Employee exposure to specific risks often increases work-related stress, negatively impacting their effectiveness and potentially leading to illnesses, mistakes, or accidents.
We aimed to determine the psychosocial risks experienced by nurses in tertiary hospitals and their association with attitudes toward safety and the occurrence of medication errors.
A cross-sectional study was conducted between September 30, 2022 and December 31, 2023 in four Greek tertiary hospitals (Evangelismos, Nikaia “Agios Panteleimon”, University Hospital of Larissa, and “G. Papanikolaou”). The study involved 514 nurses aged 20–67, employed for at least 12 months, fluent in Greek, and completing questionnaires on stress, burnout, and medication errors. The questionnaire used in the study included demographic information of the nursing staff (age, gender, marital status, work experience, and education level), characteristics of the nursing unit (medical, surgical, long-term care unit, Intensive Care Unit), the COPSOQ III (Copenhagen Psychosocial Questionnaire Version III), the HSOPSC (Hospital Survey on Patient Safety Culture), and the questionnaire for Investigating Nursing Errors in Medication Administration.
Nurses exposed to psychosocial risks, such as bullying and high demands, reported increased medication errors. Supportive work environments with sufficient staffing and collaborative culture significantly mitigated these risks. Factors such as “Staffing” and “Handoffs” partially mediated the relationship between demands and errors. Thus, targeted interventions to reduce bullying and enhance teamwork are essential. Continuous education emerged as crucial for improving safety and performance.
The study underscores the necessity of social support, job autonomy, and work-life balance as critical factors in reducing stress and improving the quality of care. Specific strategies are proposed to enhance nurses' mental health and improve working conditions.
Citation: Vasileios Tzenetidis, Aristomenis Kotsakis, Mary Gouva, Konstantinos Tsaras, Maria Malliarou. Examining psychosocial risks and their impact on nurses' safety attitudes and medication error rates: A cross-sectional study[J]. AIMS Public Health, 2025, 12(2): 378-398. doi: 10.3934/publichealth.2025022
Employee exposure to specific risks often increases work-related stress, negatively impacting their effectiveness and potentially leading to illnesses, mistakes, or accidents.
We aimed to determine the psychosocial risks experienced by nurses in tertiary hospitals and their association with attitudes toward safety and the occurrence of medication errors.
A cross-sectional study was conducted between September 30, 2022 and December 31, 2023 in four Greek tertiary hospitals (Evangelismos, Nikaia “Agios Panteleimon”, University Hospital of Larissa, and “G. Papanikolaou”). The study involved 514 nurses aged 20–67, employed for at least 12 months, fluent in Greek, and completing questionnaires on stress, burnout, and medication errors. The questionnaire used in the study included demographic information of the nursing staff (age, gender, marital status, work experience, and education level), characteristics of the nursing unit (medical, surgical, long-term care unit, Intensive Care Unit), the COPSOQ III (Copenhagen Psychosocial Questionnaire Version III), the HSOPSC (Hospital Survey on Patient Safety Culture), and the questionnaire for Investigating Nursing Errors in Medication Administration.
Nurses exposed to psychosocial risks, such as bullying and high demands, reported increased medication errors. Supportive work environments with sufficient staffing and collaborative culture significantly mitigated these risks. Factors such as “Staffing” and “Handoffs” partially mediated the relationship between demands and errors. Thus, targeted interventions to reduce bullying and enhance teamwork are essential. Continuous education emerged as crucial for improving safety and performance.
The study underscores the necessity of social support, job autonomy, and work-life balance as critical factors in reducing stress and improving the quality of care. Specific strategies are proposed to enhance nurses' mental health and improve working conditions.
