Predicting the prognosis of HER2-positive breast cancer patients by fusing pathological whole slide images and clinical features using multiple instance learning

1.   Introduction

A surface that arises when a curve $\alpha (u)$ is translated over another curve $\beta (v)$ is called a translation surface. A translation surface is defined to be the sum of two curves $\alpha (u)$ and $\beta (v)$, which are called generating curves. Therefore, translation surfaces are made up of quadrilateral, that is, four sided, facets. Because of this property, translation surfaces are used in architecture to design and construct free-form glass roofing structures. A translation surface in Euclidean 3-space by two curves in orthogonal planes, is given in ^[2,3] as a graph of the function $z(u, v) = f(u)+g(v),$ such that $f(u)$ and $g(v)$ are smooth functions defined on an interval of $\mathbb{R}$.

The translation surfaces in $\mathbb{E}^{3}$ studied by H. F. Scherk ^[1] are obtained as a graph of the sum $z(u, v) = f(u)+g(v)$, and where he proved that the only minimal translation surfaces are the those denoted by

where $a$ is a non-zero constant. These surfaces^[12,13] are nowadays said to be Scherk's minimal surfaces.

Constant mean curvature and constant Gaussian curvature surfaces have been the main problem for the geometers for a long time. Translation surfaces with constant mean curvature, in particular, zero mean curvature, in the Euclidean space and the Minkowski space are stated in ^[7]. Lone and Karacan yield categorization of dual translation surface, which has constant dual isotropic mean curvature or constant dual isotropic Gaussian curvature ^[8]. Dillen, Goemans and Woestyne obtained a categorization of translation surfaces in the 3-dimensional Euclidean and Minkowski space such that the Weingarten circumstance is satisfying ^[5].

Sipus and Divjak ^[11] explained translation surfaces in the Galilean space having constant Gaussian and mean curvatures together with translation Weingarten surfaces. Yoon searched coordinate finite type translation surfaces in $\mathbb{G}_{3}$ and explained some examples of new classes of translation surfaces ^[12]. He also studied a translation surface in $\mathbb{G}_{3}$ with a log-linear density and classified such a surface with vanishing weighted mean curvature^[13].

LN-surfaces, which were taken into account in ^[6] with enough elasticity to model smooth surfaces. Peternell and Odehnal generalized the idea of LN-surfaces to $\mathbb{R}^{4}$ ^[9]. Bulca calculated the Gaussian, normal and mean curvatures of LN- surfaces in $\mathbb{E}^{4}$. Further, she pointed out the flat and minimal points of the surfaces in ^[3]. Sampoli, Peternell and Jüttler indicate that even the convolution surface of an LN-surface and any rational surface admits rational parametrization ^[10]. Moreover, LN and LCN translation surfaces have been characterized in 3-dimensional affine and Euclidean spaces in ^[14,15].

In this study, the dual translation surfaces defined by $z = f(u)+g(v)$, are considered in the three dimensional Galilean space $\mathbb{G}_{3}$.

2.   Preliminaries

We emphasize that the Galilean space $\mathbb{G}_{3}$ is a Cayley-Klein space associated with a 3-dimensional projective space $\mathcal{P}(\mathbb{R}^{3})$ with the absolute figure. The reader is referred to ^[11,12] for more details of

The group of motions of $G_{3}$ is a six-parameter group given in affine coordinates by

with respect to the absolute figure, there are two types of lines in the Galilean space - isotropic lines which intersect the absolute line $f$ and non-isotropic lines which do not. A plane is called Euclidean if it includes $f$, whereas it is said isotropic. In the given affine coordinates, isotropic vectors are of the form $(0, y, z)$, but Euclidean planes are of the form $x = k, k\in$ $\mathbb{R}$. The induced geometry of a Euclidean plane is Euclidean, and of an isotropic plane isotropic (i.e., 2-dimensional Galilean or flag-geometry).

A $C^{r}$-surface $S$, $r\geq 1$, immersed in the Galilean space, $\Psi$ $:U\rightarrow \mathbb{G}_{3}, U\subset \mathbb{R}^{2}$, $\Psi (u, v) = (x(u, v), y(u, v), z(u, v))$ has the following first fundamental form

where the symbols $g_{i} = x_{i},$ $h_{ij} = \overset{\sim }{\Psi _{i}}.\overset{ \sim }{\Psi _{j}}$ stand for derivatives of the first coordinate function $x(u, v)$ with respect to $u, v$ and for the Euclidean scalar product of the projections $\overset{\sim }{\Psi }_{k}$ of vectors $\Psi _{k}$ onto the $yz$ -plane, respectively. Furthermore,

