DNA direct repair pathways in cancer

  • Received: 21 June 2018 Accepted: 15 August 2018 Published: 24 August 2018
  • DNA direct repair (DR) pathways are unique in DNA repair because those mechanisms restore the genetic information without any DNA synthesis and are thus error free. We review the DR mechanisms, consequences of the absence of those systems in cells, their occurrence in cancer, regulation of their genes and proteins in cancer cells, and the potential exploitation of inhibitors to enhance chemotherapy.

    Citation: Roberto Gutierrez, Yesenia Thompson, Timothy R. O’Connor. DNA direct repair pathways in cancer[J]. AIMS Medical Science, 2018, 5(3): 284-302. doi: 10.3934/medsci.2018.3.284

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  • DNA direct repair (DR) pathways are unique in DNA repair because those mechanisms restore the genetic information without any DNA synthesis and are thus error free. We review the DR mechanisms, consequences of the absence of those systems in cells, their occurrence in cancer, regulation of their genes and proteins in cancer cells, and the potential exploitation of inhibitors to enhance chemotherapy.

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