Fα(ui), thus AVi is inactive.
● If both AVi and AVj are inactive, we may have either a constant density or a classical shock coinciding with one of the AV trajectories. In any case, the density must satisfy ρ(t,x)∈[0,ˇρui]∪[ˆρuj,R].
We remark that AVi and AVj cannot be both active at the same time, unless other waves are present between them.
To detail the problem evolution after the interaction (at t>ˉt), we distinguish if AVs are moving in different lanes or if they are located on the same lane.
Same lane interactions.
Let us assume that the two vehicles are in the same lane, so for t>ˉt the upstream vehicle must adapt to the downstream vehicle speed: we will have yi(t)=yj(t) with ui(t)=uj(t) for t≥ˉt. Three situations may occur, see Figure 3:
● If, before the interaction, AVi was active and AVj inactive, at t>ˉt the solution will consists of a classical shock joining ˆρui to ˆρuj, followed by a non-classical shock at x=yj(t)=yi(t) between ˆρuj and ˇρuj and a rarefaction wave from ˇρuj to ˇρui, see Figure 3a. In particular, after the interaction, both AVs will be active.
● If, before the interaction, AVi was inactive and AVj active, at t>ˉt the solution will consists only of a non-classical shock joining ˆρuj to ˇρuj, see Figure 3b. Again, after the interaction, both AVs will be active.
● If, before the interaction, AVi and AVj were both inactive, at t>ˉt the solution will consists at most of the classical shock that was already present before the interaction, see Figure 3c. After the interaction, both AVs will still be inactive.
In any case, after the interaction, the two vehicles behave as AVj.
Different lane interactions.
If the two interacting vehicles travel in different lanes, for t>ˉt they will follow their own trajectory and AVi will overtake AVj: we will have yi(t)≥yj(t) with ui(t)≥uj(t) for t≥ˉt. Three situations may occur, see Figure 4:
● If, before the interaction, AVi was active and AVj inactive, at t>ˉt the solution will consists of a classical shock joining ˆρui to ˆρuj, followed by a non-classical shock at x=yj(t) from ˆρuj to ˇρuj, a classical shock from ˇρuj to ˆρui and a non-classical shock at x=yi(t) from ˆρui to ˇρui, see Figure 4a. In particular, after the interaction, both AVs will be active.
● If, before the interaction, AVi was inactive and AVj active, at t>ˉt the solution will consists of a non-classical shock at x=yj(t) from ˆρuj to ˇρuj, followed by a classical shock from ˇρuj to ˆρui, a non-classical shock at x=yi(t) from ˆρui to ˇρui and a classical shock from ˇρui to ˇρuj, see Figure 4b. In particular, after the interaction, both AVs will be active.
● If, before the interaction, AVi and AVj were both inactive, at t>ˉt the solution will consists at most of the classical shock that was already present before the interaction, see Figure 4c. After the interaction, both AVs will still be inactive.
We extend the reconstruction strategy introduced in [3] to include moving bottleneck interactions. The scheme is composed of two parts:
Numerical approximation of Eqs (2.1a)–(2.1c).
To approximate the conservation equation (2.1a), we use a conservative finite volume scheme for the constrained hyperbolic PDE using a flux reconstruction technique at the constraint locations, which allows to capture the non-classical shocks sharply. Let Δx and Δt be the fixed space and time steps satisfying the standard Courant-Friedrichs-Lewy (CFL) condition [10]:
maxρ∈[0,R]|f′(ρ)|Δt<Δx, |
and set xj−1/2=jΔx, xj=(j+1/2)Δx for j∈Z, and tn=nΔt for n∈N. The initial data ρ0 is approximated by the piece-wise constant function obtained by averaging it on the discretization cells Cj=[xj−1/2,xj+1/2], namely
ρ0j=1Δx∫xj+1/2xj−1/2ρ0(x)dx,j∈Z. |
Away from AV positions, Eq (2.1a) is approximated by the standard Godunov scheme [22], whose numerical fluxes at cell interfaces Fnj+12=F(ρnj,ρnj+1) can in this case be derived using the supply-demand formula [29]
F(ρnj,ρnj+1)=min{D(ρnj),S(ρnj+1)}, | (3.1) |
where
D(ρ)=f(min{ρ,ρcr}),S(ρ)=f(max{ρ,ρcr}), |
ρcr=argminρ∈[0,R]f(ρ) being the point of maximum of the flux function f.