At every point of a surface, there exists a unique isotropic direction defined by $g_{1}du+g_{2}dv = 0$. In that direction, the arc length is measured by

where $g_{1}\neq 0$. A surface is called admissible if it has no Euclidean tangent planes. Therefore, for an admissible surface either $g_{1}\neq 0$ or $g_{2}\neq 0$ holds. The Gaussian curvature $K$ and mean curvature $H$ are $C^{r-2}$ functions, $r\geq 2$, defined by

where

We will use $L_{ij}$, $i, j = 1, 2,$ for $L,$ $M,$ $N$. The vector $U$ defines a normal vector to a surface and given by

where $W^{2} = \left(x_{2}\Psi _{1}-x_{1}\Psi _{2}\right)^{2}$ ^[11]. It is well known that in terms of local coordinates $\left \{ u, v\right \}$ of $S$, the Laplacian operator $\Delta ^{II}$ according to the second fundamental form on $S$ is defined by ^[4]

Consider a surface in $G_3$ as the graph of a function $z = h(u, v)$. We will consider translation surfaces of Type 1 that are obtained by translating two planar curves. Translation surfaces of Type 1 in the Galilean 3-space can be locally represented by

which yields the parametrization

One translated curve is a non-isotropic curve in the plane $y = 0$ and given as

and the other is an isotropic curve in the plane $x = 0$ and it is expressed as

Let $S$ be a Monge patch parametrized by $z = h(u, v)$, then the surface

is called a dual surface of $\ S^{\ast }$ in $\mathbb{G}_{3}$ and the normal vector of $S^{\ast }$ is given by

The Gaussian curvature of the dual surface is

Definition 1. A surface $S$ in $\mathbb{G}_{3}$ is said to be Weingarten surface if and only if there exists a non-trivial functional relation $\Phi \left(K, H\right) = 0$ between the Gaussian curvature and mean curvature of $S$. The condition $\Phi \left(K, H\right) = 0$ is equivalent to the vanishing of the corresponding Jacobian determinant, i.e., $\left \vert \frac{\partial \left(K, H\right) }{ \partial \left(u, v\right) }\right \vert = 0$. A linear Weingarten surface in Galilean 3-space is a surface where there exists a relation $aK+bH = c$ for some non-zero real numbers $a, b, c$ ^[5,10].

In ^[11], Sipus and Divjak analyzed the translation surface of Type 1, which has the constant Gaussian and mean curvatures in the Galilean 3-space $\mathbb{G}_{3}$ and they showed the following theorems:

Theorem 1. If $S$ is a translation surface of Type 1 of constant Gaussian curvature in the Galilean 3-space, then $S$ is congruent to a particular surface with

$a, b, c\in \mathbb{R}$, and

for $A, B, C, C_1\in \mathbb{R}$, where $K = f^{\prime \prime }(x)k^{\prime \prime }(u)$ and $h^{\prime ^{2}}+k^{\prime ^{2}} = 1.$

Theorem 2. If $S$ is a translation surface of Type 1 of constant mean curvature $H\neq$ $0$ in the Galilean 3-space, then $S$ is congruent to a surface

where $c_{1}, c_{2}\in \mathbb{R}.$

3.   Dual translation surfaces in $\mathbb{G}_{3}$

The main aim of this section is to give a classification of dual translation surfaces with constant Gaussian and mean curvatures in the Galilean 3-space. Let $S^{\ast {\text{ }}}$ be a dual translation surface. Using (2.3) and (2.5), we can define dual translation surfaces as

The unit normal vector field $U^{\ast }$ of the surface (3.1) is

By a straightforward computation, the Gaussian and mean curvatures of the dual translation surface are given by

where $f^{\prime \prime }, g^{\prime \prime }\neq 0$. Thus we have the following result.

Corollary 1. If $S^{\ast }$ is a dual translation surface in the Galilean 3-space, then there are no flat and minimal dual translation surfaces.

Proof. The proof is obvious by Eq (3.3).

Theorem 3. Let $S^{\ast }$ be a dual translation surface which has constant Gaussian curvature in $\mathbb{G}_{3}$. Then it is congruent to an open part of the surface (3.1) with

Proof. Dual translation surface with constant curvature $K_{0}^{\ast }$ is described by the ordinary differential equation

By partial differentiation of the previous expression with respect to $v$, we get

Therefore either $f^{\prime \prime } = 0$ or

If $f^{\prime \prime } = 0$, then we have a contradiction. The general solution of (3.5) is given by

where $c_{i}\in \mathbb{R}$. Therefore, $S$ is determined by

where $f^{\prime \prime }\neq 0$ (see Figure 1).

Theorem 4. Let $S^{\ast }$ be a dual translation surface which has constant mean curvature in $\mathbb{G}_{3}$. Then it is congruent to an open part of the surface (3.1) with

Proof. We suppose that dual translation surface has constant mean curvature. Then we obtain

After solving (3.7), we get

Therefore $S$ is determined by

where $c_{i}\in \mathbb{R}$ (see Figure 2).

