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Transforming healthcare with the synergy of biotechnology and information technology

  • We explore the integration of biotechnology and information technology in healthcare innovation. The convergence of these fields has revolutionized diagnostics, therapeutics and patient management. Biotechnology advancements, such as genomics and molecular diagnostics, enable personalized medicine, while information technology facilitates data management and analysis. The integration also extends healthcare access through telemedicine and remote patient monitoring, enhancing healthcare delivery in underserved areas. Challenges include data security and privacy concerns. Looking ahead, the integration of biotechnology and information technology holds immense potential for further healthcare innovation, transforming patient outcomes and healthcare delivery.

    Citation: Leelakrishna Reddy, Segun Akinola. Transforming healthcare with the synergy of biotechnology and information technology[J]. AIMS Bioengineering, 2023, 10(4): 421-439. doi: 10.3934/bioeng.2023025

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  • We explore the integration of biotechnology and information technology in healthcare innovation. The convergence of these fields has revolutionized diagnostics, therapeutics and patient management. Biotechnology advancements, such as genomics and molecular diagnostics, enable personalized medicine, while information technology facilitates data management and analysis. The integration also extends healthcare access through telemedicine and remote patient monitoring, enhancing healthcare delivery in underserved areas. Challenges include data security and privacy concerns. Looking ahead, the integration of biotechnology and information technology holds immense potential for further healthcare innovation, transforming patient outcomes and healthcare delivery.



    The study of a hyperplane arrangement typically goes along with the study of its characteristic polynomial as the polynomial carries combinatorial and topological information of the arrangement (e.g., [10,16,17]). Terao's factorization theorem shows that if an arrangement is free, then its characteristic polynomial factors into the product of linear polynomials over the integer ring. Many attempts have been made in order to compute and to make a broader understanding the characteristic polynomials (e.g., [1,2,6,7,9,12,13,15,23,24]). It is well-known that the characteristic polynomial of any hyperplane arrangement gets generalized to the Tutte polynomial [22]. More recently, the generalizations of the polynomials, the arithmetic Tutte polynomial, the characteristic quasi-polynomial and the chromatic quasi-polynomials were introduced (e.g., [12,14,15,21]).

    The braid arrangement (or type A Coxeter arrangement) is the hyperplane arrangement in Rn defined by

    An1:={xixj=0:1i<jn}.

    Deformations of the braid arrangement are often studied in the literature, among these deformations are the Linial arrangement, Shi arrangement, Catalan arrangement, semiorder arrangement, generic braid arrangement, and semigeneric braid arrangement, etc, see [3,4,5,8,11,19,20,23] for a discussion of the combinatorics and freeness of these arrangements. The semigeneric braid arrangement is the hyperplane arrangement in Rn defined by

    Sn:={xixj=ai:1i<jn},

    where ais are generic. Stanley asked to find the characteristic polynomial of this arrangement. In this paper, we give a formula for the characteristic polynomials of the semigeneric braid arrangement and its subarrangements, which we call the semigeneric graphical arrangements.

    The remainder of the paper is organized as follows. In Section 2, we recall definitions and basic facts of arrangements. In Section 3, we prove our main results which provide the characterizations of a central semigeneric graphical arrangement, and induce a formula for the characteristic polynomial of a semigeneric graphical arrangement. In Section 4, we show some applications of our main results.

    We first review some basic concepts and preliminary results on arrangements. Our standard reference is [17,18]. Let K be a field, n be a positive integer and V=Kn be the n-dimensional vector space over K. A hyperplane in V is a affine subspace of codimension one of V. An arrangement A is a finite set of hyperplanes in V. An intersection lattice L(A) of A is defined by

    L(A):={HBH:BA},

    with an order by reverse inclusion XYYX for X,YL(A). The characteristic polynomial χA(t)Z[t] of A is defined by

    χA(t):=XL(A)μ(X)tdimX,

    where μ denotes the Möbius function μ:L(A)Z defined recursively by

    μ(V)=1andμ(X)=YL(A)XYμ(Y).