Let now the approximate ℓ-th AV position be ynℓ∈Cmℓ for some mℓ∈Z, ℓ=1,…,N. If
f(R(ρnmℓ−1,ρnmℓ+1)(unℓ))>Fα(unℓ)+unℓR(ρnmℓ−1,ρnmℓ+1)(unℓ), |
we assume a moving bottleneck at ˉxmℓ=xmℓ−1/2+dnmℓΔx with dnmℓ=ˇρunℓ−ρnmℓˇρunℓ−ˆρunℓ. If 0≤dnmℓ≤1, then ˉxmℓ∈Cmℓ and we set
Δtnmℓ=1−dnmℓunℓΔx,Fnmℓ−12=F(ρnmℓ−1,ˆρunℓ),ΔtFnmℓ+12=min(Δtnmℓ,Δt)f(ˇρunℓ)+max(Δt−Δtnmℓ,0)f(ˆρunℓ). |
We can then update the density by means of the conservative formula
ρn+1j=ρnj−ΔtΔx(Fnj+12−Fnj−12),j∈Z. | (3.2) |
Above, we set unℓ=uℓ(tn). If two or more AVs are located in the same cell, the moving bottlenecks are treated sequentially one after the other, starting from those which are not active (i.e., satisfy Eq (2.1c)), then processing those which are active (violating Eq (2.1c)).
Remark 1. For better resolution, we also apply the above reconstruction technique to classical shocks, as described in [3,Section 3.1].
Numerical approximation of Eq (2.1b).
To track the AV trajectories, at each time step, we update the positions ynℓ using an explicit Euler scheme
yn+1ℓ=ynℓ+v(ρn)Δtn,ℓ=1,…,N. |
If two AVs are in the same lane and in the same cell, and the upstream AVℓ1 moves faster than the downstream AVℓ2, i.e., unℓ1>unℓ2, then we set
yn+1ℓ1=yn+1ℓ2=ynℓ2+v(ρn)Δtn and unℓ1=unℓ2. |
(A more accurate computation of the interaction point could be implemented to improve simulation accuracy.)
Remark 2. The above procedure seems not coherent with the observation that two vehicles travelling at close speeds ui≈uj would act as a single bottleneck with αij=αi+αj−1. In this perspective, another option could be to reconstruct a single front moving at speed uij=(ui+uj)/2 with α=αij whenever two vehicles are in the same cell on two different lanes. In this case, the procedure should be the following:
If f(R(ρnm−1,ρnm+1)(uij))>Fαij(uij)+uijR(ρnm−1,ρnm+1)(uij),
we replace ρnm by ˆρuij and ˇρuij, with the jump located at
ˉxm=xm−12+dnmΔx, |
where dnm∈[0,1] is given by
dnm=ˇρuij−ρmˇρuij−ˆρuij. |
To reconstruct the numerical flux at the cell interface xm+12, we compute
Δtm+12=1−dnmuijΔx |
and we set
ΔtFnm+12=min{Δtm+12,Δt}f(ˇρuij)+max{Δt−Δtm+12,0}f(ˆρuij). |
In this section we illustrate the performances of the numerical scheme described in the previous Section 3 in capturing AV interactions correctly. We first analyze the Riemann-like cases described in Section 2, to conclude with a more general test case.
We consider a three lane stretch of road of length 50 km, parametrized by the interval [0,50] with absorbing boundary conditions. We consider the quadratic flux function proposed by Greenshields [23] that assumes a linear decreasing dependence of the speed on the traffic density
f(ρ)=Vρ(1−ρR), | (4.1) |
where V=140 km/h denotes the maximal speed and R=400 veh/km the maximal (bump-to-bump) density on the road. The capacity reduction ratio is set to α=0.6. In all simulations, we set Δx=0.2 and Δt=0.9Δx/V.
For the Riemann-like cases, we consider the following initial data:
AV1:{y1(0)=7.5,u1=50,AV2:{y2(0)=15,u2=20, |
(a) ρ0(x)={ˆρu1≈210if x<7.5,ˇρu1≈47if x>7.5, (b) ρ0(x)={ˆρu2≈280if x<15,ˇρu2≈63if x>15, (c) ρ0(x)≡20. |
The results are depicted in Figures 5 and 6. Except small spurious oscillations emerging from AV interactions in some cases, the solutions, and in particular non-classical shocks, are accurately reproduced.
To give a more general example, we consider the following initial data: ρ0(x)≡200 and
AV1:{y1(0)=2.5,u1=120,AV2:{y2(0)=7.5,u2=30,AV3:{y3(0)=10,u3=55,AV4:{y4(0)=20,u4=20, | (4.2) |
Moreover, AV1 and AV3 are on the same lane.
Figure 7 displays the solution, accounting for the different interaction types (queuing and overtaking). We observe that AV1 and AV3 are initially inactive while AV2 and AV4 are active. Moreover, AV1 and AV3 overtake the preceding vehicles and finally merge. Also, AV1 is always inactive until it merges with AV3, which becomes active after the interaction with AV4, while AV4 is always active. On the contrary, AV2 becomes inactive when it reaches an high traffic density region.
We have presented a strongly coupled PDE-ODE model describing the interaction of a small number of autonomous vehicles with bulk traffic on a multi-lane highway. The model allows for AV queuing and overtaking, expanding the range of traffic control applications of previous works [4,5,6,7,8,34]. A first study on traffic management opportunities offered by this framework is presented in [12], showing that low penetration rates are sufficient to reach nearly optimal improvements of a selected performance index.
The second author was partially supported by ERASMUS+/KA1 "NORTH SOUTH TRAINEESHIP" academic year 2020/21.
The authors declare there is no conflict of interest.
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