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Chitosan-Based Nanomaterials for Skin Regeneration

Center of Natural and Human Sciences, Federal University of ABC (UFABC), Santo André, SP, Brazil

Chitosan (CS) is a renewable polysaccharide widely used for the preparation of biomaterials due to its special properties such as its biodegradability and biocompatibility, mucoadhesive behavior, and antibacterial and anti-inflammatory effects. These features are very important for biomedical applications, especially for tissue engineering and skin regeneration. From the clinical point of view, there is an increasing demand for the development of new materials/scaffolds with dual roles: the promotion of skin tissue repair and the simultaneous exertion of potent antimicrobial effects. Nanotechnology has been extensively employed in several pharmacological applications, including cutaneous tissue repair and antimicrobial treatments. The combination of CS and nanotechnology might create new avenues in tissue engineering. In this sense, this review presents and discusses recent advantages and challenges in the design of CS-based nanomaterials (in the form of nanofibers, composite nanoparticles, and nanogels) for cutaneous tissue regeneration. The combination of CS-based nanomaterials with other polymers, active drugs and metallic nanoparticles is also discussed from the viewpoint of designing suitable platforms for regenerative medicine and tissue engineering.
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