Research article Special Issues

Track the dynamical features for mutant variants of COVID-19 in the UK


  • Received: 21 March 2021 Accepted: 17 May 2021 Published: 26 May 2021
  • Aims

    The main purpose of this study is to explore whether the new variant SARS-CoV-2 VOC 202012/01 in the UK is equipped with some leading or underlying features.

    Methods

    We apply a systematic and persuasive approach to reveal the underlying dynamical features of this variant. The approach utilises extracting the main features, which consist of 3-valued features, via the time-series data for new cases, 28-day deaths and 60-day deaths. The experimental samples chosen rely on the the rolling sets of regional data vectors whose dimensions are all 7 days. These data sets are projected onto the 3-valued features to yield the vector rejections. Then the minimal features are thus extracted by the minimal total norms. Then we map out the traces of the similarities between all the extracted time-varying features.

    Results

    Our findings, no matter in preliminary or follow-up study, clearly show there is no consistent and substantial shift in the 3-valued features even after the occurrence of this new variant - this might validate the efficacy of the current vaccines against this variant.

    Conclusions

    Since the underlying features of the mutant is unchanged, and the leading feature of B1.1.7 is not yet present, it might help us make the lockdown decision "choose the lesser of the two evils: pandemic and economic woes", and validate vaccine developments or adopt preventive measures.

    Citation: Ray-Ming Chen. Track the dynamical features for mutant variants of COVID-19 in the UK[J]. Mathematical Biosciences and Engineering, 2021, 18(4): 4572-4585. doi: 10.3934/mbe.2021232

    Related Papers:

  • Aims

    The main purpose of this study is to explore whether the new variant SARS-CoV-2 VOC 202012/01 in the UK is equipped with some leading or underlying features.

    Methods

    We apply a systematic and persuasive approach to reveal the underlying dynamical features of this variant. The approach utilises extracting the main features, which consist of 3-valued features, via the time-series data for new cases, 28-day deaths and 60-day deaths. The experimental samples chosen rely on the the rolling sets of regional data vectors whose dimensions are all 7 days. These data sets are projected onto the 3-valued features to yield the vector rejections. Then the minimal features are thus extracted by the minimal total norms. Then we map out the traces of the similarities between all the extracted time-varying features.

    Results

    Our findings, no matter in preliminary or follow-up study, clearly show there is no consistent and substantial shift in the 3-valued features even after the occurrence of this new variant - this might validate the efficacy of the current vaccines against this variant.

    Conclusions

    Since the underlying features of the mutant is unchanged, and the leading feature of B1.1.7 is not yet present, it might help us make the lockdown decision "choose the lesser of the two evils: pandemic and economic woes", and validate vaccine developments or adopt preventive measures.



    加载中


    [1] European Centre for Disease Prevention and Control, Rapid increase of a SARS-CoV-2 variant with multiple spike protein mutations observed in the United Kingdom, Threat Assess. Brief, 2020 (2020), 1–13.
    [2] A. S. Lauring, E. B. Hodcroft, Genetic Variants of SARS-CoV-2—What Do They Mean?, JAMA, 325 (2021), 529–531. doi: 10.1001/jama.2020.27124
    [3] Public Health England, Investigation of novel SARS-CoV-2 variant Variant of Concern 202012/01 Technical briefing 2, 2020.
    [4] R. S. Baric, Emergence of a Highly Fit SARS-CoV-2 Variant, N. Engl. J. Med., 383 (2020), 2684–2686. doi: 10.1056/NEJMcibr2032888
    [5] J. W. Tang, P. A Tambyah, D. C. Hui, Emergence of a new SARS-CoV-2 variant in the UK, J. Infect., 82 (2020), E27–E28.
    [6] J. Wise, Covid-19: New coronavirus variant is identified in UK, BMJ, 371 (2020), m4857.
    [7] New coronavirus variants aren't cause for alarm yet, but mutations could make COVID-19 harder to fight, experts say, Accessed at 11th, January, 2021. Available from: https://www.usatoday.com/story/news/health/2021/01/09/new-coronavirus-strains-variants-not-yet-cause-for-more-covid-vaccine-concerns-experts-say/6575267002/.
    [8] Coronavirus mutation no reason to panic: virologist, Accessed at 10th, January, 2021. Available from: https://www.dw.com/en/coronavirus-mutation-no-reason-to-panic-virologist/a-56008220.
    [9] World Health Organization, SARS-CoV-2 Variants, Accessed at 11th, January, 2021. Available from: https://www.who.int/csr/don/31-december-2020-sars-cov2-variants/en/.
    [10] K. Kupferschmidt, Viral mutations may cause another 'very, very bad' COVID-19 wave, scientists warn, Science, Jan. 5, 2021.
    [11] Centers for Disease Control and Prevention, Interim: Implications of the Emerging SARS-CoV-2 Variant VOC 202012/01, Accessed at 10th, January, 2021.
    [12] E. Callaway, Could new COVID variants undermine vaccines? Labs scramble to find out, Nature, 589 (2021), 177–178. doi: 10.1038/d41586-021-00031-0
    [13] GOV.UK, Coronavirus (COVID-19) in the UK, Accessed at 9th, January, 2021. Available from: https://coronavirus.data.gov.uk/details/download.
    [14] I. Jolliffe, Principal component analysis, in International Encyclopedia of Statistical Science, Springer, Berlin, 2011.
    [15] S. Nagarajaiah, B. Basu, Output only modal identification and structural damage detection using time frequency & wavelet techniques, Earthquake Eng. Eng. Vib., 8 (2009), 583–605. doi: 10.1007/s11803-009-9120-6
    [16] GOV. UK, Coronavirus (COVID-19) in the UK, Accessed at 12th, May, 2021. https://api.coronavirus.data.gov.uk/v2/data?areaType=region&metric=newCasesBySpecimenDate&metric=newDeaths28DaysByDeathDate&metric=newDeaths60DaysByDeathDate&format=csv&release=2021-05-12
    [17] R. M. Chen, Randomness for Nucleotide Sequences of SARS-CoV-2 and Its Related Subfamilies, Comput. Math. Methods Med., 2020 (2020), 1–8.
    [18] European Centre for Disease Prevention and Control, Risk related to spread of new SARS-CoV-2 variants of concern in the EU/EEA-first update, ECDC: Stockholm, 21 January 2021.
  • Reader Comments
  • © 2021 the Author(s), licensee AIMS Press. This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0)
通讯作者: 陈斌, bchen63@163.com
  • 1. 

    沈阳化工大学材料科学与工程学院 沈阳 110142

  1. 本站搜索
  2. 百度学术搜索
  3. 万方数据库搜索
  4. CNKI搜索

Metrics

Article views(2195) PDF downloads(99) Cited by(3)

Article outline

Figures and Tables

Figures(4)  /  Tables(4)

Other Articles By Authors

/

DownLoad:  Full-Size Img  PowerPoint
Return
Return

Catalog