Biomarkers for the selection of a single competent embryo for transfer with IVF.

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Guest Editor
Dr. Kelly Pagidas, MD
Faculty Research Mentor, Residency Program
Department of Obstetrics and Gynecology, Tufts New England Medical Center
Tufts University School of Medicine, Boston, MA
Email: kelly.pagidas@louisville.edu

Manuscript Topics
The selection of the most competent human embryo to result in a successful health pregnancy during in-vitro fertilization (IVF) remains the most challenging aspect of assisted reproductive technology. A number of milestones of human embryonic development have been used as the classic measure for the selection process but are far from being perfect. Recent advances in genetic technology suggest that selection of a “euploid” embryo with preimplantation genetic testing (PGT) of embryos prior to embryo transfer may optimize the chance of a successful outcome, yet such testing is invasive to the embryo and long-term outcomes remain to be elucidated. Currently, there is no reliable and predictable non-invasive way for embryo selection devoid of embryo morphology with IVF technology. Therefore, there is an urgency to develop biomarkers that are objective and quantifiable for early detection and selection of the most competent single embryo for transfer with IVF technology. Important sources for biomarker development include culture media that bathe the fertilized zygote from creation to blastocyst development with IVF technology. The culture media can capture biological and chemical contents released by the diving blastomeres overtime and link them to the embryonic morphological milestones and ploidy complement of the embryo and associated reproductive outcome. Besides their development as diagnostics and prognostic tools, biomarkers may also provide new insights for the molecular mechanisms of the development of aneuploidy in embryos and generate new therapeutic targets for correction of aneuploidy in vitro.

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The deadline for manuscript submission is 31th March 2016.

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