    Let G be a simple graph with vertex set V(G)=[n]={1,,n} and edge set E(G). The graphical arrangement AG in Kn is defined by

    AG:={xixj=0:ijE(G)}.

    A simple graph is chordal if it does not contain an induced cycle of length greater than three, or Cn-free for all n>3 in shorthand notation. The freeness of graphical arrangements is completely characterized by chordality. If G=Kn, the complete graph on [n], then AG=An1.

    A natural deformation of the graphical arrangement turns up if we use generic elements ais to replace 0s in the equations of hyperplanes. Stanley explained the meaning of generic elements in [18] as follows.

    Let A be an arrangement in an n-dimensional vector space V and L1(x),,Lm(x) be linear forms, not necessarily distinct, in the variables x=(x1,,xn) over the field K. Let A be defined by L1(x)=a1,,Lm(x)=am, where a1,,am are generic elements of K. This means if Hi=ker(Li(x)ai), then

    Hi1HikLi1,,Likare linearly independent.

    Definition 2.1. Let G be a simple graph with vertex set V(G)=[n] and edge set E(G). The semigeneric graphical arrangement in Rn is defined by

    SG:={xixj=ai:ijE(G),1i<jn},

    where ais are generic. SG is simply a subarrangement of the semigeneric braid arrangement Sn. In particular, if G=Kn, then SG=Sn.

    According to the definitions of generic elements and SG, the genericity of ais can be sure when they take any numbers in R. We do not emphasize that ais are generic in later section.

    Clearer comprehending can be achieved by a simple example.

    Example 2.2. Figure 1 shows a simple graph G, a subgraph of K6, the semigeneric graphical arrangement SG consists of the following hyperplanes:

    x1x2=a1,x1x5=a1,x2x3=a2,x2x4=a2,x2x5=a2,x2x6=a2,x3x4=a3,x3x5=a3,x4x6=a4.
    Figure 1.  A subgraph of K6.

    There are a few powerful methods for computing the characteristic polynomials of hyperplane arrangements. In [7], Athanasiadis showed that simply by computing the number of points missing the hyperplanes (over finite fields) and by using the Möbius formula, the characteristic polynomials of many hyperplane arrangements can be computed. Our method is closer in spirit to [18] in which Stanley gives an interpretation of linearly independent subarrangement B of the generic braid arrangement in terms of the graph GB. We will provide a necessary and sufficient condition for a central semigeneric graphical arrangement SG from the point of graph G (i.e., Theorem 3.4).

    Lemma 3.1. The semigeneric graphical arrangement SG is central (i.e. HSGH) if the graph G is an acyclic graph.

    Proof. SG is central if the intersection of all the hyperplanes contains at least one point (x1,,xn). We can find such an assignment (x1,,xn) satisfying xixj=ai(ijE(G)). That can be done by just picking one from xis at a time since the graph G is acyclic and ai's are generic.

    Owing to Lemma 3.1, we consider the centrality of SG where G is a cycle.

    Lemma 3.2. If the arrangement S:={xijxij+1=bj:1ijn,j=1,,k,ik+1=i1}, then S is central if and only if kj=1bj=0.

    Proof. The arrangment S is central means there exists at least one point on all the hyperplanes, that is, at least a solution to the system of the equations of all the hyperplanes in S. That means rank(M(S))=rank((¯M(S)), where M(S) and ¯M(S) are the coefficient matrix and augmented matrix of the system of the equations, respectively.

    Perform the following series of elementary row operations on M(S) and ¯M(S), we have

    P(k,1(1))P(k,k1(1))M(S)=(B0)k×k,

    and

    P(k,1(1))P(k,k1(1))¯M(S)=(Bβ0kj=1bj)k×(k+1),

    where B is a (k1)×k matrix, βT=(b1,,bk1), vector 0=(0,,0)Rk, and P(i,j(m)) denotes the elementary matrix by adding m multiple of j-th row of the identity matrix to i-th row of the identity matrix. Distinctly, kj=1bj=0 if and only if rank(¯M(S))=rank(B)=rank(M(S)), that is, the arrangement S is central.