Theorem 5. Let $S^{\ast }$ be a Weingarten dual translation surface in $\mathbb{G}_{3}$. Then it is congruent to an open part of the surface (3.1) with

or

Proof. The condition $\frac{\partial \left(K^{\ast }, H^{\ast }\right) }{\partial \left(u, v\right) } = 0$ must be satisfied for the Weingarten surface $S^{\ast }$, it leads to $K_{u}^{\ast }H_{v}^{\ast }-K_{v}^{\ast }H_{u}^{\ast } = 0.$ Since the mean curvature $H_{v}^{\ast }$ is a function of $v$ only, the previous equation reduces $K_{u}^{\ast }H_{v}^{\ast } = 0.$ Therefore, either $K_{u}^{\ast }$ $= 0$ or $H_{v}^{\ast } = 0$. The first condition $K_{u}^{\ast }$ $= 0$ describes that a dual translation surface satisfies

Therefore $f^{\prime \prime \prime }$ $= 0$ which implies

If the second condition $H_{v}^{\ast } = 0,$ then we have

and

where $c_{i}\in \mathbb{R}$. Thus $S$ is determined by either

see Figure 3,

or

see Figure 4.

Theorem 6. Let $S^{\ast }$ be a linear Weingarten dual translation surface satisfying $aK^{\ast }+bH^{\ast } = c$, where $a, b, c$ are real constants. Then $S^{\ast }$ is congruent to (3.1) with

Proof. Let us consider surface with $a\neq 0, b\neq 0$. A dual translation surface is linear Weingarten if and only if

which can be written as

where $m\in \mathbb{R}$. Therefore, we get

where $c_{i}, m\in \mathbb{R}$ and they satisfy the functional relationship $aK^{\ast }+bH^{\ast } = c$ for any constants $a, b, c$, (see Figure 5).

Theorem 7. Let $S^{\ast }$ be a dual translation surface given by (3.1) in the three dimensional Galilean space $\mathbb{G}_{3}$. Then there is no surface $S^{\ast }$ satisfies the condition $\Delta ^{II}\Psi = \lambda _{i}\Psi _{i},$ where $\lambda _{i}\bf{\in }\mathbb{R}\bf{, }$ $i\bf{ = }1, 2, 3.$

Proof. We classify dual translation surfaces in $\mathbb{G}_{3}$ satisfying the equation

where $\lambda _{i}\bf{\in }\mathbb{R}\bf{, }$ $i\bf{ = }1, 2, 3$ and

By a straightforward computation, using Eq (2.2), the Laplacian operator on $S^{\ast }$ turns out to be

So Eq (3.13) by means of (3.15) gives the following system of ordinary differential equations

where $\lambda _{i}\in$ $\mathbb{R}.$ On combining Eqs (3.16)–(3.18), we have

which can be written as

where $\lambda _{i}, m\in$ $\mathbb{R}.$ If $\left \{ \lambda _{1}, \lambda _{2}, \lambda _{3}\right \} = \left \{ 0, 0, 0\right \},$ hence we have a contradiction. In the cases $\left \{ \lambda _{1}, \lambda _{2}\neq 0, \lambda _{3}\neq 0\right \}$, there are no analytical solutions for the function $g(v)$. We discuss three cases with respect to constants $\lambda _{1}, \lambda _{2}, \lambda _{3}$. We summarized the solutions of (3.20) in the following:

for some constants $c_{i}\neq 0$ and $\lambda _{i}\neq 0$. In the third row, we have a contradiction for the function $f(u)$, because substituting the first and second rows into (3.14)–(3.16), respectively we can easily see that they do not satisfy these equations.

Theorem 8. The dual translation surface $H^{\ast ^{2}}-K^{\ast }$ $= 0$ is locally a generalized umbilical surface and it can be stated to be a surface (3.1) by

Proof. Next, we aim to classify the dual translation surfaces given by (3.1) in $\mathbb{G}_{3}$ that satisfy

$H^{\ast ^{2}}-K^{\ast }$ $= 0$. By considering Eq (3.3), we have

We can rewrite (3.21) as

which implies

Solving this, we obtain

where $m, c_{i}\in$ $\mathbb{R}$ (see Figure 6).

4.   Results

A rational surface $S^{\ast }$ in $\mathbb{R}^{3}$ is called LN-surface if its tangent planes admit the representation $T(u, v) = ux+vy+z = h(u, v)$ with a rational function $h(u, v) = f(u)+g(v).$ In the present study, we have defined these surfaces in Galilean 3-space and called these surfaces as dual translation surfaces.

We also have calculated the Gaussian and mean curvatures of these surfaces. Further, we have pointed out the constant Gaussian and mean curvatures of these surfaces.

We have discussed whether these surfaces satisfy the Laplacian operator with respect to the second fundamental form.

Conflict of interest

The author states that she has no conflict of interests.