| [1] | Leka S, Jain A (2010) Health impact of psychosocial hazards at work: An overview. Biblioteca responsável : who-44428. |
| [2] | Koinis A, Saridis M (2014) Work-related stress and its impact on the professional and personal life of healthcare professionals. Rostrum of Asclepius/Vima tou Asklipiou 13. |
| [3] |
Velázquez M (2017) Comparative study of the psychosocial risks prevention enforcement by the European labour inspectorates. Psychosocial risks in labour and social security law: A comparative legal overview from Europe . North America, Australia and Japan: 31-52. https://doi.org/10.1007/978-3-319-63065-6_3
|
| [4] |
Da Costa BR, Vieira ER (2010) Risk factors for work-related musculoskeletal disorders: A systematic review of recent longitudinal studies. Am J Ind Med 53: 285-323. https://doi.org/10.1002/ajim.20750
|
| [5] |
Huber M, Knottnerus JA, Green L, et al. (2011) How should we define health?. BMJ 343: d4163. https://doi.org/10.1136/bmj.d4163
|
| [6] | Niebrój LT (2006) Defining health/illness: Societal and/or clinical medicine?. J Physiol Pharmacol 57: 251-262. |
| [7] |
Krishnan KS, Raju G, Shawkataly O (2021) Prevalence of work-related musculoskeletal disorders: Psychological and physical risk factors. Int J Environ Res Public Health 18: 9361. https://doi.org/10.3390/ijerph18179361
|
| [8] |
Brennan EJ (2017) Towards resilience and wellbeing in nurses. Br J Nurs 26: 43-47. https://doi.org/10.12968/bjon.2017.26.1.43
|
| [9] |
Garcia CL, Abreu LC, Ramos JLS, et al. (2019) Influence of burnout on patient safety: Systematic review and meta-analysis. Medicina (Kaunas) 55: 553. https://doi.org/10.3390/medicina55090553
|
| [10] | Wazqar DY, Kerr M, Regan S, et al. (2017) An integrative review of the influence of job strain and coping on nurses' work performance: Understanding the gaps in oncology nursing research. Int J Nurs Sci 4: 418-429. https://doi.org/10.1016/j.ijnss.2017.09.003 |
| [11] | Bambi S, Foà C, De Felippis C, et al. (2018) Workplace incivility, lateral violence and bullying among nurses. A review about their prevalence and related factors. Acta Bio Medica: Atenei Parmensis 89: 51-79. |
| [12] |
Khamisa N, Oldenburg B, Peltzer K, et al. (2015) Work related stress, burnout, job satisfaction and general health of nurses. Int J Environ Res Public Health 12: 652-666. https://doi.org/10.3390/ijerph120100652
|
| [13] |
Sitzman K (2017) Theory-guided self-care for mitigating emotional strain in nursing: Watson's caring science. Int J Human Caring 21: 66-76. https://doi.org/10.20467/HumanCaring-D-17-00009.1
|
| [14] |
Kowitlawkul Y, Yap S, Makabe S, et al. (2019) Investigating nurses' quality of life and work-life balance statuses in Singapore. Int Nurs Rev 66: 61-69. https://doi.org/10.1111/inr.12457
|
| [15] |
Cicolini G, Comparcini D, Simonetti V (2014) Workplace empowerment and nurses' job satisfaction: A systematic literature review. J Nurs Manag 22: 855-871. https://doi.org/10.1111/jonm.12028
|
| [16] |
Flinkman M, Leino-Kilpi H, Salanterä S (2010) Nurses' intention to leave the profession: integrative review. J Adv Nurs 66: 1422-1434. https://doi.org/10.1111/j.1365-2648.2010.05322.x
|
| [17] |
Kim H, Kim EG (2021) A meta-analysis on predictors of turnover intention of hospital nurses in South Korea (2000–2020). Nurs Open 8: 2406-2418. https://doi.org/10.1002/nop2.872
|
| [18] |
Chakraborty S, Mashreky SR, Dalal K (2022) Violence against physicians and nurses: A systematic literature review. Z Gesundh Wiss 30: 1837-1855. https://doi.org/10.1007/s10389-021-01689-6
|
| [19] |
Carton AM, Steinhardt K, Cordwell J (2022) Exploring factors which contribute to the resilience of nurses working in the neonatal care unit: A grounded theory study. Intensive Crit Care Nurs 68: 103137. https://doi.org/10.1016/j.iccn.2021.103137
|
| [20] |
Navajas-Romero V, Ariza-Montes A, Hernández-Perlines F (2020) Analyzing the job demands-control-support model in work-life balance: A study among nurses in the European context. Int J Environ Res Public Health 17: 2847. https://doi.org/10.3390/ijerph17082847
|
| [21] |
Morello RT, Lowthian JA, Barker AL, et al. (2013) Strategies for improving patient safety culture in hospitals: A systematic review. BMJ Qual Saf 22: 11-18. https://doi.org/10.1136/bmjqs-2011-000582
|
| [22] |
Weaver SJ, Lubomksi LH, Wilson RF, et al. (2013) Promoting a culture of safety as a patient safety strategy: A systematic review. Ann Intern Med 158: 369-374. https://doi.org/10.7326/0003-4819-158-5-201303051-00002
