Genetic Basis of Infertility

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Guest Editor
Sophia Zachaki
Genesis Genoma Lab, Genetic Diagnosis, Clinical Genetics and Research, Athens, Greece

Manuscript Topics
Infertility is defined as the inability to conceive after one year of regular unprotected intercourse. Based on WHO, nowadays 1 in every 4 couples in developing countries is affected by infertility. The diagnosis of infertility in many cases remain unexplained. However, many reasons including lack of ovulation, sperm deficiencies, parental age and other hormonological reasons or infectious diseases have been implicated.

Genetics are also implicated to infertility. Several genetic changes form the basis of infertility as the majority of all pathological conditions are likely to have a genetic component, for example susceptibility to infection. Nevertheless, a significant number of specific genetic anomalies have been directly associated with infertility. Some genetic factors influence males specifically, other affect females, whereas others are implicated to both male and female infertility.

These genetic causes of infertility mainly include chromosomal abnormalities and single gene disorders. Several studies have reported that in infertile couples the frequency of chromosomal abnormalities is higher than the general population ranging between 1.3–15% including polymorphisms. The most frequently are balanced translocations, inversions and sex chromosomal mosaicism. Also, single gene such as CFTR may influence normal gametogenesis.

The special issue “Genetic basis of infertility” focuses on genetic factors affect both males and females. Original manuscripts, short communications, case reports or reviews relevant to the subject are invited.

Paper submission
All manuscripts will be peer-reviewed before their acceptance for publication.
The deadline for manuscript submission is 30th September 2017.

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