    Applying Lemma 3.2 to a semigeneric graphical arrangement, we get the following theorem.

    Theorem 3.3. Let G be a k-cycle with V(G)={i1,,ik}{1,,n}, the semigeneric graphical arrangement SG consists of the following hyperplanes:

    xijxij+1={aij,ifij<ij+1aij+1,ifij>ij+1.

    The arrangement SG is central if and only if kj=1(1)δjaij+δj=0, where δj={0,ifij<ij+11,ifij>ij+1.

    In the theorem below, we will characterize the central semigeneric graphical arrangement SG in terms of G.

    Theorem 3.4. The semigeneric graphical arrangement SG is central if and only if graph G satisfies one of the following two conditions:

    (1) G is an acyclic graph;

    (2) the semigeneric graphical arrangements of all cycles in G are central.

    Proof. Suppose C1,,Cp are p connected components of G which are not the isolated vertices. If all the subarrangements corresponding to C1,,Cp are central, then SG is central. Therefore, it suffices to prove SC is central, where C is a connected component of G containing cycles.

    Assume |E(C)|=t and SC:={ker(αixai)|1it}. Let T be a spanning tree of C which is a tree that contains every vertex of C, then ¯T=CE(T) is the cotree of T in C. Assume |V(C)|=s, then |V(T)|=s. Since a connected graph with s vertices is a tree if and only if it has s1 edges, let the normal vectors of the hyperplanes of ST be αu1,,αus1. Firstly, we will prove the vectors αu1,,αus1 form a basis of span(α1,,αt), a space spanned by α1,,αt. By Lemma 3.1, the vectors αu1,,αus1 are linearly independent, i.e., rank(αu1,,αus1)=s1. Moreover, by the definition of spanning tree, we know that T+e will generate a cycle D satisfying eE(D) for all eE(¯T). Assume |E(D)|=k and αv1,,αvk1 are the normal vectors of hyperplanes of SDe, it follows that

    αv1,,αvk1{αu1,,αus1},

    and the normal vector of hyperplane corresponding to e is αvk{α1,,αt}{αu1,,αus1}. Since D is a cycle, αvk is a linear combination of αv1,,αvk1, i.e.,

    αvkspan(αv1,,αvk1)span(αu1,,αus1).

    Since αvk is the normal vector of hyperplane for any eE(¯T), hence α1,,αtspan(αu1,,αus1), and the vectors αu1,,αus1 form a basis of span(α1,,αt).

    Let M(SC) and ¯M(SC) be the coefficient matrix and the augmented matrix of the linear system of the hyperplane equations of SC, respectively, that is,

    M(SC)=(α1αt)and¯M(SC)=(α1a1αtat).

    Since αu1,,αus1 form a basis of span(α1,,αt) and the semigeneric graphical arrangements of all cycles in G are central, according to Lemma 3.2, ¯M(SC) can be changed as follows by performing the same series of elementary row operations :

    (αu1au1αus1aus10000).

    So rank(M(SC))=rank(¯M(SC))=s1, i.e., SC is central.

    We complete the proof.

    For the characteristic polynomial of an arrangement A in n-dimensional vector space, we adopt Whitney's theorem [18] which gives a basic formula,

    χA(t)=BABiscentral(1)#Btnrank(B).

    Combining Whitney's theorem and Theorem 3.4, we will give a formula for the characteristic polynomial of the semigeneric graphical arrangement SG.

    Corollary 3.5. Let G be a simple graph with V(G)=[n], then the characteristic polynomial of SG is

    χSG(t)=D(1)|E(D)|tp(D),

    where D ranges over all spanning subgraphs of G, and D is an acyclic graph or semigeneric graphical arrangements of all cycles in D are central. |E(D)| denotes the number of the edges, and p(D) denotes the number of the connected components of D.