|
| [23] |
Elkin PL, Johnson HC, Callahan MR, et al. (2016) Improving patient safety reporting with the common formats: Common data representation for patient safety organizations. J Biomed Inform 64: 116-121. https://doi.org/10.1016/j.jbi.2016.09.020
|
| [24] |
Waterson P, Carman EM, Manser T, et al. (2019) Hospital Survey on Patient Safety Culture (HSPSC): A systematic review of the psychometric properties of 62 international studies. BMJ Open 9: e026896. https://doi.org/10.1136/bmjopen-2018-026896
|
| [25] | Campione J, Famolaro T (2018) Promising practices for improving hospital patient safety culture. Jt Comm J Qual Patient Saf 44: 23-32. https://doi.org/10.1016/j.jcjq.2017.09.001 |
| [26] |
Stavropoulou C, Doherty C, Tosey P (2015) How effective are incident-reporting systems for improving patient safety? A systematic literature review. Milbank Q 93: 826-866. https://doi.org/10.1111/1468-0009.12166
|
| [27] |
Upadhyay S, Stephenson AL, Weech-Maldonado R, et al. (2022) Hospital cultural competency and attributes of patient safety culture: A study of U.S. hospitals. J Patient Saf 18: e680-e686. https://doi.org/10.1097/PTS.0000000000000901
|
| [28] |
Mesfin D, Woldie M, Adamu A, et al. (2020) Perceived organizational culture and its relationship with job satisfaction in primary hospitals of Jimma zone and Jimma town administration, correlational study. BMC Health Serv Res 20: 438. https://doi.org/10.1186/s12913-020-05319-x
|
| [29] |
Tsai Y (2011) Relationship between organizational culture, leadership behavior and job satisfaction. BMC Health Serv Res 11: 98. https://doi.org/10.1186/1472-6963-11-98
|
| [30] |
Körner M, Wirtz MA, Bengel J, et al. (2015) Relationship of organizational culture, teamwork and job satisfaction in interprofessional teams. BMC Health Serv Res 15: 243. https://doi.org/10.1186/s12913-015-0888-y
|
| [31] |
Mannion R, Davies H (2018) Understanding organisational culture for healthcare quality improvement. BMJ 363: k4907. https://doi.org/10.1136/bmj.k4907
|
| [32] |
Sandlin D (2007) Improving patient safety by implementing a standardized and consistent approach to hand-off communication. J Perianesth Nurs 22: 289-292. https://doi.org/10.1016/j.jopan.2007.05.010
|
| [33] |
Leonard M, Graham S, Bonacum D (2004) The human factor: The critical importance of effective teamwork and communication in providing safe care. Qual Saf Health Care 131: i85-90. https://doi.org/10.1136/qshc.2004.010033
|
| [34] |
Schnock KO, Dykes PC, Albert J, et al. (2017) The frequency of intravenous medication administration errors related to smart infusion pumps: A multihospital observational study. BMJ Qual Saf 26: 131-140. https://doi.org/10.1136/bmjqs-2015-004465
|
| [35] |
Keers RN, Williams SD, Cooke J, et al. (2013) Causes of medication administration errors in hospitals: A systematic review of quantitative and qualitative evidence. Drug Saf 36: 1045-1067. https://doi.org/10.1007/s40264-013-0090-2
|
| [36] |
Westbrook JI, Li L, Hooper TD, et al. (2017) Effectiveness of a ‘Do not interrupt’ bundled intervention to reduce interruptions during medication administration: A cluster randomized controlled feasibility study. BMJ Qual Saf 26: 734-742. https://doi.org/10.1136/bmjqs-2016-006123
|
| [37] |
Armitage G, Knapman H (2003) Adverse events in drug administration: A literature review. J Nurs Manag 11: 130-140. https://doi.org/10.1046/j.1365-2834.2003.00359.x
|
| [38] |
Ferner RE, Aronson JK (2006) Clarification of terminology in medication errors: Definitions and classification. Drug Saf 29: 1011-1022. https://doi.org/10.2165/00002018-200629110-00001
|
| [39] |
Parry AM, Barriball KL, While AE (2015) Factors contributing to registered nurse medication administration error: A narrative review. Int J Nurs Stud 52: 403-420. https://doi.org/10.1016/j.ijnurstu.2014.07.003
|
| [40] | Rodziewicz TL, Hipskind JE (2020) Medical error prevention. StatPearls Treasure Island (FL): StatPearls Publishing. |
| [41] |
Lesar TS (2002) Prescribing errors involving medication dosage forms. J Gen Intern Med 17: 579-587. https://doi.org/10.1046/j.1525-1497.2002.11056.x
|
| [42] |
Wilson K, Sullivan M (2004) Preventing medication errors with smart infusion technology. Am J Health Syst Pharm 61: 177-183. https://doi.org/10.1093/ajhp/61.2.177
|
| [43] | Serembus JF, Wolf ZR, Youngblood N (2001) Consequences of fatal medication errors for health care providers: A secondary analysis study. MedSurg Nurs 10: 193. |
| [44] |
Lisby M, Nielsen LP, Mainz J (2005) Errors in the medication process: Frequency, type, and potential clinical consequences. Int J Qual Health Care 17: 15-22. https://doi.org/10.1093/intqhc/mzi015
|
| [45] |
Dimant J (2002) Medication errors and adverse drug events in nursing homes: Problems, causes, regulations, and proposed solutions. J Am Med Dir Assoc 2: 81-93. https://doi.org/10.1016/S1525-8610(04)70166-8
|
| [46] | Cohen MR, Smetzer JL, Tuohy NR, et al. (2007) High-alert medications: Safeguarding against errors. Medication Errors . Washington (DC): American Pharmaceutical Association 317-411. https://doi.org/10.21019/9781582120928.ch14 |
| [47] | Kotsakis A, Avraam D, Malliarou M, et al. Psychosocial factors in evidence-based management interventions and policymaking: The COPSOQ III Greek validation study (2024). [Preprint]. https://doi.org/10.21203/rs.3.rs-4888710/v1 |
| [48] |
Burr H, Berthelsen H, Moncada S, et al. (2019) The third version of the Copenhagen psychosocial questionnaire. Saf Health Work 10: 482-503. https://doi.org/10.1016/j.shaw.2019.10.002
|
| [49] | Kotsakis A, Nübling M (2018) Employability in the 21st Century. The Greek COPSOQ v. 3 Validation Study, a post crisis assessment of the Psychosocial Risks . Leuven, Belgium: Conference Book 63. |
| [50] |
Malliarou M, Kotsakis A (2023) Psychosocial work environment during the COVID-19 pandemic. Front Public Health 11: 1272290. https://doi.org/10.3389/fpubh.2023.1272290
|
| [51] | Kapaki V, Souliotis K Psychometric properties of the hospital survey on patient safety culture (HSOPSC): Findings from Greece: InTech Rijeka (2018). https://doi.org/10.5772/intechopen.69997 |
| [52] | Abdou HA, Saber KM (2011) A baseline assessment of patient safety culture among nurses at student university hospital. World J Med Sci 6: 17-26. |
| [53] | Mitsis D, Kelesi M, Kapadothos T Risk factors for pharmaceutical errors by nurses in intensive care units (2014)53: 55-64. Available from: https://www.researchgate.net/publication/310617569_Risk_factors_for_pharmaceutical_errors_by_nurses_in_intensive_care_units. |
| [54] |
Hayes AF (2009) Beyond Baron and Kenny: Statistical mediation analysis in the new millennium. Commun Monogr 76: 408-420. https://doi.org/10.1080/03637750903310360
|
| [55] |
Preacher KJ, Hayes AF (2004) SPSS and SAS procedures for estimating indirect effects in simple mediation models. Behav Res Methods Instrum Comput 36: 717-731. https://doi.org/10.3758/BF03206553
|
| [56] |
Preacher KJ, Hayes AF (2008) Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. Behav Res Methods 40: 879-891. https://doi.org/10.3758/BRM.40.3.879
|
| [57] |
Baron RM, Kenny DA (1986) The moderator–mediator variable distinction in social psychological research: Conceptual, strategic, and statistical considerations. J Pers Soc Psychol 51: 1173-1182. https://doi.org/10.1037/0022-3514.51.6.1173
|
| [58] |
Sobel ME (1982) Asymptotic confidence intervals for indirect effects in structural equation models. Sociol Methodol 13: 290-312. https://doi.org/10.2307/270723
|
| [59] | England N, Improvement N The NHS patient safety strategy. Safer culture, safer systems, safer patients (2019). https://www.improvementacademy.org/wp-content/uploads/2022/04/Report-template-NHSI-website-for-PSC-Page.pdf |
| [60] |
Hoenders R, Ghelman R, Portella C, et al. (2024) A review of the WHO strategy on traditional, complementary, and integrative medicine from the perspective of academic consortia for integrative medicine and health. Front Med (Lausanne) 11: 1395698. https://doi.org/10.3389/fmed.2024.1395698
|
| [61] |
MacPhee M, Dahinten VS, Havaei F (2017) The impact of heavy perceived nurse workloads on patient and nurse outcomes. Adm Sci 7: 7. https://doi.org/10.3390/admsci7010007
|
| [62] | (2021) Systems EOOH, PoliciesState of health in the EU France: Country health profile 2021. OECD Publishing. |
| [63] |
Ball JE, Bruyneel L, Aiken LH, et al. (2018) Post-operative mortality, missed care and nurse staffing in nine countries: A cross-sectional study. Int J Nurs Stud 78: 10-15. https://doi.org/10.1016/j.ijnurstu.2017.08.004
|
| [64] |
He J, Staggs VS, Bergquist-Beringer S, et al. (2016) Nurse staffing and patient outcomes: A longitudinal study on trend and seasonality. BMC Nurs 15: 60. https://doi.org/10.1186/s12912-016-0181-3
|