    Proof. Assume D is the spanning subgraph of G corresponding to the subarrangement B of SG. It is clear that #B=|E(D)|. The rank of B is the number of the edges of a spanning forest of D. Since a connected graph with n vertices is a tree if and only if it has n1 edges, the number of the edges of a spanning forest of a graph D is the number of vertices minus the number of connected components, that is rank(B)=np(D).

    In this section, we will give some applications of Theorem 3.4 and Corollary 3.5.

    Example 4.1. The defining polynomial of S4 (i.e., 4-dimensional semigeneric braid arrangement) is

    QS4=(x1x2a1)(x1x3a1)(x1x4a1)(x2x3a2)(x2x4a2)(x3x4a3),

    where a1,a2,a3 are generic elements. Table 1 illustrates all types of characteristic polynomials for S4, which depend on the values of a2,a3,a2+a3,a2a3. The symbol "T" in Table 1 indicates that the condition is met, and "F" indicates that the condition is not met.

    Table 1.  All types of characteristic polynomials for S4.
    a2=0 a3=0 a2+a3=0 a2a3=0 χS4(t)
    F F F F t46t3+15t215t
    F F T / F F / T t46t3+15t214t
    T / F F / T F F t46t3+13t210t
    T T T T t46t3+11t26t

     | Show Table
    DownLoad: CSV

    Example 4.2. For the semigeneric graphical arrangement SG of Example 2.2, we take a1=1,a2=3,a3=0,a4=2. Compute the characteristic polynomial χSG(t).

    According to Theorem 3.4, we need to figure out the central subarrangements of cycles in G, which depend on the values of the generic elements ais. In Figure 2, it is not difficult to see the semigeneric graphical arrangements corresponding to cycles (a)–(c) are central, the others are non-central.

    Figure 2.  Cycles in G.

    Obviously, a subarrangement of SG is central if and only if the corresponding subgraph D is an acyclic graph or only contains cycles (a), (b) or (c) in Figure 2. The isomorphism types of spanning subgraph D (with the number of distinct labelings written below D) are given by Figure 3.

    Figure 3.  The spanning subgraph D corresponding to a central subarrangement.

    For all the subgraphs D in Figure 3, we will list the number of connected components p(D), the number of edges |E(D)|, and the number of distinct labelings of D in Table 2.

    Table 2.  The values of p(D), |E(D)| and the number of distinct labelings of D.
    p(D) type |E(D)| the number of distinct labelings of D
    6 (a) 0 1
    5 (b) 1 9
    4 (c) 2 36
    (d), (e) 3 2
    3 (f) 3 80
    (g), (h), (i) 4 13
    (k) 5 1
    2 (j) 4 99
    (l), (m), (n) 5 30
    (p) 6 4
    1 (o) 5 55
    (q), (r), (s) 6 24
    (t) 7 4

     | Show Table
    DownLoad: CSV

    Hence, from Corollary 3.5, we get

    χSG(t)=t69t5+(362)t4(8013+1)t3+(9930+4)t2(5524+4)t=t69t5+34t468t3+73t235t.

    In this paper, we study the characteristic polynomial of the semigeneric graphical arrangement SG, which is a deformation of the graphical arrangement. The formula of the characteristic polynomial is obtained by characterizing central subarrangements of SG via the corresponding graph G. The semigeneric graphical arrangement SG is a subarrangement of the semigeneric braid arrangement (or type A semigeneric arrangement). It would be interesting to develop a new method for computing the characteristic polynomials of others types (e.g., type B and type D) of semigeneric arrangements in the future.

    The work was partially supported by Science and Technology Research Project of Jilin Province (No. JJKH20220719KJ) and NSF of China (No. 11501051).

    The authors declare no conflict of interest in this paper.



    Conflict of interest



    The authors declare no conflict of interest

    Author Contributions:



    Reddy will do the editing and Akinola do correction.

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